The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2020

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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis, Camila Martinez Calejman, S. Trefely, S. W. Entwisle, Amelia K. Luciano, Su Myung. Jung, Wen-Yu Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villen, K. E. Wellen, and David A. Guertin

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Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults, Yuming Cao, Zhiru Guo, Pranitha Vangala, Elisa Donnard, Ping Liu, Patrick McDonel, Jose Ordovas Montanes, Alex K. Shalek, Robert W. Finberg, Jennifer P. Wang, and Manuel Garber

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Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution, Gaurav Chauhan, Jesse McClure, Jessica Hekman, Patrick W. Marsh, Jeffrey A. Bailey, Rachel F. Daniels, Diane P. Genereux, and Elinor K. Karlsson

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen, Qi Li, Niraj K. Nirala, and Y. Tony Ip

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Mechanisms of insulin resistance related to white, beige, and brown adipocytes, Michael P. Czech

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Tacrolimus- and sirolimus-induced human beta cell dysfunction is reversible and preventable, Chunhua Dai, John T. Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle. Dean, Nripesh Prasad, Shawn E. Levy, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C. Powers

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Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates, Joana Damas, Elinor K. Karlsson, and Harris A. Lewin

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics, Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, and James B. Munro

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Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor alpha and beta Repertoires, Anna Gil, Larisa Kamga, Ramakanth Chirravuri-Venkata, Nuray Aslan, Fransenio G. Clark, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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The Role of BMP Signaling in the Melanocyte Lineage and as a Therapeutic Target in Melanoma, Alec K. Gramann

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Regulation of adipose tissue inflammation by interleukin 6, Myoung Souk Han, Alexis White, Rachel J. Perry, Joao-Paulo Camporez, Juan Hidalgo, Gerald I. Shulman, and Roger J. Davis

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Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone, Celine A. Hayden, Danilo Landrock, Chiung Yu Hung, Gary R. Ostroff, Gina M. Fake, John H. Walker, Ann Kier, and John A. Howard

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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, Tingting Jiang, Xiao-Ou Zhang, Yueying Cao, Zhiping Weng, and Wen Xue

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Ultrastructural Details of Mammalian Chromosome Architecture, Nils Krietenstein, Sameer Abraham, Sergey V. Venev, Nezar Abdennur, Johan H. Gibcus, Tsung-Han S. Hsieh, Krishna M. Parsi, Liyan Yang, Rene Maehr, Leonid A. Mirny, Job Dekker, and Oliver J. Rando (Molecular cell, 2020-03-14)

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Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111, Aaron E. Lin, William E. Diehl, Yingyun Cai, Courtney L. Finch, Chidiebere Akusobi, Robert N. Kirchdoerfer, Laura Bollinger, Stephen F. Schaffner, Elizabeth A. Brown, Erica Ollmann Saphire, Kristian G. Andersen, Jens H. Kuhn, Jeremy Luban, and Pardis C. Sabeti

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SARS-CoV-2, Jeremy Luban

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Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation, Asia N. Matthew-Onabanjo, Jenny Janusis, Jose Mercado-Matos, Anne E. Carlisle, Dohoon Kim, Fayola Levine, Peter Cruz-Gordillo, Ryan Richards, Michael J. Lee, and Leslie M. Shaw (Cancer research, 2020-01-15)

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Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt(Q140/Q140) mouse model of Huntington's disease, Robyn L. McAdam, Andrew Morton, Sarah L. Gordon, Julia F. Alterman, Anastasia Khvorova, Michael A. Cousin, and Karen J. Smillie

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Proteomic and Transcriptional Profiles of Human Stem Cell-Derived beta Cells Following Enteroviral Challenge, Julius O. Nyalwidhe, Agata Jurczyk, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Melanie I. Trombly, Pranitha Vangala, Riccardo Racicot, Rita Bortell, David M. Harlan, Dale L. Greiner, Michael A. Brehm, Jerry L. Nadler, and Jennifer P. Wang

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TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner, Molly Ohainle, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy Luban, and Michael Emerman

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Adaptive Evolution Targets a piRNA Precursor Transcription Network, Swapnil Parhad, Tianxiong Yu, Gen Zhang, Nicholas P. Rice, Zhiping Weng, and William E. Theurkauf

