Title

TRAPPing a Rab GTPase by the Tail

UMMS Affiliation

Program in Molecular Medicine; Department of Biochemistry and Molecular Pharmacology

Publication Date

2019-01-07

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Biochemistry | Cell and Developmental Biology | Cells | Enzymes and Coenzymes | Molecular Biology | Molecular Genetics

Abstract

GEFs play a key role in activation and membrane targeting of Rab GTPases. In this issue of Developmental Cell, Thomas et al. (2018) demonstrate how two TRAPP complexes with a common GEF core select distinct Rab substrates through a steric gating mechanism involving their hypervariable tails.

DOI of Published Version

10.1016/j.devcel.2018.12.008

Source

Dev Cell. 2019 Jan 7;48(1):9-11. doi: 10.1016/j.devcel.2018.12.008. Link to article on publisher's site

Journal/Book/Conference Title

Developmental cell

Related Resources

Link to Article in PubMed

PubMed ID

30620905

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