The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 1997

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The importance of the protein in controlling the electrochemistry of heme metalloproteins: methods of calculation and analysis, M. R. Gunner, Emil Alexov, Eduardo M. Torres, and Samir Lipovaca

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YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene, Bo Guo, Fauzia Aslam, Andre J. Van Wijnen, Stefan G. E. Roberts, Baruch Frenkel, Michael R. Green, Hector F. DeLuca, Jane B. Lian, Gary S. Stein, and Janet L. Stein

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Differential regulation of gastrulation and neuroectodermal gene expression by Snail in the Drosophila embryo, Kirugaval Hemavathy, Xiangjun Meng, and Y. Tony Ip

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Cytokine-facilitated transduction leads to low-level engraftment in nonablated hosts, Ellen L. W. Kittler, Stefan O. Peters, Rowena B. Crittenden, Michelle E. Debatis, Hayley S. Ramshaw, F. Marc Stewart, and Peter J. Quesenberry

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Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains, Jes K. Klarlund, Adilson L. Guilherme, John Holik, Joseph V. Virbasius, Anil Chawla, and Michael P. Czech

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The Chlamydomonas reinhardtii ODA3 gene encodes a protein of the outer dynein arm docking complex, Anthony Koutoulis, Gregory J. Pazour, Curtis G. Wilkerson, Kazuo Inaba, Hong Sheng, Saeko Takada, and George B. Witman (The Journal of cell biology)

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Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development, Herman Meisner, Andrea Daga, Joanne M. Buxton, Belen Fernandez, Anil Chawla, Utpal Banerjee, and Michael P. Czech

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Mutation of residue Phe97 to Leu disrupts the central allosteric pathway in Scapharca dimeric hemoglobin, Animesh Dev Pardanani, Quentin H. Gibson, Gianni Colotti, and William E. Royer

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Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase, Varsha Patki, Joseph V. Virbasius, William S. Lane, Ban-Hock Toh, Howard S. Shpetner, and Silvia Corvera

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Mitochondrial association of a plus end-directed microtubule motor expressed during mitosis in Drosophila, Andrea J. Pereira, Brian Dalby, Russell J. Stewart, Stephen J. Doxsey, and Lawrence S. B. Goldstein

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Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants, Cheryl A. Pikora, John L. Sullivan, Dennis Panicali, and Katherine Luzuriaga

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Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold, Shirwin M. Pockwinse, Gabriela Krockmalnic, Stephen J. Doxsey, Jeffrey A. Nickerson, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Sheldon Penman

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Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression, Kerri Jeanne Pollard and Craig L. Peterson

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Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos, Christian Ernest Rocheleau, William D. Downs, Rueyling Lin, Claudia Wittman, Yanxia Bei, Yoon-Hee Cha, Mussa Ali, James R. Priess, and Craig C. Mello

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Ligand linked assembly of Scapharca dimeric hemoglobin, William E. Royer Jr., Rachael A. Fox, Francine R. Smith, Dan Zhu, and Emory H. Braswell

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DNA-replication checkpoint control at the Drosophila midblastula transition, Ody C. M. Sibon, Victoria A. Stevenson, and William E. Theurkauf

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Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase, Cathy Tournier, Alan J. Whitmarsh, Julie Cavanagh, Tamera Barrett, and Roger J. Davis

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c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene, Albertha J. M. Walhout, J. M. Gubbels, R. Bernards, P. C. van der Vliet, and H. Th. M. Timmers

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Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state, Scott S. Walker, Wu-Cheng Shen, Joseph C. Reese, Lynne Marie Apone, and Michael R. Green

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Effects of Sin- versions of histone H4 on yeast chromatin structure and function, Mark A. Wechser, Michael P. Kladde, Jennifer A. Alfieri, and Craig L. Peterson

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Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors, Alan J. Whitmarsh, Shen-Hsi Yang, Michael S. S. Su, Andrew D. Sharrocks, and Roger J. Davis

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Identification of a human protein that recognizes the 3' splice site during the second step of pre-mRNA splicing, Shaoping Wu and Michael R. Green

