The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 1999

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The mammalian homolog of the frog type II selenodeiodinase does not encode a functional enzyme in the rat, Jack L. Leonard, Deborah M. Leonard, Marjorie Safran, Rui Wu, Maria L. Zapp, and Alan P. Farwell

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Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice, Hong-Tao Lu, Derek D. Yang, Mark Allen Wysk, Evelina Gatti, Ira Mellman, Roger J. Davis, and Richard A. Flavell

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Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor, Xiangjun Meng, Bhupinder S. Khanuja, and Y. Tony Ip

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LC2, the chlamydomonas homologue of the t complex-encoded protein Tctex2, is essential for outer dynein arm assembly, Gregory J. Pazour, Anthony Koutoulis, Sharon E. Benashski, Bethany L. Dickert, Hong Sheng, Ramila S. Patel-King, Stephen M. King, and George B. Witman

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The hepatitis B pX protein promotes dimerization and DNA binding of cellular basic region/leucine zipper proteins by targeting the conserved basic region, Giovanni Perini, Elke Oetjen, and Michael R. Green

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Functional interaction between GCN5 and polyamines: a new role for core histone acetylation, Kerri Jeanne Pollard, Michael L. Samuels, Kimberly A. Crowley, Jeffrey C. Hansen, and Craig L. Peterson

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Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization, Aruna Purohit, Sharon H. Tynan, Richard B. Vallee, and Stephen J. Doxsey

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WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans, Christian Ernest Rocheleau, Jun Yasuda, Tae Ho Shin, Rueyling Lin, Hitoshi Sawa, Hideyuki Okano, James R. Priess, Roger J. Davis, and Craig C. Mello

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Functional analysis of TFIID components, Wu-Cheng Shen, Lynne Marie Apone, Ching-man A. Virbasius, Xiao-Yong Li, M. Monsalve, and Michael R. Green

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MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans, Tae Ho Shin, Jun Yasuda, Christian Ernest Rocheleau, Rueyling Lin, Martha C. Soto, Yanxia Bei, Roger J. Davis, and Craig C. Mello

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The abnormal gene in X-linked lymphoproliferative syndrome, John L. Sullivan

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The rde-1 gene, RNA interference, and transposon silencing in C. elegans, Hiroaki Tabara, Madathia Sarkissian, William G. Kelly, Jamie Fleenor, Alla Grishok, Lisa Timmons, Andrew Z. Fire, and Craig C. Mello

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Crystal structure of the nuclear matrix targeting signal of the transcription factor acute myelogenous leukemia-1/polyoma enhancer-binding protein 2alphaB/core binding factor alpha2, Lei Tang, Bo Guo, Amjad Javed, Je-Yong Choi, Scott W. Hiebert, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and G. Wayne Zhou

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The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases, Cathy Tournier, Alan J. Whitmarsh, Julie Cavanagh, Tamera Barrett, and Roger J. Davis

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Profound misregulation of muscle-specific gene expression in facioscapulohumeral muscular dystrophy, Rossella Tupler, Giovanni Perini, Maria Antonietta Pellegrino, and Michael R. Green

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Protein interaction mapping in C. elegans using proteins involved in vulval development, Albertha J. M. Walhout, Raffaella Sordella, Xiaowei Lu, James L. Hartley, Gary F. Temple, Michael A. Brasch, Nicolas Thierry-Mieg, and Marc Vidal

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A genetic strategy to eliminate self-activator baits prior to high-throughput yeast two-hybrid screens, Albertha J. M. Walhout and Marc Vidal

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Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression, Mark Allen Wysk, Derek D. Yang, Hong-Tao Lu, Richard A. Flavell, and Roger J. Davis

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The JIP group of mitogen-activated protein kinase scaffold proteins, Jun Yasuda, Alan J. Whitmarsh, Julie Cavanagh, Manoj Sharma, and Roger J. Davis

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Centrosome dynamics in living cells, Aaron Isadore Young, Richard A. Tuft, Walter A. Carrington, and Stephen J. Doxsey

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Amorphous no longer: the centrosome comes into focus, Wendy Cherie Zimmerman, Cynthia A. Sparks, and Stephen J. Doxsey

Publications from 1998

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Transcription sans TBP, Lynne Marie Apone and Michael R. Green

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Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA, Lynne M. Apone, Ching-man A. Virbasius, Frank C. P. Holstege, Jing Wang, Richard A. Young, and Michael R. Green

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Transcriptional control: repression by local chromatin modification, Shovon Imtiaz Ashraf and Y. Tony Ip

