The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2019

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Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo, Thiago M. Batista, Ruben Garcia-Martin, Weikang Cai, Masahiro Konishi, Brian T. O'Neill, Masaji Sakaguchi, Jong Hun Kim, Dae Young Jung, Jason K. Kim, and C. Ronald Kahn

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Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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The C. elegans heterochronic gene lin-28 coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesis, Sungwook Choi and Victor R. Ambros

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Towards Understanding the Molecular Basis of Human Endoderm Development Using CRISPR-Effector and Single-Cell Technologies, Ryan M. Genga

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Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development, Ryan M. Genga, Eric M. Kernfeld, Krishna M. Parsi, Teagan J. Parsons, Michael J. Ziller, and Rene Maehr

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DEBrowser: interactive differential expression analysis and visualization tool for count data, Alper Kucukural, Onur Yukselen, Deniz M. Ozata, Melissa J. Moore, and Manuel Garber

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Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice, Botao Liu, Gemma Molinaro, Huan Shu, Emily E. Stackpole, Kimberly M. Huber, and Joel D. Richter

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue, So Yun Min, Heather Learnard, Shashi Kant, Olga Gaelikman, Raziel Rojas-Rodriguez, Tiffany DeSouza, Anand Desai, John F. Keaney Jr., Silvia Corvera, and Siobhan M. Craige

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Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity, Charles Nelson and Victor R. Ambros

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A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection, Jason B. Noon, Erich M. Schwarz, Gary R. Ostroff, and Raffi V. Aroian

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Enhanced Cas12a editing in mammalian cells and zebrafish, Pengpeng Liu, Kevin Luk, Masahiro Shin, Feston Idrizi, Samantha F. Kwok, Benjamin P. Roscoe, Esther Mintzer, Sneha Suresh, Kyle Morrison, Josias B. Frazao, Mehmet Fatih Bolukbasi, Karthikeyan Ponnienselvan, Jeremy Luban, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia, Tyler Picariello, Jason M. Brown, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Oliver D. King, Karl Lechtreck, Gregory J. Pazour, and George B. Witman

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No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications, Briana Quitadamo, Paul J. Peters, Matthew Koch, Katherine Luzuriaga, Cecilia Cheng-Mayer, Paul R. Clapham, and Maria Paz Gonzalez-Perez

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HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet beta-Cells From Donors With Type 1 Diabetes, Mark A. Russell, Sambra D. Redick, David Blodgett, Jenny Aurielle B. Babon, Chaoxing Yang, Sally C. Kent, Alan G. Derr, Alper Kucukural, Manuel Garber, and David M. Harlan

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Brown fat organogenesis and maintenance requires AKT1 and AKT2, Joan Sanchez-Gurmaches, Camila Martinez Calejman, Su Myung Jung, Huawei Li, and David A. Guertin

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Transient Kinetic Analysis of SWR1C-Catalyzed H2A.Z Deposition Unravels the Impact of Nucleosome Dynamics and the Asymmetry of Histone Exchange, Raushan K. Singh, Jiayi Fan, Nathan Gioacchini, Shinya Watanabe, Osman Bilsel, and Craig L. Peterson

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Hypomorphic mutations of TRIP11 cause odontochondrodysplasia, Anika Wehrle, John A. Follit, Gregory J. Pazour, Andrea Superti-Furga, Martin Lowe, and Ekkehart Lausch

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SENP3-mediated host defense response contains HBV replication and restores protein synthesis, Rui Xi, Botao Liu, Yan Han, and Xiling Shen

Publications from 2018

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Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs, Victor R. Ambros and Gary Ruvkun

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NmeCas9 is an intrinsically high-fidelity genome editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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NmeCas9 is an intrinsically high-fidelity genome-editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery, Baharak Bahmani, Mayuko Uehara, Farideh Ordikhani, Xiaofei Li, Liwei Jiang, Naima Banouni, Takaharu Ichimura, Vivek Kasinath, Siawosh K. Eskandari, Nasim Annabi, Jonathan S. Bromberg, Leonard D. Shultz, Dale L. Greiner, and Reza Abdi

