The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2005

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Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling, David A. Hill, Craig L. Peterson, and Anthony N. Imbalzano

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A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation, Peter J. Horn, Jean-Noel M. Bastie, and Craig L. Peterson

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Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes, Anja Jaeschke, Mercedes Rincon, Beth Doran, Judith Reilly, Donna S. Neuberg, Dale L. Greiner, Leonard D. Shultz, Aldo A. Rossini, Richard A. Flavell, and Roger J. Davis

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Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells, Zhen Y. Jiang, Qiong L. Zhou, John Holik, Shraddha Patel, John D. Leszyk, Kerri Coleman, My T. Chouinard, and Michael P. Czech

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XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress, Soshi Kanemoto, Shinichi Kondo, Maiko Ogata, Tomohiko Murakami, Fumihiko Urano, and Kazunori Imaizumi

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Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways, Nyaya Kelkar, Claire L. Standen, and Roger J. Davis

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Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation, Kaori Kubota, Daniel H. Lee, Masahiro Tsuchiya, Conan S. Young, Eric T. Everett, Esperanza A. Martinez-Mier, Malcolm Snead, Linh X. Nguyen, Fumihiko Urano, and John D. Bartlett

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Characterization of the protein dimerization domain responsible for assembly of functional selenodeiodinases, Jack L. Leonard, Gregory I. C. Simpson, and Deborah Marie Leonard

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The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma, Brian C. Lewis, David S. Klimstra, Nicholas D. Socci, Su Xu, Jason A. Koutcher, and Harold E. Varmus

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BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ, Rachel Litman, Min Peng, Zhe Jin, Fan Zhang, Junran Zhang, Simon N. Powell, Paul R. Andreassen, and Sharon B. Cantor

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C. elegans tubby regulates life span and fat storage by two independent mechanisms, Arnab Mukhopadhyay, Bart Deplancke, Albertha J. M. Walhout, and Heidi A. Tissenbaum

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Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos, Tatsuya Nakamura, Soyoung Kim, Takao Ishidate, Yanxia Bei, Ka Ming Pang, Masaki Shirayama, Chris Trzepacz, Daniel R. Brownell, and Craig C. Mello

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JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16, Seung Wook Oh, Arnab Mukhopadhyay, Nenad Svrzikapa, Feng Jiang, Roger J. Davis, and Heidi A. Tissenbaum

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DNA replication origins fire stochastically in fission yeast, Prasanta K. Patel, Benoit Arcangioli, Stephen P. Baker, Aaron Bensimon, and Nicholas R. Rhind

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Proteomic analysis of a eukaryotic cilium, Gregory J. Pazour, Nathan S. Agrin, John D. Leszyk, and George B. Witman

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Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2, Shirwin M. Pockwinse, Arun Rajgopal, Daniel W. Young, Khwaja A. Mujeeb, Jeffrey A. Nickerson, Amjad Javed, Sambra D. Redick, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Stephen J. Doxsey

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Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes, Aimee M. Powelka, Asha Seth, Joseph V. Virbasius, Evangelos Kiskinis, Sarah M. Nicoloro, Adilson L. Guilherme, Xiaoqing Tang, Juerg R. Straubhaar, Andrew D. Cherniack, Malcolm G. Parker, and Michael P. Czech

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HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs, Tamal Raha, S. W. Grace Cheng, and Michael R. Green

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A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1), Alexander Repik, Steve E. Pincus, Ionita Ghiran, Anne Nicholson-Weller, Damon R. Asher, Anna M. Cerny, Leslie S. Casey, S. M. Jones, Stephen N. Jones, Nehal Mohamed, Lloyd B. Klickstein, George L. Spitalny, and Robert W. Finberg

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Characterization of JNK Binding Proteins: A Dissertation, Jeffrey Scott Rogers

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HIV-1-specific CD8+ T cell responses and viral evolution in women and infants, Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga

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In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA, Mark E. Sharkey, Karine Triques, Daniel R. Kuritzkes, and Mario Stevenson

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Macrophages archive HIV-1 virions for dissemination in trans, Natalia Sharova, Catherine Swingler, Mark Sharkey, and Mario Stevenson

