The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2020

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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis, Camila Martinez Calejman, S. Trefely, S. W. Entwisle, Amelia K. Luciano, Su Myung. Jung, Wen-Yu Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villen, K. E. Wellen, and David A. Guertin

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Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults, Yuming Cao, Zhiru Guo, Pranitha Vangala, Elisa Donnard, Ping Liu, Patrick McDonel, Jose Ordovas Montanes, Alex K. Shalek, Robert W. Finberg, Jennifer P. Wang, and Manuel Garber

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Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution, Gaurav Chauhan, Jesse McClure, Jessica Hekman, Patrick W. Marsh, Jeffrey A. Bailey, Rachel F. Daniels, Diane P. Genereux, and Elinor K. Karlsson

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The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans, Daniel A. Chaves, Hui Dai, Lichao Li, James J. Moresco, Myung Eun Oh, Darryl Conte Jr., John R. Yates III, Craig C. Mello, and Weifeng Gu

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen, Qi Li, Niraj K. Nirala, and Y. Tony Ip

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Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice, Martina Chrudinová, Francois Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Czech Academy of Sciences, Harvard Medical School, and Boston College

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A big-data approach to understanding metabolic rate and response to obesity in laboratory mice, June K. Corrigan, Deepti Ramachandran, Yuchen He, Colin J. Palmer, Michael J. Jurczak, Rui Chen, Bingshan Li, Randall H. Friedline, Jason K. Kim, Jon J. Ramsey, Louise Lantier, Owen P. McGuinness, and Alexander S. Banks

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Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma, Francisco Javier Cubero, Mohamed Ramadan Mohamed, Marius M. Woitok, Gang Zhao, Maximilian Hatting, Yulia A. Nevzorova, Chaobo Chen, Johannes Haybaeck, Alain de Bruin, Matias A. Avila, Mark V. Boekschoten, Roger J. Davis, and Christian Trautwein

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Mechanisms of insulin resistance related to white, beige, and brown adipocytes, Michael P. Czech

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Tacrolimus- and sirolimus-induced human beta cell dysfunction is reversible and preventable, Chunhua Dai, John T. Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle. Dean, Nripesh Prasad, Shawn E. Levy, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C. Powers

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Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates, Joana Damas, Elinor K. Karlsson, and Harris A. Lewin

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Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates [preprint], Joana Damas, Elinor K. Karlsson, and Harris A. Lewin

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Single Cell Transcriptomics Reveals Dysregulated Cellular and Molecular Networks in a Fragile X Syndrome model, Elisa Donnard, Huan Shu, and Manuel Garber

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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics, Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, and James B. Munro

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A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears, Amanda Fazzalari, Giacomo Basadonna, Alper Kucukural, Kahraman Tanriverdi, Milka Koupenova-Zamor, Eric W. Dickson, Meghan Blackwood, Christian Mueller, Jane E. Freedman, and Mitchell A. Cahan

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From Tank to Treatment: Modeling Melanoma in Zebrafish, William Tyler Frantz and Craig J. Ceol

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Melting dsDNA donor molecules potentiates precision genome editing in C. elegans, Krishna S. Ghanta and Craig C. Mello

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Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor alpha and beta Repertoires, Anna Gil, Larisa Kamga, Ramakanth Chirravuri-Venkata, Nuray Aslan, Fransenio G. Clark, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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The Role of BMP Signaling in the Melanocyte Lineage and as a Therapeutic Target in Melanoma, Alec K. Gramann

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Control of Adipocyte Thermogenesis and Lipogenesis through beta3-Adrenergic and Thyroid Hormone Signal Integration, Adilson L. Guilherme, Batuhan Yenilmez, Alexander H. Bedard, Felipe Henriques, Dianxin Liu, Alexandra Lee, Lauren Goldstein, Mark Kelly, Sarah M. Nicoloro, Min Chen, Lee Weinstein, Sheila Collins, and Michael P. Czech

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Regulation of adipose tissue inflammation by interleukin 6, Myoung Souk Han, Alexis White, Rachel J. Perry, Joao-Paulo Camporez, Juan Hidalgo, Gerald I. Shulman, and Roger J. Davis

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Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone, Celine A. Hayden, Danilo Landrock, Chiung Yu Hung, Gary R. Ostroff, Gina M. Fake, John H. Walker, Ann Kier, and John A. Howard

