UMass Worcester PRC Publications

UMMS Affiliation

Department of Population and Quantitative Health Sciences, Division of Preventive and Behavioral Medicine; UMass Worcester Prevention Research Center

Publication Date


Document Type



Behavioral Medicine | Community Health and Preventive Medicine | Health Services Administration | Health Services Research | Preventive Medicine | Virus Diseases


Importance: Hepatitis C virus (HCV) is the most common chronic blood-borne pathogen in the US and a leading cause of complications from chronic liver disease. HCV is associated with more deaths than the top 60 other reportable infectious diseases combined, including HIV. Cases of acute HCV infection have increased approximately 3.8-fold over the last decade because of increasing injection drug use and improved surveillance.

Objective: To update its 2013 recommendation, the USPSTF commissioned a review of the evidence on screening for HCV infection in adolescents and adults.

Population: This recommendation applies to all asymptomatic adults aged 18 to 79 years without known liver disease.

Evidence Assessment: The USPSTF concludes with moderate certainty that screening for HCV infection in adults aged 18 to 79 years has substantial net benefit.

Recommendation: The USPSTF recommends screening for HCV infection in adults aged 18 to 79 years. (B recommendation).


Screening, Hepatitis C, HCV, recommendations

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© 2020 American Medical Association. Publisher PDF posted after 6 months as allowed by publisher's policy at

DOI of Published Version



US Preventive Services Task Force, Owens DK, Davidson KW, Krist AH, Barry MJ, Cabana M, Caughey AB, Donahue K, Doubeni CA, Epling JW Jr, Kubik M, Ogedegbe G, Pbert L, Silverstein M, Simon MA, Tseng CW, Wong JB. Screening for Hepatitis C Virus Infection in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2020 Mar 2;323(10):970-975. doi: 10.1001/jama.2020.1123. PMID: 32119076. Link to article on publisher's site

Journal/Book/Conference Title



Full author list omitted for brevity. For the full list of authors, see article.

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