The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2019

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Humanized immune system mouse models: progress, challenges and opportunities, Todd M. Allen, Michael A. Brehm, Sandra Bridges, Stacy Ferguson, Priti Kumar, Oleg Mirochnitchenko, Karolina Palucka, Roberta Pelanda, Brigitte Sanders-Beer, Leonard D. Shultz, Lishan Su, and Mercy PrabhuDas

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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Chantal M. Ferguson, Dimas Echeverria, Ellen Sapp, Reka A. Haraszti, Andrew H. Coles, Faith Conroy, Rachael Miller, Loic Roux, Paul Yan, Emily G. Knox, Anton A. Turanov, Robert M. King, Gwladys Gernoux, Christian Mueller, Heather Gray-Edwards, Richard P. Moser, N Bishop, Samer M. Jaber, Matthew J. Gounis, Miguel Sena-Esteves, Athma A. Pai, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

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Progressive alignment with Cactus: a multiple-genome aligner for the thousand-genome era, Joel Armstrong, Elinor K. Karlsson, and Benedict Paten

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Utilizing Humanized Mice to Study Human Specific Innate Immune Responses in Immuno-Oncology, Ken-Edwin Aryee

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Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo, Thiago M. Batista, Ruben Garcia-Martin, Weikang Cai, Masahiro Konishi, Brian T. O'Neill, Masaji Sakaguchi, Jong Hun Kim, Dae Young Jung, Jason K. Kim, and C. Ronald Kahn

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Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo, Annabelle Biscans, Andrew H. Coles, Reka A. Haraszti, Dimas Echeverria, Matthew R. Hassler, Maire F. Osborn, and Anastasia Khvorova

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Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism, Alecia M. Blaszczak, Valerie P. Wright, Kajol Anandani, Joey Liu, Anahita Jalilvand, Stephen Bergin, Sarah M. Nicoloro, Michael P. Czech, William Lafuse, Tuo Deng, David Bradley, and Willa A. Hsueh

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Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon

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Defective daily temperature regulation in a mouse model of amyotrophic lateral sclerosis, Maurine C. Braun, Alexandra Castillo-Ruiz, Premananda Indic, Dae Young Jung, Jason K. Kim, Robert H. Brown Jr., Steven J. Swoap, and William J. Schwartz

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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TRIM5alpha Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation, Abhilash I. Chiramel, Nicholas R. Meyerson, Kristin L. McNally, Rebecca M. Broeckel, Vanessa R. Montoya, Omayra Mendez-Solis, Shelly J. Robertson, Gail L. Sturdevant, Kirk J. Lubick, Vinod Nair, Brian H. Youseff, Robin M. Ireland, Catharine M. Bosio, Kyusik Kim, Jeremy Luban, Vanessa M. Hirsch, R. Travis Taylor, Fadila Bouamr, Sara L. Sawyer, and Sonja M. Best

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The C. elegans heterochronic gene lin-28 coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesis, Sungwook Choi and Victor R. Ambros

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Toll family members bind multiple Spatzle proteins and activate antimicrobial peptide gene expression in Drosophila, Munmun Chowdhury, Chun-Feng Li, Zhen He, Yuzhen Lu, Xu-Sheng Liu, Yu-Feng Wang, Y. Tony Ip, Michael R. Strand, and Xiao-Qiang Yu

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Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling, Luca D'Agostino, Yingchao Nie, Qi Li, Y. Tony Ip, and Nan Gao

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Harnessing robotic automation and web-based technologies to modernize scientific outreach, Orna Dahan, Bat-Shahar Dorfman, Serkan Sayin, Brittany Rosener, Tiffany Hua, Anat Yarden, and Amir Mitchell

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High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network, Antje Dittmann, Norman J. Kennedy, Nina L. Soltero, Nader Morshed, Miyeko D. Mana, Omer H. Yilmaz, Roger J. Davis, and Forest M. White

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TRAPPing a Rab GTPase by the Tail, Jianjun Duan and David G. Lambright

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Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver, Sabrina N. Dumas, Chang-An Guo, Jason K. Kim, Randall H. Friedline, and James M. Ntambi

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A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ildar Gainetdinov, Yeonsoo Yoon, Chun-Qing Song, Yueying Cao, Judith Gallant, Wen Xue, Jaime A. Rivera, and Erik J. Sontheimer

