The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2018

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The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5alpha, Damien Morger, Franziska Zosel, Martin Buhlmann, Sara Zuger, Maximilian Mittelviefhaus, Benjamin Schuler, Jeremy Luban, and Markus G. Grutter

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MYC amplification in subtypes of breast cancers in African American women, Tammey J. Naab, Anita Gautam, Luisel Ricks-Santi, Ashwini K. Esnakula, Yasmine M. Kanaan, Robert L. DeWitty, Girmay Asgedom, Khepher H. Makambi, Massih Abawi, and Jan K. Blancato

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C. elegans MRP-5 Exports Vitamin B12 from Mother to Offspring to Support Embryonic Development, Huimin Na, Olga Ponomarova, Gabrielle E. Giese, and Albertha J. M. Walhout (Cell reports, 2018-03-20)

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C. elegans Multidrug Resistance Protein 5 (MRP-5) Transports Vitamin B12 from the Intestine to the Gonad to Support Embryonic Development, Huimin Na, Olga Ponomarova, Gabrielle E. Giese, and Albertha J. M. Walhout

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Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs, Maire F. Osborn, Andrew H. Coles, Diane Golebiowski, Dimas Echeverria, Michael P. Moazami, Jonathan K. Watts, Miguel Sena-Esteves, and Anastasia Khvorova

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A comparative analysis of preservation techniques for the optimal molecular detection of hookworm DNA in a human fecal specimen, Marina Papaiakovou, Nils Pilotte, Ben Baumer, Jessica Grant, Kristjana Asbjornsdottir, Fabian Schaer, Yan Hu, Raffi V. Aroian, Judd Walson, and Steven A. Williams

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Adaptive Evolution of piRNA pathway in Drosophila, Swapnil S. Parhad

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Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus, Sofia A. Quinodoz, Barbara Tabak, Patrick McDonel, Manuel Garber, and Mitchell Guttman

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HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded, Briana Quitadamo, Paul J. Peters, Alexander Repik, Olivia O'Connell, Zhongming Mou, Matthew Koch, Mohan Somasundaran, Robin M. Brody, Katherine Luzuriaga, Aaron Wallace, Shixia Wang, Shan Lu, Sean M. McCauley, Jeremy Luban, Maria J. Duenas-Decamp, Maria Paz Paz Gonzalez-Perez, and Paul R. Clapham

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Gateway-Compatible Yeast One-Hybrid and Two-Hybrid Assays, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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Gateway Recombinational Cloning, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-01-02)

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Generating an Open Reading Frame (ORF) Entry Clone and Destination Clone, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-01-02)

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Generating Yeast One-Hybrid DNA-Bait Strains, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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Generating Yeast Two-Hybrid Bait Strains, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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High-Efficiency Yeast Transformation, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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Identifying Interactors from an Activation Domain Prey Library, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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Propagating Gateway Vectors, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-01-02)

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Using Multisite LR Cloning to Generate a Destination Clone, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-01-02)

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OMEGA: a software tool for the management, analysis, and dissemination of intracellular trafficking data that incorporates motion type classification and quality control, Alessandro Rigano, Vanni Galli, Jasmine M. Clark, Lara E. Pereira, Loris Grossi, Jeremy Luban, Raffaello Giulietti, Tiziano Leidi, Eric Hunter, Mario Valle, Ivo F. Sbalzarini, and Caterina Strambio-De-Castilla

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Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis, Joan Sanchez-Gurmaches, Yuefeng Tang, Naja Zenius. Jespersen, Martina Wallace, Camila Martinez Calejman, Sharvari Gujja, Huawei Li, Yvonne J. K. Edwards, Christian Wolfrum, Christian M. Metallo, Soren Nielsen, Camilla Scheele, and David A. Guertin

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CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure, Yuefei Shen, Jessica L. Cohen, Sarah M. Nicoloro, Mark Kelly, Batuhan Yenilmez, Felipe Henriques, Emmanouela Tsagkaraki, Yvonne J. K. Edwards, Xiaodi Hu, Randall H. Friedline, Jason K. Kim, and Michael P. Czech