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The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans, Masaki Shirayama, Martha C. Soto, Takao Ishidate, Soyoung Kim, Kuniaki Nakamura, Yanxia Bei, Sander van den Heuvel, and Craig C. Mello

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A conserved Swi2/Snf2 ATPase motif couples ATP hydrolysis to chromatin remodeling, Corey Lewis Smith and Craig L. Peterson

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ATP-dependent chromatin remodeling, Corey Lewis Smith and Craig L. Peterson

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Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells, Tatyana A. Souza, B. David Stollar, John L. Sullivan, Katherine Luzuriaga, and David A. Thorley-Lawson

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Developments in basic science research, Mario Stevenson

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Structural basis of family-wide Rab GTPase recognition by rabenosyn-5, Eathiraj Sudharshan, Xiaojing Pan, Christopher Ritacco, and David G. Lambright

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PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes, Xiaoqing Tang, Aimee M. Powelka, Neil A. Soriano, Michael P. Czech, and Adilson L. Guilherme

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The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones, Baris Tursun, Anne Schluter, Marvin A. Peters, Birte Viehweger, Heather P. Ostendorff, Juliana Soosairajah, Alexander Drung, Michael Bossenz, Steven A. Johnsen, Michaela Schweizer, Ora Bernard, and Ingolf Bach

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ATP-dependent and ATP-independent roles for the Rad54 chromatin remodeling enzyme during recombinational repair of a DNA double strand break, Branden Wolner and Craig L. Peterson

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Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila, Yoshimasa Yagi and Y. Tony Ip

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The cellular HIV-1 Rev cofactor hRIP is required for viral replication, Zhong Yu, Nuria Sanchez-Velar, Irina E. Catrina, Ellen L. W. Kittler, Enyeneama B. Udofia, and Maria L. Zapp

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Importin 7 may be dispensable for human immunodeficiency virus type 1 and simian immunodeficiency virus infection of primary macrophages, Steven P. Zielske and Mario Stevenson

Publications from 2004

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High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin, Jenny R. Allen, Linh X. Nguyen, Karen E.G. Sargent, Kathryn L. Lipson, Anthony Hackett, and Fumihiko Urano

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Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila, Shovon Imtiaz Ashraf, Atish Ganguly, John Roote, and Y. Tony Ip

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Human immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: impact on association with membrane lipid rafts and incorporation onto budding virus particles, Jayanta Bhattacharya, Paul J. Peters, and Paul R. Clapham

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In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer, Sukesh R. Bhaumik, Tamal Raha, David P. Aiello, and Michael R. Green

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Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway, Avirup Bose, Stacey I. Robida, Paul S. Furcinitti, Anil Chawla, Kevin E. Fogarty, Silvia Corvera, and Michael P. Czech

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The SANT domain: a unique histone-tail-binding module, Laurie A. Boyer, Robert R. Latek, and Craig L. Peterson

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Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage, Michael H. Brodsky, Brian T. Weinert, Garson Tsang, Yikang S. Rong, Nadine Schultz, Kent G. Golic, Donald C. Rio, and Gerald M. Rubin

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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations, Sharon B. Cantor, Ronny Drapkin, Fan Zhang, Yafang Lin, Juliana Han, Sushmita Pamidi, and David M. Livingston

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Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1), Ya-Lin Chiu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, and Tariq M. Rana

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Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains, Thomas Charles Cronin, Jonathan P. DiNitto, Michael P. Czech, and David G. Lambright

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A peptidyl transferase ribozyme capable of combinatorial peptide synthesis, Zhiyong Cui, Lele Sun, and Biliang Zhang

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The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316, Coleen K. Cunningham, Rajalakshmmi Balasubramanian, Isaac Delke, Robert Maupin, Lynne M. Mofenson, Alejandro Dorenbaum, John L. Sullivan, Adolfo Gonzalez-Garcia, Edwin Thorpe, Mobeen H. Rathore, and Richard D. Gelber

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Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5, Anna M. Delprato, Eric Lee Merithew, and David G. Lambright

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A first version of the Caenorhabditis elegans Promoterome, Denis Dupuy, Qian-Ru Li, Bart Deplancke, Mike Boxem, Tong Hao, Philippe Lamesch, Reynaldo Sequerra, Stephanie Bosak, Lynn Doucette-Stamm, Ian A. Hope, David E. Hill, Albertha J. M. Walhout, and Marc Vidal

