Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry
Department of Medicine, Division of Preventive and Behavioral Medicine
Adult; Cocaine-Related Disorders; Follow-Up Studies; Heart Transplantation; Humans; Proportional Hazards Models; Registries; Retrospective Studies; Risk Assessment; Survival Rate; *Tissue Donors
Substance Abuse and Addiction | Surgery
Heart transplantation from donors with a history of cocaine abuse remains controversial. Therefore, we examined the consequence of donor cocaine-use history on all-cause mortality and the development of coronary artery disease after heart transplantation. Using the United Network for Organ Sharing Thoracic Registry we identified 9,217 first-time heart-only adult transplant recipients between January 1999 and December 2003, and then divided this cohort into sub-groups based on the reported history of donor cocaine use. Multivariate analysis revealed no difference in mortality or development of coronary artery disease at 1 and 5 years between transplant recipients who received an organ from donors with a history of cocaine use when compared with donors having no history of cocaine use.
DOI of Published Version
Brieke A, Krishnamani R, Rocha MJ, Li W, Patten RD, Konstam MA, Patel AR, Udelson JE, Denofrio D. Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry. J Heart Lung Transplant. 2008 Dec;27(12):1350-2. doi:10.1016/j.healun.2008.08.008. Link to article on publisher's site
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Brieke, Andreas; Krishnamani, Rajan; Rocha, Michael J.; Li, Wenjun; Patten, Richard D.; Konstam, Marvin A.; Patel, Ayan R.; Udelson, James E.; and Denofrio, David, "Influence of donor cocaine use on outcome after cardiac transplantation: analysis of the United Network for Organ Sharing Thoracic Registry" (2008). Preventive and Behavioral Medicine Publications. 293.