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Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor, Amit Shraga, Payam Khoshkenar, Amir Mitchell, and Nir London (Cell chemical biology, 2018-10-24)

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Understanding and repurposing CRISPR-mediated alternative splicing, Jordan L. Smith, Haiwei Mou, and Wen Xue

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In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency, Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O'Connor, Qiushi Tang, Lingling Cai, Xiangrui Li, Zhiping Weng, Hao Yin, Guangping Gao, Christian Mueller, Terence R. Flotte, and Wen Xue

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Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras, Phillip W. L. Tai, Jun Xie, Kaiyuen Fong, Matthew Seetin, Cheryl Heiner, Qin Su, Michael Weiand, Daniella Wilmot, Maria L. Zapp, and Guangping Gao

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Distinct adipocyte progenitor cells are associated with regional phenotypes of perivascular aortic fat in mice, Khanh-Van T. Tran, Timothy P. Fitzgibbons, So Yun Min, Tiffany DeSouza, and Silvia Corvera

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RNAi modulation of placental sFLT1 for the treatment of preeclampsia, Anton A. Turanov, Matthew R. Hassler, Ami Ashar-Patel, Julia F. Alterman, Andrew H. Coles, Reka A. Haraszti, Loic Roux, Bruno M. D. C. Godinho, Dimas Echeverria, S. Ananth Karumanchi, Melissa J. Moore, and Anastasia Khvorova

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Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma, Arvind Venkatesan, Rajesh Vyas, Alec Gramann, Karen A. Dresser, Sharvari Gujja, Sanchita Bhatnagar, Sagar Chhangawala, Camilla Borges Ferreira Gomes, Hualin Simon Xi, Christine G. Lian, Yariv Houvras, Yvonne J. K. Edwards, April C. Deng, Michael R. Green, and Craig J. Ceol

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If two deletions don't stop growth, try three, Albertha J. M. Walhout (Science (New York, N.Y.), 2018-04-20)

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Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues, Martina Wallace, David A. Guertin, and Christian M. Metallo

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Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice, Dan Wang, Jia Li, Chun-Qing Song, Karen Tran, Haiwei Mou, Pei-Hsuan Wu, Phillip W. L. Tai L, Craig A. Mendonca, Lingzhi Ren, Blake Y. Wang, Qin Su, Dominic J. Gessler, Phillip D. Zamore, Wen Xue, and Guangping Gao

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Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy, Minan Wang, Michael A. Brehm, and Dale L. Greiner

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HIV-1 unmasks the plasticity of innate lymphoid cells, Yetao Wang, Kyle Gellatly, Alan G. Derr, Smita Jaiswal, Alper Kucukural, Patrick McDonel, Thomas C. Greenough, JeanMarie Houghton, Manuel Garber, and Jeremy Luban

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Early Epstein-Barr Virus Genomic Diversity and Convergence toward the B95.8 Genome in Primary Infection, Eric R. Weiss, Susanna L. Lamers, Jennifer L. Henderson, Alexandre Melnikov, Mohan Somasundaran, Manuel Garber, Liisa K. Selin, Chad Nusbaum, and Katherine Luzuriaga

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Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles, Adam O. Whelan, Helen C. Flick-Smith, Jane Homan, Zu T. Shen, Zoe Carpenter, Payam Khoshkenar, Ambily Abraham, Nicola J. Walker, Stuart M. Levitz, Gary R. Ostroff, and Petra C. F. Oyston

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Partial DNA-guided Cas9 enables genome editing with reduced off-target activity, Hao Yin, Chun-Qing Song, Sneha Suresh, Suet-Yan Kwan, Qiongqiong Wu, Stephen Walsh, Junmei Ding, Roman L. Bogorad, Lihua Julie Zhu, Scot A. Wolfe, Victor Koteliansky, Wen Xue, Robert Langer, and Daniel G. Anderson

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Primate immunodeficiency virus Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex, Leonid Yurkovetskiy, Mehmet Hakan Guney, Kyusik Kim, Shih Lin Goh, Sean M. McCauley, Ann Dauphin, William E. Diehl, and Jeremy Luban

