The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.
Publications from 2016
Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain, Mehran Nikan, Maire F. Osborn, Andrew H. Coles, Bruno M. D. C. Godinho, Lauren M. Hall, Reka A. Haraszti, Dimas Echeverria, Neil Aronin, Matthew R. Hassler, and Anastasia Khvorova
A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome, Machteld M. Oud, Gregory J. Pazour, Bruno Reversade, and Heleen H. Arts
Using an Inducible CRISPR-dCas9-KRAB Effector System to Dissect Transcriptional Regulation in Human Embryonic Stem Cells, Krishna M. Parsi, Erica Hennessy, Nicola A. Kearns, and Rene Maehr
Regulatory T Cells in Endemic Burkitt Lymphoma Patients Are Associated with Poor Outcomes: A Prospective, Longitudinal Study, Emily Parsons, Juliana A. Otieno, John Michael Ong'echa, Christina E. Nixon, John Vulule, Christian Munz, V. Ann Stewart, and Ann M. Moormann
Naturally Occurring Off-Switches for CRISPR-Cas9, April Pawluk, Nadia Amrani, Yan Zhang, Bianca Garcia, Yurima Hidalgo-Reyes, Jooyoung Lee, Alireza Edraki, Megha Shah, Erik J. Sontheimer, Karen L. Maxwell, and Alan R. Davidson
Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development, Kasmir Ramo, Koichi Sugamura, Siobhan M. Craige, John F. Keaney Jr., and Roger J. Davis
Identification and Characterization of MicroRNA Modulators in Caenorhabditis Elegans: A Dissertation, Zhiji Ren
Staufen Negatively Modulates microRNA Activity in Caenorhabditis elegans, Zhiji Ren, Isana Veksler-Lublinsky, David Morrissey, and Victor R. Ambros
Impact of Plasmodium falciparum Coinfection on Longitudinal Epstein-Barr Virus Kinetics in Kenyan Children, Arnold Reynaldi, Timothy E. Schlub, Kiprotich Chelimo, Peter Odada Sumba, Erwan Piriou, Sidney Ogolla, Ann M. Moormann, Rosemary A. Rochford, and Miles P. Davenport
Modeling of EBV Infection and Antibody Responses in Kenyan Infants With Different Levels of Malaria Exposure Shows Maternal Antibody Decay is a Major Determinant of Early EBV Infection, Arnold Reynaldi, Timothy E. Schlub, Erwan Piriou, Sidney Ogolla, Odada P. Sumba, Ann M. Moormann, Rosemary Rochford, and Miles P. Davenport
Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia, Rachel J. Roth Flach, Laura V. Danai, Marina DiStefano, Mark Kelly, Lorena Garcia Menendez, Agata Jurczyk, Rohit B. Sharma, Dae Young Jung, Jong Hun Kim, Jason K. Kim, Rita Bortell, Laura C. Alonso, and Michael P. Czech
Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function, Rachel J. Roth Flach, Chang-An Guo, Laura V. Danai, Joseph C. Yawe, Sharvari Gujja, Yvonne J.K. Edwards, and Michael P. Czech
Genetic link between renal birth defects and congenital heart disease, Jovenal T. San Agustin, Nikolai Klena, Kristi Granath, Ashok Panigrahy, Eileen Stewart, William Devine, Lara Strittmatter, Julie A. Jonassen, Xiaoqin Liu, Cecilia W. Lo, and Gregory J. Pazour
Emerging Complexities in Adipocyte Origins and Identity, Joan Sanchez-Gurmaches, Chien-Min Hung, and David A. Guertin
Activation of WNT/beta-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61, Makoto Sano, David R. Driscoll, Wilfredo E. De Jesus-Monge, Brian J. Quattrochi, Victoria A. Appleman, Jianhong Ou, Lihua (Julie) Zhu, and Brian C. Lewis
beta1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation, Aejaz Sayeed, Huimin Lu, Qin Liu, David Deming Ii, Alexander Duffy, Peter McCue, Adam P. Dicker, Roger J. Davis, Dmitry Gabrilovich, Ulrich Rodeck, Dario C. Altieri, and Lucia R. Languino