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Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis, Felipe Henriques, Alexander H. Bedard, Adilson L. Guilherme, Mark Kelly, Lawrence M. Lifshitz, Karl D. Bellve, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, and Michael P. Czech

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Single Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis, Felipe Henriques, Alexander H. Bedard, Adilson L. Guilherme, Mark Kelly, Lawrence M. Lifshitz, Karl D. Bellve, Leslie Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, and Michael P. Czech

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Regulation of Translation and Synaptic Plasticity by TSC2, Annie Hien

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The Lipid Handling Capacity of Subcutaneous Fat Requires mTORC2 during Development, Wen-Yu Hsiao

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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, Tingting Jiang, Xiao-Ou Zhang, Yueying Cao, Zhiping Weng, and Wen Xue

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HIV-1 Evasion of Human TRIM5α via Cyclophilin A, Kyusik Kim

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Ultrastructural Details of Mammalian Chromosome Architecture, Nils Krietenstein, Sameer Abraham, Sergey V. Venev, Nezar Abdennur, Johan H. Gibcus, Tsung-Han S. Hsieh, Krishna M. Parsi, Liyan Yang, Rene Maehr, Leonid A. Mirny, Job Dekker, and Oliver J. Rando (Molecular cell, 2020-03-14)

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An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes, Nathan D. Lawson, Rui Li, Masahiro Shin, Ann S. Grosse, Onur Yukselen, Oliver A. Stone, Alper Kucukural, and Lihua Julie Zhu

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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells, Nayara C. Leite, Elad Sintov, Torsten B. Meissner, Michael A. Brehm, Dale L. Greiner, David M. Harlan, and Douglas A. Melton

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Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events, Jacob Lemieux, Katherine J. Siddle, Jeremy Luban, Glen R. Gallagher, Lawrence C. Madoff, Sandra Smole, Virginia M. Pierce, Eric Rosenberg, Pardis C. Sabeti, Daniel J. Park, and Bronwyn L. MacInnis

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Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Toward Goblet Cell Lineage in the Mouse Intestine, Joyce H. Li, Subir Ray, Alper Kucukural, Gerard Gradwohl, and Andrew B. Leiter

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Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111, Aaron E. Lin, William E. Diehl, Yingyun Cai, Courtney L. Finch, Chidiebere Akusobi, Robert N. Kirchdoerfer, Laura Bollinger, Stephen F. Schaffner, Elizabeth A. Brown, Erica Ollmann Saphire, Kristian G. Andersen, Jens H. Kuhn, Jeremy Luban, and Pardis C. Sabeti

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The History of Farm Foxes Undermines the Animal Domestication Syndrome, Kathryn A. Lord, Greger Larson, Raymond P. Coppinger, and Elinor K. Karlsson

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SARS-CoV-2, Jeremy Luban

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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines, Jeremy Luban, Caterina Strambio De Castilla, Yetao Wang, Allan Jacobson, and Stuart Peltz

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JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma, Elisa Manieri, Tamera Barrett, Julie Cavanagh-Kyros, Roger J. Davis, Alfonso Mora, and Guadalupe Sabio

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Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation, Asia N. Matthew-Onabanjo, Jenny Janusis, Jose Mercado-Matos, Anne E. Carlisle, Dohoon Kim, Fayola Levine, Peter Cruz-Gordillo, Ryan Richards, Michael J. Lee, and Leslie M. Shaw (Cancer research, 2020-01-15)

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Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt(Q140/Q140) mouse model of Huntington's disease, Robyn L. McAdam, Andrew Morton, Sarah L. Gordon, Julia F. Alterman, Anastasia Khvorova, Michael A. Cousin, and Karen J. Smillie

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Proteomic and Transcriptional Profiles of Human Stem Cell-Derived beta Cells Following Enteroviral Challenge, Julius O. Nyalwidhe, Agata Jurczyk, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Melanie I. Trombly, Pranitha Vangala, Riccardo Racicot, Rita Bortell, David M. Harlan, Dale L. Greiner, Michael A. Brehm, Jerry L. Nadler, and Jennifer P. Wang

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TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner, Molly Ohainle, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy Luban, and Michael Emerman