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Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans, Nicole Ehrhardt, Jinrui Cui, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Helen S. Goodridge, Jason K. Kim, Louise Lantier, Xiuqing Guo, Yii-Der I. Chen, Leslie J. Raffel, Thomas A. Buchanan, Willa A. Hsueh, Jerome I. Rotter, Mark O. Goodarzi, and Miklos Peterfy

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Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations, Shady Farah, Dale L. Greiner, and Daniel G. Anderson

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Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability, Jessica L. Feldman and Craig L. Peterson

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Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females, Sully Fernandez, John M. Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, and Kathryn E. Wellen

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Inferring population dynamics from single-cell RNA-sequencing time series data, David S. Fischer, Anna K. Fiedler, Eric M. Kernfeld, Ryan Genga, Aimee Bastidas-Ponce, Mostafa Bakhti, Heiko Lickert, Jan Hasenauer, Rene Maehr, and Fabian J. Theis

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Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1, Melissa A. Gawron, Mark Duval, Claudia Carbone, Smita Jaiswal, Aaron Wallace, Joseph C. Martin 3rd, Ann Dauphin, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Jeremy Luban, and Lisa A. Cavacini

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Towards Understanding the Molecular Basis of Human Endoderm Development Using CRISPR-Effector and Single-Cell Technologies, Ryan M. Genga

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Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development, Ryan M. Genga, Eric M. Kernfeld, Krishna M. Parsi, Teagan J. Parsons, Michael J. Ziller, and Rene Maehr

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Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis, Hilda E. Ghadieh, Lucia Russo, Harrison T. Muturi, Simona S. Ghanem, Iyad H. Manaserh, Hye Lim Noh, Sujin Suk, Jason K. Kim, Jennifer W. Hill, and Sonia M. Najjar

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Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus, Adilson L. Guilherme, Felipe Henriques, Alexander H. Bedard, and Michael P. Czech

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Preparation and characterization of yeast cell wall beta-glucan encapsulated humic acid nanoparticles as an enhanced aflatoxin B1 binder, Zeinab Hamza, Maher El-Hashash, Soher Aly, Amal Hathout, Ernesto Soto, Bassem Sabry, and Gary R. Ostroff

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, and Anastasia Khvorova

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Maize-Produced Ag2 as a Subunit Vaccine for Valley Fever, Celine A. Hayden, Chiung-Yu Hung, Hao Zhang, Austin Negron, Raymond Esquerra, Gary R. Ostroff, Ambily Abraham, Alejandro Gabriel Lopez, Juliet Elizabeth Gonzales, and John A. Howard

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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity, Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G. E. de Vries, Michael J. Lee, and Marcel A T M van Vugt

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A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis, Carmen Hurtado Del Pozo, Randall H. Friedline, Hye Lim Noh, Jason K. Kim, and Ann Marie. Schmidt

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Pheromones and Nutritional Signals Regulate the Developmental Reliance on let-7 Family MicroRNAs in C. elegans, Orkan Ilbay and Victor R. Ambros

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Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim, Sonal Jangalwe, Varun N. Kapoor, Jia Xu, Nomeda Girnius, Norman J. Kennedy, Yvonne J. K. Edwards, Raymond M. Welsh, Roger J. Davis, and Michael A. Brehm

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1, Su Myung Jung, Chien-Min Hung, Samuel R. Hildebrand, Joan Sanchez-Gurmaches, Dimpi Mukhopadhyay, Camila Martinez Calejman, Amelia K. Luciano, Wen-Yu Hsiao, Yuefeng Tang, Huawei Li, and David A. Guertin

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Conserved Features of the T Cell Receptor Repertoire Contribute to the Persistence of EBV-Specific CD8 T Cells, Larisa Kamga

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Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features, Joyce E. Karlinsey, Taylor A. Stepien, Matthew Mayho, Larissa A. Singletary, Lacey K. Bingham-Ramos, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Larry A. Gallagher, Matt Bawn, Robert A. Kingsley, Stephen J. Libby, and Ferric C. Fang

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DEBrowser: interactive differential expression analysis and visualization tool for count data, Alper Kucukural, Onur Yukselen, Deniz M. Ozata, Melissa J. Moore, and Manuel Garber

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Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes, Suet-Yan Kwan, Ankur Sheel, Chun-Qing Song, Xiao-Ou Zhang, Tingting Jiang, Hien Dang, Yueying Cao, Deniz M. Ozata, Haiwei Mou, Hao Yin, Zhiping Weng, Xin Wei Wang, and Wen Xue

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The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium, Qi Li, Niraj K. Nirala, Hsi-Ju Chen, Yingchao Nie, Wei Wang, Biliang Zhang, Michael P. Czech, Qi Wang, Lan Xu, Junhao Mao, and Y. Tony Ip