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Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice, Sambra D. Redick, Linda Leehy, Ann R. Rittenhouse, David M. Blodgett, Alan G. Derr, Alper Kucukural, Manuel Garber, Leonard D. Shultz, Dale L. Greiner, Jennifer P. Wang, David M. Harlan, Rita Bortell, and Agata Jurczyk

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An atlas of cell types in the mammalian epididymis and vas deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

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SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC, Christian F. Ruiz, Emily D. Montal, John A. Haley, and John D. Haley

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Adenine base editing in an adult mouse model of tyrosinaemia, Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M. Schatoff, Jordan L. Doman, Yueying Cao, Lukas E. Dow, Lihua Julie Zhu, Daniel G. Anderson, David R. Liu, Hao Yin, and Wen Xue

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Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models, Jos L. van der Velden, John F. Alcorn, David G. Chapman, Lennart K. A. Lundblad, Charles G. Irvin, Roger J. Davis, Kelly Butnor, and Yvonne M. W. Janssen-Heininger

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Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice, Ryan G. Walker, Hye Lim Noh, Taekyoon Kim, Jason K. Kim, and Richard T. Lee

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HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells, Yetao Wang, Lawrence M. Lifshitz, Kyle Gellatly, Sean M. McCauley, Pranitha Vangala, Kyusik Kim, Alan G. Derr, Smita Jaiswal, Alper Kucukural, Patrick McDonel, Thomas C. Greenough, JeanMarie Houghton, Manuel Garber, and Jeremy Luban

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Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice, Zhenyu Wang, Yuqin Shi, Suheng Ma, Qian Huang, Yi Tian Yap, Lin Shi, Shiyang Zhang, Ting Zhou, Wei Li, Bo Hu, Ling Zhang, Stephen A. Krawetz, Gregory J. Pazour, Rex A. Hess, and Zhibing Zhang

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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View, Joao B. Xavier and Amir Mitchell

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DolphinNext: a distributed data processing platform for high throughput genomics, Onur Yukselen, Osman Turkyilmaz, Ahmet R. Ozturk, Manuel Garber, and Alper Kucukural

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SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues, Carly G. K. Ziegler, Yuming Cao, Zhiru Guo, Jennifer P. Wang, Robert W. Finberg, Manuel Garber, Alex K. Shalek, Jose Ordovas-Montanes, and HCA Lung Biological Network

Publications from 2019

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A novel vaccine platform using glucan particles for induction of protective responses against Francisella tularensis and other pathogens, Ambily Abraham, Gary R. Ostroff, Stuart M. Levitz, and P. C. F. Oyston

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Humanized immune system mouse models: progress, challenges and opportunities, Todd M. Allen, Michael A. Brehm, Sandra Bridges, Stacy Ferguson, Priti Kumar, Oleg Mirochnitchenko, Karolina Palucka, Roberta Pelanda, Brigitte Sanders-Beer, Leonard D. Shultz, Lishan Su, and Mercy PrabhuDas

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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Chantal M. Ferguson, Dimas Echeverria, Ellen Sapp, Reka A. Haraszti, Andrew H. Coles, Faith Conroy, Rachael Miller, Loic Roux, Paul Yan, Emily G. Knox, Anton A. Turanov, Robert M. King, Gwladys Gernoux, Christian Mueller, Heather Gray-Edwards, Richard P. Moser, N Bishop, Samer M. Jaber, Matthew J. Gounis, Miguel Sena-Esteves, Athma A. Pai, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

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Progressive alignment with Cactus: a multiple-genome aligner for the thousand-genome era, Joel Armstrong, Elinor K. Karlsson, and Benedict Paten

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Utilizing Humanized Mice to Study Human Specific Innate Immune Responses in Immuno-Oncology, Ken-Edwin Aryee

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Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo, Thiago M. Batista, Ruben Garcia-Martin, Weikang Cai, Masahiro Konishi, Brian T. O'Neill, Masaji Sakaguchi, Jong Hun Kim, Dae Young Jung, Jason K. Kim, and C. Ronald Kahn

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Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo, Annabelle Biscans, Andrew H. Coles, Reka A. Haraszti, Dimas Echeverria, Matthew R. Hassler, Maire F. Osborn, and Anastasia Khvorova

