UMMS Affiliation

Department of Population and Quantitative Health Sciences, Division of Preventive and Behavioral Medicine; UMass Worcester Prevention Research Center

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Behavioral Medicine | Community Health | Community Health and Preventive Medicine | Neoplasms | Oncology | Preventive Medicine | Psychiatry and Psychology | Race and Ethnicity


Background: Anxiety and depression symptoms are known to increase cancer symptom burden, yet little is known about the longitudinal integrations of these among Hispanic/Latinx patients. The goal of this study was to explore the trajectory and longitudinal interactions among anxiety and depression, cancer symptom burden, and health-related quality of life in Hispanic/Latinx cancer patients undergoing chemotherapy.

METHODS: Baseline behavioral assessments were performed before starting chemotherapy. Follow-up behavioral assessments were performed at 3, 6, and 9 months after starting chemotherapy. Descriptive statistics, chi-square tests, Fisher's exact tests, and Mann-Whitney tests explored associations among outcome variables. Adjusted multilevel mixed-effects linear regression models were also used to evaluate the association between HADS scores, follow-up visits, FACT-G scale, MDASI scale, and sociodemographic variables.

RESULTS: Increased cancer symptom burden was significantly related to changes in anxiety symptoms' scores (adjusted beta^ = 0.11 [95% CI: 0.02, 0.19]. Increased quality of life was significantly associated with decreased depression and anxiety symptoms (adjusted beta^ = -0.33; 95% CI: -0.47, -0.18, and 0.38 adjusted beta^= -0.38; 95% CI: -0.55, -0.20, respectively).

CONCLUSIONS: Findings highlight the need to conduct periodic mental health screenings among cancer patients initiating cancer treatment.


Anxiety, Cancer, Cancer Symptom Burden, Depression, Hispanic/Latinx, Quality of Life

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Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (

DOI of Published Version



Castro-Figueroa EM, Torres-Blasco N, Rosal MC, Jiménez JC, Castro-Rodríguez WP, González-Lorenzo M, Vélez-Cortés H, Toro-Bahamonde A, Costas-Muñiz R, Armaiz-Peña GN, Jim H. Brief Report: Hispanic Patients' Trajectory of Cancer Symptom Burden, Depression, Anxiety, and Quality of Life. Nurs Rep. 2021 Jun 9;11(2):475-483. doi: 10.3390/nursrep11020044. PMID: 34968222; PMCID: PMC8608069. Link to article on publisher's site

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Nursing reports (Pavia, Italy)

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Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.