The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2004

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Human immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: impact on association with membrane lipid rafts and incorporation onto budding virus particles, Jayanta Bhattacharya, Paul J. Peters, and Paul R. Clapham

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In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer, Sukesh R. Bhaumik, Tamal Raha, David P. Aiello, and Michael R. Green

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Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway, Avirup Bose, Stacey I. Robida, Paul S. Furcinitti, Anil Chawla, Kevin E. Fogarty, Silvia Corvera, and Michael P. Czech

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The SANT domain: a unique histone-tail-binding module, Laurie A. Boyer, Robert R. Latek, and Craig L. Peterson

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Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage, Michael H. Brodsky, Brian T. Weinert, Garson Tsang, Yikang S. Rong, Nadine Schultz, Kent G. Golic, Donald C. Rio, and Gerald M. Rubin

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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations, Sharon B. Cantor, Ronny Drapkin, Fan Zhang, Yafang Lin, Juliana Han, Sushmita Pamidi, and David M. Livingston

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Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1), Ya-Lin Chiu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, and Tariq M. Rana

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Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains, Thomas Charles Cronin, Jonathan P. DiNitto, Michael P. Czech, and David G. Lambright

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A peptidyl transferase ribozyme capable of combinatorial peptide synthesis, Zhiyong Cui, Lele Sun, and Biliang Zhang

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The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316, Coleen K. Cunningham, Rajalakshmmi Balasubramanian, Isaac Delke, Robert Maupin, Lynne M. Mofenson, Alejandro Dorenbaum, John L. Sullivan, Adolfo Gonzalez-Garcia, Edwin Thorpe, Mobeen H. Rathore, and Richard D. Gelber

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Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5, Anna M. Delprato, Eric Lee Merithew, and David G. Lambright

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A first version of the Caenorhabditis elegans Promoterome, Denis Dupuy, Qian-Ru Li, Bart Deplancke, Mike Boxem, Tong Hao, Philippe Lamesch, Reynaldo Sequerra, Stephanie Bosak, Lynn Doucette-Stamm, Ian A. Hope, David E. Hill, Albertha J. M. Walhout, and Marc Vidal

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PPARs and the complex journey to obesity, Ronald M. Evans, Grant D. Barrish, and Yong-Xu Wang

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When enough is enough: genetic diseases associated with transcriptional derepression, Davide Gabellini, Michael R. Green, and Rossella Tupler

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Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice, Irina Catrinel Gavanescu, German A. Pihan, Ensar Halilovic, Eva Szomolanyi-Tsuda, Raymond M. Welsh, and Stephen J. Doxsey

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Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection, Laura L. Gibson, Giampiero Piccinini, Daniele Lilleri, Maria Grazia Revello, Zhongde Wang, Susan F. Markel, Don J. Diamond, and Katherine Luzuriaga

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Identification of critical domains and putative partners for the Caenorhabditis elegans spindle component LIN-5, Ridgely Fisk Green, Monique A. Lorson, Albertha J. M. Walhout, Marc Vidal, and Sander van den Heuvel

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The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins, Anastasia P. Grigorenko, Yuri K. Moliaka, Martha C. Soto, Craig C. Mello, and Evgeny I. Rogaev

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Midbody Anchoring of SNARE and Exocyst Complexes by Centriolin is Required for Completion of Cytokinesis: A Dissertation, Adam Scott Gromley

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Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes, Adilson L. Guilherme, Neil A. Soriano, Paul S. Furcinitti, and Michael P. Czech

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Conformational changes of lysozyme refolding intermediates and implications for aggregation and renaturation, Zhenyu Gu, Xiaonan Zhu, Shaowei Ni, Zhiguo Su, and Hai-Meng Zhou

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Evidence for dynamically organized modularity in the yeast protein-protein interaction network, Jing-Dong J. Han, Nicolas Bertin, Tong Hao, Debra S. Goldberg, Gabriel F. Berriz, Lan V. Zhang, Denis Dupuy, Albertha J. M. Walhout, Michael E. Cusick, Frederick P. Roth, and Marc Vidal

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Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells, John E. Harris, Kenneth D. Bishop, Nancy E. Phillips, John P. Mordes, Dale L. Greiner, Aldo A. Rossini, and Michael P. Czech

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The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu, Kirugaval Hemavathy, Xiaodi Hu, Shovon Imtiaz Ashraf, Stephen J. Small, and Y. Tony Ip

