The effect of micronutrient supplementation on disease progression and death in simian immunodeficiency virus-infected juvenile male rhesus macaques
Department of Medicine, Division of Preventive and Behavioral Medicine
Animals; Body Mass Index; Body Weight; Bone Density; *Dietary Supplements; Macaca mulatta; Micronutrients; Nutritional Requirements; Simian Acquired Immunodeficiency Syndrome; Survival Analysis
Infectious Disease | Veterinary Medicine
BACKGROUND: We investigated the impact that micronutrient supplementation has on the progression of simian acquired immunodeficiency syndrome (SAIDS).
METHODS: Twenty-four simian immunodeficiency virus-infected juvenile male rhesus macaques were randomized into 2 groups. One group was given certified chow, and the other group was given chow and a supplement that contained 2-3 times the estimated nutritional requirement of micronutrients. Virological, immunological, and body composition measurements were taken every 4 weeks for 120 weeks.
RESULTS: There was no difference between groups in weight gain, body mass index (BMI), crown-heel length, waist circumference, total tissue mass, lean mass, bone mineral content, or bone mineral density. The rhesus macaques on the supplemented diet had a higher death rate (hazard ratio, 2.39; P<.001) than those on the nonsupplemented diet; death in both groups was associated with a higher viral load set point during the early phase of infection. Additionally, higher body weight, BMI, crown-rump length, and lower viral load set point were protective from death in both groups.
CONCLUSIONS: Micronutrient supplementation did not significantly alter the progression of SAIDS with respect to changes in body composition and immunological characteristics. A significantly higher rate of death was observed in rhesus macaques on the supplemented diet.
DOI of Published Version
Goldin BR, Li W, Mansfield K, Woods M, Wanke C, Freeman L, Shevitz A, Gualtieri L, Bussell S, Gorbach SL. The effect of micronutrient supplementation on disease progression and death in simian immunodeficiency virus-infected juvenile male rhesus macaques. J Infect Dis. 2005 Jul 15;192(2):311-8. Link to article on publisher's site
The Journal of infectious diseases
Goldin, Barry; Li, Wenjun; Mansfield, Keith G.; Woods, Margo; Wanke, Christine; Freeman, Lisa M.; Shevitz, Abby; Gualtieri, Lisa; Bussell, Sarah; and Gorbach, Sherwood L., "The effect of micronutrient supplementation on disease progression and death in simian immunodeficiency virus-infected juvenile male rhesus macaques" (2005). Preventive and Behavioral Medicine Publications. 302.