The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.
Publications from 2017
Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma, Cliff I. Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey
Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma, Cliff I. Oduor, Mercedeh Movassagh, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John M. Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey
Adaptive Evolution Leads to Cross-Species Incompatibility in the piRNA Transposon Silencing Machinery, Swapnil S. Parhad, Shikui Tu, Zhiping Weng, and William E. Theurkauf
Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration, Jillian N. Pearring, Jovenal T. San Agustin, Ekaterina S. Lobanova, Christopher J. Gabriel, Eric C. Lieu, William J. Monis, Michael W. Stuck, Lara Strittmatter, Samer M. Jaber, Vadim Y. Arshavsky, and Gregory J. Pazour
Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection, Kaitlin Rainwater-Lovett, Carrie Ziemniak, Douglas Watson, Katherine Luzuriaga, George Siberry, Ann Petru, YaHui Chen, Priyanka Uprety, Margaret M. McManus, Ya-Chi Ho, Susanna L. Lamers, and Deborah Persaud
Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model, Frederick R. Roberts, Clinton Hupple, Elaine Norowski, Nicole C. Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M. Van Dessel, Agata Jurczyk, David M. Harlan, Dale L. Greiner, Rita Bortell, and Chaoxing Yang
MAP4K4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity, Rachel J. Roth Flach, Marina T. DiStefano, Laura V. Danai, Ozlem Senol-Cosar, Joseph C. Yawe, Mark Kelly, Lorena Garcia Menendez, and Michael P. Czech
Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia, Louis A. Saddic, Sarah M. Nicoloro, Olga T. Gupta, Michael P. Czech, Joshua Gorham, Stanton K. Shernan, Christine E. Seidman, Jon G. Seidman, Sary F. Aranki, Simon C. Body, Timothy P. Fitzgibbons, and Jochen D. Muehlschlegel
Amplification of Adipogenic Commitment by VSTM2A, Blandine Secco, Peter L. Lee, David A. Guertin, and Mathieu Laplante
miRNAs cooperate in apoptosis regulation during C. elegans development, Ryan Sherrard, Sebastian Luehr, Heinke Holzkamp, Katherine McJunkin, Nadin Memar, and Barbara Conradt
Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism, Jihae Shin, Ki Young Paek, Mariya Ivshina, Emily E. Stackpole, and Joel D. Richter
Super-Resolution Microscopy Reveals That Disruption Of Ciliary Transition Zone Architecture Is A Cause Of Joubert Syndrome [preprint], Xiaoyu Shi; Galo Garcia III; Julie C. Van De Weghe; University of California, San Francisco; Gregory J. Pazour; Dan Doherty; Bo Huang; and Jeremy F. Reiter
Hepatic Dysfunction Caused by Consumption of a High-Fat Diet, Anthony R. Soltis, Norman J. Kennedy, Xiaofeng Xin, Feng Zhou, Scott B. Ficarro, Yoon Sing Yap, Bryan J. Matthews, Douglas A. Lauffenburger, Forest M. White, Jarrod A. Marto, Roger J. Davis, and Ernest Fraenkel
Hyper- and hypo- nutrition studies of the hepatic transcriptome and epigenome suggest that PPARα regulates anaerobic glycolysis, Anthony R. Soltis, Shmulik Motola, Santiago Vernia, Christopher W. Ng, Norman J. Kennedy, Simona Dalin, Bryan J. Matthews, Roger J. Davis, and Ernest Fraenkel
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice, Chun-Qing Song, Yingxiang Li, Haiwei Mou, Jill Moore, Angela I. Park, Soren Hough, Zachary Kennedy, Andrew H. Fischer, Darryl Conte Jr., Zhiping Weng, and Wen Xue
Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species, Charles A. Specht, Chrono K. Lee, Haibin Huang, Maureen M. Hester, Jianhua Liu, Bridget A. Luckie, Melanie A. Torres Santana, Zeynep Mirza, Payam Khoshkenar, Ambily Abraham, Zu T. Shen, Ali Akalin, Gary R. Ostroff, and Stuart M. Levitz
Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice, Sujin Suk, Gyoo Taik Kwon, Eunjung Lee, Woo Jung Jang, Hee Yang, Jong Hun Kim, N. R. Thimmegowda, Min-Yu Chung, Jung Yeon Kwon, Seunghee Yang, Jason K. Kim, Jung Han Park Yoon, and Ki Won Lee