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PPARs and the complex journey to obesity, Ronald M. Evans, Grant D. Barrish, and Yong-Xu Wang

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When enough is enough: genetic diseases associated with transcriptional derepression, Davide Gabellini, Michael R. Green, and Rossella Tupler

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Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice, Irina Catrinel Gavanescu, German A. Pihan, Ensar Halilovic, Eva Szomolanyi-Tsuda, Raymond M. Welsh, and Stephen J. Doxsey

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Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection, Laura L. Gibson, Giampiero Piccinini, Daniele Lilleri, Maria Grazia Revello, Zhongde Wang, Susan F. Markel, Don J. Diamond, and Katherine Luzuriaga

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Identification of critical domains and putative partners for the Caenorhabditis elegans spindle component LIN-5, Ridgely Fisk Green, Monique A. Lorson, Albertha J. M. Walhout, Marc Vidal, and Sander van den Heuvel

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The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins, Anastasia P. Grigorenko, Yuri K. Moliaka, Martha C. Soto, Craig C. Mello, and Evgeny I. Rogaev

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Midbody Anchoring of SNARE and Exocyst Complexes by Centriolin is Required for Completion of Cytokinesis: A Dissertation, Adam Scott Gromley

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Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes, Adilson L. Guilherme, Neil A. Soriano, Paul S. Furcinitti, and Michael P. Czech

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Conformational changes of lysozyme refolding intermediates and implications for aggregation and renaturation, Zhenyu Gu, Xiaonan Zhu, Shaowei Ni, Zhiguo Su, and Hai-Meng Zhou

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Evidence for dynamically organized modularity in the yeast protein-protein interaction network, Jing-Dong J. Han, Nicolas Bertin, Tong Hao, Debra S. Goldberg, Gabriel F. Berriz, Lan V. Zhang, Denis Dupuy, Albertha J. M. Walhout, Michael E. Cusick, Frederick P. Roth, and Marc Vidal

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Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells, John E. Harris, Kenneth D. Bishop, Nancy E. Phillips, John P. Mordes, Dale L. Greiner, Aldo A. Rossini, and Michael P. Czech

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The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu, Kirugaval Hemavathy, Xiaodi Hu, Shovon Imtiaz Ashraf, Stephen J. Small, and Y. Tony Ip

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Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo, Donna Hochberg, Jaap M. Middeldorp, Michelle D. Catalina, John L. Sullivan, Katherine Luzuriaga, and David A. Thorley-Lawson

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Acute infection with Epstein-Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells, Donna Hochberg, Tatyana Souza, Michelle D. Catalina, John L. Sullivan, Katherine Luzuriaga, and David A. Thorley-Lawson

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A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport, Yuqing Hou, Gregory J. Pazour, and George B. Witman

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Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes, Shaohui Huang, Lawrence M. Lifshitz, Varsha Patki, Richard A. Tuft, Kevin E. Fogarty, and Michael P. Czech

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Sequence-specific inhibition of small RNA function, Gyorgy Hutvagner, Martin J. Simard, Craig C. Mello, and Phillip D. Zamore

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Sequence-specific inhibition of small RNA function, Gyorgy Hutvagner, Martin J. Simard, Craig C. Mello, and Phillip D. Zamore

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Multimerization and interaction of Toll and Spatzle in Drosophila, Xiaodi Hu, Yoshimasa Yagi, Takahiro Tanji, Sili L. Zhou, and Y. Tony Ip

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An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue, Anja Jaeschke, Michael P. Czech, and Roger J. Davis

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Centrosomes in Cytokinesis, Cell Cycle Progression and Ciliogenesis: a Dissertation, Agata Jurczyk

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Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly, Agata Jurczyk, Adam Scott Gromley, Sambra D. Redick, Jovenal T. San Agustin, George B. Witman, Gregory J. Pazour, Dorien J. M. Peters, and Stephen J. Doxsey

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Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation, H. Kadowaki, H. Nishitoh, Fumihiko Urano, C. Sadamitsu, A. Matsuzawa, K. Takeda, H. Masutani, J. Yodoi, Y. Urano, T. Nagano, and H. Ichijo