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Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice, Botao Liu, Gemma Molinaro, Huan Shu, Emily E. Stackpole, Kimberly M. Huber, and Joel D. Richter

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JNK(1/2) represses Lkb(1)-deficiency-induced lung squamous cell carcinoma progression, Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis, and Francesco J. DeMayo

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The hidden cost of genetic resistance to HIV-1, Jeremy Luban

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Oncogenic AKTivation by methylation, Amelia K. Luciano and David A. Guertin

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Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells, Leyuan Ma, Magnolia L. Pak, Jianhong Ou, Jun Yu, Pamela St Louis, Yi Shan, Lloyd Hutchinson, Shaoguang Li, Michael A. Brehm, Lihua Julie Zhu, and Michael R. Green

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mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis, Nuria Martinez, Catherine Y. Cheng, Natkunam Ketheesan, Aidan Cullen, Yuefeng Tang, Josephine Lum, Kim West, Michael Poidinger, David A. Guertin, Amit Singhal, and Hardy Kornfeld

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Nordic OCD and Related Disorders Consortium: Rationale, design, and methods, David Mataix-Cols, Bjarne Hansen, Manuel Mattheisen, Elinor K. Karlsson, Anjene M. Addington, Julia Boberg, Diana R. Djurfeldt, Matthew Halvorsen, Paul Lichtenstein, Stian Solem, Kerstin Lindblad-Toh, Jan Haavik, Gerd Kvale, Christian Ruck, and James J. Crowley

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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BarkBase: Epigenomic Annotation of Canine Genomes, Kate Megquier, Xue Li, Kathleen Morrill, Brittney Logan, and Elinor K. Karlsson

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Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells, So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Tiffany DeSouza, Ryan Genga, Alper Kucukural, Lawrence M. Lifshitz, Soren Nielsen, Camilla Scheele, Rene Maehr, Manuel Garber, and Silvia Corvera

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Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue, So Yun Min, Heather Learnard, Shashi Kant, Olga Gaelikman, Raziel Rojas-Rodriguez, Tiffany DeSouza, Anand Desai, John F. Keaney Jr., Silvia Corvera, and Siobhan M. Craige

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Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes, Elfawal A. Mostafa, Sergey N. Savinov, and Raffi V. Aroian

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CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling, Haiwei Mou, Deniz M. Ozata, Jordan L. Smith, Ankur Sheel, Suet-Yan Kwan, Soren Hough, Alper Kucukural, Zachary Kennedy, Yueying Cao, and Wen Xue

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Kaposi Sarcoma-associated Herpesvirus Glycoprotein H is Indispensable for Infection of Epithelial, Endothelial, and Fibroblast Cell Types, Murali Muniraju, Lorraine Z. Mutsvunguma, Joslyn Foley, Gabriela M. Escalante, Esther Rodriguez, Romina Nabiee, Jennifer Totonchy, David H. Mulama, Joshua Nyagol, Felix Wussow, Anne K. Barasa, Michael A. Brehm, and Javier Gordon Ogembo

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Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity, Charles Nelson and Victor R. Ambros

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Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila, Yingchao Nie, Shiyan Yu, Qi Li, Niraj K. Nirala, Alla Amcheslavsky, Yvonne J. K. Edwards, Patrick W. Shum, Zhong Jiang, Wei Wang, Biliang Zhang, Nan Gao, and Y. Tony Ip

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A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection, Jason B. Noon, Erich M. Schwarz, Gary R. Ostroff, and Raffi V. Aroian

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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways, Maire F. Osborn, Andrew H. Coles, Annabelle Biscans, Reka A. Haraszti, Loic Roux, Sarah M. Davis, Socheata Ly, Dimas Echeverria, Matthew R. Hassler, Bruno M. D. C. Godinho, Mehran Nikan, and Anastasia Khvorova

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Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters, Samuel C. Pan, Doyle V. Ward, Yunqiang Yin, Yan Hu, Elfawal A. Mostafa, Robert E. Clark, and Raffi V. Aroian

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Rapid evolution and conserved function of the piRNA pathway, Swapnil S. Parhad and William E. Theurkauf

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Adaptive evolution targets a piRNA precursor transcription network, Swapnil S. Parhad, Tianxiong Yu, Gen Zhang, Nicholas P. Rice, Zhiping Weng, and William E. Theurkauf