PRIMA: a gene-centered, RNA-to-protein method for mapping RNA-protein interactions, Alex M. Tamburino, Ebru Kaymak, Shaleen Shrestha, Amy D. Holdorf, Sean P. Ryder, and Albertha J. M. Walhout (Translation (Austin, Tex.), 2017-02-28)
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma, Tuomas Tammela, Wen Xue, and Tyler Jacks
Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS, Technische Universitat München, Roger J. Davis, and Mathias Heikenwalder
Comparative Oncogenomics Identifies Novel Regulators and Clinical Relevance of Neural Crest Identities in Melanoma, Arvind M. Venkatesan
Humanized Mouse Models of Clinical Disease, Nicole C. Walsh, Laurie L. Kenney, Sonal Jangalwe, Ken-Edwin Aryee, Dale L. Greiner, Michael A. Brehm, and Leonard D. Shultz
MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance, J. Wang, D. H. Kho, J-Y Zhou, Roger J. Davis, and G. S. Wu
Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines, Shixia Wang, Te-Hui Chou, Anthony Hackett, Veronica Efros, Yan Wang, Dong Han, Aaron Wallace, Yuxin Chen, Guangnan Hu, Shuying Liu, Paul R. Clapham, James Arthos, David Montefiori, and Shan Lu
Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion, Levi B. Watkin, Rabinarayan Mishra, Anna Gil, Nuray Aslan, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin
The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach, Sijia Wu, Rita R. Fagan, Chayasith Uttamapinant, Lawrence M. Lifshitz, Kevin E. Fogarty, Alice Y. Ting, and Haley Melikian
c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo, Ren Xu, Chao Zhang, Dong Yeon Shin, Jung-Min Kim, Sarfaraz Lalani, Na Li, Yeon-Suk Yang, Yifang Liu, Mark Eiseman, Roger J. Davis, Jae-Hyuck Shim, and Matthew B. Greenblatt
INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma, N. Yang, E. L.-H. Leung, C. Liu, L. Li, Thibaut Eguether, X.-J. Jun Yao, E. C. Jones, D. A. Norris, A. Liu, R. A. Clark, D. R. Roop, Gregory J. Pazour, K. R. Shroyer, and J. Chen
Metabolic network modeling with model organisms, L. Safak Yilmaz and Albertha J. M. Walhout (Current opinion in chemical biology, 2017-02-01)
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing, Hao Yin, Chun-Qing Song, Esther Mintzer, Mehmet F. Bolukbasi, Lihua Julie Zhu, Haiwei Mou, Suet-Yan Kwan, Scot A. Wolfe, Wen Xue, and Daniel G. Anderson
C. elegans and its bacterial diet as a model for systems-level understanding of host-microbiota interactions, Jing Zhang, Amy D. Holdorf, and Albertha J. M. Walhout (Current opinion in biotechnology, 2017-02-08)
Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice, Yong Zhang, Hong Liu, Wei Li, Zhengang Zhang, Xuejun Shang, David Zhang, Yuhong Li, Shiyang Zhang, Junpin Liu, Rex A. Hess, Gregory J. Pazour, and Zhibing Zhang
Bitter taste receptors as targets for tocolytics in preterm labor therapy, Kaizhi Zheng, Ping Lu, Ellen Delpapa, Karl D. Bellve, Ruitang Deng, Jennifer C. Condon, Kevin E. Fogarty, Lawrence M. Lifshitz, Tiffany A. Moore Simas, Fangxiong Shi, and Ronghua ZhuGe
GUIDEseq: a bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases, Lihua Julie Zhu, Michael Lawrence, Ankit Gupta, Herve Pages, Alper Kucukural, Manuel Garber, and Scot A. Wolfe
Publications from 2016
A Modular Assembly Platform for Rapid Generation of DNA Constructs, Elliot Akama-Garren, Nik Joshi, Tuomas Tammela, Gregory P. Chang, Bethany L. Wagner, Da-Yae Lee, William M. Rideout Iii, Thales Papagiannakopoulos, Wen Xue, and Tyler Jacks
Examination of Huntington's disease with atypical clinical features in a Bangladeshi family tree, Md Mahfuz Al-Mamun, Suprovath Kumar Sarker, Syeda Kashfi Qadri, Tahmina Shirin, Quazi Deen Mohammad, Regina LaRocque, Elinor K. Karlsson, Narayan Saha, Muhammad Asaduzzaman, Firdausi Qadri, and Md Kaiissar Mannoor
In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery, Raman Bahal, Dale L. Greiner, Michael A. Brehm, and Peter M. Glazer