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U2AF homology motifs: protein recognition in the RRM world, Clara L. Kielkopf, Stephan Lucke, and Michael R. Green

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Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome, Elizabeth D. Kilpatrick, Masanori Terajima, Frederick T. Koster, Michelle D. Catalina, John Cruz, and Francis A. Ennis

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Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2, Wenhui Li, Thomas C. Greenough, Michael J. Moore, Natalya Vasilieva, Mohan Somasundaran, John L. Sullivan, Michael Farzan, and Hyeryun Choe

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Structural Basis for Rab5 Activation and Effector Specificity in Endosome Tethering: A Dissertation, Eric Lee Merithew

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RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin, Prasenjit Mitra, Xuexiu Zheng, and Michael P. Czech

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Lhx9 and lhx9alpha: differential biochemical properties and effects on neuronal differentiation, Bertrand Molle, Stephane Pere, Vieri Failli, Ingolf Bach, and Sylvie Retaux

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Immunogenicity and efficacy of childhood vaccines in HIV-1-infected children, S. K. Obaro, D. Pugatch, and Katherine Luzuriaga

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Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect, Sarah R. Oikemus, Nadine Schultz, Joana Queiroz-Machado, Hanna Tukachinsky, Saeko Takada, Claudio E. Sunkel, and Michael H. Brodsky

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Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease, Gregory J. Pazour

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Cellular machineries for chromosomal DNA repair, Craig L. Peterson and Jacques Cote

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Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages, Paul J. Peters, Jayanta Bhattacharya, Samantha Hibbitts, Matthias T. Dittmar, Graham Simmons, Jeanne E. Bell, Peter Simmonds, and Paul R. Clapham

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Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5, Yueh-Hsin Ping, Chia-ying Chu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, and Tariq M. Rana

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Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5, Yueh-Hsin Ping, Chia-ying Chu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, and Tariq M. Rana

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EBV-Specific CD4+ T Cell Responses in Acute Infectious Mononucleosis: a Dissertation, Melissa Lynn Precopio

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Immunoprophylaxis to prevent mother-to-child transmission of HIV-1, Jeffrey T. Safrit, Ruth Ruprecht, Flavia Ferrantelli, Weidong Xu, Moiz Kitabwalla, Koen Van Rompay, Marta Marthas, Nancy Haigwood, John R. Mascola, Katherine Luzuriaga, Samuel Adeniyi Jones, Bonnie J. Mathieson, and Marie-Louise Newell

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hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region, Nuria Sanchez-Velar, Enyeneama B. Udofia, Zhong Yu, and Maria L. Zapp

Signaling Events Leading to CPEB-Mediated Translation: a Dissertation, Madathia Sarkissian

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Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3, Madathia Sarkissian, Raul Mendez, and Joel D. Richter

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A pathway of sequential arginine-serine-rich domain-splicing signal interactions during mammalian spliceosome assembly, Haihong Shen and Michael R. Green

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A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2, Haihong Shen, Julie L. C. Kan, Claudia Ghigna, Giuseppe Biamonti, and Michael R. Green

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Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly, Haihong Shen, Julie L. C. Kan, and Michael R. Green

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In vivo labeling of fission yeast DNA with thymidine and thymidine analogs, Sasirekha Sivakumar, Mary Elizabeth Porter-Goff, Prasanta K. Patel, Kristen Benoit, and Nicholas R. Rhind

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Functional and Structural Analysis of the Yeast SWI/SNF Complex: a Dissertation, Corey Lewis Smith

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Developments in basic science research. Highlights of the 11th Conference on Retroviruses and Opportunistic Infections, February 8-11, 2004, San Francisco, California, USA, Mario Stevenson

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The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53, Jose G. Teodoro, Destin W. Heilman, Albert E Parker, and Michael R. Green

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RISC assembly defects in the Drosophila RNAi mutant armitage, Yukihide Tomari, Tingting Du, Benjamin Haley, Dianne S. Schwarz, Ryan Bennett, Heather A. Cook, Birgit S. Koppetsch, William E. Theurkauf, and Phillip D. Zamore

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Characterization of restrictions to human immunodeficiency virus type 1 infection of monocytes, Karine Triques and Mario Stevenson

[Stress signaling from the endoplasmic reticulum], Fumihiko Urano