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Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export, Peter Lawrence Bangs, Brian Burke, Christine M. Powers, Roger W. Craig, Aruna Purohit, and Stephen J. Doxsey

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Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton, Alissa G. Bukrinskaya, Beda Brichacek, Angela Mann, and Mario Stevenson

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Pericentrin and gamma-tubulin form a protein complex and are organized into a novel lattice at the centrosome, Jason B. Dictenburg, Wendy Cherie Zimmerman, Cynthia A. Sparks, Aaron Isadore Young, Charles A. Vidair, Yixian Zheng, Walter A. Carrington, Fredric S. Fay, and Stephen J. Doxsey

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Defective T cell differentiation in the absence of Jnk1, Chen Dong, Derek D. Yang, Mark Allen Wysk, Alan J. Whitmarsh, Roger J. Davis, and Richard A. Flavell

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Changes in thymic function with age and during the treatment of HIV infection, Daniel C. Douek, Richard D. McFarland, Phillip H. Keiser, Earl A. Gage, Janice M. Massey, Barton F. Haynes, Michael A. Polis, Ashley T. Haase, Mark B. Feinberg, John L. Sullivan, Beth D. Jamieson, Jerome A. Zack, Louis J. Picker, and Richard A. Koup

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Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases, Kimberly K. Elbirt, Alan J. Whitmarsh, Roger J. Davis, and Herbert L. Bonkovsky

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Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6, Herve Enslen, Joel Raingeaud, and Roger J. Davis

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The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells, Zoya Galcheva-Gargova, Laxman Gangwani, Konstantin N. Konstantinov, Monique Mikrut, Steven J. Theroux, Tamar Enoch, and Roger J. Davis

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Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells, Laxman Gangwani, Monique Mikrut, Zoya Galcheva-Gargova, and Roger J. Davis

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Wilson disease in 1998: genetic, diagnostic and therapeutic aspects, John L. Gollan and Timothy J. Gollan

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Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by beta1-integrin signaling in rat adipocytes, Adilson L. Guilherme and Michael P. Czech

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Cross-talk between insulin receptor and integrin alpha5 beta1 signaling pathways, Adilson L. Guilherme, Kevin Torres, and Michael P. Czech

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A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression, Zhiqiang Han, Herve Enslen, Xiaodi Hu, Xiangjun Meng, I-Huan Wu, Tamera Barrett, Roger J. Davis, and Y. Tony Ip

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Crystal structure of deoxy-human hemoglobin beta6 Glu --> Trp. Implications for the structure and formation of the sickle cell fiber, Daniel John Harrington, Kengo Adachi, and William E. Royer

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High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats, Neal N. Iwakoshi, Irving Goldschneider, Frances Tausche, John P. Mordes, Aldo A. Rossini, and Dale L. Greiner

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Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase, Jean-Marc Jacque, Angela Mann, Herve Enslen, Natalia Sharova, Beda Brichacek, Roger J. Davis, and Mario Stevenson

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Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate, Jes K. Klarlund, Lucia E. Rameh, Lewis C. Cantley, Joanne M. Buxton, John Holik, Christoper Sakelis, Varsha Patki, Silvia Corvera, and Michael P. Czech

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The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor, Xiao-Yong Li and Michael R. Green

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Catalytic activity of the yeast SWI/SNF complex on reconstituted nucleosome arrays, Colin Logie and Craig L. Peterson

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Prevention and treatment of pediatric HIV infection, Katherine Luzuriaga and John L. Sullivan

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Analysis of the Mechanism of Ras Activation: Mapping of Important Functional Domains of the Son of Sevenless Protein, Linda Sue McCollam-Guilani

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Pharmacokinetics of nevirapine in human immunodeficiency virus type 1-infected pregnant women and their neonates. Pediatric AIDS Clinical Trials Group Protocol 250 Team, Mark Mirochnick, Terry Fenton, Paul Gagnier, Joseph W. Pav, Meg Gwynne, Sue Siminski, Rhoda S. Sperling, Karen Beckerman, Eleanor Jimenez, Ram Yogev, Stephen A. Spector, and John L. Sullivan

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Mutational destabilization of the critical interface water cluster in Scapharca dimeric hemoglobin: structural basis for altered allosteric activity, Animesh Dev Pardanani, Alessandra Gambacurta, Franca Ascoli, and William E. Royer

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A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT), Gregory J. Pazour, Curtis G. Wilkerson, and George B. Witman (The Journal of cell biology)

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Subunits of the yeast SWI/SNF complex are members of the actin-related protein (ARP) family, Craig L. Peterson, Yingming Zhao, and Brian T. Chait