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Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo, Donna Hochberg, Jaap M. Middeldorp, Michelle D. Catalina, John L. Sullivan, Katherine Luzuriaga, and David A. Thorley-Lawson

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Acute infection with Epstein-Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells, Donna Hochberg, Tatyana Souza, Michelle D. Catalina, John L. Sullivan, Katherine Luzuriaga, and David A. Thorley-Lawson

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A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport, Yuqing Hou, Gregory J. Pazour, and George B. Witman

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Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes, Shaohui Huang, Lawrence M. Lifshitz, Varsha Patki, Richard A. Tuft, Kevin E. Fogarty, and Michael P. Czech

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Sequence-specific inhibition of small RNA function, Gyorgy Hutvagner, Martin J. Simard, Craig C. Mello, and Phillip D. Zamore

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Sequence-specific inhibition of small RNA function, Gyorgy Hutvagner, Martin J. Simard, Craig C. Mello, and Phillip D. Zamore

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Multimerization and interaction of Toll and Spatzle in Drosophila, Xiaodi Hu, Yoshimasa Yagi, Takahiro Tanji, Sili L. Zhou, and Y. Tony Ip

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An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue, Anja Jaeschke, Michael P. Czech, and Roger J. Davis

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Centrosomes in Cytokinesis, Cell Cycle Progression and Ciliogenesis: a Dissertation, Agata Jurczyk

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Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly, Agata Jurczyk, Adam Scott Gromley, Sambra D. Redick, Jovenal T. San Agustin, George B. Witman, Gregory J. Pazour, Dorien J. M. Peters, and Stephen J. Doxsey

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Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation, H. Kadowaki, H. Nishitoh, Fumihiko Urano, C. Sadamitsu, A. Matsuzawa, K. Takeda, H. Masutani, J. Yodoi, Y. Urano, T. Nagano, and H. Ichijo

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U2AF homology motifs: protein recognition in the RRM world, Clara L. Kielkopf, Stephan Lucke, and Michael R. Green

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Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome, Elizabeth D. Kilpatrick, Masanori Terajima, Frederick T. Koster, Michelle D. Catalina, John Cruz, and Francis A. Ennis

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Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2, Wenhui Li, Thomas C. Greenough, Michael J. Moore, Natalya Vasilieva, Mohan Somasundaran, John L. Sullivan, Michael Farzan, and Hyeryun Choe

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Structural Basis for Rab5 Activation and Effector Specificity in Endosome Tethering: A Dissertation, Eric Lee Merithew

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RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin, Prasenjit Mitra, Xuexiu Zheng, and Michael P. Czech

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Lhx9 and lhx9alpha: differential biochemical properties and effects on neuronal differentiation, Bertrand Molle, Stephane Pere, Vieri Failli, Ingolf Bach, and Sylvie Retaux

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Immunogenicity and efficacy of childhood vaccines in HIV-1-infected children, S. K. Obaro, D. Pugatch, and Katherine Luzuriaga

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Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect, Sarah R. Oikemus, Nadine Schultz, Joana Queiroz-Machado, Hanna Tukachinsky, Saeko Takada, Claudio E. Sunkel, and Michael H. Brodsky

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Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease, Gregory J. Pazour

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Cellular machineries for chromosomal DNA repair, Craig L. Peterson and Jacques Cote

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Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages, Paul J. Peters, Jayanta Bhattacharya, Samantha Hibbitts, Matthias T. Dittmar, Graham Simmons, Jeanne E. Bell, Peter Simmonds, and Paul R. Clapham

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Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5, Yueh-Hsin Ping, Chia-ying Chu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, and Tariq M. Rana

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Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5, Yueh-Hsin Ping, Chia-ying Chu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, and Tariq M. Rana

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EBV-Specific CD4+ T Cell Responses in Acute Infectious Mononucleosis: a Dissertation, Melissa Lynn Precopio

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Immunoprophylaxis to prevent mother-to-child transmission of HIV-1, Jeffrey T. Safrit, Ruth Ruprecht, Flavia Ferrantelli, Weidong Xu, Moiz Kitabwalla, Koen Van Rompay, Marta Marthas, Nancy Haigwood, John R. Mascola, Katherine Luzuriaga, Samuel Adeniyi Jones, Bonnie J. Mathieson, and Marie-Louise Newell

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hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region, Nuria Sanchez-Velar, Enyeneama B. Udofia, Zhong Yu, and Maria L. Zapp