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The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV, Paolo Palma, Margaret M. McManus, Nicola Cotugno, Salvatore Rocca, Paolo Rossi, and Katherine Luzuriaga

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Adaptive Evolution Targets a piRNA Precursor Transcription Network, Swapnil Parhad, Tianxiong Yu, Gen Zhang, Nicholas P. Rice, Zhiping Weng, and William E. Theurkauf

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Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice, Sambra D. Redick, Linda Leehy, Ann R. Rittenhouse, David M. Blodgett, Alan G. Derr, Alper Kucukural, Manuel Garber, Leonard D. Shultz, Dale L. Greiner, Jennifer P. Wang, David M. Harlan, Rita Bortell, and Agata Jurczyk

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Drug antagonism and single-agent dominance result from differences in death kinetics, Ryan Richards, Hannah R. Schwartz, Megan E. Honeywell, Mariah S. Stewart, Peter Cruz-Gordillo, Anna J. Joyce, Benjamin D. Landry, and Michael J. Lee

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An atlas of cell types in the mammalian epididymis and vas deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

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An atlas of cell types in the mouse epididymis and vas deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

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SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC, Christian F. Ruiz, Emily D. Montal, John A. Haley, and John D. Haley

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FMRP Links Optimal Codons to mRNA stability in Neurons, Huan Shu, Elisa Donnard, Botao Liu, Ruijia Wang, and Joel D. Richter

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YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells, Jordan L. Smith, Tomas Rodriguez, Haiwei Mou, Suet-Yan Kwan, Henry E. Pratt, Xiao-Ou Zhang, Yueying Cao, Shun-Qing Liang, Deniz M. Ozata, Tianxiong Yu, Qiangzong Yin, Max Hazeltine, Zhiping Weng, Erik J. Sontheimer, and Wen Xue

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Adenine base editing in an adult mouse model of tyrosinaemia, Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M. Schatoff, Jordan L. Doman, Yueying Cao, Lukas E. Dow, Lihua Julie Zhu, Daniel G. Anderson, David R. Liu, Hao Yin, and Wen Xue

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Innovations, challenges, and minimal information for standardization of humanized mice, Renata Stripecke and Michael A. Brehm

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Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models, Jos L. van der Velden, John F. Alcorn, David G. Chapman, Lennart K. A. Lundblad, Charles G. Irvin, Roger J. Davis, Kelly Butnor, and Yvonne M. W. Janssen-Heininger

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Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice, Ryan G. Walker, Hye Lim Noh, Taekyoon Kim, Jason K. Kim, and Richard T. Lee

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HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells, Yetao Wang, Lawrence M. Lifshitz, Kyle Gellatly, Sean M. McCauley, Pranitha Vangala, Kyusik Kim, Alan G. Derr, Smita Jaiswal, Alper Kucukural, Patrick McDonel, Thomas C. Greenough, JeanMarie Houghton, Manuel Garber, and Jeremy Luban

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Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice, Zhenyu Wang, Yuqin Shi, Suheng Ma, Qian Huang, Yi Tian Yap, Lin Shi, Shiyang Zhang, Ting Zhou, Wei Li, Bo Hu, Ling Zhang, Stephen A. Krawetz, Gregory J. Pazour, Rex A. Hess, and Zhibing Zhang

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DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity, Daniel J. Wilcock, Melissa Kasheta, and Craig J. Ceol

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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View, Joao B. Xavier and Amir Mitchell

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A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome, Chunting Ye, Hongyuan Yang, Mingshan Cheng, Leonard D. Shultz, Dale L. Greiner, Michael A. Brehm, and James G. Keck

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DolphinNext: a distributed data processing platform for high throughput genomics, Onur Yukselen, Osman Turkyilmaz, Ahmet R. Ozturk, Manuel Garber, and Alper Kucukural

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SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain., Leonid Yurkovetskiy, Thomas Nyalile, Yetao Wang, William E. Diehl, Ann Dauphin, Claudia Carbone, Kristen Veinotte, Shawn B. Egri, Pardis C. Sabeti, Christos Kyratsous, James B. Munro, Kuang Shen, and Jeremy Luban

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Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity, Xuming Zhou, Elinor K. Karlsson, and Vadim N. Gladyshev