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Enhanced Cas12a editing in mammalian cells and zebrafish, Pengpeng Liu, Kevin Luk, Masahiro Shin, Feston Idrizi, Samantha F. Kwok, Benjamin P. Roscoe, Esther Mintzer, Sneha Suresh, Kyle Morrison, Josias B. Frazao, Mehmet Fatih Bolukbasi, Karthikeyan Ponnienselvan, Jeremy Luban, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4(th) pharyngeal arch artery morphogenesis, Helen M. Phillips, Rene Maehr, and Simon D. Bamforth

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A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia, Tyler Picariello, Jason M. Brown, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Oliver D. King, Karl Lechtreck, Gregory J. Pazour, and George B. Witman

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No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications, Briana Quitadamo, Paul J. Peters, Matthew Koch, Katherine Luzuriaga, Cecilia Cheng-Mayer, Paul R. Clapham, and Maria Paz Gonzalez-Perez

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Smooth muscle cell-specific TMEM16A deletion does not alter Ca2+ signaling, uterine contraction, gestation length or litter size in micedagger, Mingzi Qu, Ping Lu, Karl D. Bellve, Kevin E. Fogarty, Lawrence M. Lifshitz, Fangxiong Shi, and Ronghua ZhuGe

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Adaptations of Adipose Tissue Expandability in Gestation are Associated with Maternal Glucose Metabolism, Raziel Rojas-Rodriguez

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Generation of Functional Human Adipose Tissue in Mice from Primed Progenitor Cells, Raziel Rojas-Rodriguez, Jorge Lujan-Hernandez, So Yun Min, Tiffany DeSouza, Patrick Teebagy, Anand Desai, Heather Tessier, Robert Slamin, Leah Siegel-Reamer, Cara Berg, Angel Baez, Janice F. Lalikos, and Silvia Corvera

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HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet beta-Cells From Donors With Type 1 Diabetes, Mark A. Russell, Sambra D. Redick, David Blodgett, Jenny Aurielle B. Babon, Chaoxing Yang, Sally C. Kent, Alan G. Derr, Alper Kucukural, Manuel Garber, and David M. Harlan

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Brown fat organogenesis and maintenance requires AKT1 and AKT2, Joan Sanchez-Gurmaches, Camila Martinez Calejman, Su Myung Jung, Huawei Li, and David A. Guertin

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Intraflagellar transport protein 74 is essential for spermatogenesis and male fertility in micedouble dagger, Lin Shi, Ting Zhou, Qian Huang, Shiyang Zhang, Wei Li, Ling Zhang, Rex A. Hess, Gregory J. Pazour, and Zhibing Zhang

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Transient Kinetic Analysis of SWR1C-Catalyzed H2A.Z Deposition Unravels the Impact of Nucleosome Dynamics and the Asymmetry of Histone Exchange, Raushan K. Singh, Jiayi Fan, Nathan Gioacchini, Shinya Watanabe, Osman Bilsel, and Craig L. Peterson

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Spatiotemporal structure of cell fate decisions in murine neural crest, Ruslan Soldatov, Wen-Yu Hsiao, David A. Guertin, Peter V. Kharchenko, and Igor Adameyko

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EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons, Emily E. Stackpole, Michael R. Akins, Mariya Ivshina, Anastasia C. Murthy, Nicolas L. Fawzi, and Justin R. Fallon

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TALE and NF-Y co-occupancy marks enhancers of developmental control genes during zygotic genome activation in zebrafish, William J. Stanney III, Franck Ladam, Ian J. Donaldson, Teagan J. Parsons, Rene Maehr, Nicoletta Bobola, and Charles G. Sagerstrom

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ARF GTPases and their GEFs and GAPs: concepts and challenges, Elizabeth Sztul, Pei-Wen Chen, James E. Casanova, Jacqueline Cherfils, Joel B. Dacks, David G. Lambright, Fang-Jen S. Lee, Paul A. Randazzo, Lorraine C. Santy, Annette Schurmann, Ilka Wilhelmi, Marielle E. Yohe, and Richard A. Kahn

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Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2, Annoj Thavalingam, Erik J. Sontheimer, Yanli Wang, and Karen L. Maxwell

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Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics, Rahul Tyagi, Elfawal A. Mostafa, Scott A. Wildman, Jon Helander, Christina A. Bulman, Judy Sakanari, Bruce A. Rosa, Paul J. Brindley, James W. Janetka, Raffi V. Aroian, and Makedonka Mitreva