Signaling Events Leading to CPEB-Mediated Translation: a Dissertation, Madathia Sarkissian

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Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3, Madathia Sarkissian, Raul Mendez, and Joel D. Richter

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A pathway of sequential arginine-serine-rich domain-splicing signal interactions during mammalian spliceosome assembly, Haihong Shen and Michael R. Green

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A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2, Haihong Shen, Julie L. C. Kan, Claudia Ghigna, Giuseppe Biamonti, and Michael R. Green

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Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly, Haihong Shen, Julie L. C. Kan, and Michael R. Green

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In vivo labeling of fission yeast DNA with thymidine and thymidine analogs, Sasirekha Sivakumar, Mary Elizabeth Porter-Goff, Prasanta K. Patel, Kristen Benoit, and Nicholas R. Rhind

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Functional and Structural Analysis of the Yeast SWI/SNF Complex: a Dissertation, Corey Lewis Smith

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Developments in basic science research. Highlights of the 11th Conference on Retroviruses and Opportunistic Infections, February 8-11, 2004, San Francisco, California, USA, Mario Stevenson

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The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53, Jose G. Teodoro, Destin W. Heilman, Albert E Parker, and Michael R. Green

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RISC assembly defects in the Drosophila RNAi mutant armitage, Yukihide Tomari, Tingting Du, Benjamin Haley, Dianne S. Schwarz, Ryan Bennett, Heather A. Cook, Birgit S. Koppetsch, William E. Theurkauf, and Phillip D. Zamore

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Characterization of restrictions to human immunodeficiency virus type 1 infection of monocytes, Karine Triques and Mario Stevenson

[Stress signaling from the endoplasmic reticulum], Fumihiko Urano

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JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species, Juan-Jose Ventura, Patricia C. Cogswell, Richard A. Flavell, Albert S. Baldwin Jr., and Roger J. Davis

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DNA instructed displacement of histones H2A and H2B at an inducible promoter, Guillermo P. Vicent, A. Silvina Nacht, Corey Lewis Smith, Craig L. Peterson, Stefan Dimitrov, and Miguel Beato

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Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression, Hong Wang, Jovenal T. San Agustin, George B. Witman, and Daniel L. Kilpatrick

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Regulation of muscle fiber type and running endurance by PPARdelta, Yong-Xu Wang, Chung-Li Zhang, Ruth T. Yu, Helen K. Cho, Michael C. Nelson, Corinne R. Bayuga-Ocampo, Jungyeob Ham, Heonjoong Kang, and Ronald M. Evans

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The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis, Claire R. Weston, Anthony Wong, J. Perry Hall, Mary E. P. Goad, Richard A. Flavell, and Roger J. Davis

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Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone, Leanne Wilson-Fritch, Sarah M. Nicoloro, My T. Chouinard, Mitchell A. Lazar, Patricia C. Chui, John D. Leszyk, Juerg R. Straubhaar, Michael P. Czech, and Silvia Corvera

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Mother-to-child transmission of HIV-1: strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanisms, Robert Winchester, Jane Pitt, Manhattan Charurat, Laurence S. Magder, Harald H. H. Goring, Alan Landay, Jennifer S. Read, William T. Shearer, Edward Handelsman, Katherine Luzuriaga, George V. Hillyer, and William A. Blattner

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Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase, Maureen Wirschell, Gregory J. Pazour, Akinori Yoda, Masafumi Hirono, Ritsu Kamiya, and George B. Witman

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Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones, Takunari Yoneda, Cristina Benedetti, Fumihiko Urano, Scott G. Clark, Heather P. Harding, and David Ron

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Quantitative signature for architectural organization of regulatory factors using intranuclear informatics, Daniel W. Young, Sayyed K. Zaidi, Paul S. Furcinitti, Amjad Javed, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, and Gary S. Stein

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Association of Pericentrin with the γ Tubulin Ring Complex: a Dissertation, Wendy Cherie Zimmerman

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Mitosis-specific anchoring of gamma tubulin complexes by pericentrin controls spindle organization and mitotic entry, Wendy Cherie Zimmerman, James Sillibourne, Jack Rosa, and Stephen J. Doxsey

Publications from 2003

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Mechanism of p38 MAP kinase activation in vivo, Deborah Marie Brancho, Nobuyuki Tanaka, Anja Jaeschke, Juan-Jose Ventura, Nyaya Kelkar, Yoshinori Tanaka, Masanao Kyuuma, Toshikazu Takeshita, Richard A. Flavell, and Roger J. Davis

