The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2019

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TRIM34 acts with TRIM5 to restrict HIV and SIV capsids, Molly Ohainle, Kyusik Kim, Sevnur Keceli, Abby Felton, Ed Campbell, Jeremy Luban, and Michael Emerman

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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways, Maire F. Osborn, Andrew H. Coles, Annabelle Biscans, Reka A. Haraszti, Loic Roux, Sarah M. Davis, Socheata Ly, Dimas Echeverria, Matthew R. Hassler, Bruno M. D. C. Godinho, Mehran Nikan, and Anastasia Khvorova

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Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters, Samuel C. Pan, Doyle V. Ward, Yunqiang Yin, Yan Hu, Elfawal A. Mostafa, Robert E. Clark, and Raffi V. Aroian

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Rapid evolution and conserved function of the piRNA pathway, Swapnil S. Parhad and William E. Theurkauf

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Adaptive evolution targets a piRNA precursor transcription network, Swapnil S. Parhad, Tianxiong Yu, Gen Zhang, Nicholas P. Rice, Zhiping Weng, and William E. Theurkauf

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Ciliary Doublet Microtubules at Near-Atomic Resolution, Gregory J. Pazour and Stephen M. King

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Cilia in cystic kidney and other diseases, Gregory J. Pazour, Lynne Quarmby, Abigail O. Smith, Paurav B. Desai, and Miriam Schmidts

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Enhanced Cas12a editing in mammalian cells and zebrafish, Pengpeng Liu, Kevin Luk, Masahiro Shin, Feston Idrizi, Samantha F. Kwok, Benjamin P. Roscoe, Esther Mintzer, Sneha Suresh, Kyle Morrison, Josias B. Frazao, Mehmet Fatih Bolukbasi, Karthikeyan Ponnienselvan, Jeremy Luban, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4(th) pharyngeal arch artery morphogenesis, Helen M. Phillips, Rene Maehr, and Simon D. Bamforth

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A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia, Tyler Picariello, Jason M. Brown, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Oliver D. King, Karl Lechtreck, Gregory J. Pazour, and George B. Witman

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No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications, Briana Quitadamo, Paul J. Peters, Matthew Koch, Katherine Luzuriaga, Cecilia Cheng-Mayer, Paul R. Clapham, and Maria Paz Gonzalez-Perez

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Smooth muscle cell-specific TMEM16A deletion does not alter Ca2+ signaling, uterine contraction, gestation length or litter size in micedagger, Mingzi Qu, Ping Lu, Karl D. Bellve, Kevin E. Fogarty, Lawrence M. Lifshitz, Fangxiong Shi, and Ronghua ZhuGe

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Adaptations of Adipose Tissue Expandability in Gestation are Associated with Maternal Glucose Metabolism, Raziel Rojas-Rodriguez

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Generation of Functional Human Adipose Tissue in Mice from Primed Progenitor Cells, Raziel Rojas-Rodriguez, Jorge Lujan-Hernandez, So Yun Min, Tiffany DeSouza, Patrick Teebagy, Anand Desai, Heather Tessier, Robert Slamin, Leah Siegel-Reamer, Cara Berg, Angel Baez, Janice F. Lalikos, and Silvia Corvera

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Mss51 deletion enhances muscle metabolism and glucose homeostasis in mice, Yazmin I. Rovira Gonzalez, Hye Lim Noh, Sujin Suk, Jason K. Kim, and Kathryn R. Wagner

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HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet beta-Cells From Donors With Type 1 Diabetes, Mark A. Russell, Sambra D. Redick, David Blodgett, Jenny Aurielle B. Babon, Chaoxing Yang, Sally C. Kent, Alan G. Derr, Alper Kucukural, Manuel Garber, and David M. Harlan

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Brown fat organogenesis and maintenance requires AKT1 and AKT2, Joan Sanchez-Gurmaches, Camila Martinez Calejman, Su Myung Jung, Huawei Li, and David A. Guertin

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FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism, Sneha Shah, Gemma Molinaro, Botao Liu, Ruijia Wang, Kimberly M. Huber, and Joel D. Richter

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Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex, Kuang Shen, Kacper B. Rogala, Hui-Ting Chou, Rick K. Huang, Zhiheng Yu, and David M. Sabatini

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Intraflagellar transport protein 74 is essential for spermatogenesis and male fertility in micedouble dagger, Lin Shi, Ting Zhou, Qian Huang, Shiyang Zhang, Wei Li, Ling Zhang, Rex A. Hess, Gregory J. Pazour, and Zhibing Zhang

