The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.
Publications from 2014
TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein, Sanchita Bhatnagar, Claude Gazin, Lynn Chamberlain, Jianhong Ou, Xiaochun Zhu, Jogender S. Tushir, Ching-Man A. Virbasius, Ling Lin, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green
Genetic and pharmacological reactivation of the mammalian inactive X chromosome, Sanchita Bhatnagar, Xiaochun Zhu, Jianhong Ou, Ling Lin, Lynn Chamberlain, Lihua Julie Zhu, Narendra Wajapeyee, and Michael R. Green
Spectrum and mechanisms of inflammasome activation by chitosan, Chelsea L. Bueter, Chrono K. Lee, Jennifer P. Wang, Gary R. Ostroff, Charles A. Specht, and Stuart M. Levitz
A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation, Chun-Ting Chen, Heidi Hehnly, Qing Yu, Debby Farkas, Guoqiang Zheng, Sambra D. Redick, Hui-Fang Hung, Rajeev Samtani, Agata Jurczyk, Schahram Akbarian, Carol Wise, Andrew Jackson, Michael Bober, Yin Guo, Cecilia W. Lo, and Stephen J. Doxsey
Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo, Poshen B. Chen, Lihua Julie Zhu, Sarah J. Hainer, Kurtis N. McCannell, and Thomas G. Fazzio
Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport, Kyoko Chiba, Masahiko Araseki, Keisuke Nozawa, Keiko Furukori, Yoichi Araki, Takahide Matsushima, Tadashi Nakaya, Saori Hata, Yuhki Saito, Seiichi Uchida, Yasushi Okada, Angus C. Nairn, Roger J. Davis, Tohru Yamamoto, Masataka Kinjo, Hidenori Taru, and Toshiharu Suzuki
PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion, Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Hyun Kyung Oh, Darren Reese Williams, D. Joshua Liao, Jianhua Zhou, Michael R. Green, Xuexiu Zheng, and Haihong Shen
Adipose tissue angiogenesis: impact on obesity and type-2 diabetes, Silvia Corvera and Olga Gaelekman
Distinct functions for IFT140 and IFT20 in opsin transport, Jacquelin A. Crouse, Vanda S. Lopes, Jovenal T. San Agustin, Brian T. Keady, David S. Williams, and Gregory J. Pazour
Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma, Clare C. Davies, Emma Harvey, Raymond F. T. McMahon, Katherine G. Finegan, Frances Connor, Roger J. Davis, David A. Tuveson, and Cathy Tournier
Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA, Alberto De Iaco and Jeremy Luban
Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM, Claudia M. Del Campo, Ashwini K. Mishra, Yu-Hsiu Wang, Craig R. Roy, Paul A. Janmey, and David G. Lambright
Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice, Shuping Dou, John Virostko, Mary Rusckowski, Dale L. Greiner, Alvin C. Powers, and Guozheng Liu
Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach, Shuping Dou, Yuzhen Wang, Bruce A. Barton, Ling Chen, Mary Rusckowski, Leonard D. Shultz, Dale L. Greiner, and Guozheng Liu
The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype, Minggang Fang, Jianhong Ou, Lloyd Hutchinson, and Michael R. Green
Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour
Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters, Juan I. Fuxman Bass, Alex M. Tamburino, Akihiro Mori, Nathan Beittel, Matthew T. Weirauch, John S. Reece-Hoyes, and Albertha J. M. Walhout (Nucleic acids research, 2014-01-07)
A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection, Don B. Gammon, Sophie Duraffour, Daniel K. Rozelle, Heidi Hehnly, Rita Sharma, Michael E. Sparks, Cara C. West, Ying Chen, James J. Moresco, Graciela Andrei, John H. Connor, Darryl Conte Jr., Dawn E. Gundersen-Rindal, William L. Marshall, John R. Yates, Neal S. Silverman, and Craig C. Mello
Regulated splicing of the alpha6 integrin cytoplasmic domain determines the fate of breast cancer stem cells, Hira Lal Goel, Tatiana Gritsko, Bryan Pursell, Cheng Chang, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Leslie M. Shaw, and Arthur M. Mercurio