Platelet functional and transcriptional changes induced by intralipid infusion, Lea M. Beaulieu, Olga Vitseva, Kahraman Tanriverdi, Alper Kucukural, Eric O. Mick, Naomi Hamburg, Joseph Vita, and Jane E. Freedman
Longevity of Genotype-Specific Immune Responses to Plasmodium falciparum Merozoite Surface Protein 1 in Kenyan Children from Regions of Different Malaria Transmission Intensity, Natalie M. Bowman, Jonathan J. Juliano, Cynthia J. Snider, Oksana Kharabora, Steven R. Meshnick, John Vulule, Chandy C. John, and Ann M. Moormann
Tissue Compartmentalization and Tropism of HIV-1: A Dissertation, Robin L. Brese
Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study, Geoffrey C. Buckle, Louise Maranda, Jodi Skiles, John Michael Ong'echa, Joslyn Foley, Mara M. Epstein, Terry A. Vik, Andrew Schroeder, Jennifer Lemberger, Alan G. Rosmarin, Scot C. Remick, Jeffrey A. Bailey, John Vulule, Juliana A. Otieno, and Ann M. Moormann
ASM Journals Eliminate Impact Factor Information from Journal Websites, Arturo Casadevall, Roger J. Davis, and ASM Journal Editors and Leadership
A Novel SMC-Like Protein Modulates C. Elegans Condensin Functions: A Dissertation, Lucy F. Chao
Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs, Jenny Chen, Alexander A. Shishkin, Xiaopeng Zhu, Sabah Kadri, Itay Maza, Mitchell Guttman, Jacob H. Hanna, Aviv Regev, and Manuel Garber
HIV-1 capsid is involved in post-nuclear entry steps, Nan-Yu Chen, Lihong Zhou, Paul J. Gane, Silvana Opp, Neil J. Ball, Giuseppe Nicastro, Madeleine Zufferey, Cindy Buffone, Jeremy Luban, David Selwood, Felipe Diaz-Griffero, Ian Taylor, and Ariberto Fassati
Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA, Jessica L. Cohen, Yuefei Shen, Myriam Aouadi, Pranitha Vangala, Michaela Tencerova, Shinya U. Amano, Sarah M. Nicoloro, Joseph Yawe, and Michael P. Czech
Multipolar mitosis and aneuploidy after chrysotile treatment: a consequence of abscission failure and cytokinesis regression, Beatriz Araujo Cortez, Paula Rezende-Teixeira, Sambra D. Redick, Stephen J. Doxsey, and Glaucia Maria Machado-Santelli
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury, Francisco Javier Cubero, Miguel Eugenio Zoubek, Wei Hu, Jin Peng, Gang Zhao, Yulia A. Nevzorova, Malika Al Masaoudi, Lars P. Bechmann, Mark V. Boekschoten, Michael Muller, Christian Preisinger, Nikolaus Gassler, Ali E. Canbay, Tom Luedde, Roger J. Davis, Christian Liedtke, and Christian Trautwein
The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis, Sezin Dagdeviren
IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle, Sezin Dagdeviren, Dae Young Jung, Randall H. Friedline, Hye Lim Noh, Jong Hun Kim, Payal R. Patel, Nicholas Tsitsilianos, Kunikazu Inashima, Duy A. Tran, Xiaodi Hu, Marilia M. Loubato, Siobhan M. Craige, Jung Yeon Kwon, Ki Won. Lee, and Jason K. Kim
Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance, Sezin Dagdeviren, Dae Young Jung, Eunjung Lee, Randall H. Friedline, Hye Lim Noh, Jong Hun. Kim, Payal R. Patel, Nicholas Tsitsilianos, Andrew V. Tsitsilianos, Duy A. Tran, George H. Tsougranis, Caitlyn C. Kearns, Cecilia P. Uong, Jung Yeon. Kwon, Werner Muller, Ki Won. Lee, and Jason K. Kim
The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins, Alexey Dementiev, Anand Sitaram, Yan Hu, Raffi V. Aroian, and Colin Berry
End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data, Alan G. Derr, Chaoxing Yang, Rapolas Zilionis, Alexey Sergushichev, David Blodgett, Sambra D. Redick, Rita Bortell, Jeremy Luban, David M. Harlan, Sebastian Kadener, Dale L. Greiner, Allon Klein, Maxim N. Artyomov, and Manuel Garber
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing, Marie C. Didiot, Lauren M. Hall, Andrew H. Coles, Reka A. Haraszti, Bruno M. D. C. Godinho, Kathryn O. Chase, Socheata Ly, Julia F. Alterman, Matthew R. Hassler, Dimas Echeverria, Neil Aronin, and Anastasia Khvorova
Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic, William E. Diehl, Kyusik Kim, Pyae Phyo Kyawe, Sean M. McCauley, Elisa Donnard, Alper Kucukural, Patrick E. McDonel, Manuel Garber, and Jeremy Luban
Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance, Marina DiStefano, Rachel J. Roth Flach, Ozlem Senol-Cosar, Laura V. Danai, Joseph V. Virbasius, Sarah M. Nicoloro, Juerg R. Straubhaar, Sezin Dagdeviren, Martin Wabitsch, Olga T. Gupta, Jason K. Kim, and Michael P. Czech
A Role for the Lipid Droplet Protein HIG2 in Promoting Lipid Deposition in Liver and Adipose Tissue: A Dissertation, Marina T. DiStefano
Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations, Maria J. Duenas-Decamp, Li Jiang, Daniel N. Bolon, and Paul R. Clapham
Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice, Asma Ejaz, Jason K. Kim, Mary-Elizabeth Patti, and Carles Lerin
Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance, Timothy P. Fitzgibbons and Michael P. Czech
Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance, Randall H. Friedline, Hwi Jin Ko, Dae Young Jung, Yongjin Lee, Rita Bortell, Sezin Dagdeviren, Payal R. Patel, Xiaodi Hu, Kunikazu Inashima, Caitlyn C. Kearns, Nicholas Tsitsilianos, Umber Shafiq, Dale L. Greiner, and Jason K. Kim
A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions, Juan Fuxman Bass, Carles Pons, Lucie Kozlowski, John S. Reece-Hoyes, Shaleen Shrestha, Amy D. Holdorf, Akihiro Mori, Chad L. Myers, and Albertha J. M. Walhout
Colony Lift Colorimetric Assay for beta-Galactosidase Activity, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2016-12-01)
Gene-Centered Yeast One-Hybrid Assays, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2016-12-01)
Generating Bait Strains for Yeast One-Hybrid Assays, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2016-12-01)
Performing Yeast One-Hybrid Library Screens, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2016-12-01)
Zymolyase-Treatment and Polymerase Chain Reaction Amplification from Genomic and Plasmid Templates from Yeast, Juan Fuxman Bass, John S. Reece-Hoyes, and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2016-12-01)
Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2), Simona S. Ghanem, Dae Young Jung, Yongjin Lee, Jason K. Kim, and Sonia M. Najjar
TNFalpha-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38alpha MAPK Pathway, Nomeda Girnius and Roger J. Davis
The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4, Megan M. Gnazzo, Eva-Maria E. Uhlemann, Alex R. Villarreal, Masaki Shirayama, Eddie G. Dominguez, and Ahna R. Skop
P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer, Hira Lal Goel, Bryan M. Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A. Brekken, Craig W. Vander Kooi, and Arthur M. Mercurio
Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma, Myoung Souk Han, Tamera Barrett, Michael A. Brehm, and Roger J. Davis
High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources, Reka A. Haraszti, Marie-Cecile Didiot, Ellen Sapp, John D. Leszyk, Scott A. Shaffer, Hannah E. Rockwell, Fei Gao, Niven R. Narain, Marian DiFiglia, Michael A. Kiebish, Neil Aronin, and Anastasia Khvorova
Mechanism of early dissemination and metastasis in Her2+ mammary cancer, Kathryn L. Harper, Maria Soledad Sosa, Nomeda Girnius, Roger J. Davis, and Julio A. Aguirre-Ghiso
Cell Signaling and Stress Responses, Gokhan S. Hotamisligil and Roger J. Davis
The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation, Hui-Fan Hung, Heidi Hehnly, and Stephen J. Doxsey
Improved B cell development in humanized NOD-scid IL2Rgammanull mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3, Sonal Jangalwe, Leonard D. Shultz, Anuja Mathew, and Michael A. Brehm
GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis, Guillaume Jannot, Pascale Michaud, Miguel Quevillon Huberdeau, Louis Morel-Berryman, James A. Brackbill, Sandra Piquet, Katherine McJunkin, Kotaro Nakanishi, and Martin J. Simard
Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice, Adam Jara, Xingbo Liu, Don Sim, Chance M. Benner, Silvana Duran-Ortiz, Yanrong Qian, Edward O. List, Darlene E. Berryman, Jason K. Kim, and John J. Kopchick
Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo, Hyein Jeon, Jae Hwan Kim, Eunjung Lee, Young Jin Jang, Joe Eun Son, Jung Yeon Kwon, Tae-Gyu Lim, Sunghoon Kim, Jung Han Yoon Park, Jong-Eun Kim, and Ki Won Lee
Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation, Siddharth Jhunjhunwala, David Alvarez, Stephanie Aresta-DaSilva, Katherine Tang, Benjamin C. Tang, Dale Greiner, Peter E. Newburger, Ulrich H. von Andrian, Robert Langer, and Daniel G. Anderson
ChREBP Regulates Fructose-induced Glucose Production Independently of Insulin Signaling, Mi-Sung Kim, Sarah A. Krawczyk, Ludivine Doridot, Alan J. Fowler, Jennifer X. Wang, Sunia A. Trauger, Hye Lim Noh, Hee Joon Kang, John K. Meissen, Matthew Blatnik, Jason K. Kim, Michelle Lai, and Mark A. Herman
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Daniel J. Klionsky, Roger J. Davis, Fen-Biao Gao, and Panagiotis D. Velentzas
Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease, Peter L. Lee, Yuefeng Tang, Huawei Li, and David A. Guertin
Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress, Chen Lin, Xinyuan Zhao, Desen Sun, Lingda Zhang, Wenpan Fang, Tingjia Zhu, Qiang Wang, Botao Liu, Saisai Wei, Guangdi Chen, Zhengping Xu, and Xiangwei Gao
Activation of mTORC1 is essential for beta-adrenergic stimulation of adipose browning, Dianxin Liu, Marica Bordicchia, Chaoying Zhang, Huafeng Fang, Wan Wei, Jian-Liang Li, Adilson L. Guilherme, Kalyani V. P. Guntur, Michael P. Czech, and Sheila Collins
Tead and AP1 Coordinate Transcription and Motility, Xiangfan Liu, Huapeng Li, Mihir S. Rajurkar, Qi Li, Jennifer L. Cotton, Jianhong Ou, Lihua J. Zhu, Hira L. Goel, Arthur M. Mercurio, Joo-Seop Park, Roger J. Davis, and Junhao Mao
DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia, You Li, Hisato Yagi, Gregory M. Hendricks, Gregory J. Pazour, and Cecilia W. Lo
Closing the net on retroviruses, Jeremy Luban
alphavbeta6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor, Huimin Lu, Tao Wang, Zhong Jiang, Roger J. Davis, Thomas J. Fitzgerald, and Lucia R. Languino
Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants, Margaret M. McManus, Eric O. Mick, Richard W. Hudson Jr., Lynne M. Mofenson, John L. Sullivan, Mohan Somasundaran, Katherine Luzuriaga, and PACTG 356 Investigators
A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours, Regino Mercado-Lubo, Yuanwei Zhang, Liang Zhao, Kyle Rossi, Xiang Wu, Yekui Zou, Antonio Castillo, Jack L. Leonard, Rita Bortell, Dale L. Greiner, Leonard D. Shultz, Gang Han, and Beth A. McCormick
The Origin of Human White, Brown, and Brite/Beige Adipocytes, So Yun Min
Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice, So Yun Min, Jamie Kady, Minwoo Nam, Raziel Rojas-Rodriguez, Aaron Berkenwald, Jong Hun Kim, Hye Lim Noh, Jason K. Kim, Marcus P. Cooper, Timothy P. Fitzgibbons, Michael A. Brehm, and Silvia Corvera
Cellular perception and misperception: Internal models for decision-making shaped by evolutionary experience, Amir Mitchell and Wendell Lim (BioEssays : news and reviews in molecular, cellular and developmental biology, 2016-09-01)
Malaria - how this parasitic infection aids and abets EBV-associated Burkitt lymphomagenesis, Ann M. Moormann and Jeffrey A. Bailey
Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury, Jill Moser, Joris van Ark, Marcory C. van Dijk, Dale L. Greiner, Leonard D. Shultz, Harry van Goor, and Jan-Luuk Hillebrands
CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis, Kentaro Nagaoka, K. Fujii, H. Zhang, K. Usuda, G. Watanabe, Maria Ivshina, and Joel D. Richter