Oncogenic AKTivation by methylation
Program in Molecular Medicine; Department of Molecular, Cell, and Cancer Biology
Cancer Biology | Cell Biology | Cellular and Molecular Physiology
AKT, also known as protein kinase B, is one of the most frequently dysregulated serine/threonine kinases in cancer, and its hyperactivity drives tumorigenesis and chemotherapy resistance. Two studies now find that AKT methylation by the methyltransferase SETDB1 is an early step in its oncogenic activation.
Cancer, Growth factor signalling, Methylation, Ubiquitylation
DOI of Published Version
Nat Cell Biol. 2019 Feb;21(2):114-115. doi: 10.1038/s41556-019-0275-8. Link to article on publisher's site
Nature cell biology
Luciano, Amelia K. and Guertin, David A., "Oncogenic AKTivation by methylation" (2019). Program in Molecular Medicine Publications and Presentations. 114.