An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J. Keith Joung, Scot A. Wolfe, and Gary D. Stormo
Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A, Romi Gupta, Yuying Dong, Peter D. Solomon, Hiromi I. Wettersten, Christopher J. Cheng, JIn-Na Min, Jeremy Henson, Shaillay Kumar Dogra, Sung H. Hwang, Bruce D. Hammock, Lihua Julie Zhu, Roger R. Reddel, W. Mark Saltzman, Robert H. Weiss, Sandy Chang, Michael R. Green, and Narendra Wajapeyee
Rab11 endosomes contribute to mitotic spindle organization and orientation, Heidi Hehnly and Stephen J. Doxsey
The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins, Andree Hubber, Kohei Arasaki, Fubito Nakatsu, Camille Hardiman, David G. Lambright, Pietro De Camilli, Hiroki Nagai, and Craig R. Roy
Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease, Chien-Min Hung, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Huawei Li, Clary B. Clish, Simone Hettmer, Amy J. Wagers, and David A. Guertin
Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8, Ha Na Jang, Minho Lee, Tiing Jen Loh, Seung-Woo Choi, Hyun Kyung Oh, Heegyum Moon, Sunghee Cho, Seong-Eui Hong, Do Han Kim, Zhi Sheng, Michael R. Green, Daeho Park, Xuexiu Zheng, and Haihong Shen
A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling beta-glucan microparticles, Magdia De Jesus, Gary R. Ostroff, Stuart M. Levitz, Toni R. Bartling, and Nicholas J. Mantis
Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells, Nicola A. Kearns, Ryan M. J. Genga, Metewo Selase Enuameh, Manuel Garber, Scot A. Wolfe, and Rene Maehr
A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans, Heesun Kim, Takao Ishidate, Krishna S. Ghanta, Meetu Seth, Darryl Conte Jr., Masaki Shirayama, and Craig C. Mello
Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes, Nora M. Kochupurakkal, Annie J. Kruger, Sudipta Tripathi, Bing Zhu, La Tonya Adams, Daniel B. Rainbow, Aldo A. Rossini, Dale L. Greiner, Mohamed H. Sayegh, Linda S. Wicker, and Indira Guleria
Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression, Benjamin D. Landry, Claudine E. Mapa, Heather E. Arsenault, Kristin E. Poti, and Jennifer A. Benanti
A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors that Repress FGFR Signaling, Ling Lin, Lynn Chamberlain, Magnolia L. Pak, Arvindhan Nagarajan, Romi Gupta, Lihua Julie Zhu, Casey M. Wright, Kwun M. Fong, Narendra Wajapeyee, and Michael R. Green
The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila, Qi Li, Sebastian Mana-Capelli, Rachel J. Roth Flach, Laura V. Danai, Alla Amcheslavsky, Yingchao Nie, Satoshi Kaneko, Xiaohao Yao, Xiaochu Chen, Jennifer L. Cotton, Junhao Mao, Dannel McCollum, Michael P. Czech, Lan Xu, and Y. Tony Ip
Cancer-Relevant Splicing Factor CAPERalpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex, Sarah Loerch, Alexandre Maucuer, Valerie Manceau, Michael R. Green, and Clara L. Kielkopf
Cyclophilin A and HIV-1 Replication, Jeremy Luban
HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatment, Katherine Luzuriaga, Barbara Tabak, Manuel Garber, Ya Hui Chen, Carrie Ziemniak, Margaret M. McManus, Danielle Murray, Matthew Strain, Douglas Richman, Tae-Wook Chun, Coleen K. Cunningham, and Deborah Persaud
Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation, Avraham Maimon, Maxim Mogilevsky, Asaf Shilo, Regina Golan-Gerstl, Akram Obiedat, Vered Ben-Hur, Ilana Lebenthal-Loinger, Ilan Stein, Reuven Reich, Jonah Beenstock, Eldar Zehorai, Claus L. Andersen, Kasper Thorsen, Torben F. Orntoft, Roger J. Davis, Ben Davidson, David Mu, and Rotem Karni
An Integrated Structural Mechanism for Relief of Autoinhibition and Membrane Targeting in Cytohesin Family Guanine Nucleotide Exchange Factors: A Dissertation, Andrew W. Malaby
