Humanized immune system mouse models: progress, challenges and opportunities
Program in Molecular Medicine
Response or Comment
Hemic and Immune Systems | Immune System Diseases | Immunity | Immunopathology
Over 30 key leaders in the field participated in a 1-day workshop entitled ‘Recent Advances and Opportunities in the Development and Use of Humanized Immune System Mouse Models’ to discuss the benefits and limitations of using human fetal tissue versus non-fetal tissue sources to generate mice with a humanized immune system. This Comment summarizes the workshop discussions, including highlights of some of the key advances made through the use of humanized mice in improving the understanding of immune system function and developing novel therapeutics for the treatment of infectious, immunological and allergic diseases, as well as current challenges in the production, characterization and utilization of these animal models.
DOI of Published Version
Nat Immunol. 2019 Jul;20(7):770-774. doi: 10.1038/s41590-019-0416-z. Link to article on publisher's site
Allen TM, Brehm MA, Bridges S, Ferguson S, Kumar P, Mirochnitchenko O, Palucka K, Pelanda R, Sanders-Beer B, Shultz LD, Su L, PrabhuDas M. (2019). Humanized immune system mouse models: progress, challenges and opportunities. Program in Molecular Medicine Publications. https://doi.org/10.1038/s41590-019-0416-z. Retrieved from https://escholarship.umassmed.edu/pmm_pp/131