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Role of JIP1-JNK Signaling in Beta-Cell Function and Autophagy, Seda Barutcu

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Role of the MAPK/cJun NH2-Terminal Kinase signaling pathway in starvation-induced autophagy, Seda Barutcu, Nomeda Girnius, Santiago Vernia, and Roger J. Davis

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Analysis and Correction of Inappropriate Image Duplication: the Molecular and Cellular Biology Experience, Elisabeth M. Bik, Ferric C. Fang, Amy L. Kullas, Roger J. Davis, and Arturo Casadevall

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Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing, Mehmet F. Bolukbasi, Pengpeng Liu, Kevin Luk, Samantha F. Kwok, Ankit Gupta, Nadia Amrani, Erik J. Sontheimer, Lihua Julie Zhu, and Scot A. Wolfe

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Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways, Daniel L. Bourque, Diane P. Genereux, Elinor K. Karlsson, Firdausi Qadri, and Jason B. Harris

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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Mixed Lineage Kinase 3 (MLK3) Prevents Cardiac Dysfunction and Structural Remodeling with Pressure Overload, Timothy Dean Calamaras, Robert A. Baumgartner, Mark J. Aronovitz, Angela L. McLaughlin, Kelly Tam, Daniel A. Richards, Craig W. Cooper, Nathan Li, Wendy E. Baur, Xiaoying Qiao, Guang-Rong Wang, Roger J. Davis, Navin Kumar Kapur, Richard H. Karas, and Robert Morris Blanton Jr.

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Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis, Qingbo Chen, Lei Huang, Dongning Pan, Lihua (Julie) Zhu, and Yong-Xu Wang

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Investigation of LIN-28 Function in Somatic Gonadal Development and Fertility, and Characterization of the LIN-28 Isoforms in C. elegans Hermaphrodites, Sungwook Choi

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Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin, Marie C. Didiot, Chantal M. Ferguson, Socheata Ly, Andrew H. Coles, Abigail O. Smith, Alicia A. Bicknell, Lauren M. Hall, Ellen Sapp, Dimas Echeverria, Athma A. Pai, Marian DiFiglia, Melissa J. Moore, Lawrence J. Hayward, Neil Aronin, and Anastasia Khvorova

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Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine, Wei Ding, Daniel P. Higgins, Dilip K. Yadav, Adwait A. Godbole, Read Pukkila-Worley, and Amy K. Walker

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Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon, Elisa Donnard, Pranitha Vangala, Shaked Afik, Sean M. McCauley, Anetta Nowosielska, Alper Kucukural, Barbara Tabak, Xiaopeng Zhu, William E. Diehl, Patrick McDonel, Nir Yosef, Jeremy Luban, and Manuel Garber

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Congenital Heart Defects and Ciliopathies Associated With Renal Phenotypes, George C. Gabriel, Gregory J. Pazour, and Cecilia W. Lo

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C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer (Nature methods, 2018-05-07)

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Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance, Devram S. Ghorpade, Lale Ozcan, Ze Zheng, Sarah M. Nicoloro, Yuefei Shen, Emily Chen, Matthias Bluher, Michael P. Czech, and Ira Tabas

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The cJUN NH2-terminal kinase pathway in mammary gland biology and carcinogenesis, Nomeda A. Girnius

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The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution, Nomeda A. Girnius, Yvonne J. K. Edwards, and Roger J. Davis

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The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation, Nomeda A. Girnius, Yvonne J. K. Edwards, David S. Garlick, and Roger J. Davis

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America's lost dogs, Linda Goodman and Elinor K. Karlsson

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Unexpected cell population gives fat a brake, David A. Guertin

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Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis, Adilson L. Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark Kelly, Donald A. Morgan, Kamal Rahmouni, and Michael P. Czech

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Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis, Adilson L. Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark Kelly, Kamal Rahmouni, Donald A. Morgan, and Michael P. Czech

