UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2010-01-27Keywords
*Behavior, AddictiveBias (Epidemiology)
Female
Humans
*Models, Statistical
Smoking Cessation
Behavioral Disciplines and Activities
Behavior and Behavior Mechanisms
Community Health and Preventive Medicine
Preventive Medicine
Metadata
Show full item recordAbstract
INTRODUCTION: If not handled appropriately, missing data can result in biased estimates and, quite possibly, incorrect conclusions about treatment efficacy. This article aimed to demonstrate how ordinary use of generalized estimating equations (GEE) can be problematic if the assumption of missing completely at random (MCAR) is not met. METHODS: We tested whether results differed for different analytic methods depending on whether the MCAR assumption was violated. This example used data from a published randomized controlled trial examining whether varying the timing of a weight management intervention, in concert with smoking cessation, improved cessation rates for adult female smokers. Participants were 284 women with at least one report of smoking status during Visits 4-16. Smoking status was assessed at each visit via self-report and biologically verified using expired carbon monoxide. RESULTS: Results showed that while the GEE analysis found differences in smoking status between conditions, tests of the MCAR assumption demonstrated that it was not valid for this dataset. Additional analyses using tests that do not require the MCAR assumption found no differences between conditions. Thus, GEE is not an appropriate choice for this analysis. DISCUSSION: While GEE is an appropriate technique for analyzing dichotomous data when the MCAR assumption is not violated, weighted GEE or mixed-effects logistic regression are more appropriate when the missing data mechanism is not MCAR.Source
Nicotine Tob Res. 2010 Apr;12(4):445-8. Epub 2010 Jan 25. Link to article on publisher's siteDOI
10.1093/ntr/ntp213Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44695PubMed ID
20100810Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1093/ntr/ntp213
Scopus Count
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