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Centrosome defects and genetic instability in malignant tumors, G A Pihan, A Purohit, J Wallace, H Knecht, Bruce A. Woda, Peter J. Quesenberry, and Stephen J. Doxsey

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Chromatin remodeling: a marriage between two families, Kerri Jeanne Pollard and Craig L. Peterson

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The catalytic subunit of the cAMP-dependent protein kinase of ovine sperm flagella has a unique amino-terminal sequence, Jovenal T. San Agustin, John D. Leszyk, Lydia M. Nuwaysir, and George B. Witman (The Journal of biological chemistry)

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Association of acyl-CoA synthetase-1 with GLUT4-containing vesicles, Mark W. Sleeman, Niles P. Donegan, Robin A. Heller-Harrison, William S. Lane, and Michael P. Czech

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RNAi in C. elegans: soaking in the genome sequence, Hiroaki Tabara, Alla Grishok, and Craig C. Mello

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Preliminary crystallographic study of glutathione S-transferase fused with the nuclear matrix targeting signal of the transcription factor AML-1/CBF-alpha2, Lei Tang, Bo Guo, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein, and G. Wayne Zhou

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A tribute to Fredric Stewart Fay: June 5, 1943 - March 18, 1997, Richard A. Tuft and Leslie M. Loew

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Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes, Barbara VanRenterghem, Michelle Morin, Michael P. Czech, and Robin A. Heller-Harrison

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A model of elegance, Albertha J. M. Walhout, Hideki Endoh, Nicolas Thierry-Mieg, Wendy Wong, and Marc Vidal

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Sequences flanking the E-box contribute to cooperative binding by c-Myc/Max heterodimers to adjacent binding sites, Albertha J. M. Walhout, P. C. van der Vliet, and H. Th. M. Timmers

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Controlling gene expression in living cells through small molecule-RNA interactions, Geoffrey Werstuck and Michael R. Green

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A mammalian scaffold complex that selectively mediates MAP kinase activation, Alan J. Whitmarsh, Julie Cavanagh, Cathy Tournier, Jun Yasuda, and Roger J. Davis

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CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses, Lin Wu, David G. Wells, Joyce Tay, Duane Mendis, Mary-Alice Abbott, Allan Barnitt, Elizabeth Quinlan, Arnold Heynen, Justin R. Fallon, and Joel D. Richter

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Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1, Jian Yang, Xiaoshan Liang, Tian-Qi Niu, Wuyi Meng, Zhizhuang Joe Zhao, and G. Wayne Zhou

Publications from 1997

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Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo, Mark J. Birnbaum, Brigitte van Zundert, Patricia S. Vaughan, Alan J. Whitmarsh, Andre J. Van Wijnen, Roger J. Davis, Gary S. Stein, and Janet L. Stein

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In Vivo Functional Analysis of the Saccharomyces Cerevisiae SWI/SNF Complex: A Dissertation, Loree Griffin Burns

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The yeast SWI-SNF complex facilitates binding of a transcriptional activator to nucleosomal sites in vivo, Loree Griffin Burns and Craig L. Peterson

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Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway, Chi-Wing Chow, Mercedes Rincon, Julie Cavanagh, Martin Dickens, and Roger J. Davis

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The Mos pathway regulates cytoplasmic polyadenylation in Xenopus oocytes, Cornelia H. de Moor and Joel D. Richter

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A cytoplasmic inhibitor of the JNK signal transduction pathway, Martin Dickens, Jeffrey Scott Rogers, Julie Cavanagh, Art Raitano, Zhengui Xia, Jocelyn R. Halpern, Michael E. Greenberg, Charles L. Sawyers, and Roger J. Davis

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U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction, Jan Fleckner, Meng Zhang, Juan Valcarcel, and Michael R. Green

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Functional group substitutions of the branchpoint adenosine in a nuclear pre-mRNA and a group II intron, Rajesh K. Gaur, Larry W. McLaughlin, and Michael R. Green

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The importance of the protein in controlling the electrochemistry of heme metalloproteins: methods of calculation and analysis, M. R. Gunner, Emil Alexov, Eduardo M. Torres, and Samir Lipovaca

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YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene, Bo Guo, Fauzia Aslam, Andre J. Van Wijnen, Stefan G. E. Roberts, Baruch Frenkel, Michael R. Green, Hector F. DeLuca, Jane B. Lian, Gary S. Stein, and Janet L. Stein

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Differential regulation of gastrulation and neuroectodermal gene expression by Snail in the Drosophila embryo, Kirugaval Hemavathy, Xiangjun Meng, and Y. Tony Ip