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Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles, Reka A. Haraszti, Rachael Miller, Marie C. Didiot, Annabelle Biscans, Julia F. Alterman, Matthew R. Hassler, Loic Roux, Dimas Echeverria, Ellen Sapp, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo, Matthew R. Hassler, Anton A. Turanov, Julia F. Alterman, Reka A. Haraszti, Andrew H. Coles, Maire F. Osborn, Dimas Echeverria, Mehran Nikan, William E. Salomon, Loic Roux, Bruno M. D. C. Godinho, Sarah M. Davis, David V. Morrissey, Phillip D. Zamore, S. Ananth Karumanchi, Melissa J. Moore, Neil Aronin, and Anastasia Khvorova

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Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin, Florian Haun, Simon Neumann, Lukas Peintner, Katrin Wieland, Juri Habicht, Carsten Schwan, Kristine Ostevold, Maria Magdalena Koczorowska, Martin Biniossek, Matthias Kist, Hauke Busch, Melanie Boerries, Roger J. Davis, Ulrich Maurer, Oliver Schilling, Klaus Aktories, and Christoph Borner

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Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome, Felipe Henriques, Magno A. Lopes, Felipe O. Franco, Pamela Knobl, Kaltinaitis B. Santos, Luana L. Bueno, Victor A. Correa, Alexander H. Bedard, Adilson L. Guilherme, Alexander Birbrair, Sidney B. Peres, Stephen R. Farmer, and Miguel L. Batista Jr.

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The Caenorhabditis elegans Oxidative Stress Response Requires the NHR-49 Transcription Factor, Queenie Hu, Dayana R. D'Amora, Lesley T. MacNeil, Albertha J. M. Walhout, and Terrance J. Kubiseski

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In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites, Yan Hu, Melanie Miller, Bo Zhang, Thanh-thanh Nguyen, Martin K. Nielsen, and Raffi V. Aroian

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Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure, Yan Hu, Thanh-thanh Nguyen, Alice C. Lee Y, Joseph F. Urban Jr, Melanie M. Miller, Bin Zhan, David Koch, Jason B. Noon, Ricardo Toshio. Fujiwara, Dwight D. Bowman, Gary R. Ostroff, and Raffi V. Aroian

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All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo, Raed Ibraheim, Chun-Qing Song, Aamir Mir, Nadia Amrani, Wen Xue, and Erik J. Sontheimer

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All-in-One Adeno-associated Virus Delivery and Genome Editing by Neisseria meningitidis Cas9 in vivo, Raed Ibraheim, Chun-Qing Song, Aamir Mir, Nadia Amrani, Wen Xue, and Erik J. Sontheimer

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A synthetic, three-dimensional bone marrow hydrogel, Lauren Jansen, Thomas McCarthy, Michael J. Lee, and Shelly Peyton

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Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity, Jong Hun Kim, Eunjung Lee, Randall H. Friedline, Sujin Suk, Dae Young Jung, Sezin Dagdeviren, Xiaodi Hu, Kunikazu Inashima, Hye Lim Noh, Jung Yeon Kwon, Aya Nambu, Jun R. Huh, Myoung Souk Han, Roger J. Davis, Ki Won Lee, and Jason K. Kim

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Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells, Benjamin D. Landry, Thomas Leete, Ryan Richards, Peter Cruz-Gordillo, Hannah R. Schwartz, Megan E. Honeywell, Gary Ren, Alyssa D. Schwartz, Shelly R. Peyton, and Michael J. Lee (Molecular systems biology, 2018-08-06)

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Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins, Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E. Lou, Ildar Gainetdinov, April Pawluk, Raed Ibraheim, Xin D. Gao, Pengpeng Liu, Alan R. Davidson, Karen L. Maxwell, and Erik J. Sontheimer

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Adipocyte mTORC1 Signaling Separately Regulates Metabolic Homeostasis and Adipose Tissue Mass, Independent of RagGTPase Activity, Peter L. Lee

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JNK regulates muscle remodeling via myostatin/SMAD inhibition, Sarah J. Lessard, Tara L. MacDonald, Prerana Pathak, Myoung Souk Han, Vernon G. Coffey, Johann Edge, Donato A. Rivas, Michael F. Hirshman, Roger J. Davis, and Laurie J. Goodyear

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth, Qi Li, Niraj K. Nirala, Yingchao Nie, Hsi-Ju Chen, Gary R. Ostroff, Junhao Mao, Qi Wang, Lan Xu, and Y. Tony Ip

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LLC tumor cells-derivated factors reduces adipogenesis in co-culture system, Magno Alves Lopes, Felipe Oliveira Franco, Felipe Henriques, Sidney Barnabe Peres, and Miguel Luiz Batista Jr.