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Genetic Rescue of Fragile X Syndrome Links FMRP Deficiency to Codon Optimality-Dependent RNA Destabilization, Huan Shu, Elisa Donnard, Botao Liu, and Joel D. Richter

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Transient Kinetic Analysis of SWR1C-Catalyzed H2A.Z Deposition Unravels the Impact of Nucleosome Dynamics and the Asymmetry of Histone Exchange, Raushan K. Singh, Jiayi Fan, Nathan Gioacchini, Shinya Watanabe, Osman Bilsel, and Craig L. Peterson

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Spatiotemporal structure of cell fate decisions in murine neural crest, Ruslan Soldatov, Wen-Yu Hsiao, David A. Guertin, Peter V. Kharchenko, and Igor Adameyko

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EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons, Emily E. Stackpole, Michael R. Akins, Mariya Ivshina, Anastasia C. Murthy, Nicolas L. Fawzi, and Justin R. Fallon

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TALE and NF-Y co-occupancy marks enhancers of developmental control genes during zygotic genome activation in zebrafish, William J. Stanney III, Franck Ladam, Ian J. Donaldson, Teagan J. Parsons, Rene Maehr, Nicoletta Bobola, and Charles G. Sagerstrom

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Combinatorial action of NF-Y and TALE at embryonic enhancers defines distinct gene expression programs during zygotic genome activation in zebrafish, William Stanney, Franck Ladam, Ian J. Donaldson, Teagan J. Parsons, Rene Maehr, Nicoletta Bobola, and Charles G. Sagerstrom

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ARF GTPases and their GEFs and GAPs: concepts and challenges, Elizabeth Sztul, Pei-Wen Chen, James E. Casanova, Jacqueline Cherfils, Joel B. Dacks, David G. Lambright, Fang-Jen S. Lee, Paul A. Randazzo, Lorraine C. Santy, Annette Schurmann, Ilka Wilhelmi, Marielle E. Yohe, and Richard A. Kahn

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Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2, Annoj Thavalingam, Erik J. Sontheimer, Yanli Wang, and Karen L. Maxwell

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Chromatin Dynamics Regulate Transcriptional Homeostasis, Salih Topal

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Distinct transcriptional roles for Histone H3-K56 acetylation during the cell cycle in Yeast, Salih Topal, Pauline Vasseur, Marta Radman-Livaja, and Craig L. Peterson

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Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics, Rahul Tyagi, Elfawal A. Mostafa, Scott A. Wildman, Jon Helander, Christina A. Bulman, Judy Sakanari, Bruce A. Rosa, Paul J. Brindley, James W. Janetka, Raffi V. Aroian, and Makedonka Mitreva

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The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans, Alejandro Vasquez-Rifo, Isana Veksler-Lublinsky, Zhenyu Cheng, Frederick M. Ausubel, and Victor R. Ambros

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Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin, Anastassiia Vertii, Jianhong Ou, Jun Yu, Aimin Yan, Herve Pages, Haibo Liu, Lihua Julie Zhu, and Paul D. Kaufman

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Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis, Weicang Wang, Jun Yang, Matthew L. Edin, Yuxin Wang, Ying Luo, Debin Wan, Haixia Yang, Chun-Qing Song, Wen Xue, Katherine Z. Sanidad, Mingyue Song, Heather A. Bisbee, Jennifer A. Bradbury, Guanjun Nan, Jianan Zhang, Pei-An Betty Shih, Kin Sing Stephen Lee, Lisa M. Minter, Daeyoung Kim, Hang Xiao, Jun-Yan Liu, Bruce D. Hammock, Darryl C. Zeldin, and Guodong Zhang

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Hypomorphic mutations of TRIP11 cause odontochondrodysplasia, Anika Wehrle, John A. Follit, Gregory J. Pazour, Andrea Superti-Furga, Martin Lowe, and Ekkehart Lausch

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foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish, Thomas R. Whitesell, Paul W. Chrystal, Jae-Ryeon Ryu, Nicole Munsie, Ann S. Grosse, Curtis R. French, Matthew L. Workentine, Rui Li, Lihua Julie Zhu, Andrew Waskiewicz, Ordan J. Lehmann, Nathan D. Lawson, and Sarah J. Childs

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Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury, Sanda Win, Robert W. M. Min, Christopher Q. Chen, Jun Zhang, Yibu Chen, Meng Li, Ayako Suzuki, Manal F. Abdelmalek, Ying Wang, Mariam Aghajan, Filbert W. M. Aung, Anna Mae Diehl, Roger J. Davis, Tin A. Than, and Neil Kaplowitz