A Role for TNMD in Adipocyte Differentiation and Adipose Tissue Function: A Dissertation, Ozlem Senol-Cosar
Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion, Ozlem Senol-Cosar, Rachel J. Roth Flach, Marina DiStefano, Anil K. Chawla, Sarah M. Nicoloro, Juerg R. Straubhaar, Olga T. Hardy, Hye Lim Noh, Jason K. Kim, Martin Wabitsch, Philipp E. Scherer, and Michael P. Czech
Association between First Trimester Pregnancy Associated Plasma Protein–A (PAPP-A) and Gestational Diabetes Mellitus Development, Aylin Sert, Katherine Leung, Molly E. Waring, Raziel Rojas-Rodriguez, Silvia Corvera, and Tiffany A. Moore Simas
Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals, Upasna Sharma, Colin C. Conine, Jeremy Shea, Ana Boskovic, Alan G. Derr, Xin Y. Bing, Clemence Belleannee, Alper Kucukural, Ryan W. Serra, Fengyun Sun, Lina Song, Benjamin R. Carone, Emiliano P. Ricci, Xin Z. Li, Lucas Fauquier, Melissa J. Moore, Robert Sullivan, Craig C. Mello, Manuel Garber, and Oliver J. Rando
Genomic Amplifications Cause False Positives in CRISPR Screens, Ankur Sheel and Wen Xue
Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration, Jihae Shin, Johnny S. Salameh, and Joel D. Richter
Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation, Lorissa J. Smulan, Wei Ding, Elizaveta Freinkman, Sharvari Gujja, Yvonne J. Edwards K, and Amy K. Walker
Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages, Ernesto R. Soto, Olivia O'Connell, Fusun Dikengil, Paul J. Peters, Paul R. Clapham, and Gary R. Ostroff
PRIMA: a gene-centered, RNA-to-protein method for mapping RNA-protein interactions [preprint], Alex M. Tamburino, Ebru Kaymak, Shaleen Shrestha, Amy D. Holdorf, Sean P. Ryder, and Albertha J. M. Walhout
The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans, Wen Tang, Shikui Tu, Heng-Chi Lee, Zhiping Weng, and Craig C. Mello
Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism, Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L. Lee, Santiago Vernia, Christian M. Metallo, and David A. Guertin
Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative polymerase chain reaction, Kahraman Tanriverdi, Alper Kucukural, Ekaterina Mikhalev, Selim E. Tanriverdi, Rosalind Lee, Victor R. Ambros, and Jane Freedman
Inactivation of nuclear GSK3beta by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response, Tina M. Thornton, Pilar Delgado, Liang Chen, Beatriz Salas, Dimitry Krementsov, Miriam Fernandez, Santiago Vernia, Roger J. Davis, Ruth Heimann, Cory Teuscher, Michael S. Krangel, Almudena R. Ramiro, and Mercedes Rincon
Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK, Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Cathy Tournier, and Roger J. Davis
An alternative splicing program promotes adipose tissue thermogenesis, Santiago Vernia, Yvonne J. K. Edwards, Myoung Souk Han, Julie Cavanagh-Kyros, Tamera Barrett, Jason K. Kim, and Roger J. Davis
Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress, Santiago Vernia, Caroline Morel, Joseph C. Madara, Julie Cavanagh-Kyros, Tamera Barrett, Kathryn O. Chase, Norman J. Kennedy, Dae Young Jung, Jason K. Kim, Neil Aronin, Richard A. Flavell, Bradford B. Lowell, and Roger J. Davis
Human basal body basics, Anastassiia Vertii, Hui-Fang Hung, Heidi Hehnly, and Stephen J. Doxsey
Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases, Joseph V. Virbasius and Michael P. Czech
Germ Cells Need Folate to Proliferate, Amy K. Walker
Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants, Doyle V. Ward, Matthias Scholz, Moreno Zolfo, Diana H. Taft, Kurt R. Schibler, Adrian Tett, Nicola Segata, and Ardythe L. Morrow
Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans, Emma Watson, Viridiana Olin-Sandoval, Michael J. Hoy, Chi-Hua Li, Timo Louisse, Victoria Yao, Akihiro Mori, Amy D. Holdorf, Olga G. Troyanskaya, Markus Ralser, and Albertha J. M. Walhout
High Epstein-Barr Virus Load and Genomic Diversity Are Associated with Generation of gp350-Specific Neutralizing Antibodies following Acute Infectious Mononucleosis, Eric R. Weiss, Galit Alter, Javier Gordon Ogembo, Jennifer L. Henderson, Barbara Tabak, Yasin Bakis, Mohan Somasundaran, Manuel Garber, Liisa K. Selin, and Katherine Luzuriaga
Multisite phosphorylation by MAPK, Alan J. Whitmarsh and Roger J. Davis
Macrophages Are Regulators of Whole Body Metabolism: A Dissertation, Joseph C. Yawe
A Caenorhabditis elegans Genome-Scale Metabolic Network Model, L. Safak Yilmaz and Albertha J. M. Walhout (Cell systems, 2016-05-25)
RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver, Hao Yin, Roman L. Bogorad, Carmen Barnes, Stephen Walsh, Iris Zhuang, Hidenori Nonaka, Vera Ruda, Satya Kuchimanchi, Lubomir Nechev, Akin Akinc, Wen Xue, Marino Zerial, Robert Langer, Daniel G. Anderson, and Victor Koteliansky
RNA polymerase II depletion promotes transcription of alternative mRNA species, Lijian Yu, Mayuri Rege, Craig L. Peterson, and Michael R. Volkert
The molecular basis of the genesis of basal tone in internal anal sphincter, Cheng-Hai Zhang, Donghai Lui, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence Lifshitz, John F. Keaney Jr., Kevin E. Fogarty, Ronghua Zhuge, and Min-Sheng Zhu
Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice, Zhengang Zhang, Wei Li, Yong Zhang, Ling Zhang, Maria E. Teves, Hong Liu, Jerome F. Strauss 3rd, Gregory J. Pazour, James A. Foster, Rex A. Hess, and Zhibing Zhang
Publications from 2015
The p53R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression, Leanne G. Ahronian, David R. Driscoll, David S. Klimstra, and Brian C. Lewis
Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain, Julia F. Alterman, Lauren M. Hall, Andrew H. Coles, Matthew R. Hassler, Marie C. Didiot, Kathryn O. Chase, Jasmin Abraham, Emily Sottosanti, Emily S. Johnson, Ellen Sapp, Maire F. Osborn, Marian Difiglia, Neil Aronin, and Anastasia Khvorova
Biodistribution and function of extracellular miRNA-155 in mice, Shashi Bala, Timea Csak, Fatemeh Momen-Heravi, Dora Lippai, Karen Kodys, Donna Catalano, Abhishek Satishchandran, Victor R. Ambros, and Gyongyi Szabo
Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants, Ankita Bansal, Lihua Julie Zhu, Kelvin Yen, and Heidi A. Tissenbaum
SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases, Gwendolyn M. Bennett and Craig L. Peterson
Processing strategies and software solutions for data-independent acquisition in mass spectrometry, Aivett Bilbao, Emmanuel Varesio, Jeremy Luban, Caterina Strambio-De-Castillia, Gerard Hopfgartner, Markus Muller, and Frederique Lisacek
Ranking Fragment Ions Based on Outlier Detection for Improved Label-Free Quantification in Data-Independent Acquisition LC-MS/MS, Aivett Bilbao, Ying Zhang, Emmanuel Varesio, Jeremy Luban, Caterina Strambio-De-Castillia, Frederique Lisacek, and Gerard Hopfgartner
Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets, David M. Blodgett, Anetta Nowosielska, Shaked Afik, Susanne Pechhold, Anthony J. Cura, Norman J. Kennedy, Soyoung Kim, Alper Kucukural, Roger J. Davis, Sally C. Kent, Dale L. Greiner, Manuel Garber, David M. Harlan, and Philip J. diLorio Jr.
