Classification of dengue illness based on readily available laboratory data
Center for Infectious Disease and Vaccine Research; Department of Medicine, Division of Infectious Diseases and Immunology; Department of Medicine, Division of Preventive and Behavioral Medicine
Adolescent; Algorithms; Child; Child, Preschool; Dengue; Female; Humans; Infant; Male; Multivariate Analysis; Odds Ratio; Physicians; Retrospective Studies; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; World Health Organization
Infectious Disease | Virus Diseases
The aim of this study was to examine retrospective dengue-illness classification using only clinical laboratory data, without relying on X-ray, ultrasound, or percent hemoconcentration. We analyzed data from a study of children who presented with acute febrile illness to two hospitals in Thailand. Multivariable logistic regression models were used to distinguish: (1) dengue hemorrhagic fever (DHF) versus dengue fever (DF), (2) DHF versus DF + other febrile illness (OFI), (3) dengue versus OFI, and (4) severe dengue versus non-severe dengue + OFI. Data from the second hospital served as a validation set. There were 1,227 patients in the analysis. The sensitivity of the models ranged from 89.2% (dengue versus OFI) to 79.6% (DHF versus DF). The models showed high sensitivity in the validation dataset. These models could be used to calculate a probability and classify patients based on readily available clinical laboratory data, and they will need to be validated in other dengue-endemic regions.
DOI of Published Version
Potts JA, Thomas SJ, Srikiatkhachorn A, Supradish PO, Li W, Nisalak A, Nimmannitya S, Endy TP, Libraty DH, Gibbons RV, Green S, Rothman AL, Kalayanarooj S. Classification of dengue illness based on readily available laboratory data. Am J Trop Med Hyg. 2010 Oct;83(4):781-8. doi: 10.4269/ajtmh.2010.10-0135.
The American journal of tropical medicine and hygiene
Potts, James A.; Thomas, Stephen J.; Srikiatkhachorn, Anon; Supradish, Pra-On; Li, Wenjun; Nisalak, Ananda; Nimmannitya, Suchitra; Endy, Timothy P.; Libraty, Daniel H.; Gibbons, Robert V.; Green, Sharone; Rothman, Alan; and Kalayanarooj, Siripen, "Classification of dengue illness based on readily available laboratory data" (2010). Preventive and Behavioral Medicine Publications. 288.