Title

The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans

UMMS Affiliation

Program in Molecular Medicine

Publication Date

1-1-2011

Document Type

Article

Subjects

Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Insulin; Larva; Signal Transduction; Time Factors; Transcription Factors; Transforming Growth Factor beta

Disciplines

Biochemistry | Developmental Biology | Molecular Biology | Molecular Genetics

Abstract

Animals developing in the wild encounter a range of environmental conditions, and so developmental mechanisms have evolved that can accommodate different environmental contingencies. Harsh environmental conditions cause Caenorhabditis elegans larvae to arrest as stress-resistant "dauer" larvae after the second larval stage (L2), thereby indefinitely postponing L3 cell fates. HBL-1 is a key transcriptional regulator of L2 vs. L3 cell fate. Through the analysis of genetic interactions between mutations of hbl-1 and of genes encoding regulators of dauer larva formation, we find that hbl-1 can also modulate the dauer formation decision in a complex manner. We propose that dynamic interactions between genes that regulate stage-specific cell fate decisions and those that regulate dauer formation promote the robustness of developmental outcomes to changing environmental conditions.

DOI of Published Version

10.1534/genetics.110.123992

Source

Genetics. 2011 Jan;187(1):345-53. doi: 10.1534/genetics.110.123992. Epub 2010 Oct 26. Link to article on publisher's site

Journal/Book/Conference Title

Genetics

Related Resources

Link to Article in PubMed

PubMed ID

20980238

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