MicroRNAs and developmental timing
Program in Molecular Medicine
Animals; Caenorhabditis elegans; Cell Differentiation; Cell Lineage; *Gene Expression Regulation, Developmental; Humans; MicroRNAs
Developmental Biology | Molecular Biology | Molecular Genetics
MicroRNAs regulate temporal transitions in gene expression associated with cell fate progression and differentiation throughout animal development. Genetic analysis of developmental timing in the nematode Caenorhabditis elegans identified two evolutionarily conserved microRNAs, lin-4/mir-125 and let-7, that regulate cell fate progression and differentiation in C. elegans cell lineages. MicroRNAs perform analogous developmental timing functions in other animals, including mammals. By regulating cell fate choices and transitions between pluripotency and differentiation, microRNAs help to orchestrate developmental events throughout the developing animal, and to play tissue homeostasis roles important for disease, including cancer.
DOI of Published Version
Curr Opin Genet Dev. 2011 Aug;21(4):511-7. doi: 10.1016/j.gde.2011.04.003. Epub 2011 Apr 29. Link to article on publisher's site
Current opinion in genetics and development
Ambros, Victor R., "MicroRNAs and developmental timing" (2011). Program in Molecular Medicine Publications and Presentations. 28.