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SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues, Carly G. K. Ziegler, Yuming Cao, Zhiru Guo, Jennifer P. Wang, Robert W. Finberg, Manuel Garber, Alex K. Shalek, Jose Ordovas-Montanes, and HCA Lung Biological Network

Publications from 2019

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A novel vaccine platform using glucan particles for induction of protective responses against Francisella tularensis and other pathogens, Ambily Abraham, Gary R. Ostroff, Stuart M. Levitz, and P. C. F. Oyston

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Humanized immune system mouse models: progress, challenges and opportunities, Todd M. Allen, Michael A. Brehm, Sandra Bridges, Stacy Ferguson, Priti Kumar, Oleg Mirochnitchenko, Karolina Palucka, Roberta Pelanda, Brigitte Sanders-Beer, Leonard D. Shultz, Lishan Su, and Mercy PrabhuDas

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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Chantal M. Ferguson, Dimas Echeverria, Ellen Sapp, Reka A. Haraszti, Andrew H. Coles, Faith Conroy, Rachael Miller, Loic Roux, Paul Yan, Emily G. Knox, Anton A. Turanov, Robert M. King, Gwladys Gernoux, Christian Mueller, Heather Gray-Edwards, Richard P. Moser, N Bishop, Samer M. Jaber, Matthew J. Gounis, Miguel Sena-Esteves, Athma A. Pai, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

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Progressive alignment with Cactus: a multiple-genome aligner for the thousand-genome era, Joel Armstrong, Elinor K. Karlsson, and Benedict Paten

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Utilizing Humanized Mice to Study Human Specific Innate Immune Responses in Immuno-Oncology, Ken-Edwin Aryee

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Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo, Thiago M. Batista, Ruben Garcia-Martin, Weikang Cai, Masahiro Konishi, Brian T. O'Neill, Masaji Sakaguchi, Jong Hun Kim, Dae Young Jung, Jason K. Kim, and C. Ronald Kahn

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Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo, Annabelle Biscans, Andrew H. Coles, Reka A. Haraszti, Dimas Echeverria, Matthew R. Hassler, Maire F. Osborn, and Anastasia Khvorova

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Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism, Alecia M. Blaszczak, Valerie P. Wright, Kajol Anandani, Joey Liu, Anahita Jalilvand, Stephen Bergin, Sarah M. Nicoloro, Michael P. Czech, William Lafuse, Tuo Deng, David Bradley, and Willa A. Hsueh

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Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon

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Defective daily temperature regulation in a mouse model of amyotrophic lateral sclerosis, Maurine C. Braun, Alexandra Castillo-Ruiz, Premananda Indic, Dae Young Jung, Jason K. Kim, Robert H. Brown Jr., Steven J. Swoap, and William J. Schwartz

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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Circulating microRNA Profiles in Acetaminophen Toxicity, Stephanie Carreiro, James Marvel-Coen, Rosalind Lee, Brittany Chapman, and Victor R. Ambros

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Bacillus thuringiensis Cry5B is Active against Strongyloides stercoralis in vitro, Sarit Charuchaibovorn, Vivornpun Sanprasert, Nataya Sutthanont, Yan Hu, Ambily Abraham, Gary R. Ostroff, Raffi V. Aroian, Tegegn G. Jaleta, James B. Lok, and Surang Nuchprayoon

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TRIM5alpha Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation, Abhilash I. Chiramel, Nicholas R. Meyerson, Kristin L. McNally, Rebecca M. Broeckel, Vanessa R. Montoya, Omayra Mendez-Solis, Shelly J. Robertson, Gail L. Sturdevant, Kirk J. Lubick, Vinod Nair, Brian H. Youseff, Robin M. Ireland, Catharine M. Bosio, Kyusik Kim, Jeremy Luban, Vanessa M. Hirsch, R. Travis Taylor, Fadila Bouamr, Sara L. Sawyer, and Sonja M. Best

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The C. elegans heterochronic gene lin-28 coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesis, Sungwook Choi and Victor R. Ambros

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Toll family members bind multiple Spatzle proteins and activate antimicrobial peptide gene expression in Drosophila, Munmun Chowdhury, Chun-Feng Li, Zhen He, Yuzhen Lu, Xu-Sheng Liu, Yu-Feng Wang, Y. Tony Ip, Michael R. Strand, and Xiao-Qiang Yu

