Title

Humanized immune system mouse models: progress, challenges and opportunities

UMMS Affiliation

Program in Molecular Medicine

Publication Date

2019-07-01

Document Type

Response or Comment

Disciplines

Hemic and Immune Systems | Immune System Diseases | Immunity | Immunopathology

Abstract

Over 30 key leaders in the field participated in a 1-day workshop entitled ‘Recent Advances and Opportunities in the Development and Use of Humanized Immune System Mouse Models’ to discuss the benefits and limitations of using human fetal tissue versus non-fetal tissue sources to generate mice with a humanized immune system. This Comment summarizes the workshop discussions, including highlights of some of the key advances made through the use of humanized mice in improving the understanding of immune system function and developing novel therapeutics for the treatment of infectious, immunological and allergic diseases, as well as current challenges in the production, characterization and utilization of these animal models.

Keywords

Diseases, Immunology

DOI of Published Version

10.1038/s41590-019-0416-z

Source

Nat Immunol. 2019 Jul;20(7):770-774. doi: 10.1038/s41590-019-0416-z. Link to article on publisher's site

Journal/Book/Conference Title

Nature immunology

Related Resources

Link to Article in PubMed

PubMed ID

31160798

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