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization, Markus-Frederik Bohn, Shivender Shandilya, Tania V. Silvas, Ellen A. Nalivaika, Takahide Kouno, Brian Kelch, Sean P. Ryder, Nese Kurt Yilmaz, Mohan Somasundaran, and Celia A. Schiffer
DNA-binding-domain fusions enhance the targeting range and precision of Cas9, Mehmet Fatih Bolukbasi, Ankit Gupta, Sarah Oikemus, Alan G. Derr, Manuel Garber, Michael H. Brodsky, Lihua Julie Zhu, and Scot A. Wolfe
MicroRNAs Protect the Robustness of Distal Tip Cell Migrations from Temperature Changes in Caenorhabditis elegans: A Dissertation, Samantha L. Burke
Robust Distal Tip Cell Pathfinding in the Face of Temperature Stress Is Ensured by Two Conserved microRNAS in Caenorhabditis elegans, Samantha L. Burke, Molly Hammell, and Victor R. Ambros
A laminin 511 matrix is regulated by TAZ and functions as the ligand for the alpha6Bbeta1 integrin to sustain breast cancer stem cells, Cheng Chang, Hira Lal Goel, Huijie Gao, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Sulev Ingerpuu, Manuel Patarroyo, Shiliang Cao, Elgene Lim, Junhao Mao, Karen Kulju. McKee, Peter D. Yurchenco, and Arthur M. Mercurio
Alternatively Activated M2 Macrophages Improve Autologous Fat Graft Survival in a Mouse Model through Induction of Angiogenesis, Ava Chappell, Jorge Lujan-Hernandez, Dylan Perry, Silvia Corvera, and Janice F. Lalikos
Evolutionary analysis across mammals reveals distinct classes of long noncoding RNAs [preprint], Jenny Chen, Alexander A. Shishkin, Xiaopeng Zhu, Sabah Kadri, Itay Maza, Jacob H. Hanna, Aviv Regev, and Manuel Garber
R loops regulate promoter-proximal chromatin architecture and cellular differentiation, Poshen B. Chen, Hsiuyi V. Chen, Diwash Acharya, Oliver J. Rando, and Thomas G. Fazzio
RNA Interference in Caenorhabditis elegans, Darryl Conte Jr., Lesley T. MacNeil, Albertha J. M. Walhout, and Craig C. Mello (Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], 2015-01-05)
Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury, Francisco Javier Cubero, Gang Zhao, Yulia A. Nevzorova, Maximilian Hatting, Malika Al Masaoudi, Julien Verdier, Jin Peng, Frederik M. Schaefer, Nadine Hermanns, Mark V. Boekschoten, Christoph Grouls, Nikolaus Gassler, Fabian Kiessling, Michael Muller, Roger J. Davis, Christian Liedtke, and Christian Trautwein
Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies, Rama Rao Damerla, Cheng Cui, George C. Gabriel, Xiaoqin Liu, Branch Craige, Brian C. Gibbs, Richard Francis, You Li, Bishwanath Chatterjee, Jovenal T. San Agustin, Thibaut Eguether, Ramiah Subramanian, George B. Witman, Jacques L. Michaud, Gregory J. Pazour, and Cecilia W. Lo (Human molecular genetics)
Role of Protein Kinase Map4k4 in Energy Metabolism: A Dissertation, Laura V. Danai
Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues, Laura V. Danai, Rachel J. Roth Flach, Joseph V Virbasius, Lorena Garcia Menendez, Dae Young Jung, Jong Hun Kim, Jason K. Kim, and Michael P. Czech
Plasmodium falciparum Protein Microarray Antibody Profiles Correlate With Protection From Symptomatic Malaria in Kenya, Arlene E. Dent, Rie Nakajima, Li Liang, Elisabeth Baum, Ann M. Moormann, Peter Odada Sumba, John Vulule, Denise Babineau, Arlo Randall, D. Huw Davies, Philip L. Felgner, and James W. Kazura