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MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans, Kang Xie, Peng Zhang, Huimin Na, Yangli Liu, Hong Zhang, and Pingsheng Liu

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SENP3-mediated host defense response contains HBV replication and restores protein synthesis, Rui Xi, Botao Liu, Yan Han, and Xiling Shen

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Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility, Xiuying Yang, Hye Lim Noh, Suchaorn Saengnipanthkul, Jason K. Kim, Chi Wai Lee, and Chi Bun Chan

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AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice, Bradford A. Youngblood, Emily C. Brock, John Leung, Rustom Falahati, Paul J. Bryce, Jessica Bright, Jason Williams, Leonard D. Shultz, Dale L. Greiner, Michael A. Brehm, Christopher Bebbington, and Nenad Tomasevic

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The piRNA Response to Retroviral Invasion of the Koala Genome, Tianxiong Yu, Birgit S. Koppetsch, Sara Pagliarani, Stephen Johnston, Noah J. Silverstein, Jeremy Luban, Keith Chappell, Zhiping Weng, and William E. Theurkauf

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TREX Function in piRNA Biogenesis and Transposon Silencing, Gen Zhang

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A Delicate Balance between Bacterial Iron and Reactive Oxygen Species Supports Optimal C. elegans Development, Jingyan Zhang, Xuhang Li, Maria Olmedo, Amy D. Holdorf, Ye Shang, Marta Artal-Sanz, L. Safak Yilmaz, and Albertha J. M. Walhout (Cell host and microbe, 2019-09-11)

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Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse, Andres Ernesto Zucchetti, Laurence Bataille, Jean-Marie Carpier, Stephanie Dogniaux, Mabel San Roman-Jouve, Mathieu Maurin, Michael W. Stuck, Rosa M. Rios, Cosima T. Baldari, Gregory J. Pazour, and Claire Hivroz

Publications from 2018

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Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs, Victor R. Ambros and Gary Ruvkun

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NmeCas9 is an intrinsically high-fidelity genome editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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NmeCas9 is an intrinsically high-fidelity genome-editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery, Baharak Bahmani, Mayuko Uehara, Farideh Ordikhani, Xiaofei Li, Liwei Jiang, Naima Banouni, Takaharu Ichimura, Vivek Kasinath, Siawosh K. Eskandari, Nasim Annabi, Jonathan S. Bromberg, Leonard D. Shultz, Dale L. Greiner, and Reza Abdi

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Role of JIP1-JNK Signaling in Beta-Cell Function and Autophagy, Seda Barutcu

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Role of the MAPK/cJun NH2-Terminal Kinase signaling pathway in starvation-induced autophagy, Seda Barutcu, Nomeda Girnius, Santiago Vernia, and Roger J. Davis

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Analysis and Correction of Inappropriate Image Duplication: the Molecular and Cellular Biology Experience, Elisabeth M. Bik, Ferric C. Fang, Amy L. Kullas, Roger J. Davis, and Arturo Casadevall

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Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles, Annabelle Biscans, Reka A. Haraszti, Dimas Echeverria, Rachael Miller, Marie C. Didiot, Mehran Nikan, Loic Roux, Neil Aronin, and Anastasia Khvorova

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Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing, Mehmet F. Bolukbasi, Pengpeng Liu, Kevin Luk, Samantha F. Kwok, Ankit Gupta, Nadia Amrani, Erik J. Sontheimer, Lihua Julie Zhu, and Scot A. Wolfe

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Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways, Daniel L. Bourque, Diane P. Genereux, Elinor K. Karlsson, Firdausi Qadri, and Jason B. Harris

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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Mixed Lineage Kinase 3 (MLK3) Prevents Cardiac Dysfunction and Structural Remodeling with Pressure Overload, Timothy Dean Calamaras, Robert A. Baumgartner, Mark J. Aronovitz, Angela L. McLaughlin, Kelly Tam, Daniel A. Richards, Craig W. Cooper, Nathan Li, Wendy E. Baur, Xiaoying Qiao, Guang-Rong Wang, Roger J. Davis, Navin Kumar Kapur, Richard H. Karas, and Robert Morris Blanton Jr.