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A big-data approach to understanding metabolic rate and response to obesity in laboratory mice, June K. Corrigan, Deepti Ramachandran, Yuchen He, Colin Palmer, Michael J. Jurczak, Bingshan Li, Randall H. Friedline, Jason K. Kim, Jon J. Ramsey, Louise Lantier, Owen P. McGuinness, Alexander S. Banks, and Mouse Metabolic Phenotyping Center Energy Balance Working Group

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A minimal CRISPR-Cas3 system for genome engineering, Bálint Csörgő, Lina M. León, Ilea J. Chau-Ly, Alejandro Vasquez-Rifo, Joel D. Berry, Caroline Mahendra, Emily D. Crawford, Jennifer D. Lewis, and Joseph Bondy-Denomy

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Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling, Luca D'Agostino, Yingchao Nie, Qi Li, Y. Tony Ip, and Nan Gao

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Harnessing robotic automation and web-based technologies to modernize scientific outreach, Orna Dahan, Bat-Shahar Dorfman, Serkan Sayin, Brittany Rosener, Tiffany Hua, Anat Yarden, and Amir Mitchell

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Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes, Sanchaita Das, Andrew W. Malaby, Agata Nawrotek, Wenhua Zhang, Mahel Zeghouf, Sarah Maslen, Mark Skehel, Srinivas Chakravarthy, Thomas C. Irving, Osman Bilsel, Jacqueline Cherfils, and David G. Lambright

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Point-of-care technologies in heart, lung, blood and sleep disorders from the Center for Advancing Point-of-Care Technologies, Eric Y. Ding, Emily Ensom, Nathaniel Hafer, Bryan Buchholz, Mary Ann Picard, Denise Dunlap, Eugene Rogers, Carl Lawton, Ainat Koren, Craig M. Lilly, Timothy P. Fitzgibbons, and David D. McManus

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High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network, Antje Dittmann, Norman J. Kennedy, Nina L. Soltero, Nader Morshed, Miyeko D. Mana, Omer H. Yilmaz, Roger J. Davis, and Forest M. White

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TRAPPing a Rab GTPase by the Tail, Jianjun Duan and David G. Lambright

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Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver, Sabrina N. Dumas, Chang-An Guo, Jason K. Kim, Randall H. Friedline, and James M. Ntambi

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A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ildar Gainetdinov, Yeonsoo Yoon, Chun-Qing Song, Yueying Cao, Judith Gallant, Wen Xue, Jaime A. Rivera, and Erik J. Sontheimer

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Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans, Nicole Ehrhardt, Jinrui Cui, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Helen S. Goodridge, Jason K. Kim, Louise Lantier, Xiuqing Guo, Yii-Der I. Chen, Leslie J. Raffel, Thomas A. Buchanan, Willa A. Hsueh, Jerome I. Rotter, Mark O. Goodarzi, and Miklos Peterfy

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Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations, Shady Farah, Dale L. Greiner, and Daniel G. Anderson

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Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability, Jessica L. Feldman and Craig L. Peterson

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Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females, Sully Fernandez, John M. Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, and Kathryn E. Wellen

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Inferring population dynamics from single-cell RNA-sequencing time series data, David S. Fischer, Anna K. Fiedler, Eric M. Kernfeld, Ryan Genga, Aimee Bastidas-Ponce, Mostafa Bakhti, Heiko Lickert, Jan Hasenauer, Rene Maehr, and Fabian J. Theis

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Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat, Timothy P. Fitzgibbons, Nancy Lee, Khanh-Van T. Tran, Sarah M. Nicoloro, Mark Kelly, Stanley Kc Tam, and Michael P. Czech

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Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing, Bianca Garcia, Jooyoung Lee, Alireza Edraki, Yurima Hidalgo-Reyes, Steven Erwood, Aamir Mir, Chantel N. Trost, Uri Seroussi, Sabrina Y. Stanley, Ronald D. Cohn, Julie M. Claycomb, Erik J. Sontheimer, Karen L. Maxwell, and Alan R. Davidson

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Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1, Melissa A. Gawron, Mark Duval, Claudia Carbone, Smita Jaiswal, Aaron Wallace, Joseph C. Martin 3rd, Ann Dauphin, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Jeremy Luban, and Lisa A. Cavacini