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Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin, Gen Zhang, Shikui Tu, Tianxiong Yu, Xiao-Ou Zhang, Swapnil S. Parhad, Zhiping Weng, and William E. Theurkauf

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The temporal landscape of recursive splicing during Pol II transcription elongation in human cells, Xiao-Ou Zhang, Yu Fu, Haiwei Mou, Wen Xue, and Zhiping Weng

Publications from 2017

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Proposal for minimum information guidelines to report and reproduce results of particle tracking and motion analysis, Alessandro Rigano and Caterina Strambio-De-Castilla

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Optimization by infusion of multiple reaction monitoring transitions for sensitive quantification of peptides by liquid chromatography/mass spectrometry, Bandar Alghanem, Frederic Nikitin, Thomas Stricker, Eva Duchoslav, Jeremy Luban, Caterina Strambio-De-Castilla, Markus Muller, Frederique Lisacek, Emmanuel Varesio, and Gerard Hopfgartner

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A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics, Julia F. Alterman, Andrew H. Coles, Lauren M. Hall, Neil Aronin, Anastasia Khvorova, and Marie C. Didiot

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Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires, Nuray Aslan, Levi B. Watkin, Anna Gil, Rabinarayan Mishra, Fransenio G. Clark, Raymond M. Welsh, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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Nucleosomes influence multiple steps during replication initiation, Ishara F. Azmi, Shinya Watanabe, Michael F. Maloney, Sukhyun Kang, Jason A. Belsky, David M. MacAlpine, Craig L. Peterson, and Stephen P. Bell

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Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality, David Beauparlant, Peter Rusert, Carsten Magnus, Claus Kadelka, Jacqueline Weber, Therese Uhr, Osvaldo Zagordi, Corinna Oberle, Maria J. Duenas-Decamp, Paul R. Clapham, Karin J. Metzner, Huldrych F. Gunthard, and Alexandra Trkola

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A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development, Yannick Boege, Roger J. Davis, and Achim Weber

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Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of alpha-1 Antitrypsin Deficiency, Florie Borel, Qiushi Tang, Gwladys Gernoux, Cynthia Greer, Ziqiong Wang, Adi Barzel, Mark A. Kay, Leonard D. Shultz, Dale L. Greiner, Terence R. Flotte, Michael A. Brehm, and Christian Mueller

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A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes, Julianna Bozler, Balint Z. Kacsoh, Hao Chen, William E. Theurkauf, Zhiping Weng, and Giovanni Bosco

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Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes, Ange-Line Bruel, Thibaut Eguether, Gregory J. Pazour, and Christel Thauvin-Robinet

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Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue, Carly T. Cederquist, Claudia Lentucci, Camila Martinez Calejman, Vanessa Hayashi, Joseph Orofino, David A. Guertin, Susan K. Fried, Mi-Jeong Lee, M. Dafne Cardamone, and Valentina Perissi

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An SMC-like protein binds and regulates Caenorhabditis elegans condensins, Lucy Fang-I Chao, Meha Singh, James Thompson, John R. Yates 3rd, and Kirsten A. Hagstrom

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HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans, Huan-Da Chen, Raffi V. Aroian, and Chang-Shi Chen

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Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders, Zhimin Chen, Guo-Xiao Wang, Sara L. Ma, Dae Young Jung, Hyekyung Ha, Tariq Altamimi, Xu-Yun Zhao, Liang Guo, Peng Zhang, Chun-Rui Hu, Ji-Xin Cheng, Gary D. Lopaschuk, Jason K. Kim, and Jiandie D. Lin

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Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation, Hsin-Jung Chou, Elisa Donnard, H. Tobias Gustafsson, Manuel Garber, and Oliver J. Rando

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JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21, B. Colleoni, S. Paternot, J. M. Pita, X. Bisteau, K. Coulonval, Roger J. Davis, E. Raspe, and P. P. Roger

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Insulin action and resistance in obesity and type 2 diabetes, Michael P. Czech

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Macrophages dispose of catecholamines in adipose tissue, Michael P. Czech

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Age-dependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling, Chunhua Dai, Yan Hang, Alena Shostak, Greg Poffenberger, Nathaniel Hart, Nripesh Prasad, Neil Phillips, Shawn E. Levy, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, Seung K. Kim, and Alvin C. Powers

