UMMS Affiliation
Department of Pediatrics; Program in Molecular Medicine
Publication Date
2013-11-07
Document Type
Article
Subjects
Anti-Retroviral Agents; Child, Preschool; HIV Antibodies; HIV Infections; *HIV-1; Humans; Male; RNA, Viral; Viral Load; *Viremia; Withholding Treatment
Disciplines
Immunology of Infectious Disease | Immunoprophylaxis and Therapy | Infectious Disease | Pediatrics | Virus Diseases
Abstract
An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.
Keywords
UMCCTS funding
Rights and Permissions
Copyright © 2013 Massachusetts Medical Society. Publisher PDF posted as allowed by the publisher's author rights policy at http://www.nejm.org/page/author-center/permissions.
DOI of Published Version
10.1056/NEJMoa1302976
Source
Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M Jr, Chun TW, Strain M, Richman D, Luzuriaga K. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med. 2013 Nov 7;369(19):1828-35. doi: 10.1056/NEJMoa1302976. Link to article on publisher's site
Journal/Book/Conference Title
The New England journal of medicine
Related Resources
PubMed ID
24152233
Repository Citation
Persaud, Deborah; Gay, Hannah; Ziemniak, Carrie; Chen, Ya Hui; Piatak, Michael Jr.; Chun, Tae-Wook; Strain, Matthew; Richman, Douglas; and Luzuriaga, Katherine, "Absence of detectable HIV-1 viremia after treatment cessation in an infant" (2013). Program in Molecular Medicine Publications and Presentations. 10.
https://escholarship.umassmed.edu/pmm_pp/10
Included in
Immunology of Infectious Disease Commons, Immunoprophylaxis and Therapy Commons, Infectious Disease Commons, Pediatrics Commons, Virus Diseases Commons