UMass Chan Affiliations
Department of Molecular, Cell, and Cancer BiologyProgram in Molecular Medicine
Document Type
Journal ArticlePublication Date
2019-02-01Keywords
CancerGrowth factor signalling
Methylation
Ubiquitylation
Cancer Biology
Cell Biology
Cellular and Molecular Physiology
Metadata
Show full item recordAbstract
AKT, also known as protein kinase B, is one of the most frequently dysregulated serine/threonine kinases in cancer, and its hyperactivity drives tumorigenesis and chemotherapy resistance. Two studies now find that AKT methylation by the methyltransferase SETDB1 is an early step in its oncogenic activation.Source
Nat Cell Biol. 2019 Feb;21(2):114-115. doi: 10.1038/s41556-019-0275-8. Link to article on publisher's site
DOI
10.1038/s41556-019-0275-8Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44387PubMed ID
30692624Related Resources
ae974a485f413a2113503eed53cd6c53
10.1038/s41556-019-0275-8