The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2022

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Consensus nomenclature for dyneins and associated assembly factors, Bryony Braschi, Heymut Omran, George B. Witman, Gregory J. Pazour, K. Kevin Pfister, Elspeth A. Bruford, and Stephen M. King

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Transcriptional Homeostasis and Chromatin Dynamics, Alysia Bryll

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Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike, Marco A. Diaz-Salinas, Qi Li, Ejemel Monir, Leonid Yurkovetskiy, Jeremy Luban, Kuang Shen, Yang Wang, and James B. Munro

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Uncovering the Asymmetry and ATP-Dependent Phases of Nucleosome Editing, Jiayi Fan

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The Role of the Nucleosomal Acidic Patch in Histone Dimer Exchange, Nathan Gioacchini

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Innate Immune Sensing of HIV-1 RNA in Human Myeloid Cells, Mehmet Hakan Güney

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iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling, Dongsheng Guo, Katelyn Daman, Jennifer Jc Chen, Meng-Jiao Shi, Jing Yan, Zdenka Matijasevic, Rene Maehr, Oliver D. King, Lawrence J. Hayward, and Charles P. Emerson Jr.

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Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness [preprint], Fritz Obermeyer, Martin Jankowiak, Nikolaos Barkas, Stephen F. Schaffner, Jesse D. Pyle, Lonya Yurkovetskiy, Matteo Bosso, Daniel J. Park, Mehrtash Babadi, Bronwyn L. MacInnis, Jeremy Luban, Pardis C. Sabeti, and Jacob E. Lemieux

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Vaccine Breakthrough Infection with the SARS-CoV-2 Delta or Omicron (BA.1) Variant Leads to Distinct Profiles of Neutralizing Antibody Responses [preprint], Michael S. Seaman, Jeremy Luban, and Jacob E. Lemieux

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Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection, Noah J. Silverstein, Yetao Wang, Claudia Carbone, Ann Dauphin, and Jeremy Luban

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Mechanisms Driving Human Adipose Tissue Thermogenesis in vivo and its Clinical Applications in Metabolic Health, Javier Solivan-Rivera

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Comparison of Rapid Antigen Tests’ Performance between Delta (B.1.61.7; AY.X) and Omicron (B.1.1.529; BA1) Variants of SARS-CoV-2: Secondary Analysis from a Serial Home Self-Testing Study [preprint], Apurv Soni, Carly Herbert, Andreas Filippaios, John P. Broach, Andres Colubri, Nisha Fahey, Kelsey Woods, Janvi Nanavati, Colton Wright, Taylor Orwig, Karen Gilliam, Honghuang Lin, Laurel O'Connor, Caitlin Pretz, M. Didem Ayturk, Elizabeth Aaker Orvek, Julie M. Flahive, Peter Lazar, Qiming Shi, Laura L. Gibson, Pamela Stamegna, Nathaniel S. Hafer, Katherine Luzuriaga, Bruce A. Barton, David D. McManus, and RADx Clinical Studies Core team and Test Us At Home Investigators

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Understanding Healthcare Professionals' Perspectives on Point-of-Care Testing, Sean Teebagy, Zi-Yue Wang, Denise Dunlap, Connor Saleeba, Danielle DiMezza, JoAnn Crain, Craig M. Lilly, Bryan Buchholz, David D. McManus, and Nathaniel S. Hafer

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Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing, I-Hao Wang, Gregory Andrews, Elisa Donnard, Violeta Duran-Laforet, Travis E. Faust, Manuel Garber, Christina E. Baer, Dorothy P. Schafer, Zhiping Weng, and Paul L. Greer

Publications from 2021

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Distinct Changes in Gut Microbiota Are Associated with Estradiol-Mediated Protection from Diet-Induced Obesity in Female Mice, Kalpana D. Acharya, Hye Lim Noh, Madeline E. Graham, Sujin Suk, Randall H. Friedline, Cesiah C. Gomez, Abigail E.R. Parakoyi, Jun Chen, Jason K. Kim, and Marc J. Tetel

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Systematic evaluation of chromosome conformation capture assays, Betul Akgol-Oksuz, Liyan Yang, Sameer Abraham, Sergey V. Venev, Nils Krietenstein, Krishna M. Parsi, Hakan Ozadam, Marlies E. Oomen, Ankita Nand, Hui Mao, Ryan Genga, Rene Maehr, Oliver J. Rando, Leonid A. Mirny, Johan H. Gibcus, and Job Dekker