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Cytokine-facilitated transduction leads to low-level engraftment in nonablated hosts, Ellen L. W. Kittler, Stefan O. Peters, Rowena B. Crittenden, Michelle E. Debatis, Hayley S. Ramshaw, F. Marc Stewart, and Peter J. Quesenberry

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Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains, Jes K. Klarlund, Adilson L. Guilherme, John Holik, Joseph V. Virbasius, Anil Chawla, and Michael P. Czech

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The Chlamydomonas reinhardtii ODA3 gene encodes a protein of the outer dynein arm docking complex, Anthony Koutoulis, Gregory J. Pazour, Curtis G. Wilkerson, Kazuo Inaba, Hong Sheng, Saeko Takada, and George B. Witman (The Journal of cell biology)

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Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development, Herman Meisner, Andrea Daga, Joanne M. Buxton, Belen Fernandez, Anil Chawla, Utpal Banerjee, and Michael P. Czech

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Mutation of residue Phe97 to Leu disrupts the central allosteric pathway in Scapharca dimeric hemoglobin, Animesh Dev Pardanani, Quentin H. Gibson, Gianni Colotti, and William E. Royer

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Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase, Varsha Patki, Joseph V. Virbasius, William S. Lane, Ban-Hock Toh, Howard S. Shpetner, and Silvia Corvera

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Mitochondrial association of a plus end-directed microtubule motor expressed during mitosis in Drosophila, Andrea J. Pereira, Brian Dalby, Russell J. Stewart, Stephen J. Doxsey, and Lawrence S. B. Goldstein

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Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants, Cheryl A. Pikora, John L. Sullivan, Dennis Panicali, and Katherine Luzuriaga

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Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold, Shirwin M. Pockwinse, Gabriela Krockmalnic, Stephen J. Doxsey, Jeffrey A. Nickerson, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Sheldon Penman

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Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression, Kerri Jeanne Pollard and Craig L. Peterson

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Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos, Christian Ernest Rocheleau, William D. Downs, Rueyling Lin, Claudia Wittman, Yanxia Bei, Yoon-Hee Cha, Mussa Ali, James R. Priess, and Craig C. Mello

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Ligand linked assembly of Scapharca dimeric hemoglobin, William E. Royer Jr., Rachael A. Fox, Francine R. Smith, Dan Zhu, and Emory H. Braswell

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DNA-replication checkpoint control at the Drosophila midblastula transition, Ody C. M. Sibon, Victoria A. Stevenson, and William E. Theurkauf

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Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase, Cathy Tournier, Alan J. Whitmarsh, Julie Cavanagh, Tamera Barrett, and Roger J. Davis

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c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene, Albertha J. M. Walhout, J. M. Gubbels, R. Bernards, P. C. van der Vliet, and H. Th. M. Timmers

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Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state, Scott S. Walker, Wu-Cheng Shen, Joseph C. Reese, Lynne Marie Apone, and Michael R. Green

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Effects of Sin- versions of histone H4 on yeast chromatin structure and function, Mark A. Wechser, Michael P. Kladde, Jennifer A. Alfieri, and Craig L. Peterson

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Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors, Alan J. Whitmarsh, Shen-Hsi Yang, Michael S. S. Su, Andrew D. Sharrocks, and Roger J. Davis

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Identification of a human protein that recognizes the 3' splice site during the second step of pre-mRNA splicing, Shaoping Wu and Michael R. Green

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Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity, Di Yang, Cathy Tournier, Mark Allen Wysk, Hong-Tao Lu, Jie Xu, Roger J. Davis, and Richard A. Flavell

Publications from 1996

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Yeast TAF(II)90 is required for cell-cycle progression through G2/M but not for general transcription activation, Lynne Marie Apone, Ching-man A. Virbasius, Joseph C. Reese, and Michael R. Green

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The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase, Kurt Baltensperger, Vijaya Karoor, Hyacinth Paul, Arnold E. Ruoho, Michael P. Czech, and Craig C. Malbon

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Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex, Peter Lawrence Bangs, Cynthia A. Sparks, Paul R. Odgren, and Edward G. Fey

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A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator, Gerald V. Denis and Michael R. Green

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A large-conductance K+ channel that is inhibited by the cytoskeleton in the smooth muscle cell line DDT1 MF-2, Anka G. Ehrhardt, Neil Frankish, and Gerrit Isenberg

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In vitro characterization of HIV type 1 biological clones from asymptomatic and symptomatic pediatric patients, Serene Elizabeth Forte, John L. Sullivan, and Mohan Somasundaran