Statin therapy and the risk for diabetes among adult women: do the benefits outweigh the risk
Department of Medicine, Division of Preventive and Behavioral Medicine; Department of Medicine, Division of General Medicine; Department of Medicine, Division of Cardiovascular Medicine
Diabetes Mellitus, Type 2; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiovascular Diseases | Community Health and Preventive Medicine | Digestive System Diseases | Endocrine System Diseases | Preventive Medicine | Women's Health
Purpose of review: The purpose of this review was to examine statin therapy and the risk for diabetes among adult women using a selective review.
Recent findings: The literature contains reports of new-onset diabetes associated with statin use. While many studies do not report sex-specific results, there is evidence indicating the risk to benefit ratio may vary by gender. However, the absolute effects are not clear because women have historically been under-represented in clinical trials.
Summary: A review of the literature indicates that the cardiovascular benefits of statins appear to outweigh the risk for statin-related diabetes. However, the effect may depend upon baseline diabetes risk, dose, and statin potency. Rigorous, long-term studies focused on the risks and benefits of statins in women are unavailable to sort for gender-specific differences. Until this changes, individualized attention to risk assessment, and strong prevention with lifestyle changes must prevail.
DOI of Published Version
Ther Adv Cardiovasc Dis. 2013 Feb;7(1):41-4. doi: 10.1177/1753944712468499. Link to article on publisher's site
Therapeutic advances in cardiovascular disease
Ma Y, Culver AL, Rossouw JE, Olendzki BC, Merriam PA, Lian B, Ockene IS. (2013). Statin therapy and the risk for diabetes among adult women: do the benefits outweigh the risk. Preventive and Behavioral Medicine Publications. https://doi.org/10.1177/1753944712468499. Retrieved from https://escholarship.umassmed.edu/prevbeh_pp/261