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Micro-Meta App: an interactive software tool to facilitate the collection of microscopy metadata based on community-driven specifications [preprint], Alessandro Rigano, Mathias Hammer, Karl D. Bellve, Kevin E. Fogarty, David Grunwald, and Caterina Strambio-De-Castillia

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Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis, Semir Beyaz, Charlie Chung, Haiwei Mou, Khristian E. Bauer-Rowe, Michael E. Xifaras, Ilgin Ergin, Lenka Dohnalova, Moshe Biton, Karthik Shekhar, Onur Eskiocak, Katherine Papciak, Kadir Ozler, Mohammad Almeqdadi, Brian Yueh, Miriam Fein, Damodaran Annamalai, Eider Valle-Encinas, Aysegul Erdemir, Karoline Dogum, Vyom Shah, Aybuke Alici-Garipcan, Hannah V. Meyer, Deniz M. Ozata, Eran Elinav, Alper Kucukural, Pawan Kumar, Jeremy P. McAleer, James G. Fox, Christoph A. Thaiss, Aviv Regev, Jatin Roper, Stuart H. Orkin, and Omer H. Yilmaz

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Akt Is S-Palmitoylated: A New Layer of Regulation for Akt, Matias Blaustein, Estefania Piegari, Camila Martinez Calejman, Antonella Vila, Analia Amante, Maria Victoria. Manese, Ari Zeida, Laurence Abrami, Mariela Veggetti, David A. Guertin, F. Gisou van der Goot, Maria Martha Corvi, and Alejandro Colman-Lerner

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QUAREP-LiMi: a community endeavor to advance quality assessment and reproducibility in light microscopy, Ulrike Boehm, Caterina Strambio-De-Castillia, and Roland Nitschke

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MLK3 mediates impact of PKG1alpha on cardiac function and controls blood pressure through separate mechanisms, Timothy D. Calamaras, Roger J. Davis, and Robert M. Blanton

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Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice, Amada D. Caliz, Hyung-Jin Yoo, Anastassiia Vertii, Ana C. Dolan, Cathy Tournier, Roger J. Davis, John F. Keaney Jr., and Shashi Kant

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Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science, Frances L. Chen, Madeline Zimmermann, Jessica P. Hekman, Kathryn A. Lord, Brittney Logan, Jane Russenberger, Eldin A. Leighton, and Elinor K. Karlsson

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Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis, Benjamin Cyge, Vera Voronina, Mohammed Hoque, Eunice N. Kim, Jason Hall, Jennifer M. Bailey-Lundberg, Gregory J. Pazour, Howard C. Crawford, Randall T. Moon, Feng-Qian Li, and Ken-Ichi Takemaru

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Insights into the Role of Oncogenic BRAF in Tetraploidy and Melanoma Initiation, Revati A. Darp

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Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity, William E. Diehl, Mehmet Hakan Guney, Teresa Vanzo, Pyae Phyo Kyawe, Judith M. White, Massimo Pizzato, and Jeremy Luban

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An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids, Shawn B. Egri and Kuang Shen

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SwarmTCR: a computational approach to predict the specificity of T cell receptors, Ryan Ehrlich, Larisa Kamga, Anna Gil, Katherine Luzuriaga, Liisa K. Selin, and Dario Ghersi

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Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep, Chantal M. Ferguson, Bruno M. D. C. Godinho, Julia F. Alterman, Andrew H. Coles, Matthew R. Hassler, Dimas Echeverria, James W. Gilbert, Emily G. Knox, Jillian Caiazzi, Reka A. Haraszti, Robert M. King, Toloo Taghian, Ajit S. Puri, Richard P. Moser, Matthew J. Gounis, Neil Aronin, Heather L. Gray-Edwards, and Anastasia Khvorova

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Dissection of Zebrafish Adult Melanocyte Stem Cell Signaling During Regeneration, William Tyler Frantz

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Disrupted glucose homeostasis and skeletal muscle-specific glucose uptake in an exocyst knockout mouse model, Brent A. Fujimoto, Madison Young, Nicole Nakamura, Herena Ha, Lamar Carter, Matthew W. Pitts, Daniel Torres, Hye Lim Noh, Sujin Suk, Jason K. Kim, and Noemi Polgar