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Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity, Di Yang, Cathy Tournier, Mark Allen Wysk, Hong-Tao Lu, Jie Xu, Roger J. Davis, and Richard A. Flavell

Publications from 1996

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Yeast TAF(II)90 is required for cell-cycle progression through G2/M but not for general transcription activation, Lynne Marie Apone, Ching-man A. Virbasius, Joseph C. Reese, and Michael R. Green

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The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase, Kurt Baltensperger, Vijaya Karoor, Hyacinth Paul, Arnold E. Ruoho, Michael P. Czech, and Craig C. Malbon

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Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex, Peter Lawrence Bangs, Cynthia A. Sparks, Paul R. Odgren, and Edward G. Fey

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A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator, Gerald V. Denis and Michael R. Green

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A large-conductance K+ channel that is inhibited by the cytoskeleton in the smooth muscle cell line DDT1 MF-2, Anka G. Ehrhardt, Neil Frankish, and Gerrit Isenberg

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In vitro characterization of HIV type 1 biological clones from asymptomatic and symptomatic pediatric patients, Serene Elizabeth Forte, John L. Sullivan, and Mohan Somasundaran

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Regulation of phosphatidylinositol 3,4,5-trisphosphate 5'-phosphatase activity by insulin, Adilson L. Guilherme, Jes K. Klarlund, Gerald Krystal, and Michael P. Czech

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Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism, David Alan Hartley and Silvia Corvera

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Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles, Robin A. Heller-Harrison, Michelle Morin, Adilson L. Guilherme, and Michael P. Czech

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Role of the Raf/mitogen-activated protein kinase pathway in p21ras desensitization, Jes K. Klarlund, Andrew D. Cherniack, Martin McMahon, and Michael P. Czech

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Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations, Hans Knecht, Martine Raphael, Cathy McQuain, Sylvia Rothenberger, German A. Pihan, Sophie Camilleri-Broët, Edith Bachmann, Glenn R. Kershaw, Shannon Ryan, Ellen L. W. Kittler, Peter J. Quesenberry, Daniel Schlaifer, Bruce A. Woda, and Pierre Brousset

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Intramolecular inhibition of activating transcription factor-2 function by its DNA-binding domain, Xiao-Yong Li and Michael R. Green

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Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts, Stefan O. Peters, Ellen L. W. Kittler, Hayley S. Ramshaw, and Peter J. Quesenberry

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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway, Joel Raingeaud, Alan J. Whitmarsh, Tamera Barrett, Benoit Derijard, and Roger J. Davis

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Functional analysis of the DNA-stimulated ATPase domain of yeast SWI2/SNF2, Emilie Richmond and Craig L. Peterson

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The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal, Mark R. Rigby, Rita Bortell, Dale L. Greiner, Michael P. Czech, Jes K. Klarlund, John P. Mordes, and Aldo A. Rossini

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Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin, William E. Royer, Animesh Dev Pardanani, Quentin H. Gibson, Eric S. Peterson, and Joel M. Friedman

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Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin, Howard S. Shpetner, Marguerite Joly, David Alan Hartley, and Silvia Corvera

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A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila, Hayla Karen Sluss, Zhiqiang Han, Tamera Barrett, Deborah C. I. Goberdhan, Clive Wilson, Roger J. Davis, and Y. Tony Ip

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Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain, Joseph V. Virbasius, Adilson L. Guilherme, and Michael P. Czech

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Transcription activation in cells lacking TAFIIS, Scott S. Walker, Joseph C. Reese, Lynne Marie Apone, and Michael R. Green

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Localization of HIV-1 RNA in mammalian nuclei, Guohong Zhang, Maria L. Zapp, Guochen Yan, and Michael R. Green

Publications from 1995

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Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin, Andrew D. Cherniack, Jes K. Klarlund, Bruce R. Conway, and Michael P. Czech

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Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein, Rajesh K. Gaur, Juan Valcarcel, and Michael R. Green

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Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl, David Alan Hartley, Herman Meisner, and Silvia Corvera

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Insulin regulation of membrane-associated insulin receptor substrate 1, Robin A. Heller-Harrison, Michelle Morin, and Michael P. Czech

