Common genetic variants in peroxisome proliferator-activated receptor-gamma (PPARG) and type 2 diabetes risk among Women's Health Initiative postmenopausal women
Authors
Chan, Kei Hang K.Niu, Tianhua
Ma, Yunsheng
You, Nai-chieh Y
Song, Yiqing
Sobel, Eric M.
Hsu, Yi-Hsiang
Balasubramanian, Raji
Qiao, Yongxia
Tinker, Lesley F.
Liu, Simin
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2013-03-01Keywords
AdipogenesisAfrican Americans
Aged
Asian Americans
Blood Glucose
Case-Control Studies
Diabetes Mellitus, Type 2
European Continental Ancestry Group
Female
Haplotypes
Hispanic Americans
Humans
Logistic Models
Middle Aged
Multivariate Analysis
PPAR gamma
Polymorphism, Single Nucleotide
Postmenopause
Risk Factors
United States
Cellular and Molecular Physiology
Endocrinology
Nutritional and Metabolic Diseases
Women's Health
Metadata
Show full item recordAbstract
CONTEXT: Peroxisome proliferator-activated receptor-gamma (PPARG) plays a pivotal role in adipogenesis and glucose homeostasis. OBJECTIVE: We investigated whether PPARG gene variants were associated with type 2 diabetes (T2D) risk in the multiethnic Women's Health Initiative (WHI). RESEARCH DESIGN AND METHODS: We assessed PPARG single-nucleotide polymorphisms (SNPs) in a case-control study nested in the prospective WHI observational study (WHI-OS) (1543 T2D cases and 2170 matched controls). After identifying 24 tagSNPs, we used multivariable logistic regression models and haplotype-based analyses to estimate these tagSNP-T2D associations. Single-SNP analyses were also conducted in another study of 5642 African American and Hispanic American women in the WHI SNP Health Association Resource (WHI-SHARe). RESULTS: We found a borderline significant association between the Pro12Ala (rs1801282) variant and T2D risk in WHI-OS [odds ratio (OR) 0.51, 95% confidence interval (CI) 0.31-0.83, P = .01, combined group, additive model; P = .04, Hispanic American] and WHI-SHARe (OR 0.25, 95% CI 0.08-0.77, P = .02, Hispanic American) participants. In promoter region, rs6809631, rs9817428, rs10510411, rs12629293, and rs12636454 were also associated with T2D risk (range ORs 0.68-0.78, 95% CIs 0.52-0.91 to 0.60-1.00, P CONCLUSIONS: The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele. Additional significant loci included 5 PPARG promoter variants.Source
J Clin Endocrinol Metab. 2013 Mar;98(3):E600-4. doi: 10.1210/jc.2012-3644. Link to article on publisher's siteDOI
10.1210/jc.2012-3644Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44846PubMed ID
23386649Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1210/jc.2012-3644