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AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma, Keitaro Fukuda, Ken Okamura, Rebecca L. Riding, Xueli Fan, Khashayar Afshari, Nazgol-Sadat Haddadi, Sean M. McCauley, Mehmet Hakan Guney, Jeremy Luban, Takeru Funakoshi, Tomonori Yaguchi, Yutaka Kawakami, Anastasia Khvorova, Katherine A. Fitzgerald, and John E. Harris

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Microinjection for precision genome editing in Caenorhabditis elegans, Krishna S. Ghanta, Takao Ishidate, and Craig C. Mello

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BMP Signaling Promotes Neural Crest Identity and Accelerates Melanoma Onset, Alec K. Gramann, William Tyler Frantz, Karen A. Dresser, Camilla Borges Ferreira Gomes, Christine G. Lian, April C. Deng, and Craig J. Ceol

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JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury, Keren Grynberg, Elyce Ozols, William R. Mulley, Roger J. Davis, Richard A. Flavell, David J. Nikolic-Paterson, and Frank Y. Ma

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SWI/SNF senses carbon starvation with a pH-sensitive low complexity sequence [preprint], J. Ignacio Gutiérrez, Gregory P. Brittingham, Yonca Karadeniz, Kathleen D. Tran, Arnob Dutta, Alex S. Holehouse, Craig L. Peterson, and Liam J. Holt

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Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model [preprint], Mathias Hammer, Maximiliaan Huisman, Farzin Farzam, David Grünwald, and Caterina Strambio-De-Castillia

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Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model, Mathias Hammer, Maximiliaan Huisman, Alessandro Rigano, Farzin Farzam, David Grunwald, and Caterina Strambio-De-Castillia

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A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21, Myoung Souk Han, Rachel J. Perry, Joao-Paulo Camporez, Philipp E. Scherer, Gerald I. Shulman, Guangping Gao, and Roger J. Davis

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Loss of function of lysosomal acid lipase (LAL) profoundly impacts osteoblastogenesis and increases fracture risk in humans, Ron C. Helderman, Daniel G. Whitney, Madalina Duta-Mare, Alena Akhmetshina, Nemanja Vujic, Shobana Jayapalan, Jeffry S. Nyman, Biswapriya B. Misra, Clifford J. Rosen, Michael P. Czech, Dagmar Kratky, and Elizabeth Rendina-Ruedy

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WormCat 2.0 defines characteristics and conservation of poorly annotated genes in Caenorhabditis elegans [preprint], Daniel P. Higgins, Caroline M. Weisman, Dominique Lui, Frank A. D’Agostino, and Amy K. Walker

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Towards a Common Standard for Data and Specimen Provenance in Life Sciences [preprint], Petr Holub and Caterina Strambio-De-Castillia

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A perspective on Microscopy Metadata: data provenance and quality control [preprint], Maximiliaan Huisman, Mathias Hammer, Alex Rigano, David Grunwald, and Caterina Strambio-De-Castillia

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A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection, Fiachra Humphries, Liraz Shmuel-Galia, Zhaozhao Jiang, Ruth Wilson, Philip Landis, Sze-Ling Ng, Krishna M. Parsi, Rene Maehr, John Cruz, Angel Morales-Ramos, Joshi M. Ramanjulu, John Bertin, G. Scott Pesiridis, and Katherine A. Fitzgerald

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C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA, Orkan Ilbay, Charles J. Nelson, and Victor R. Ambros

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In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate, Su Myung Jung, Will G. Doxsey, Johnny Le, John A. Haley, Lorena Mazuecos, Amelia K. Luciano, Huawei Li, Cholsoon Jang, and David A. Guertin

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Modeling human T1D-associated autoimmune processes, Mohsen Khosravi-Maharlooei, Rachel Madley, Chiara Borsotti, Leonardo M. R. Ferreira, Robert C. Sharp, Michael A. Brehm, Dale L. Greiner, Audrey V. Parent, Mark S. Anderson, Megan Sykes, and Remi J. Creusot

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Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions, Jong Hyuk Kim, Kate Megquier, Rachael Thomas, Aaron L. Sarver, Jung Min. Song, Yoon Tae Kim, Nuojin Cheng, Ashley J. Schulte, Michael A. Linden, Paari Murugan, LeAnn Oseth, Colleen L. Forster, Ingegerd Elvers, Ross Swofford, Jason Turner-Maier, Elinor K. Karlsson, Matthew Breen, Kerstin Lindblad-Toh, and Jaime F. Modiano