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Melanoma mystery, Roger J. Davis

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Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates, Joshua C. Doloff, Dale L. Greiner, and Daniel G. Anderson

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Evaluation of IL2 and HLA on the Homeostasis and Function of Human CD4 and CD8 T Cells, Philip A. Durost

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Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice, Philip A. Durost, Ken-Edwin Aryee, Fatima Manzoor, Roland M. Tisch, Christian Mueller, Agata Jurczyk, Leonard D. Shultz, and Michael A. Brehm

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High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells, Yves T. Falanga, Michela Frascoli, Yasin Kaymaz, Catherine Forconi, John Michael Ong'echa, Jeffrey A. Bailey, Leslie J. Berg, and Ann M. Moormann

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Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue, Tera M. Filion, Jordan D. Skelly, Henry Huang, Dale L. Greiner, David C. Ayers, and Jie Song

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Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy, Timothy P. Fitzgibbons, Yvonne J. K. Edwards, Peter Shaw, Aline Iskandar, Mohamed Ahmed, Josiah T. Bote, Tejen Shah, Sumita Sinha, Robert E. Gerszten, John F. Keaney Jr., Michael R. Zile, and Gerard P. Aurigemma

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Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics, Aurian Garcia-Gonzalez, Ashlyn D. Ritter, Shaleen Shrestha, Erik C. Andersen, L. Safak Yilmaz, and Albertha J. M. Walhout

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JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins, Nomeda Girnius and Roger J. Davis

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Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming, Adilson L. Guilherme, David J. Pedersen, Elizabeth Henchey, Felipe S. Henriques, Laura V. Danai, Yuefei Shen, Batuhan Yenilmez, Dae Young Jung, Jason K. Kim, Irfan J. Lodhi, Clay F. Semenkovich, and Michael P. Czech

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Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System, Reka A. Haraszti, Andrew H. Coles, Neil Aronin, Anastasia Khvorova, and Marie C. Didiot

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5-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo, Reka A. Haraszti, Loic Roux, Andrew H. Coles, Anton A. Turanov, Julia F. Alterman, Dimas Echeverria, Bruno M. D. C. Godinho, Neil Aronin, and Anastasia Khvorova

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A Broad-Spectrum Inhibitor of CRISPR-Cas9, Lucas B. Harrington, Kevin W. Doxzen, Alireza Edraki, Nadia Amrani, Erik J. Sontheimer, and Jennifer A. Doudna

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The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2, Queenie Hu, Dayana R. D'Amora, Lesley T. MacNeil, Albertha J. M. Walhout, and Terrance J. Kubiseski (Genetics, 2017-06-09)

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Regulation of Alloreactive CD8 T Cell Responses by Costimulation and Inflammation, Sonal Jangalwe

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Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice, Tony Jourdan, Sarah M. Nicoloro, Zhou Zhou, Yuefei Shen, Jie Liu, Nathan J. Coffey, Resat Cinar, Grzegorz Godlewski, Bin Gao, Myriam Aouadi, Michael P. Czech, and George Kunos

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Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes, Tony Jourdan, Gergo Szanda, Resat Cinar, Grzegorz Godlewski, David J. Holovac, Joshua K. Park, Sarah M. Nicoloro, Yuefei Shen, Jie Liu, Avi Z. Rosenberg, Ziyi Liu, Michael P. Czech, and George Kunos

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A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress, Shashi Kant, Claire L. Standen, Caroline Morel, Dae Young Jung, Jason K. Kim, Wojciech Swat, Richard A. Flavell, and Roger J. Davis

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Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences., Yasin Kaymaz, Cliff I. Oduor, Hongbo Yu, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey

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Airway smooth muscle dysfunction in Pompe (Gaa-/-) mice, Allison M. Keeler, Donghai Lui, Marina Zieger, Lang Xiong, Jeffrey Salemi, Karl D. Bellve, Barry J. Byrne, David D. Fuller, Ronghua ZhuGe, and Mai K. Elmallah

