Title

Innate immune sensing of HIV-1 by dendritic cells

UMMS Affiliation

Program in Molecular Medicine

Publication Date

2012-10-18

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Immunity | Immunology of Infectious Disease | Molecular Biology | Virology | Viruses

Abstract

HIV-1-specific antibodies and CD8(+) cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively prime naive, HIV-1-specific T cells. Recent findings related to DC-expressed innate immune factors including SAMHD1, TREX1, and TRIM5 provide a molecular basis for understanding why DCs fail to adequately sense invasion by this deadly pathogen and suggest experimental approaches to improve T cell priming to HIV-1 in prophylactic vaccination protocols.

DOI of Published Version

10.1016/j.chom.2012.10.002

Source

Cell Host Microbe. 2012 Oct 18;12(4):408-18. doi: 10.1016/j.chom.2012.10.002. Link to article on publisher's site

Journal/Book/Conference Title

Cell host and microbe

Related Resources

Link to Article in PubMed

PubMed ID

23084911

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