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Bacterial processing of glucose modulates C. elegans lifespan and healthspan, Samuel F. Kingsley, Yonghak Seo, Calista Allen, Krishna S. Ghanta, Steven Finkel, and Heidi A. Tissenbaum

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SARS-CoV-2 Initiates Programmed Cell Death in Platelets, Milka Koupenova-Zamor, Heather A. Corkrey, Olga Vitseva, Kahraman Tanriverdi, Mohan Somasundaran, Ping Liu, Shaukat Soofi, Krishna M. Parsi, Alyssa Cousineau, Rene Maehr, Jennifer P. Wang, Jeffrey J. Rade, and Robert W. Finberg

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MDEmic: a metadata annotation tool to facilitate management of FAIR image data in the bioimaging community, Susanne Kunis, Sebastian Hansch, Christian Schmidt, Frances Wong, Caterina Strambio-De-Castillia, and Stefanie Weidtkamp-Peters

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MDEmic in a use case for microscopy metadata harmonization: Facilitating FAIR principles in practical application with metadata annotation tools [preprint], Susanne Kunis, Sebastian Hansch, Christian Schmidt, Frances Wong, Caterina Strambio-De-Castillia, and Stefanie Weidtkamp-Peters

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xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers, Namgyu Lee, Anne E. Carlisle, Austin Peppers, Sung Jin Park, Mihir B. Doshi, Meghan E. Spears, and Dohoon Kim

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Consulting the Oracle of Chronic SARS-CoV-2 Infection, Jacob E. Lemieux and Jeremy Luban

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Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans, Hanchen Li, Gary R. Ostroff, and Raffi V. Aroian

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines, Jeremy Luban, Caterina Strambio-De-Castillia, Yetao Wang, Allan Jacobson, and Stuart W. Peltz

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E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened, Bo Lv, Michael W. Stuck, Paurav B. Desai, Oscar A. Cabrera, and Gregory J. Pazour

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Trends in SARS-CoV-2 seroprevalence in Massachusetts estimated from newborn screening specimens [preprint], Kevin C. Ma, Jaime E. Hale, Yonatan H. Grad, Galit Alter, Katherine Luzuriaga, Roger B. Eaton, Stephanie Fischinger, Devinder Kaur, Robin M. Brody, Sameed M. Siddiqui, Dylan Leach, Catherine M. Brown, R. Monina Klevens, Lawrence Madoff, and Anne Marie Comeau

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Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels, alternative RNA processing, and synaptic plasticity but not hippocampal-dependent behaviours, Fernanda Mansur, Juan Marcos Alarcon, Emily E. Stackpole, Ruijia Wang, and Joel D. Richter

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JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging, Katrin Muller, Roger J. Davis, Achim Weber, and Tom Luedde

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Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1, Harrison T. Muturi, Saja S. Khuder, Hilda E. Ghadieh, Emily L. Esakov, Hye Lim Noh, Heejoon Kang, Marcia F. McInerney, Jason K. Kim, Abraham D. Lee, and Sonia M. Najjar

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A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA, Charles J. Nelson and Victor R. Ambros

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QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy, Glyn Nelson, Ulrike Boehm, Caterina Strambio-De-Castillia, and Roland Nitschke

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QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy [preprint], Glyn Nelson and Caterina Strambio-De-Castillia

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Emerging Immunotherapies in the Treatment of Brain Metastases, Edwin Nieblas-Bedolla, Naema Nayyar, Mohini Singh, Ryan J. Sullivan, and Priscilla K. Brastianos

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Hinfp is a guardian of the somatic genome by repressing transposable elements, Niraj K. Nirala, Qi Li, Prachi N. Ghule, Hsi-Ju Chen, Rui Li, Lihua Julie Zhu, Ruijia Wang, Nicholas P. Rice, Junhao Mao, Janet L. Stein, Gary S. Stein, Andre J. van Wijnen, and Y. Tony Ip

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Gaining Insight into Vitiligo Genetics through the Lens of a Large Epidemiologic Study, Ken Okamura, Manuel Garber, and John E. Harris

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Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation, Delayna Paulson, Rebecca Harms, Cody Ward, Mackenzie Latterell, Gregory J. Pazour, and Darci M. Fink

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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice, Pengpeng Liu, Shun-Qing Liang, Chunwei Zheng, Esther Mintzer, Yan G. Zhao, Karthikeyan Ponnienselvan, Aamir Mir, Erik J. Sontheimer, Guangping Gao, Terence R. Flotte, Scot A. Wolfe, and Wen Xue

