UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine; UMass Worcester Prevention Research Center
Publication Date
2016-05-24
Document Type
Article
Disciplines
Clinical Epidemiology | Dietetics and Clinical Nutrition | Epidemiology | Neoplasms | Women's Health
Abstract
BACKGROUND: Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death.
METHODS: The DII was calculated from a baseline food frequency questionnaire in 122 788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 years, there were 7495 breast cancer cases and 667 breast cancer deaths. We used Cox regression to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by DII quintiles (Q) for incidence of overall breast cancer, breast cancer subtypes, and deaths from breast cancer. The lowest quintile (representing the most anti-inflammatory diet) was the reference.
RESULTS: The DII was not associated with incidence of overall breast cancer (HRQ5vsQ1, 0.99; 95% CI, 0.91-1.07; Ptrend=0.83 for overall breast cancer). In a full cohort analysis, a higher risk of death from breast cancer was associated with consumption of more pro-inflammatory diets at baseline, after controlling for multiple potential confounders (HRQ5vsQ1, 1.33; 95% CI, 1.01-1.76; Ptrend=0.03).
CONCLUSIONS: Future studies are needed to examine the inflammatory potential of post-diagnosis diet given the suggestion from the current study that dietary inflammatory potential before diagnosis is related to breast cancer death.
Keywords
dietary inflammatory index, breast cancer, incidence, mortality, Women’s Health Initiative
Rights and Permissions
This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License.
DOI of Published Version
10.1038/bjc.2016.98
Source
Br J Cancer. 2016 May 24;114(11):1277-85. doi: 10.1038/bjc.2016.98. Epub 2016 Apr 21. Link to article on publisher's site
Journal/Book/Conference Title
British journal of cancer
Related Resources
PubMed ID
27100730
Repository Citation
Tabung, Fred K.; Steck, Susan E.; Liese, Angela D.; Zhang, Jiajia; Ma, Yunsheng; Caan, Bette J.; Chlebowski, Rowan T.; Freudenheim, Jo L.; Hou, Lifang; Mossavar-Rahmani, Yasmin; Shivappa, Nitin; Vitolins, Mara Z.; Wactawski-Wende, Jean; Ockene, Judith K.; and Hebert, James R., "Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative" (2016). Preventive and Behavioral Medicine Publications. 346.
https://escholarship.umassmed.edu/prevbeh_pp/346
Included in
Clinical Epidemiology Commons, Dietetics and Clinical Nutrition Commons, Epidemiology Commons, Neoplasms Commons, Women's Health Commons