A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia, Leyuan Ma, Yi Shan, Robert Bai, Liting Xue, Christopher A. Eide, Jianhong Ou, Lihua Julie Zhu, Lloyd Hutchinson, Jan Cerny, Hanna Jean Khoury, Zhi Sheng, Brian J. Druker, Shaoguang Li, and Michael R. Green
MIRAGE DNA Transposon Silencing by C. elegans Condensin II Subunit HCP-6: A Masters Thesis, Anna Malinkevich
Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme, Benjamin J. Manning and Craig L. Peterson
The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans, Katherine McJunkin and Victor R. Ambros
SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene, Heegyum Moon, Sunghee Cho, Tiing Jen Loh, Hyun Kyung Oh, Ha Na Jang, Jianhua Zhou, Young-Soo Kwon, D. Joshua Liao, Youngsoo Jun, Soohyun Eom, Claudia Ghigna, Giuseppe Biamonti, Michael R. Green, Xuexiu Zheng, and Haihong Shen
The hunt for protective correlates of immunity to Plasmodium falciparum malaria, Ann M. Moormann and V. Ann Stewart
Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation, Kimberly A. Negrin
IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis, Kimberly A. Negrin, Rachel J. Roth Flach, Marina T. DiStefano, Anouch Matevossian, Randall H. Friedline, Dae Young Jung, Jason K. Kim, and Michael P. Czech
miR-14 Regulates Autophagy during Developmental Cell Death by Targeting ip3-kinase 2, Charles Nelson, Victor R. Ambros, and Eric H. Baehrecke
MicroRNA-378 controls classical brown fat expansion to counteract obesity, Dongning Pan, Chunxiao Mao, Brian Quattrochi, Randall H. Friedline, Lihua Julie Zhu, Dae Young Jung, Jason K. Kim, Brian C. Lewis, and Yong-Xu Wang
Diversity and expression of microRNAs in the filarial parasite, Brugia malayi, Catherine B. Poole, Weifeng Gu, Sanjay Kumar, Jingmin Jin, Paul J. Davis, David Bauche, and Larry A. McReynolds
Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase beta and regulates complex V activity, Motiur Rahman, Niraj K. Nirala, Alka Singh, Lihua Julie Zhu, Kaori Taguchi, Takeshi Bamba, Eiichiro Fukusaki, Leslie M. Shaw, David G. Lambright, Jairaj K. Acharya, and Usha R. Acharya
Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration, Christian Reinhard, Dario Bottinelli, Baek Kim, and Jeremy Luban
Epstein-barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids, Nicholas Renzette, Mohan Somasundaran, Frank E. Brewster, James Coderre, Eric R. Weiss, Margaret M. McManus, Thomas C. Greenough, Barbara Tabak, Manuel Garber, Timothy F. Kowalik, and Katherine Ruiz De Luzuriaga
c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells, Justine E. Roderick, Jessica M. Tesell, Leonard D. Shultz, Michael A. Brehm, Dale L. Greiner, Marian H. Harris, Lewis B. Silverman, Stephen E. Sallan, Alejandro Gutierrez, A. Thomas Look, Jun Qi, James E. Bradner, and Michelle A. Kelliher
TNF and MAP kinase signalling pathways, Guadalupe Sabio and Roger J. Davis
Adipocyte lineages: tracing back the origins of fat, Joan Sanchez-Gurmaches and David A. Guertin
Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed, Joan Sanchez-Gurmaches and David A. Guertin
A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype, Ryan W. Serra, Minggang Fang, Sung Mi Park, Lloyd Hutchinson, and Michael R. Green
RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast, JongDae Shin, Mary C. Wallingford, Judith Gallant, Chelsea Marcho, Baowei Jiao, Meg Byron, Michael Bossenz, Jeanne B. Lawrence, Stephen N. Jones, Jesse Mager, and Ingolf Bach
TRIM5alpha and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment, Ravesh Singh, Vinod Patel, Marianne W. Mureithi, Vivek Naranbhai, Duran Ramsuran, Sahil Tulsi, Keshni Hiramen, Lise Werner, Koleka Mlisana, Marcus Altfeld, Jeremy Luban, Victoria Kasprowicz, Keertan Dheda, Salim S. Abdool Karim, and Thumbi Ndung'u