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Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking, Marguerite Joly, Andrius Kazlauskas, and Silvia Corvera

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In vivo functional analysis of the Ras exchange factor son of sevenless, Chris A. Karlovich, Laura Bonfini, Linda McCollam, Ronald D. Rogge, Andrea Daga, Michael P. Czech, and Utpal Banerjee

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Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors, Jes K. Klarlund, Andrew D. Cherniack, and Michael P. Czech

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Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless, Linda McCollam, Laura Bonfini, Chris A. Karlovich, Bruce R. Conway, Lynn M. Kozma, Utpal Banerjee, and Michael P. Czech

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Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells, Herman Meisner, Bruce R. Conway, David Alan Hartley, and Michael P. Czech

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Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor, Herman Meisner and Michael P. Czech

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Mutational analysis of the phototransduction pathway of Chlamydomonas reinhardtii, Gregory J. Pazour, Oleg A. Sineshchekov, and George B. Witman (The Journal of cell biology)

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine, Joel Raingeaud, Shashi Gupta, Jeffrey Scott Rogers, Martin Dickens, Jiahuai Han, Richard J. Ulevitch, and Roger J. Davis

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Delineating minimal protein domains and promoter elements for transcriptional activation by lentivirus Tat proteins, Christopher D. Southgate and Michael R. Green

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Phosphorylation of NUMA occurs during nuclear breakdown and not mitotic spindle assembly, Cynthia A. Sparks, Edward G. Fey, Charles A. Vidair, and Stephen J. Doxsey

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Bacterial expression of Scapharca dimeric hemoglobin: a simple model system for investigating protein cooperatively, Candace M. Summerford, Animesh Dev Pardanani, Andrew H. Betts, Anthony R. Poteete, Gianni Colotti, and William E. Royer

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The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein isa WD-repeat protein required for arm assembly, Curtis G. Wilkerson, Stephen M. King, Anthony Koutoulis, Gregory J. Pazour, and George B. Witman (The Journal of cell biology)

Publications from 1994

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Regulation by insulin of phosphatidylinositol 3'-kinase bound to alpha- and beta-isoforms of p85 regulatory subunit, Kurt Baltensperger, Lynn M. Kozma, Steven R. Jaspers, and Michael P. Czech

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Single mRNAs visualized by ultrastructural in situ hybridization are principally localized at actin filament intersections in fibroblasts, Gary J. Bassell, Christine M. Powers, Krishan L. Taneja, and Robert H. Singer

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Actin filaments and the spatial positioning of mRNAS, Gary J. Bassell, Krishan L. Taneja, Edward H. Kislauskis, Cynthia L. Sundell, Christine M. Powers, Anthony F. Ross, and Robert H. Singer

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Insulin-sensitive association of GLUT-4 with endocytic clathrin-coated vesicles revealed with the use of brefeldin A, Ranjan Chakrabarti, Joanne M. Buxton, Marguerite Joly, and Silvia Corvera

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Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase, Andrew D. Cherniack, Jes K. Klarlund, and Michael P. Czech

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Crystal structure of oxygenated Scapharca dimeric hemoglobin at 1.7-A resolution, Peter J. Condon and William E. Royer

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A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal, Silvia Corvera, Anil Chawla, Ranjan Chakrabarti, Marguerite Joly, Joanne M. Buxton, and Michael P. Czech

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Detection of changes in near-membrane Ca2+ concentration using a novel membrane-associated Ca2+ indicator, Elaine F. Etter, Michael A. Kuhn, and Fredric S. Fay

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Non-syncytium-inducing HIV type 1 isolated from infected individuals replicates in MT-2 cells, Serene Elizabeth Forte, Kevin S. Byron, John L. Sullivan, and Mohan Somasundaran

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The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein, Hyockman Kwon and Michael R. Green

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Synergistic activation of simian immunodeficiency virus and human immunodeficiency virus type 1 transcription by retinoic acid and phorbol ester through an NF-kappa B-independent mechanism, Joseph Walter Maciaszek, David A. Talmage, and Gregory A. Viglianti

