Title

Oncogenic AKTivation by methylation

UMMS Affiliation

Program in Molecular Medicine; Department of Molecular, Cell, and Cancer Biology

Publication Date

2019-02-01

Document Type

Article

Disciplines

Cancer Biology | Cell Biology | Cellular and Molecular Physiology

Abstract

AKT, also known as protein kinase B, is one of the most frequently dysregulated serine/threonine kinases in cancer, and its hyperactivity drives tumorigenesis and chemotherapy resistance. Two studies now find that AKT methylation by the methyltransferase SETDB1 is an early step in its oncogenic activation.

Keywords

Cancer, Growth factor signalling, Methylation, Ubiquitylation

DOI of Published Version

10.1038/s41556-019-0275-8

Source

Nat Cell Biol. 2019 Feb;21(2):114-115. doi: 10.1038/s41556-019-0275-8. Link to article on publisher's site

Journal/Book/Conference Title

Nature cell biology

Related Resources

Link to Article in PubMed

PubMed ID

30692624

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