Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver
Program in Molecular Medicine; Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine
Amino Acids, Peptides, and Proteins | Biochemical Phenomena, Metabolism, and Nutrition | Biochemistry, Biophysics, and Structural Biology | Enzymes and Coenzymes | Lipids | Physiology
Stearoyl-CoA desaturase 1 (SCD1), a lipogenic enzyme that adds a double bond at the delta 9 position of stearate (C18: 0) and palmitate (C16: 0), has been proven to be important in the development of obesity. Mice with skin-specific deficiency of SCD1 (SKO) display increased whole-body energy expenditure, which is protective against adiposity from a high-fat diet because it improves glucose clearance, insulin sensitivity, and hepatic steatosis. Of note, these mice also display elevated levels of the "pro-inflammatory" plasma interleukin-6 (IL-6). In whole skin of SKO mice, IL-6 mRNA levels are increased, and protein expression is evident in hair follicle cells and in keratinocytes. Recently, the well-known role of IL-6 in causing white adipose tissue lipolysis has been linked to indirectly activating the gluconeogenic enzyme pyruvate carboxylase 1 in the liver, thereby increasing hepatic glucose production. In this study, we suggest that skin-derived IL-6 leads to white adipose tissue lipolysis, which contributes to the lean phenotype of SKO mice without the incidence of meta-inflammation that is associated with IL-6 signaling.
Adipose, Diabetes, Fat, Gluconeogenesis, Glucose, IL6, Inflammation, Lipids, Liver, Metabolism, Obesity, SCD1, Skin, Steatosis
DOI of Published Version
Biochem Biophys Res Commun. 2019 Jan 1;508(1):87-91. doi: 10.1016/j.bbrc.2018.11.083. Epub 2018 Nov 22. Link to article on publisher's site
Biochemical and biophysical research communications
Dumas, Sabrina N.; Guo, Chang-An; Kim, Jason K.; Friedline, Randall H.; and Ntambi, James M., "Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver" (2019). Program in Molecular Medicine Publications and Presentations. 92.