s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways, Wei Ding, Lorissa J. Smulan, Nicole S. Hou, Stefan Taubert, Jennifer L. Watts, and Amy K. Walker
The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis, Marina T. DiStefano, Laura V. Danai, Rachel J. Roth Flach, Anil K. Chawla, David J. Pedersen, Adilson L. Guilherme, and Michael P. Czech
A feasible approach to evaluate the relative reactivity of NHS-ester activated group with primary amine-derivatized DNA analogue and non-derivatized impurity, Shuping Dou, John Virostko, Dale L. Greiner, Alvin C. Powers, and Guozheng Liu
Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody, Shuping Dou, John Virostko, Dale L. Greiner, Alvin C. Powers, and Guozheng Liu
POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA, Ahmed M. Elewa, Masaki Shirayama, Ebru Kaymak, Paul F. Harrison, David R. Powell, Zhuo Du, Christopher D. Chute, Hannah Woolf, Dongni Yi, Takao Ishidate, Jagan Srinivasan, Zhirong Bao, Traude H. Beilharz, Sean P. Ryder, and Craig C. Mello
The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse, Francesca Finetti, Laura Patrussi, Donatella Galgano, Chiara Cassioli, Giuseppe Perinetti, Gregory J. Pazour, and Cosima T. Baldari
Human gene-centered transcription factor networks for enhancers and disease variants, Juan Fuxman Bass, Nidhi Sahni, Shaleen Shrestha, Aurian Garcia-Gonzalez, Akihiro Mori, Numana Bhat, Song Yi, David E. Hill, Marc Vidal, and Albertha J. M. Walhout (Cell, 2015-04-23)
Viral infection of engrafted human islets leads to diabetes, Glen R. Gallagher, Michael A. Brehm, Robert W. Finberg, Bruce A. Barton, Leonard D. Shultz, Dale L. Greiner, Rita Bortell, and Jennifer P. Wang
Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements, Ming Gao, Travis Thomson, T Michael Creed, Shikui Tu, Sudan N. Loganathan, Christina A. Jackson, Patrick McCluskey, Yanyan Lin, Scott E. Collier, Zhiping Weng, Paul Lasko, Melanie D. Ohi, and Alexey L. Arkov
Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection, Laura L. Gibson, Constance Barysauskas, Margaret M. McManus, Sheryl Dooley, Daniele Lilleri, Donna Fisher, Tumul Srivastava, Don J. Diamond, and Katherine Ruiz De Luzuriaga
p38alpha MAPK is required for tooth morphogenesis and enamel secretion, Matthew B. Greenblatt, Jung-Min Kim, Hwanhee Oh, Kwang Hwan Park, Min-Kyung Choo, Yasuyo Sano, Coralee E. Tye, Ziedonis Skobe, Roger J. Davis, Jin Mo Park, Marianna Bei, Laurie H. Glimcher, and Jae-Hyuck Shim
A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection, Thomas C. Greenough, Juerg R. Straubhaar, Larisa Kamga, Eric R. Weiss, Robin M. Brody, Margaret M. McManus, Linda K. Lambrecht, Mohan Somasundaran, and Katherine Ruiz De Luzuriaga
Influenza A virus preferentially snatches noncoding RNA caps, Weifeng Gu, Glen R. Gallagher, Weiwei Dai, Ping Liu, Ruidong Li, Melanie I. Trombly, Don B. Gammon, Craig C. Mello, Jennifer P. Wang, and Robert W. Finberg
Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome, Sarah J. Hainer and Thomas G. Fazzio
Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF, Sarah J. Hainer, Weifeng Gu, Benjamin R. Carone, Benjamin D. Landry, Oliver J. Rando, Craig C. Mello, and Thomas G. Fazzio
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans, Omid F. Harandi and Victor R. Ambros
Methods to analyze novel liaisons between endosomes and centrosomes, Hui-Fang Hung, Heidi Hehnly, and Stephen J. Doxsey
Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6, Yu-Jie Hu, Houda Belaghzal, Wen-Yu Hsiao, Jun Qi, James E. Bradner, David A. Guertin, Said Sif, and Anthony N. Imbalzano (Nucleic acids research)
Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation, Sharanya Iyengar
Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells, Sharanya Iyengar, Melissa Kasheta, and Craig J. Ceol
Neutrophil Responses to Sterile Implant Materials, Siddharth Jhunjhunwala, Stephanie Aresta-DaSilva, Katherine Tang, David Alvarez, Matthew J. Webber, Benjamin C. Tang, Danya M. Lavin, Omid Veiseh, Joshua C. Doloff, Suman Bose, Arturo Vegas, Minglin Ma, Gaurav Sahay, Alan Chiu, Andrew Bader, Erin Langan, Sean Siebert, Jie Li, Dale L. Greiner, Peter E. Newburger, Ulrich H. von Andrian, Robert Langer, and Daniel G. Anderson
Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model, Emily S. Johnson, Kathryn O. Chase, Sarah McGowan, Erica Mondo, Edith L. Pfister, Eric Mick, Randall H. Friedline, Jason K. Kim, Ellen Sapp, Marian DiFiglia, and Neil Aronin
A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1, Richard A. Kahn and David G. Lambright
Research resource: Monitoring endoplasmic reticulum membrane integrity in beta-cells at the single-cell level, Kohsuke Kanekura, Jianhong Ou, Takashi Hara, Lihua (Julie) Zhu, and Fumihiko Urano
Functional annotation of native enhancers with a Cas9-histone demethylase fusion, Nicola A. Kearns, Hannah Pham, Barbara Tabak, Ryan M. J. Genga, Noah J. Silverstein, Manuel Garber, and Rene Maehr
Early antiretroviral therapy in children perinatally infected with HIV: a unique opportunity to implement immunotherapeutic approaches to prolong viral remission, Nigel Klein, Paolo Rossi, Katherine Luzuriaga, Savita Pahwa, Eleni Nastouli, Diane M. Gibb, Pablo Rojo, William Borkowsky, Stefania Bernardi, Paola Zangari, Vincent Calvez, Alexandra Compagnucci, Britta Wahren, Caroline Foster, and Maria Angeles Munoz-Fernandez
Studying Cellular Signal Transduction with OMIC Technologies, Benjamin D. Landry, David C. Clarke, and Michael J. Lee (Journal of molecular biology, 2015-08-03)
TRIM5 retroviral restriction activity correlates with the ability to induce innate immune signaling, Josefina Lascano, Pradeep Uchil, Walther Mothes, and Jeremy Luban
Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics, Junfeng Li, Zhaoyun Zhang, Xiaoxia Liu, Yi Wang, Fei Mao, Junjun Mao, Xiaolan Lu, Dongdong Jiang, Yun Wan, Jia-Ying Lv, Guoying Cao, Jing Zhang, Naiqing Zhao, Mark Atkinson, Dale L. Greiner, Gerald J. Prud'homme, Zheng Jiao, Yiming Li, and Qinghua Wang
Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors, Shaoyong Li, Li Zhong, Mengxin Li, Qin Su, Ran He, Qiushi Tang, Dale L. Greiner, Michael A. Brehm, Terence R. Flotte, Christian Mueller, and Guangping Gao
Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling, Shuangxi Li, Yong Suk Cho, Tao Yue, Y. Tony Ip, and Jin Jiang
A versatile reporter system for CRISPR-mediated chromosomal rearrangements, Yingxiang Li, Angela I. Park, Haiwei Mou, Cansu Colpan, Aizhan Bizhanova, Elliot Akama-Garren, Nik Joshi, Eric A. Hendrickson, David Feldser, Hao Yin, Daniel G. Anderson, Tyler Jacks, Zhiping Weng, and Wen Xue
Global genetic analysis in mice unveils central role for cilia in congenital heart disease, You Li, Jovenal T. San Agustin, Gregory J. Pazour, and Cecilia W. Lo