UMMS Affiliation

Program in Molecular Medicine

Publication Date

8-1-2015

Document Type

Article

Subjects

Caenorhabditis elegans; MicroRNAs

Disciplines

Developmental Biology | Genetics | Molecular Genetics

Abstract

Biological robustness, the ability of an organism to maintain a steady-state output as genetic or environmental inputs change, is critical for proper development. MicroRNAs have been implicated in biological robustness mechanisms through their post-transcriptional regulation of genes and gene networks. Previous research has illustrated examples of microRNAs promoting robustness as part of feedback loops and genetic switches and by buffering noisy gene expression resulting from environmental and/or internal changes. Here we show that the evolutionarily conserved microRNAs mir-34 and mir-83 (homolog of mammalian mir-29) contribute to the robust migration pattern of the distal tip cells in Caenorhabditis elegans by specifically protecting against stress from temperature changes. Furthermore, our results indicate that mir-34 and mir-83 may modulate the integrin signaling involved in distal tip cell migration by potentially targeting the GTPase cdc-42 and the beta-integrin pat-3. Our findings suggest a role for mir-34 and mir-83 in integrin-controlled cell migrations that may be conserved through higher organisms. They also provide yet another example of microRNA-based developmental robustness in response to a specific environmental stress, rapid temperature fluctuations.

Keywords

distal tip cell migrations, mir-29, mir-34, mir-83, robustness

Rights and Permissions

Available freely online through the author-supported open access option.

DOI of Published Version

10.1534/genetics.115.179184

Source

Genetics. 2015 Aug;200(4):1201-18. doi: 10.1534/genetics.115.179184. Epub 2015 Jun 15. Link to article on publisher's site

Journal/Book/Conference Title

Genetics

Related Resources

Link to Article in PubMed

PubMed ID

26078280

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