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Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production, David M. Margolis, Mohan Somasundaran, and Michael R. Green

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Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement, Craig L. Peterson, Andrew K. Dingwall, and Matthew P. Scott

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Yeast TAFIIS in a multisubunit complex required for activated transcription, Joseph C. Reese, Lynne Marie Apone, Scott S. Walker, Loree A. Griffin, and Michael R. Green

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Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes, Assia Shisheva, Joanne M. Buxton, and Michael P. Czech

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Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle, Assia Shisheva, Thomas C. Sudhof, and Michael P. Czech

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Signal transduction by tumor necrosis factor mediated by JNK protein kinases, Hayla Karen Sluss, Tamera Barrett, Benoit Derijard, and Roger J. Davis

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Localization of HIV RNA in mitochondria of infected cells: potential role in cytopathogenicity, Mohan Somasundaran, Maria L. Zapp, Lars K. Beattie, Lizhen Pang, Kevin S. Byron, Gary J. Bassell, John L. Sullivan, and Robert H. Singer

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The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex, Markus Wartmann and Roger J. Davis

Publications from 1993

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Redistribution of clathrin-coated vesicle adaptor complexes during adipocytic differentiation of 3T3-L1 cells, Ranjan Chakrabarti, Marguerite Joly, and Silvia Corvera

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Insulin action on the internalization of the GLUT4 glucose transporter in isolated rat adipocytes, Michael P. Czech and Joanne M. Buxton

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Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization, Michael P. Czech, Anil Chawla, Chee-Wai Woon, Joanne M. Buxton, Michal Armoni, Wei Tang, Marguerite Joly, and Silvia Corvera

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The mitogen-activated protein kinase signal transduction pathway, Roger J. Davis

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Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus, Fernando A. Gonzalez, Alpna Seth, David L. Raden, Douglas S. Bowman, Fredric S. Fay, and Roger J. Davis

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Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62, Shashi Gupta, Alpna Seth, and Roger J. Davis

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The ras signaling pathway mimics insulin action on glucose transporter translocation, Lynn M. Kozma, Kurt Baltensperger, Jes K. Klarlund, A Porras, E Santos, and Michael P. Czech

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E1A functions as a coactivator of retinoic acid-dependent retinoic acid receptor-beta 2 promoter activation, Frank A. E. Kruyt, Gert E. Folkers, Albertha J. M. Walhout, Bas-jan M. van der Leede, and Paul T. van der Saag

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The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators, Frederic P. Lemaigre, Christopher I. Ace, and Michael R. Green

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cPLA2 is phosphorylated and activated by MAP kinase, Lih-Ling Lin, Markus Wartmann, Alice Y. Lin, John L. Knop, Alpna Seth, and Roger J. Davis

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sieB and esc genes of Bacteriophage P22: A Dissertation, Koustubh Ranade

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Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor, Erica Marie Selva, David L. Raden, and Roger J. Davis

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Cell cycle regulation of the c-Myc transcriptional activation domain, Alpna Seth, Shashi Gupta, and Roger J. Davis

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Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13, Cynthia A. Sparks, Peter Lawrence Bangs, Gerard P. McNeil, Jeanne B. Lawrence, and Edward G. Fey

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Induction of renal adenocarcinoma by a nonmutated erbB oncogene, Cherie A. Taglienti, Barbara F. Banner, Roger J. Davis, and Harriet L. Robinson

Publications from 1992

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Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor, Kurt Baltensperger, Robert E. Lewis, Chee-Wai Woon, Prabhakar Vissavajjhala, Alonzo H. Ross, and Michael P. Czech

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Activation of cell surface glucose transporters measured by photoaffinity labeling of insulin-sensitive 3T3-L1 adipocytes, Scott A. Harrison, Brian M. Clancy, Anna Pessino, and Michael P. Czech

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Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1, Daniel N. Hebert and Anthony Carruthers

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Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics, Nandini Nair, Roger J. Davis, and Harriet L. Robinson

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Signal transduction within the nucleus by mitogen-activated protein kinase, Alpna Seth, Fernando A. Gonzalez, Shashi Gupta, David L. Raden, and Roger J. Davis