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Syndromic congenital myelofibrosis associated with a loss-of-function variant in RBSN, Pilar L. Magoulas, Silvia Corvera, and Luis M. Franco

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Innate Detection of HIV-1 in Myeloid Dendritic Cells, Sean Matthew McCauley

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Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines, Sean M. McCauley, Kyusik Kim, Anetta Nowosielska, Ann Dauphin, Leonid Yurkovetskiy, William E. Diehl, and Jeremy Luban

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Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines, Sean M. McCauley, Kyusik Kim, Anetta Nowosielska, Ann Dauphin, Leonid Yurkovetskiy, William E. Diehl, and Jeremy Luban

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Quantitative Human Immunodeficiency Virus (HIV)-1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy, Margaret M. McManus, Jennifer L. Henderson, Anita Gautam, Robin M. Brody, Eric R. Weiss, Deborah Persaud, Eric O. Mick, Katherine Luzuriaga, and PACTG 356 Investigators

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Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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Functional conservation of a developmental switch in mammals since the Jurassic age, Jayati Mookerjee-Basu, Xiang Hua, Lu Ge, Emmanuelle Nicolas, Qin Li, Philip Czyzewicz, Dai Zhongping, Suraj Peri, Juan Fuxman Bass, Albertha J. M. Walhout, and Dietmar J. Kappes (Molecular biology and evolution, 2018-10-08)

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JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory, Caroline Morel, Tessi Sherrin, Norman J. Kennedy, Kelly H. Forest, Seda Barutcu, Michael Robles, Ezekiel Carpenter-Hyland, Naghum Alfulaij, Claire L. Standen, Robert A. Nichols, Morris Benveniste, Roger J. Davis, and Cedomir Todorovic

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The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5alpha, Damien Morger, Franziska Zosel, Martin Buhlmann, Sara Zuger, Maximilian Mittelviefhaus, Benjamin Schuler, Jeremy Luban, and Markus G. Grutter

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MYC amplification in subtypes of breast cancers in African American women, Tammey J. Naab, Anita Gautam, Luisel Ricks-Santi, Ashwini K. Esnakula, Yasmine M. Kanaan, Robert L. DeWitty, Girmay Asgedom, Khepher H. Makambi, Massih Abawi, and Jan K. Blancato

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C. elegans MRP-5 Exports Vitamin B12 from Mother to Offspring to Support Embryonic Development, Huimin Na, Olga Ponomarova, Gabrielle E. Giese, and Albertha J. M. Walhout (Cell reports, 2018-03-20)

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C. elegans Multidrug Resistance Protein 5 (MRP-5) Transports Vitamin B12 from the Intestine to the Gonad to Support Embryonic Development, Huimin Na, Olga Ponomarova, Gabrielle E. Giese, and Albertha J. M. Walhout

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A comparative analysis of preservation techniques for the optimal molecular detection of hookworm DNA in a human fecal specimen, Marina Papaiakovou, Nils Pilotte, Ben Baumer, Jessica Grant, Kristjana Asbjornsdottir, Fabian Schaer, Yan Hu, Raffi V. Aroian, Judd Walson, and Steven A. Williams

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Adaptive Evolution of piRNA pathway in Drosophila, Swapnil S. Parhad

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Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus, Sofia A. Quinodoz, Barbara Tabak, Patrick McDonel, Manuel Garber, and Mitchell Guttman