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Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism, Alecia M. Blaszczak, Valerie P. Wright, Kajol Anandani, Joey Liu, Anahita Jalilvand, Stephen Bergin, Sarah M. Nicoloro, Michael P. Czech, William Lafuse, Tuo Deng, David Bradley, and Willa A. Hsueh

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Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon

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Defective daily temperature regulation in a mouse model of amyotrophic lateral sclerosis, Maurine C. Braun, Alexandra Castillo-Ruiz, Premananda Indic, Dae Young Jung, Jason K. Kim, Robert H. Brown Jr., Steven J. Swoap, and William J. Schwartz

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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Circulating microRNA Profiles in Acetaminophen Toxicity, Stephanie Carreiro, James Marvel-Coen, Rosalind Lee, Brittany Chapman, and Victor R. Ambros

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Bacillus thuringiensis Cry5B is Active against Strongyloides stercoralis in vitro, Sarit Charuchaibovorn, Vivornpun Sanprasert, Nataya Sutthanont, Yan Hu, Ambily Abraham, Gary R. Ostroff, Raffi V. Aroian, Tegegn G. Jaleta, James B. Lok, and Surang Nuchprayoon

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TRIM5alpha Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation, Abhilash I. Chiramel, Nicholas R. Meyerson, Kristin L. McNally, Rebecca M. Broeckel, Vanessa R. Montoya, Omayra Mendez-Solis, Shelly J. Robertson, Gail L. Sturdevant, Kirk J. Lubick, Vinod Nair, Brian H. Youseff, Robin M. Ireland, Catharine M. Bosio, Kyusik Kim, Jeremy Luban, Vanessa M. Hirsch, R. Travis Taylor, Fadila Bouamr, Sara L. Sawyer, and Sonja M. Best

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The C. elegans heterochronic gene lin-28 coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesis, Sungwook Choi and Victor R. Ambros

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Toll family members bind multiple Spatzle proteins and activate antimicrobial peptide gene expression in Drosophila, Munmun Chowdhury, Chun-Feng Li, Zhen He, Yuzhen Lu, Xu-Sheng Liu, Yu-Feng Wang, Y. Tony Ip, Michael R. Strand, and Xiao-Qiang Yu

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A big-data approach to understanding metabolic rate and response to obesity in laboratory mice, June K. Corrigan, Deepti Ramachandran, Yuchen He, Colin Palmer, Michael J. Jurczak, Bingshan Li, Randall H. Friedline, Jason K. Kim, Jon J. Ramsey, Louise Lantier, Owen P. McGuinness, Alexander S. Banks, and Mouse Metabolic Phenotyping Center Energy Balance Working Group

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A minimal CRISPR-Cas3 system for genome engineering, Bálint Csörgő, Lina M. León, Ilea J. Chau-Ly, Alejandro Vasquez-Rifo, Joel D. Berry, Caroline Mahendra, Emily D. Crawford, Jennifer D. Lewis, and Joseph Bondy-Denomy

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Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling, Luca D'Agostino, Yingchao Nie, Qi Li, Y. Tony Ip, and Nan Gao

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Harnessing robotic automation and web-based technologies to modernize scientific outreach, Orna Dahan, Bat-Shahar Dorfman, Serkan Sayin, Brittany Rosener, Tiffany Hua, Anat Yarden, and Amir Mitchell

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Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes, Sanchaita Das, Andrew W. Malaby, Agata Nawrotek, Wenhua Zhang, Mahel Zeghouf, Sarah Maslen, Mark Skehel, Srinivas Chakravarthy, Thomas C. Irving, Osman Bilsel, Jacqueline Cherfils, and David G. Lambright

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High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network, Antje Dittmann, Norman J. Kennedy, Nina L. Soltero, Nader Morshed, Miyeko D. Mana, Omer H. Yilmaz, Roger J. Davis, and Forest M. White

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TRAPPing a Rab GTPase by the Tail, Jianjun Duan and David G. Lambright

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Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver, Sabrina N. Dumas, Chang-An Guo, Jason K. Kim, Randall H. Friedline, and James M. Ntambi

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A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ildar Gainetdinov, Yeonsoo Yoon, Chun-Qing Song, Yueying Cao, Judith Gallant, Wen Xue, Jaime A. Rivera, and Erik J. Sontheimer