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Biophysical basis of cellular multi-specificity encoded in a model molecular switch [preprint], Tina Perica, Christopher J. P. Mathy, Jiewei Xu, Gwendolyn M. Jang, Yang Zhang, Robyn Kaake, Noah Ollikainen, Hannes Braberg, Danielle L. Swaney, David G. Lambright, Mark J. S. Kelly, Nevan J. Krogan, and Tanja Kortemme

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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Restore Thymic Architecture and T Cell Function Disrupted by Neonatal Hyperoxia, Monica Reis, Gareth R. Willis, Angeles Fernandez-Gonzalez, Vincent Yeung, Elizabeth Taglauer, Margaret Magaletta, Teagan J. Parsons, Alan G. Derr, Xianlan Liu, Rene Maehr, Stella Kourembanas, and S. Alex Mitsialis

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The molecular biology of FMRP: new insights into fragile X syndrome, Joel D. Richter and Xinyu Zhao

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Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications, Alessandro Rigano, Mathias Hammer, Karl D. Bellve, Kevin E. Fogarty, David Grunwald, and Caterina Strambio-De-Castillia

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Ultradeep HIV-1 Proviral Envelope Sequencing Reveals Complex Population Structure within and between Brain and Splenic Tissues, Rebecca Rose, Maria Paz Gonzalez-Perez, David J. Nolan, Sissy Cross, Susanna L. Lamers, and Katherine Luzuriaga

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Determinants of precocious B-cell aging in European adolescents living with perinatally acquired HIV-1 after over 10 years of suppressive therapy [preprint], Alessandra Ruggiero, Katherine Luzuriaga, and Paolo Palma

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MethodsJ2: a software tool to capture metadata and generate comprehensive microscopy methods text, Joel Ryan, Thomas Pengo, Alex Rigano, Paula Montero Llopis, Michelle S. Itano, Lisa A. Cameron, Guillermo Marques, Caterina Strambio-De-Castillia, Mark A. Sanders, and Claire M. Brown

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MethodsJ2: A Software Tool to Improve Microscopy Methods Reporting [preprint], Joel Ryan, Thomas Pengo, Alex Rigano, Paula Montero Llopis, Michelle S. Itano, Lisa Cameron, Guillermo Marqués, Caterina Strambio De Castillia, Mark A. Sanders, and Claire M. Brown

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Maternal exposure to high-fat diet during pregnancy and lactation predisposes normal weight offspring mice to develop hepatic inflammation and insulin resistance, Suchaorn Saengnipanthkul, Hye Lim Noh, Randall H. Friedline, Sujin Suk, Stephanie Choi, Nicholas K. Acosta, Duy A. Tran, Xiaodi Hu, Kunikazu Inashima, Allison M. Kim, Ki Won Lee, and Jason K. Kim

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REMBI: Recommended Metadata for Biological Images-enabling reuse of microscopy data in biology, Ugis Sarkans, David Grunwald, Caterina Strambio-De-Castillia, Gerard J. Kleywegt, and Alvis Brazma

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mTOR-activating mutations in RRAGD cause kidney tubulopathy and cardiomyopathy (KICA) syndrome [preprint], Karl P. Schlingmann, Kuang Shen, and Jeroen H.F. de Baaij

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Do Fragile X Syndrome and Other Intellectual Disorders Converge at Aberrant Pre-mRNA Splicing, Sneha Shah and Joel D. Richter

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Lessons from a local effort to screen for SARS-CoV-2, Noah J. Silverstein and Jeremy Luban

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Innate lymphoid cells and disease tolerance in SARS-CoV-2 infection [preprint], Noah J. Silverstein, Yetao Wang, Zachary Manickas-Hill, Claudia C. Carbone, Ann Dauphin, MGH COVID-19 Collection & Processing Team, Jonathan Z. Li, Bruce D. Walker, Xu G. Yu, and Jeremy Luban

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Defining the Role of c-Jun N-terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease, Abigail O. Smith

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c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease [preprint], Abigail O. Smith, Julie A. Jonassen, Kenley Preval, Roger J. Davis, and Gregory J. Pazour

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Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release, Ernesto R. Soto, Florentina Rus, Hanchen Li, Carli Garceau, Jeffrey Chicca, Elfawal A. Mostafa, David Gazzola, Martin K. Nielsen, Joseph F. Urban Jr., Raffi V. Aroian, and Gary R. Ostroff