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HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded, Briana Quitadamo, Paul J. Peters, Alexander Repik, Olivia O'Connell, Zhongming Mou, Matthew Koch, Mohan Somasundaran, Robin M. Brody, Katherine Luzuriaga, Aaron Wallace, Shixia Wang, Shan Lu, Sean M. McCauley, Jeremy Luban, Maria J. Duenas-Decamp, Maria Paz Paz Gonzalez-Perez, and Paul R. Clapham

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Gateway-Compatible Yeast One-Hybrid and Two-Hybrid Assays, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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Gateway Recombinational Cloning, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-01-02)

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Generating an Open Reading Frame (ORF) Entry Clone and Destination Clone, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-01-02)

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Generating Yeast One-Hybrid DNA-Bait Strains, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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Generating Yeast Two-Hybrid Bait Strains, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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High-Efficiency Yeast Transformation, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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Identifying Interactors from an Activation Domain Prey Library, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-07-02)

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Propagating Gateway Vectors, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-01-02)

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Using Multisite LR Cloning to Generate a Destination Clone, John S. Reece-Hoyes and Albertha J. M. Walhout (Cold Spring Harbor protocols, 2018-01-02)

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OMEGA: a software tool for the management, analysis, and dissemination of intracellular trafficking data that incorporates motion type classification and quality control, Alessandro Rigano, Vanni Galli, Jasmine M. Clark, Lara E. Pereira, Loris Grossi, Jeremy Luban, Raffaello Giulietti, Tiziano Leidi, Eric Hunter, Mario Valle, Ivo F. Sbalzarini, and Caterina Strambio-De-Castilla

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Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis, Joan Sanchez-Gurmaches, Yuefeng Tang, Naja Zenius. Jespersen, Martina Wallace, Camila Martinez Calejman, Sharvari Gujja, Huawei Li, Yvonne J. K. Edwards, Christian Wolfrum, Christian M. Metallo, Soren Nielsen, Camilla Scheele, and David A. Guertin

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CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure, Yuefei Shen, Jessica L. Cohen, Sarah M. Nicoloro, Mark Kelly, Batuhan Yenilmez, Felipe Henriques, Emmanouela Tsagkaraki, Yvonne J. K. Edwards, Xiaodi Hu, Randall H. Friedline, Jason K. Kim, and Michael P. Czech

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Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor, Amit Shraga, Payam Khoshkenar, Amir Mitchell, and Nir London (Cell chemical biology, 2018-10-24)

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Understanding and repurposing CRISPR-mediated alternative splicing, Jordan L. Smith, Haiwei Mou, and Wen Xue

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In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency, Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O'Connor, Qiushi Tang, Lingling Cai, Xiangrui Li, Zhiping Weng, Hao Yin, Guangping Gao, Christian Mueller, Terence R. Flotte, and Wen Xue

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Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras, Phillip W. L. Tai, Jun Xie, Kaiyuen Fong, Matthew Seetin, Cheryl Heiner, Qin Su, Michael Weiand, Daniella Wilmot, Maria L. Zapp, and Guangping Gao

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Distinct adipocyte progenitor cells are associated with regional phenotypes of perivascular aortic fat in mice, Khanh-Van T. Tran, Timothy P. Fitzgibbons, So Yun Min, Tiffany DeSouza, and Silvia Corvera

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RNAi modulation of placental sFLT1 for the treatment of preeclampsia, Anton A. Turanov, Matthew R. Hassler, Ami Ashar-Patel, Julia F. Alterman, Andrew H. Coles, Reka A. Haraszti, Loic Roux, Bruno M. D. C. Godinho, Dimas Echeverria, S. Ananth Karumanchi, Melissa J. Moore, and Anastasia Khvorova

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Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma, Arvind Venkatesan, Rajesh Vyas, Alec Gramann, Karen A. Dresser, Sharvari Gujja, Sanchita Bhatnagar, Sagar Chhangawala, Camilla Borges Ferreira Gomes, Hualin Simon Xi, Christine G. Lian, Yariv Houvras, Yvonne J. K. Edwards, April C. Deng, Michael R. Green, and Craig J. Ceol

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If two deletions don't stop growth, try three, Albertha J. M. Walhout (Science (New York, N.Y.), 2018-04-20)