Department of Pediatrics; Program in Molecular Medicine
Anti-Retroviral Agents; Child, Preschool; HIV Antibodies; HIV Infections; *HIV-1; Humans; Male; RNA, Viral; Viral Load; *Viremia; Withholding Treatment
Immunology of Infectious Disease | Immunoprophylaxis and Therapy | Infectious Disease | Pediatrics | Virus Diseases
An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.
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Copyright © 2013 Massachusetts Medical Society. Publisher PDF posted as allowed by the publisher's author rights policy at http://www.nejm.org/page/author-center/permissions.
DOI of Published Version
Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M Jr, Chun TW, Strain M, Richman D, Luzuriaga K. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med. 2013 Nov 7;369(19):1828-35. doi: 10.1056/NEJMoa1302976. Link to article on publisher's site
The New England journal of medicine
Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M, Chun T, Strain M, Richman D, Luzuriaga K. (2013). Absence of detectable HIV-1 viremia after treatment cessation in an infant. Program in Molecular Medicine Publications and Presentations. https://doi.org/10.1056/NEJMoa1302976. Retrieved from https://escholarship.umassmed.edu/pmm_pp/10