Innate immune sensing of HIV-1 by dendritic cells
Program in Molecular Medicine
Amino Acids, Peptides, and Proteins | Immunity | Immunology of Infectious Disease | Molecular Biology | Virology | Viruses
HIV-1-specific antibodies and CD8(+) cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively prime naive, HIV-1-specific T cells. Recent findings related to DC-expressed innate immune factors including SAMHD1, TREX1, and TRIM5 provide a molecular basis for understanding why DCs fail to adequately sense invasion by this deadly pathogen and suggest experimental approaches to improve T cell priming to HIV-1 in prophylactic vaccination protocols.
DOI of Published Version
Cell Host Microbe. 2012 Oct 18;12(4):408-18. doi: 10.1016/j.chom.2012.10.002. Link to article on publisher's site
Cell host and microbe
Luban, Jeremy, "Innate immune sensing of HIV-1 by dendritic cells" (2012). Program in Molecular Medicine Publications and Presentations. 79.