Long-term alcohol and caffeine intake and risk of sudden cardiac death in women
Authors
Bertoia, Monica L.Triche, Elizabeth W.
Michaud, Dominique S.
Baylin, Ana
Hogan, Joseph W.
Neuhouser, Marian L.
Freiberg, Matthew S.
Allison, Matthew A.
Safford, Monika M.
Li, Wenjun
Mossavar-Rahmani, Yasmin
Rosal, Milagros C.
Eaton, Charles B.
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2013-06-01Keywords
Aged*Alcohol Drinking
Body Mass Index
Caffeine
Coffee
Death, Sudden, Cardiac
Female
Humans
Intervention Studies
Middle Aged
Postmenopause
Questionnaires
Risk Factors
Smoking
Socioeconomic Factors
Tea
Behavior and Behavior Mechanisms
Clinical Epidemiology
Community Health
Community Health and Preventive Medicine
Public Health
Women's Health
Metadata
Show full item recordAbstract
BACKGROUND: Alcohol and caffeine intakes may play a role in the development of sudden cardiac death (SCD) because of their effects on cholesterol, blood pressure, heart rate variability, and inflammation. OBJECTIVE: Our objective was to examine the association between long-term alcohol and caffeine intakes and risk of SCD in women. DESIGN: We examined 93,676 postmenopausal women who participated in the Women's Health Initiative Observational Study. Women were enrolled between 1993 and 1998 and were followed until August 2009. Women completed a food-frequency questionnaire at baseline and again at year 3. We modeled exposure to alcohol 3 ways: by using baseline intake only, a cumulative average of baseline and year 3 intake, and the most recent reported intake (a simple time-varying analysis). RESULTS: Intake of 5-15 g alcohol/d (about one drink) was associated with a nonsignificantly reduced risk of SCD compared with 0.1-5 g/d of baseline intake (HR: 0.64; 95% CI: 0.40, 1.02), of cumulative average intake (HR: 0.69; 95% CI: 0.43, 1.11), and of most recent intake (HR: 0.58; 95% CI: 0.35, 0.96), with adjustment for age, race, income, smoking, body mass index, physical activity, hormone use, and total energy. No association was found between SCD and total caffeine intake (mg/d) or cups of caffeinated coffee, decaffeinated coffee, and caffeinated tea. CONCLUSIONS: Our results suggest that about one drink per day (or 5.1-15 g/d) may be associated with a reduced risk of SCD in this population; however, this association was only statistically significant for a model using the most recent alcohol intake. Total caffeine, regular coffee, decaffeinated coffee, and regular tea intake were not associated with the risk of SCD. This trial was registered at clinicaltrials.gov as NCT00000611.Source
Bertoia ML, Triche EW, Michaud DS, Baylin A, Hogan JW, Neuhouser ML, Freiberg MS, Allison MA, Safford MM, Li W, Mossavar-Rahmani Y, Rosal MC, Eaton CB. Long-term alcohol and caffeine intake and risk of sudden cardiac death in women. Am J Clin Nutr. 2013 Jun;97(6):1356-63. doi: 10.3945/ajcn.112.044248. Link to article on publisher's siteDOI
10.3945/ajcn.112.044248Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44580PubMed ID
23615825Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.3945/ajcn.112.044248