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Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism, Alison Burkart, Babak Samii, Silvia Corvera, and Howard S. Shpetner

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DC3, the 21-kDa subunit of the outer dynein arm-docking complex (ODA-DC), is a novel EF-hand protein important for assembly of both the outer arm and the ODA-DC, Diane M. Casey, Kazuo Inaba, Gregory J. Pazour, Saeko Takada, Ken-ichi Wakabayashi, Curtis G. Wilkerson, Ritsu Kamiya, and George B. Witman

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Insulin's expanding control of forkheads, Michael P. Czech

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Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor, Laxminarayana R. Devireddy and Michael R. Green

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Membrane recognition and targeting by lipid-binding domains, Jonathan P. DiNitto, Thomas Charles Cronin, and David G. Lambright

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Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation, Angela Dolganiuc, Karen Kodys, Andrea Kopasz, Christopher Marshall, Twan Do, Laszlo Romics, Pranoti Mandrekar, Maria L. Zapp, and Gyongyi Szabo

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Chromatin remodeling activities act on UV-damaged nucleosomes and modulate DNA damage accessibility to photolyase, Helene Gaillard, Daniel J. Fitzgerald, Corey Lewis Smith, Craig L. Peterson, Timothy J. Richmond, and Fritz Thoma

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The Drosophila kinesin-like protein KLP67A is essential for mitotic and male meiotic spindle assembly, Rita Gandhi, Silvia Bonaccorsi, Diana Wentworth, Stephen J. Doxsey, Maurizio Gatti, and Andrea J. Pereira

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Integrating 'omic' information: a bridge between genomics and systems biology, Hui Ge, Albertha J. M. Walhout, and Marc Vidal

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A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase, Adam Scott Gromley, Agata Jurczyk, James Sillibourne, Ensar Halilovic, Mette M. Mogensen, Irina Groisman, Maureen Blomberg, and Stephen J. Doxsey

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EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton, Adilson L. Guilherme, Neil A. Soriano, Sahana Bose, John Holik, Avirup Bose, Darcy P. Pomerleau, Paul S. Furcinitti, John D. Leszyk, Silvia Corvera, and Michael P. Czech

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Inhibition of aggregation by media selection, sample loading and elution in size exclusion chromatographic refolding of denatured bovine carbonic anhydrase B, Zhenyu Gu, Xiaonan Zhu, Shaowei Ni, Haimeng Zhou, and Zhiguo Su

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The Molecular Mechanisms of T Cell Clonal Anergy: A Dissertation, John E. Harris

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Structural basis for endosomal targeting by FYVE domains, Akira Hayakawa, Susan J. Hayes, Deirdre C. Lawe, Eathiraj Sudharshan, Richard A. Tuft, Kevin E. Fogarty, David Lambright, and Silvia Corvera

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Role of c-Jun NH-terminal Kinase in Bcr/Abl Induced Cell Transformation: a dissertation, Patricia M. Hess

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Alterations in HIV-1 LTR promoter activity during AIDS progression, Kirsten Hiebenthal-Millow, Thomas C. Greenough, Doreen B. Bretttler, Michael Schindler, Steffen Wildum, John L. Sullivan, and Frank Kirchhoff

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Facilitation of dendritic mRNA transport by CPEB, Yi-Shuian Huang, John H. Carson, Elisa Barbarese, and Joel D. Richter

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Mechanistic Analysis of Chromatin Remodeling Enzymes: a Dissertation, Mariela Jaskelioff

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Chromatin and transcription: histones continue to make their marks, Mariela Jaskelioff and Craig L. Peterson

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Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin, Mariela Jaskelioff, Stephen Van Komen, Jocelyn E. Krebs, Patrick Sung, and Craig L. Peterson

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Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing, Zhen Y. Jiang, Qiong L. Zhou, Kerri A. Coleman, My T. Chouinard, Queta Boese, and Michael P. Czech

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Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3), Nyaya Kelkar, Marie Helene Delmotte, Claire R. Weston, Tamera Barrett, Barbara J. Sheppard, Richard A. Flavell, and Roger J. Davis

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Role of JNK in tumor development, Norman J. Kennedy and Roger J. Davis

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Suppression of Ras-stimulated transformation by the JNK signal transduction pathway, Norman J. Kennedy, Hayla Karen Sluss, Stephen N. Jones, Dafna Bar-Sagi, Richard A. Flavell, and Roger J. Davis