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Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis, Weicang Wang, Jun Yang, Matthew L. Edin, Yuxin Wang, Ying Luo, Debin Wan, Haixia Yang, Chun-Qing Song, Wen Xue, Katherine Z. Sanidad, Mingyue Song, Heather A. Bisbee, Jennifer A. Bradbury, Guanjun Nan, Jianan Zhang, Pei-An Betty Shih, Kin Sing Stephen Lee, Lisa M. Minter, Daeyoung Kim, Hang Xiao, Jun-Yan Liu, Bruce D. Hammock, Darryl C. Zeldin, and Guodong Zhang

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Hypomorphic mutations of TRIP11 cause odontochondrodysplasia, Anika Wehrle, John A. Follit, Gregory J. Pazour, Andrea Superti-Furga, Martin Lowe, and Ekkehart Lausch

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foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish, Thomas R. Whitesell, Paul W. Chrystal, Jae-Ryeon Ryu, Nicole Munsie, Ann S. Grosse, Curtis R. French, Matthew L. Workentine, Rui Li, Lihua Julie Zhu, Andrew Waskiewicz, Ordan J. Lehmann, Nathan D. Lawson, and Sarah J. Childs

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SENP3-mediated host defense response contains HBV replication and restores protein synthesis, Rui Xi, Botao Liu, Yan Han, and Xiling Shen

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Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility, Xiuying Yang, Hye Lim Noh, Suchaorn Saengnipanthkul, Jason K. Kim, Chi Wai Lee, and Chi Bun Chan

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AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice, Bradford A. Youngblood, Emily C. Brock, John Leung, Rustom Falahati, Paul J. Bryce, Jessica Bright, Jason Williams, Leonard D. Shultz, Dale L. Greiner, Michael A. Brehm, Christopher Bebbington, and Nenad Tomasevic

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Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse, Andres Ernesto Zucchetti, Laurence Bataille, Jean-Marie Carpier, Stephanie Dogniaux, Mabel San Roman-Jouve, Mathieu Maurin, Michael W. Stuck, Rosa M. Rios, Cosima T. Baldari, Gregory J. Pazour, and Claire Hivroz

Publications from 2018

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Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs, Victor R. Ambros and Gary Ruvkun

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NmeCas9 is an intrinsically high-fidelity genome editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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NmeCas9 is an intrinsically high-fidelity genome-editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery, Baharak Bahmani, Mayuko Uehara, Farideh Ordikhani, Xiaofei Li, Liwei Jiang, Naima Banouni, Takaharu Ichimura, Vivek Kasinath, Siawosh K. Eskandari, Nasim Annabi, Jonathan S. Bromberg, Leonard D. Shultz, Dale L. Greiner, and Reza Abdi

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Role of JIP1-JNK Signaling in Beta-Cell Function and Autophagy, Seda Barutcu

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Role of the MAPK/cJun NH2-Terminal Kinase signaling pathway in starvation-induced autophagy, Seda Barutcu, Nomeda Girnius, Santiago Vernia, and Roger J. Davis

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Analysis and Correction of Inappropriate Image Duplication: the Molecular and Cellular Biology Experience, Elisabeth M. Bik, Ferric C. Fang, Amy L. Kullas, Roger J. Davis, and Arturo Casadevall

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Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles, Annabelle Biscans, Reka A. Haraszti, Dimas Echeverria, Rachael Miller, Marie C. Didiot, Mehran Nikan, Loic Roux, Neil Aronin, and Anastasia Khvorova

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Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing, Mehmet F. Bolukbasi, Pengpeng Liu, Kevin Luk, Samantha F. Kwok, Ankit Gupta, Nadia Amrani, Erik J. Sontheimer, Lihua Julie Zhu, and Scot A. Wolfe

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Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways, Daniel L. Bourque, Diane P. Genereux, Elinor K. Karlsson, Firdausi Qadri, and Jason B. Harris

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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Mixed Lineage Kinase 3 (MLK3) Prevents Cardiac Dysfunction and Structural Remodeling with Pressure Overload, Timothy Dean Calamaras, Robert A. Baumgartner, Mark J. Aronovitz, Angela L. McLaughlin, Kelly Tam, Daniel A. Richards, Craig W. Cooper, Nathan Li, Wendy E. Baur, Xiaoying Qiao, Guang-Rong Wang, Roger J. Davis, Navin Kumar Kapur, Richard H. Karas, and Robert Morris Blanton Jr.

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Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis, Qingbo Chen, Lei Huang, Dongning Pan, Lihua (Julie) Zhu, and Yong-Xu Wang