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Protection of mice against experimental cryptococcosis by synthesized peptides delivered in glucan particles [preprint], Charles A. Specht, E. Jane Homan, Chrono K. Lee, Zhongming Mou, Christina L. Gomez, Maureen M. Hester, Ambily Abraham, Florentina Rus, Gary R. Ostroff, and Stuart M. Levitz

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Genome-wide association study identifies new locus associated with OCD [preprint], Nora I. Strom, Elinor K. Karlsson, and Manuel Mattheisen

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SARS-CoV-2 Reinfection in a Liver Transplant Recipient, Christopher H. Tomkins-Tinch, Jennifer S. Daly, Nicole M. Theodoropoulos, Michael P. Madaio, Neng Yu, Vijay K. Vanguri, Babak Movahedi, Adel Bozorgzadeh, Karl J. Simin, Jeremy Luban, Bronwyn L. MacInnis, Pardis C. Sabeti, and Stuart M. Levitz

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Somatic piRNAs and Transposons are Differentially Regulated During Skeletal Muscle Atrophy and Programmed Cell Death [preprint], Junko Tsuji, Travis Thomson, Christine Brown, Subhanita Ghosh, William E. Theurkauf, Zhiping Weng, and Lawrence M. Schwartz

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An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals, Joseph F. Urban Jr, Martin K. Nielsen, David Gazzola, Yue Xie, Ethiopia Beshah, Yan Hu, Hanchen Li, Florentina Rus, Kelly Flanagan, Austin Draper, Sridhar Vakalapudi, Robert W. Li, Gary R. Ostroff, and Raffi V. Aroian

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Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma [preprint], Marc A. Vittoria, Nathan Kingston, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston- Lunel, Revati A. Darp, Joshua Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, and Neil J. Ganem

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WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization, Melissa D. Walker, Gabrielle E. Giese, Amy D. Holdorf, Sushila Bhattacharya, Cedric Diot, Aurian Garcia-Gonzalez, Brent Horowitz, Yong-Uk Lee, Thomas Leland, Xuhang Li, Zeynep Mirza, Huimin Na, Shivani Nanda, Olga Ponomarova, Hefei Zhang, Jingyan Zhang, L. Safak Yilmaz, and Albertha J. M. Walhout

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Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence, Bryan Wang, Yu-Cheng Lin, Alejandro Vasquez-Rifo, Jeanyoung Jo, Alexa Price-Whelan, Shujuan Tao McDonald, Lewis M. Brown, Christian Sieben, and Lars E.P. Dietrich

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Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence [preprint], Bryan Wang, Yu-Cheng Lin, Alejandro Vasquez-Rifo, Jeanyoung Jo, Alexa Price-Whelan, Shujuan Tao McDonald, Lewis M. Brown, Christian Sieben, and Lars E.P. Dietrich

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Role of epigenetics in unicellular to multicellular transition in Dictyostelium, Simon Yuan Wang, Elizabeth Ann Pollina, I-Hao Wang, Lindsay Kristina Pino, Henry L. Bushnell, Ken Takashima, Colette Fritsche, George Sabin, Benjamin Aaron. Garcia, Paul L. Greer, and Eric Lieberman Greer

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Clarification of human blood ILC subtype interrelatedness and discovery of amphiregulin production by human NK cells shed light on HIV-1 pathogenesis [preprint], Yetao Wang, Lawrence M. Lifshitz, Noah J. Silverstein, Esther Mintzer, Kevin Luk, Pamela St. Louis, Michael A. Brehm, Scot A. Wolfe, Steven G. Deeks, and Jeremy Luban

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The HIV-1 capsid core is an opportunistic nuclear import receptor [preprint], Guangai Xue, Hyun Jae Yu, University of Massachusetts Medical School, Anna T. Gres, Mehmet Hakan Guney, Stefan G. Sarafianos, Jeremy Luban, and Vineet N. KewalRamani

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A therapeutic convection-enhanced macroencapsulation device for enhancing beta cell viability and insulin secretion, Kisuk Yang, Dale L. Greiner, and Jeffrey M. Karp

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DEVELOPMENT OF AN RNAi THERAPEUTIC STRATEGY AGAINST NON-ALCOHOLIC STEATOHEPATITIS (NASH), Batuhan O. Yenilmez