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Authors
Luban, JeremyUMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2012-10-18Keywords
Amino Acids, Peptides, and ProteinsImmunity
Immunology of Infectious Disease
Molecular Biology
Virology
Viruses
Metadata
Show full item recordAbstract
HIV-1-specific antibodies and CD8(+) cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively prime naive, HIV-1-specific T cells. Recent findings related to DC-expressed innate immune factors including SAMHD1, TREX1, and TRIM5 provide a molecular basis for understanding why DCs fail to adequately sense invasion by this deadly pathogen and suggest experimental approaches to improve T cell priming to HIV-1 in prophylactic vaccination protocols.Source
Cell Host Microbe. 2012 Oct 18;12(4):408-18. doi: 10.1016/j.chom.2012.10.002. Link to article on publisher's site
DOI
10.1016/j.chom.2012.10.002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44483PubMed ID
23084911Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.chom.2012.10.002