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Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis, Qingbo Chen, Lei Huang, Dongning Pan, Lihua (Julie) Zhu, and Yong-Xu Wang

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Investigation of LIN-28 Function in Somatic Gonadal Development and Fertility, and Characterization of the LIN-28 Isoforms in C. elegans Hermaphrodites, Sungwook Choi

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Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin, Marie C. Didiot, Chantal M. Ferguson, Socheata Ly, Andrew H. Coles, Abigail O. Smith, Alicia A. Bicknell, Lauren M. Hall, Ellen Sapp, Dimas Echeverria, Athma A. Pai, Marian DiFiglia, Melissa J. Moore, Lawrence J. Hayward, Neil Aronin, and Anastasia Khvorova

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Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine, Wei Ding, Daniel P. Higgins, Dilip K. Yadav, Adwait A. Godbole, Read Pukkila-Worley, and Amy K. Walker

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Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon, Elisa Donnard, Pranitha Vangala, Shaked Afik, Sean M. McCauley, Anetta Nowosielska, Alper Kucukural, Barbara Tabak, Xiaopeng Zhu, William E. Diehl, Patrick McDonel, Nir Yosef, Jeremy Luban, and Manuel Garber

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Congenital Heart Defects and Ciliopathies Associated With Renal Phenotypes, George C. Gabriel, Gregory J. Pazour, and Cecilia W. Lo

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C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer (Nature methods, 2018-05-07)

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Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance, Devram S. Ghorpade, Lale Ozcan, Ze Zheng, Sarah M. Nicoloro, Yuefei Shen, Emily Chen, Matthias Bluher, Michael P. Czech, and Ira Tabas

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The cJUN NH2-terminal kinase pathway in mammary gland biology and carcinogenesis, Nomeda A. Girnius

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The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution, Nomeda A. Girnius, Yvonne J. K. Edwards, and Roger J. Davis

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The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation, Nomeda A. Girnius, Yvonne J. K. Edwards, David S. Garlick, and Roger J. Davis

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America's lost dogs, Linda Goodman and Elinor K. Karlsson

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Unexpected cell population gives fat a brake, David A. Guertin

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Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis, Adilson L. Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark Kelly, Donald A. Morgan, Kamal Rahmouni, and Michael P. Czech

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Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis, Adilson L. Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark Kelly, Kamal Rahmouni, Donald A. Morgan, and Michael P. Czech

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Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles, Reka A. Haraszti, Rachael Miller, Marie C. Didiot, Annabelle Biscans, Julia F. Alterman, Matthew R. Hassler, Loic Roux, Dimas Echeverria, Ellen Sapp, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo, Matthew R. Hassler, Anton A. Turanov, Julia F. Alterman, Reka A. Haraszti, Andrew H. Coles, Maire F. Osborn, Dimas Echeverria, Mehran Nikan, William E. Salomon, Loic Roux, Bruno M. D. C. Godinho, Sarah M. Davis, David V. Morrissey, Phillip D. Zamore, S. Ananth Karumanchi, Melissa J. Moore, Neil Aronin, and Anastasia Khvorova

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Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin, Florian Haun, Simon Neumann, Lukas Peintner, Katrin Wieland, Juri Habicht, Carsten Schwan, Kristine Ostevold, Maria Magdalena Koczorowska, Martin Biniossek, Matthias Kist, Hauke Busch, Melanie Boerries, Roger J. Davis, Ulrich Maurer, Oliver Schilling, Klaus Aktories, and Christoph Borner

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Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome, Felipe Henriques, Magno A. Lopes, Felipe O. Franco, Pamela Knobl, Kaltinaitis B. Santos, Luana L. Bueno, Victor A. Correa, Alexander H. Bedard, Adilson L. Guilherme, Alexander Birbrair, Sidney B. Peres, Stephen R. Farmer, and Miguel L. Batista Jr.

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The Caenorhabditis elegans Oxidative Stress Response Requires the NHR-49 Transcription Factor, Queenie Hu, Dayana R. D'Amora, Lesley T. MacNeil, Albertha J. M. Walhout, and Terrance J. Kubiseski

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In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites, Yan Hu, Melanie Miller, Bo Zhang, Thanh-thanh Nguyen, Martin K. Nielsen, and Raffi V. Aroian

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Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure, Yan Hu, Thanh-thanh Nguyen, Alice C. Lee Y, Joseph F. Urban Jr, Melanie M. Miller, Bin Zhan, David Koch, Jason B. Noon, Ricardo Toshio. Fujiwara, Dwight D. Bowman, Gary R. Ostroff, and Raffi V. Aroian