A separable domain of the p150 subunit of human Chromatin Assembly Factor-1 promotes protein and chromosome associations with nucleoli, Corey L. Smith, Timothy D. Matheson, Daniel J. Trombly, Xiaoming Sun, Eric Campeau, Xuemei Han, John R. Yates III, and Paul D. Kaufman
Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking, Sylvia Stockler, Silvia Corvera, David G. Lambright, Kevin E. Fogarty, Ekaterina Nosova, Deborah Marie Leonard, Robert Steinfeld, Cameron Ackerley, Casper Shyr, Nicolas Au, Kathrin Selby, Margot van Allen, Hilary Vallance, Ron Wevers, David Watkins, David Rosenblatt, Colin J. Ross, Elizabeth Conibear, Wyeth Wasserman, and Clara van Karnebeek
HTT-lowering reverses Huntington's disease immune dysfunction caused by NFkappaB pathway dysregulation, Ulrike Trager, Ralph Andre, Nayana Lahiri, Anna Magnusson-Lind, Andreas Weiss, Stephan Grueninger, Chris McKinnon, Eva Sirinathsinghji, Shira Kahlon, Edith L. Pfister, Roger Moser, Holger Hummerich, Michael Antoniou, Gillian P. Bates, Ruth Luthi-Carter, Mark W. Lowdell, Maria Bjorkqvist, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi
The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex, Yoshiko Usami, Sergei Popov, and Heinrich G. Gottlinger
The PPARalpha-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway, Santiago Vernia, Julie Cavanagh, Luisa Garcia-Haro, Guadalupe Sabio, Tamera Barrett, Dae Young Jung, Jason K. Kim, Jia Xu, Hennady P. Shulha, Manuel Garber, Guangping Gao, and Roger J. Davis
Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain, Timothy R. Wagenaar, Leyuan Ma, Benjamin P. Roscoe, Sung Mi Park, Daniel N. Bolon, and Michael R. Green
Genetic adaptation to diet preserves longevity, Albertha J. M. Walhout (Cell Metabolism, 2014-02-04)
Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis, Jeanine Ward, Chitra Kanchagar, Isana Veksler-Lublinsky, Rosalind C. Lee, Mitchell R. McGill, Hartmut Jaeschke, Steven C. Curry, and Victor R. Ambros
Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals, Stefan Washietl, Manolis Kellis, and Manuel Garber
Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits, Emma Watson, Lesley T. MacNeil, Ashlyn D. Ritter, L. Safak Yilmaz, Adam P. Rosebrock, Amy A. Caudy, and Albertha J. M. Walhout (Cell, 2014-02-13)
Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy, Emma Watson and Albertha J. M. Walhout (Trends in endocrinology and metabolism: TEM, 2014-10)
Determination and inference of eukaryotic transcription factor sequence specificity, Matthew T. Weirauch, Ally Yang, Mihai Albu, Atina G. Cote, Alejandro Montenegro-Montero, Philipp Drewe, Hamed S. Najafabadi, Samuel A. Lambert, Ishminder Mann, Kate Cook, Hong Zheng, Alejandra Goity, Harm van Bakel, Jean-Claude Lozano, Mary Galli, Mathew G. Lewsey, Eryong Huang, Tuhin Mukherjee, Xiaoting Chen, John S. Reece-Hoyes, Sridhar Govindarajan, Gad Shaulsky, Albertha J. M. Walhout, Francois-Yves Bouget, Gunnar Ratsch, Luis F. Larrondo, Joseph R. Ecker, and Timothy R. Hughes (Cell, 2014-09-11)
Worms, bacteria, and micronutrients: an elegant model of our diet, L. Safak Yilmaz and Albertha J. M. Walhout (Trends in genetics : TIG, 2014-11)
TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis, Shiyan Yu, Yingchao Nie, Y. Tony Ip, and Nan Gao
p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene, Syed Kashif Zaidi, Wen-Jun Shen, Stefanie Bittner, Alex Bittner, Mark P. McLean, Jiahuai Han, Roger J. Davis, Fredric B. Kraemer, and Salman Azhar
Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin, Zhao Zhang, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Zhiping Weng, William E. Theurkauf, and Phillip D. Zamore
The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing, Zhao Zhang, Jie Wang, Nadine McGinnis-Schultz, Fan Zhang, Swapnil S. Parhad, Shikui Tu, Thom Vreven, Phillip D. Zamore, Zhiping Weng, and William E. Theurkauf
Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis, Gang Zhao, Maximilian Hatting, Yulia A. Nevzorova, Jin Peng, Wei Hu, Mark V. Boekschoten, Tania Roskams, Michael Muller, Nikolaus Gassler, Christian Liedtke, Roger J. Davis, Francisco Javier Cubero, and Christian Trautwein
Retromer promotes immune quiescence by suppressing Spatzle-Toll pathway in Drosophila, Bo Zhou, Eun-Young Yun, Lorraine Ray, Jia You, Y. Tony Ip, and Xinhua Lin
TEMP: a computational method for analyzing transposable element polymorphism in populations, Jiali Zhuang, Jie Wang, William E. Theurkauf, and Zhiping Weng
CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems, Lihua Julie Zhu, Benjamin R. Holmes, Neil Aronin, and Michael H. Brodsky
Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression, Anna Y. Zinovyeva, Samir Bouasker, Martin J. Simard, Christopher M. Hammell, and Victor R. Ambros
Publications from 2013
Nucleosome dynamics regulates DNA processing, Nicholas L. Adkins, Hengyao Niu, Patrick Sung, and Craig L. Peterson
Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano
Victor Ambros: the broad scope of microRNAs. Interview by Caitlin Sedwick, Victor R. Ambros
Regulation of Toll signaling and inflammation by beta-arrestin and the SUMO protease Ulp1, Saima G. Anjum, Wenjian Xu, Niusha Nikkholgh, Sukanya Basu, Yingchao Nie, Mary Thomas, Mridula Satyamurti, Bogdan A. Budnik, Y. Tony Ip, and Alexey Veraksa
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice, Myriam Aouadi, Michaela Tencerova, Pranitha Vangala, Joseph Yawe, Sarah M. Nicoloro, Shinya U. Amano, Jessica L. Cohen, and Michael P. Czech
The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans, Gabriel D. Bosse, Stefan Ruegger, Maria C. Ow, Alejandro Vasquez-Rifo, Evelyne L. Rondeau, Victor R. Ambros, Helge Grosshans, and Martin J. Simard
Humanized mice for the study of infectious diseases, Michael A. Brehm, Nathalie Jouvet, Dale L. Greiner, and Leonard D. Shultz
Overcoming current limitations in humanized mouse research, Michael A. Brehm, Leonard D. Shultz, Jeremy Luban, and Dale L. Greiner
A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation, Alison R. Bright
Resurrecting remnants: the lives of post-mitotic midbodies, Chun-Ting Chen, Andreas W. Ettinger, Wieland B. Huttner, and Stephen J. Doxsey
Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila, Wei Cheng, Y. Tony Ip, and Zuoshang Xu
Hdac6 regulates Tip60-p400 function in stem cells, Poshen B. Chen, Jui-Hung Hung, Taylor L. Hickman, Andrew H. Coles, James F. Carey, Zhiping Weng, Feixia Chu, and Thomas G. Fazzio
p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells, Ya-Wen Chen, Hsiao-Chien Chu, Ze-Shiang Lin, Wei-Jyh Shiah, Chen-Pin Chou, David S. Klimstra, and Brian C. Lewis
Novel strategies to enhance vaccine immunity against coccidioidomycosis, Garry T. Cole, Chiung-Yu Hung, Sam D. Sanderson, Brady J. Hurtgen, Marcel Wuthrich, Bruce S. Klein, George S. Deepe, Gary R. Ostroff, and Stuart M. Levitz
Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans, Colin C. Conine, James J. Moresco, Weifeng Gu, Masaki Shirayama, Darryl Conte Jr., John R. Yates III, and Craig C. Mello
Obesity Notches up fatty liver, Michael P. Czech
Insulin signalling mechanisms for triacylglycerol storage, Michael P. Czech, Michaela Tencerova, David J. Pedersen, and Myriam Aouadi
Translational control of cell growth and malignancy by the CPEBs, Andrea D'Ambrogio, Kentaro Nagaoka, and Joel D. Richter
Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling, Laura V. Danai, Adilson L. Guilherme, Kalyani V. P. Guntur, Juerg R. Straubhaar, Sarah M. Nicoloro, and Michael P. Czech
TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm, Alberto De Iaco, Federico A. Santoni, Anne Vannier, Michel Guipponi, Stylianos E. Antonarakis, and Jeremy Luban