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The chemical evolution of oligonucleotide therapies of clinical utility, Anastasia Khvorova and Jonathan K. Watts

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Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics, Nigel G. Kooreman, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, and Joseph C. Wu

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Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity, Takahide Kouno, Tania V. Silvas, Brendan J. Hilbert, Shivender Shandilya, Markus-Frederik Bohn, Brian A. Kelch, William E. Royer, Mohan Somasundaran, Nese Kurt Yilmaz, Hiroshi Matsuo, and Celia A. Schiffer

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Setting the (Scientific) Record Straight: Molecular and Cellular Biology Responds to Postpublication Review, Amy L. Kullas and Roger J. Davis

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mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors, Jungmin Lee, Brad Dykstra, Joel A. Spencer, Laurie L. Kenney, Dale L. Greiner, Leonard D. Shultz, Michael A. Brehm, Charles P. Lin, Robert Sackstein, and Derrick J. Rossi

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The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond, Peter L. Lee, Su Myung Jung, and David A. Guertin

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The Dkk3 gene encodes a vital intracellular regulator of cell proliferation, Jack L. Leonard, Deborah Marie Leonard, Scot A. Wolfe, Jilin Liu, Jaime A. Rivera-Perez, Michelle Yang, Ryan T. Leonard, Jacob P. S. Johnson, Prashant Kumar, Kate L. Liebmann, Amanda A. Tutto, Zhongming Mou, and Karl J. Simin

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Value of circulating cell-free DNA analysis as a diagnostic tool for breast cancer: a meta-analysis, Ziqiang Lin, James Neiswender, Bin Fang, Xuelei Ma, Jing Zhang, and Xiuying Hu

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Visualization of self-delivering hydrophobically modified siRNA cellular internalization, Socheata Ly, Deanna M. Navaroli, Marie-Claire Didiot, James Cardia, Lakshmipathi Pandarinathan, Julia F. Alterman, Kevin E. Fogarty, Clive Standley, Lawrence Lifshitz, Karl D. Bellve, Matthieu Prot, Dimas Echeverria, Silvia Corvera, and Anastasia Khvorova

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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance, Noelia Martinez-Sanchez, Roger J. Davis, and Miguel Lopez

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Human white adipocytes convert into "rainbow" adipocytes in vitro, Giulia Maurizi, Antonella Poloni, Silvia Corvera, and Saverio Cinti

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Regulation of Local Translation, Synaptic Plasticity, and Cognitive Function by CNOT7, Rhonda L. McFleder

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Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function, Rhonda L. McFleder, Fernanda Mansur, and Joel D. Richter

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A microRNA family exerts maternal control on sex determination in C. elegans, Katherine McJunkin and Victor R. Ambros

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Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells, James R. C. Miller, Edith L. Pfister, Wanzhao Liu, Ralph Andre, Ulrike Trager, Lori A. Kennington, Kimberly Lo, Sipke Dijkstra, Douglas Macdonald, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi

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Membrane Proteins Take Different Trafficking Pathways to the Primary Cilium, William Joseph Monis

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Many transcription factors contribute to C. elegans growth and fat storage, Akihiro Mori, Amy D. Holdorf, and Albertha J. M. Walhout (Genes to cells : devoted to molecular and cellular mechanisms, 2017-09-01)

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Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis, Haiwei Mou, Jill Moore, Sunil K. Malonia, Yingxiang Li, Deniz M. Ozata, Soren Hough, Chun-Qing Song, Jordan L. Smith, Andrew H. Fischer, Zhiping Weng, Michael R. Green, and Wen Xue

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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

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Identification of KIT as a Suppressor of BRAFV600E-Mutant Melanoma, James V. Neiswender

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Rapid isolation of functionally intact nuclei from the yeast Saccharomyces, Mario Niepel, Julia Farr, Michael P. Rout, and Caterina Strambio-De-Castilla

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Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness, Michiru Nishita, Seung-Yeol Park, Tadashi Nishio, Koki Kamizaki, ZhiChao Wang, Kota Tamada, Toru Takumi, Ryuju Hashimoto, Hiroki Otani, Gregory J. Pazour, Victor W. Hsu, and Yasuhiro Minami