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Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans, Nicole Ehrhardt, Jinrui Cui, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Helen S. Goodridge, Jason K. Kim, Louise Lantier, Xiuqing Guo, Yii-Der I. Chen, Leslie J. Raffel, Thomas A. Buchanan, Willa A. Hsueh, Jerome I. Rotter, Mark O. Goodarzi, and Miklos Peterfy

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Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations, Shady Farah, Dale L. Greiner, and Daniel G. Anderson

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Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability, Jessica L. Feldman and Craig L. Peterson

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Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females, Sully Fernandez, John M. Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, and Kathryn E. Wellen

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Inferring population dynamics from single-cell RNA-sequencing time series data, David S. Fischer, Anna K. Fiedler, Eric M. Kernfeld, Ryan Genga, Aimee Bastidas-Ponce, Mostafa Bakhti, Heiko Lickert, Jan Hasenauer, Rene Maehr, and Fabian J. Theis

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Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat, Timothy P. Fitzgibbons, Nancy Lee, Khanh-Van T. Tran, Sarah M. Nicoloro, Mark Kelly, Stanley Kc Tam, and Michael P. Czech

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Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing, Bianca Garcia, Jooyoung Lee, Alireza Edraki, Yurima Hidalgo-Reyes, Steven Erwood, Aamir Mir, Chantel N. Trost, Uri Seroussi, Sabrina Y. Stanley, Ronald D. Cohn, Julie M. Claycomb, Erik J. Sontheimer, Karen L. Maxwell, and Alan R. Davidson

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Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1, Melissa A. Gawron, Mark Duval, Claudia Carbone, Smita Jaiswal, Aaron Wallace, Joseph C. Martin 3rd, Ann Dauphin, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Jeremy Luban, and Lisa A. Cavacini

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Towards Understanding the Molecular Basis of Human Endoderm Development Using CRISPR-Effector and Single-Cell Technologies, Ryan M. Genga

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Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development, Ryan M. Genga, Eric M. Kernfeld, Krishna M. Parsi, Teagan J. Parsons, Michael J. Ziller, and Rene Maehr

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Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis, Hilda E. Ghadieh, Lucia Russo, Harrison T. Muturi, Simona S. Ghanem, Iyad H. Manaserh, Hye Lim Noh, Sujin Suk, Jason K. Kim, Jennifer W. Hill, and Sonia M. Najjar

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Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling, Alec Gramann, Arvind M. Venkatesan, Melissa Guerin, and Craig J. Ceol

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Becoming a Principal Investigator: Designing and Navigating Your Academic Adventure, Paul L. Greer and Melanie A. Samuel

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Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus, Adilson L. Guilherme, Felipe Henriques, Alexander H. Bedard, and Michael P. Czech

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Preparation and characterization of yeast cell wall beta-glucan encapsulated humic acid nanoparticles as an enhanced aflatoxin B1 binder, Zeinab Hamza, Maher El-Hashash, Soher Aly, Amal Hathout, Ernesto Soto, Bassem Sabry, and Gary R. Ostroff

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, and Anastasia Khvorova

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Maize-Produced Ag2 as a Subunit Vaccine for Valley Fever, Celine A. Hayden, Chiung-Yu Hung, Hao Zhang, Austin Negron, Raymond Esquerra, Gary R. Ostroff, Ambily Abraham, Alejandro Gabriel Lopez, Juliet Elizabeth Gonzales, and John A. Howard

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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity, Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G. E. de Vries, Michael J. Lee, and Marcel A T M van Vugt

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WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data, Amy D. Holdorf, Daniel P. Higgins, Anne C. Hart, Peter R. Boag, Gregory J. Pazour, Albertha J. M. Walhout, and Amy K. Walker (Genetics, 2019-12-06)

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WormCat: an online tool for annotation and visualization of Caenorhabditis elegans genome-scale data, Amy D. Holdorf, Daniel P. Higgins, Anne C. Hart, Peter R. Boag, Gregory J. Pazour, Albertha J. M. Walhout, and Amy K. Walker

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De Novo Lipogenesis as a Source of Second Messengers in Adipocytes, Wen-Yu Hsiao and David A. Guertin

