UMMS Affiliation

Program in Molecular Medicine

Publication Date

6-15-2008

Document Type

Article

Subjects

Animals; Animals, Genetically Modified; Drosophila; Female; Gene Expression Regulation, Developmental; Larva; Life Cycle Stages; Male; Metamorphosis, Biological; MicroRNAs; Muscles; Nervous System; Neuromuscular Junction; Transgenes

Disciplines

Biochemistry | Developmental Biology | Molecular Biology | Molecular Genetics

Abstract

The Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: let-7, miR-100, and fly lin-4 (miR-125). We find that the let-7-C locus is principally expressed in the pupal and adult neuromusculature. let-7-C knockout flies appear normal externally but display defects in adult behaviors (e.g., flight, motility, and fertility) as well as clear juvenile features in their neuromusculature. We find that the function of let-7-C to ensure the appropriate remodeling of the abdominal neuromusculature during the larval-to-adult transition is carried out predominantly by let-7 alone. This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior.

Keywords

let-7, let-7-Complex, microRNA, heterochronic developmental timing, neuromuscular junction

Rights and Permissions

Publisher PDF posted as allowed by the publisher's author rights policy at http://genesdev.cshlp.org/site/misc/terms.xhtml.

DOI of Published Version

10.1101/gad.1671708

Source

Genes Dev. 2008 Jun 15;22(12):1591-6. doi: 10.1101/gad.1671708. Link to article on publisher's site

Journal/Book/Conference Title

Genes and development

Related Resources

Link to Article in PubMed

PubMed ID

18559475

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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