TRAPPing a Rab GTPase by the Tail
Program in Molecular Medicine; Department of Biochemistry and Molecular Pharmacology
Amino Acids, Peptides, and Proteins | Biochemistry | Cell and Developmental Biology | Cells | Enzymes and Coenzymes | Molecular Biology | Molecular Genetics
GEFs play a key role in activation and membrane targeting of Rab GTPases. In this issue of Developmental Cell, Thomas et al. (2018) demonstrate how two TRAPP complexes with a common GEF core select distinct Rab substrates through a steric gating mechanism involving their hypervariable tails.
DOI of Published Version
Dev Cell. 2019 Jan 7;48(1):9-11. doi: 10.1016/j.devcel.2018.12.008. Link to article on publisher's site
Duan J, Lambright DG. (2019). TRAPPing a Rab GTPase by the Tail. Program in Molecular Medicine Publications. https://doi.org/10.1016/j.devcel.2018.12.008. Retrieved from https://escholarship.umassmed.edu/pmm_pp/101