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A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis, Carmen Hurtado Del Pozo, Randall H. Friedline, Hye Lim Noh, Jason K. Kim, and Ann Marie. Schmidt

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Robustness Mechanisms of Temporal Cell-Fate Progression in C. Elegans, Orkan Ilbay

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Pheromones and Nutritional Signals Regulate the Developmental Reliance on let-7 Family MicroRNAs in C. elegans, Orkan Ilbay and Victor R. Ambros

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Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans, Orkan Ilbay and Victor R. Ambros

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Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim, Sonal Jangalwe, Varun N. Kapoor, Jia Xu, Nomeda Girnius, Norman J. Kennedy, Yvonne J. K. Edwards, Raymond M. Welsh, Roger J. Davis, and Michael A. Brehm

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1, Su Myung Jung, Chien-Min Hung, Samuel R. Hildebrand, Joan Sanchez-Gurmaches, Dimpi Mukhopadhyay, Camila Martinez Calejman, Amelia K. Luciano, Wen-Yu Hsiao, Yuefeng Tang, Huawei Li, and David A. Guertin

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Conserved Features of the T Cell Receptor Repertoire Contribute to the Persistence of EBV-Specific CD8 T Cells, Larisa Kamga

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CDR3alpha drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection, Larisa Kamga, Anna Gil, InYoung Song, Robin M. Brody, Dario Ghersi, Nuray Aslan, Lawrence J. Stern, Liisa K. Selin, and Katherine Luzuriaga

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Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis, Shashi Kant, Siobhan M. Craige, Kai Chen, Michaella M. Reif, Heather Learnard, Mark Kelly, Amada D. Caliz, Khanh-Van T. Tran, Kasmir Ramo, Owen M. Peters, Marc R. Freeman, Roger J. Davis, and John F. Keaney Jr.

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Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features, Joyce E. Karlinsey, Taylor A. Stepien, Matthew Mayho, Larissa A. Singletary, Lacey K. Bingham-Ramos, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Larry A. Gallagher, Matt Bawn, Robert A. Kingsley, Stephen J. Libby, and Ferric C. Fang

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Cyclophilin A protects HIV-1 from restriction by human TRIM5alpha, Kyusik Kim, Ann Dauphin, Sevnur Komurlu, Sean M. McCauley, Leonid Yurkovetskiy, Claudia Carbone, William E. Diehl, Caterina Strambio-De-Castilla, Edward M. Campbell, and Jeremy Luban

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DEBrowser: interactive differential expression analysis and visualization tool for count data, Alper Kucukural, Onur Yukselen, Deniz M. Ozata, Melissa J. Moore, and Manuel Garber

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Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes, Suet-Yan Kwan, Ankur Sheel, Chun-Qing Song, Xiao-Ou Zhang, Tingting Jiang, Hien Dang, Yueying Cao, Deniz M. Ozata, Haiwei Mou, Hao Yin, Zhiping Weng, Xin Wei Wang, and Wen Xue

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Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins, Jooyoung Lee, Haiwei Mou, Raed Ibraheim, Shun-Qing Liang, Pengpeng Liu, Wen Xue, and Erik J. Sontheimer

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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression, Huapeng Li, Qi Li, Kyvan Dang, Shan Ma, Jennifer L. Cotton, Sun Yang, Lihua Julie Zhu, April C. Deng, Y. Tony Ip, Randy L. Johnson, Xu Wu, Claudio Punzo, and Junhao Mao

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The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium, Qi Li, Niraj K. Nirala, Hsi-Ju Chen, Yingchao Nie, Wei Wang, Biliang Zhang, Michael P. Czech, Qi Wang, Lan Xu, Junhao Mao, and Y. Tony Ip

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Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice, Botao Liu, Gemma Molinaro, Huan Shu, Emily E. Stackpole, Kimberly M. Huber, and Joel D. Richter

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JNK(1/2) represses Lkb(1)-deficiency-induced lung squamous cell carcinoma progression, Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis, and Francesco J. DeMayo

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The History of Farm Foxes Undermines the Animal Domestication Syndrome, Kathryn A. Lord, Greger Larson, Raymond P. Coppinger, and Elinor K. Karlsson

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Oncogenic AKTivation by methylation, Amelia K. Luciano and David A. Guertin