Spatiotemporal structure of cell fate decisions in murine neural crest
Program in Molecular Medicine
Cell Biology | Cells | Developmental Biology | Embryonic Structures | Nervous System | Neuroscience and Neurobiology
Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs.
DOI of Published Version
Science. 2019 Jun 7;364(6444). pii: eaas9536. doi: 10.1126/science.aas9536. Link to article on publisher's site
Science (New York, N.Y.)
Soldatov, Ruslan; Hsiao, Wen-Yu; Guertin, David A.; Kharchenko, Peter V.; and Adameyko, Igor, "Spatiotemporal structure of cell fate decisions in murine neural crest" (2019). Program in Molecular Medicine Publications and Presentations. 121.