The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 1990

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Enhanced phosphorylation of a coated vesicle polypeptide in response to insulin stimulation of rat adipocytes, Silvia Corvera and Renold J. Capocasale

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Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation, Janice L. Countaway, Patricia A. McQuilkin, Nuria Girones, and Roger J. Davis

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Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter, Scott A. Harrison, Joanne M. Buxton, Brian M. Clancy, and Michael P. Czech

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Insulin action on activity and cell surface disposition of human HepG2 glucose transporters expressed in Chinese hamster ovary cells, Scott A. Harrison, Joanne M. Buxton, Amy L. Helgerson, Richard G. MacDonald, Francis J. Chlapowski, Anthony Carruthers, and Michael P. Czech

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Purification of a novel insulin-stimulated protein kinase from rat liver, Jes K. Klarlund, Andrew P. Bradford, Maria G. Milla, and Michael P. Czech

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Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase, Robert E. Lewis, G. Perry Wu, Richard G. MacDonald, and Michael P. Czech

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Translational control by cytoplasmic polyadenylation during Xenopus oocyte maturation: characterization of cis and trans elements and regulation by cyclin/MPF, Laura Lynn McGrew and Joel D. Richter

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Signal transduction by the epidermal growth factor receptor after functional desensitization of the receptor tyrosine protein kinase activity, Ingrid C. Northwood and Roger J. Davis

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Maternal mRNA expression in early development: regulation at the 3' end, Joel D. Richter, Jeannie Paris, and Laura Lynn McGrew

Publications from 1989

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Intermolecular disulfide bonds are not required for the expression of the dimeric state and functional activity of the transferrin receptor, Elvira Alvarez, Nuria Girones, and Roger J. Davis

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Chicken and Xenopus mannose 6-phosphate receptors fail to bind insulin-like growth factor II, Kevin B. Clairmont and Michael P. Czech

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Reconstitution of epidermal growth factor receptor transmodulation by platelet-derived growth factor in Chinese hamster ovary cells, Janice L. Countaway, Nuria Girones, and Roger J. Davis

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Mechanism of phosphorylation of the epidermal growth factor receptor at threonine 669, Janice L. Countaway, Ingrid C. Northwood, and Roger J. Davis

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Serum form of the rat insulin-like growth factor II/mannose 6-phosphate receptor is truncated in the carboxyl-terminal domain, Richard G. MacDonald, Mark A. Tepper, Kevin B. Clairmont, Susan B. Perregaux, and Michael P. Czech

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Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element, Laura Lynn McGrew, Eva Dworkin-Rastl, Mark B. Dworkin, and Joel D. Richter

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Protein kinase C inhibition of the epidermal growth factor receptor tyrosine protein kinase activity is independent of the oligomeric state of the receptor, Ingrid C. Northwood and Roger J. Davis

Publications from 1988

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A highly phosphorylated subpopulation of insulin-like growth factor II/mannose 6-phosphate receptors is concentrated in a clathrin-enriched plasma membrane fraction, Silvia Corvera, Kimberly L. Folander, Kevin B. Clairmont, and Michael P. Czech

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Tyrosine phosphorylation of the receptor for insulin-like growth factor II is inhibited in plasma membranes from insulin-treated rat adipocytes, Silvia Corvera, Keith A. Yagaloff, Robert E. Whitehead, and Michael P. Czech

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Insulin receptor signaling. Activation of multiple serine kinases, Michael P. Czech, Jes K. Klarlund, Keith A. Yagaloff, Andrew P. Bradford, and Robert E. Lewis

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Insulin-like growth factor I and insulin rapidly increase casein kinase II activity in BALB/c 3T3 fibroblasts, Jes K. Klarlund and Michael P. Czech

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Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization, Ingrid C. Northwood and Roger J. Davis

Publications from 1987

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Insulin-like growth factor I and epidermal growth factor regulate the expression of transferrin receptors at the cell surface by distinct mechanisms, Roger J. Davis, Mark Faucher, Lori Kuck Racaniello, Anthony Carruthers, and Michael P. Czech