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All-in-One Adeno-associated Virus Delivery and Genome Editing by Neisseria meningitidis Cas9 in vivo, Raed Ibraheim, Chun-Qing Song, Aamir Mir, Nadia Amrani, Wen Xue, and Erik J. Sontheimer

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All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo, Raed Ibraheim, Chun-Qing Song, Aamir Mir, Nadia Amrani, Wen Xue, and Erik J. Sontheimer

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A synthetic, three-dimensional bone marrow hydrogel, Lauren Jansen, Thomas McCarthy, Michael J. Lee, and Shelly Peyton

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Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity, Jong Hun Kim, Eunjung Lee, Randall H. Friedline, Sujin Suk, Dae Young Jung, Sezin Dagdeviren, Xiaodi Hu, Kunikazu Inashima, Hye Lim Noh, Jung Yeon Kwon, Aya Nambu, Jun R. Huh, Myoung Souk Han, Roger J. Davis, Ki Won Lee, and Jason K. Kim

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Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells, Benjamin D. Landry, Thomas Leete, Ryan Richards, Peter Cruz-Gordillo, Hannah R. Schwartz, Megan E. Honeywell, Gary Ren, Alyssa D. Schwartz, Shelly R. Peyton, and Michael J. Lee (Molecular systems biology, 2018-08-06)

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Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins, Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E. Lou, Ildar Gainetdinov, April Pawluk, Raed Ibraheim, Xin D. Gao, Pengpeng Liu, Alan R. Davidson, Karen L. Maxwell, and Erik J. Sontheimer

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Adipocyte mTORC1 Signaling Separately Regulates Metabolic Homeostasis and Adipose Tissue Mass, Independent of RagGTPase Activity, Peter L. Lee

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JNK regulates muscle remodeling via myostatin/SMAD inhibition, Sarah J. Lessard, Tara L. MacDonald, Prerana Pathak, Myoung Souk Han, Vernon G. Coffey, Johann Edge, Donato A. Rivas, Michael F. Hirshman, Roger J. Davis, and Laurie J. Goodyear

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth, Qi Li, Niraj K. Nirala, Yingchao Nie, Hsi-Ju Chen, Gary R. Ostroff, Junhao Mao, Qi Wang, Lan Xu, and Y. Tony Ip

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LLC tumor cells-derivated factors reduces adipogenesis in co-culture system, Magno Alves Lopes, Felipe Oliveira Franco, Felipe Henriques, Sidney Barnabe Peres, and Miguel Luiz Batista Jr.

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Syndromic congenital myelofibrosis associated with a loss-of-function variant in RBSN, Pilar L. Magoulas, Silvia Corvera, and Luis M. Franco

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Innate Detection of HIV-1 in Myeloid Dendritic Cells, Sean Matthew McCauley

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Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines, Sean M. McCauley, Kyusik Kim, Anetta Nowosielska, Ann Dauphin, Leonid Yurkovetskiy, William E. Diehl, and Jeremy Luban

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Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines, Sean M. McCauley, Kyusik Kim, Anetta Nowosielska, Ann Dauphin, Leonid Yurkovetskiy, William E. Diehl, and Jeremy Luban

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Quantitative Human Immunodeficiency Virus (HIV)-1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy, Margaret M. McManus, Jennifer L. Henderson, Anita Gautam, Robin M. Brody, Eric R. Weiss, Deborah Persaud, Eric O. Mick, Katherine Luzuriaga, and PACTG 356 Investigators

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Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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Type II-C CRISPR-Cas9 Biology, Mechanism, and Application, Aamir Mir, Alireza Edraki, Jooyoung Lee, and Erik J. Sontheimer

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Functional conservation of a developmental switch in mammals since the Jurassic age, Jayati Mookerjee-Basu, Xiang Hua, Lu Ge, Emmanuelle Nicolas, Qin Li, Philip Czyzewicz, Dai Zhongping, Suraj Peri, Juan Fuxman Bass, Albertha J. M. Walhout, and Dietmar J. Kappes (Molecular biology and evolution, 2018-10-08)

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JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory, Caroline Morel, Tessi Sherrin, Norman J. Kennedy, Kelly H. Forest, Seda Barutcu, Michael Robles, Ezekiel Carpenter-Hyland, Naghum Alfulaij, Claire L. Standen, Robert A. Nichols, Morris Benveniste, Roger J. Davis, and Cedomir Todorovic

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The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5alpha, Damien Morger, Franziska Zosel, Martin Buhlmann, Sara Zuger, Maximilian Mittelviefhaus, Benjamin Schuler, Jeremy Luban, and Markus G. Grutter