Title

MicroRNAs and developmental timing

UMMS Affiliation

Program in Molecular Medicine

Publication Date

8-1-2011

Document Type

Article

Subjects

Animals; Caenorhabditis elegans; Cell Differentiation; Cell Lineage; *Gene Expression Regulation, Developmental; Humans; MicroRNAs

Disciplines

Developmental Biology | Molecular Biology | Molecular Genetics

Abstract

MicroRNAs regulate temporal transitions in gene expression associated with cell fate progression and differentiation throughout animal development. Genetic analysis of developmental timing in the nematode Caenorhabditis elegans identified two evolutionarily conserved microRNAs, lin-4/mir-125 and let-7, that regulate cell fate progression and differentiation in C. elegans cell lineages. MicroRNAs perform analogous developmental timing functions in other animals, including mammals. By regulating cell fate choices and transitions between pluripotency and differentiation, microRNAs help to orchestrate developmental events throughout the developing animal, and to play tissue homeostasis roles important for disease, including cancer.

DOI of Published Version

10.1016/j.gde.2011.04.003

Source

Curr Opin Genet Dev. 2011 Aug;21(4):511-7. doi: 10.1016/j.gde.2011.04.003. Epub 2011 Apr 29. Link to article on publisher's site

Journal/Book/Conference Title

Current opinion in genetics and development

Related Resources

Link to Article in PubMed

PubMed ID

21530229

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