The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2021

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JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury, Keren Grynberg, Elyce Ozols, William R. Mulley, Roger J. Davis, Richard A. Flavell, David J. Nikolic-Paterson, and Frank Y. Ma

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SWI/SNF senses carbon starvation with a pH-sensitive low complexity sequence [preprint], J. Ignacio Gutiérrez, Gregory P. Brittingham, Yonca Karadeniz, Kathleen D. Tran, Arnob Dutta, Alex S. Holehouse, Craig L. Peterson, and Liam J. Holt

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A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21, Myoung Souk Han, Rachel J. Perry, Joao-Paulo Camporez, Philipp E. Scherer, Gerald I. Shulman, Guangping Gao, and Roger J. Davis

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines, Jeremy Luban, Caterina Strambio-De-Castilla, Yetao Wang, Allan Jacobson, and Stuart W. Peltz

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Innate lymphoid cells and disease tolerance in SARS-CoV-2 infection [preprint], Noah J. Silverstein, Yetao Wang, Zachary Manickas-Hill, Claudia C. Carbone, Ann Dauphin, MGH COVID-19 Collection & Processing Team, Jonathan Z. Li, Bruce D. Walker, Xu G. Yu, and Jeremy Luban

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Somatic piRNAs and Transposons are Differentially Regulated During Skeletal Muscle Atrophy and Programmed Cell Death [preprint], Junko Tsuji, Travis Thomson, Christine Brown, Subhanita Ghosh, William E. Theurkauf, Zhiping Weng, and Lawrence M. Schwartz

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Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes, Tianxiong Yu, Kaili Fan, Deniz M. Ozata, Gen Zhang, Yu Fu, William E. Theurkauf, Phillip D. Zamore, and Zhiping Weng

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A benchmark and an algorithm for detecting germline transposon insertions and measuring de novo transposon insertion frequencies, Tianxiong Yu, Xiao Huang, Shengqian Dou, Xiaolu Tang, Shiqi Luo, William E. Theurkauf, Jian Lu, and Zhiping Weng

Publications from 2020

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Systematic evaluation of chromosome conformation capture assays [preprint], Betul Akgol-Oksuz, Liyan Yang, Sergey V. Venev, Nils Krietenstein, Krishna M. Parsi, Hakan Ozadam, Marlies E. Oomen, Ankita Nand, Hui Mao, Ryan M.J. Genga, Rene Maehr, Oliver J. Rando, Johan H. Gibcus, and Job Dekker

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Progressive Cactus is a multiple-genome aligner for the thousand-genome era, Joel Armstrong, Elinor K. Karlsson, Guojie Zhang, and Benedict Paten

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The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy, Annabelle Biscans, Jillian Caiazzi, Sarah M. Davis, Nicholas McHugh, Jacquelyn Sousa, and Anastasia Khvorova

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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles, Annabelle Biscans, Jillian Caiazzi, Nicholas McHugh, Vignesh Hariharan, Manish Muhuri, and Anastasia Khvorova

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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis, Camila Martinez Calejman, S. Trefely, S. W. Entwisle, Amelia K. Luciano, Su Myung. Jung, Wen-Yu Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villen, K. E. Wellen, and David A. Guertin

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Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults [preprint], Yuming Cao, Zhiru Guo, Pranitha Vangala, Elisa Donnard, Ping Liu, Patrick McDonel, Jose Ordovas Montanes, Alex K. Shalek, Robert W. Finberg, Jennifer P. Wang, and Manuel Garber

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Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression, Ming-Ling Chang, Zinger Yang, and Sien-Sing Yang

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Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution, Gaurav Chauhan, Jesse McClure, Jessica Hekman, Patrick W. Marsh, Jeffrey A. Bailey, Rachel F. Daniels, Diane P. Genereux, and Elinor K. Karlsson

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The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans [preprint], Daniel A. Chaves, Hui Dai, Lichao Li, James J. Moresco, Myung Eun Oh, Darryl Conte Jr., John R. Yates III, Craig C. Mello, and Weifeng Gu

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen, Qi Li, Niraj K. Nirala, and Y. Tony Ip

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Characterization of viral insulins reveals white adipose tissue-specific effects in mice, Martina Chrudinova, Francois Moreau, Hye Lim Noh, Terezie Panikova, Lenka Zakova, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiri Jiracek, C. Ronald Kahn, and Emrah Altindis

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Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice [preprint], Martina Chrudinová, Francois Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiri Jiracek, C. Ronald Kahn, and Emrah Altindis

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A big-data approach to understanding metabolic rate and response to obesity in laboratory mice, June K. Corrigan, Deepti Ramachandran, Yuchen He, Colin J. Palmer, Michael J. Jurczak, Rui Chen, Bingshan Li, Randall H. Friedline, Jason K. Kim, Jon J. Ramsey, Louise Lantier, Owen P. McGuinness, and Alexander S. Banks

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Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism, Maria Crespo, Norman J. Kennedy, Roger J. Davis, Nuria Matesanz, Magdalena Leiva, and Guadalupe Sabio

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Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma, Francisco Javier Cubero, Mohamed Ramadan Mohamed, Marius M. Woitok, Gang Zhao, Maximilian Hatting, Yulia A. Nevzorova, Chaobo Chen, Johannes Haybaeck, Alain de Bruin, Matias A. Avila, Mark V. Boekschoten, Roger J. Davis, and Christian Trautwein

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Mechanisms of insulin resistance related to white, beige, and brown adipocytes, Michael P. Czech

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Tacrolimus- and sirolimus-induced human beta cell dysfunction is reversible and preventable, Chunhua Dai, John T. Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle. Dean, Nripesh Prasad, Shawn E. Levy, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C. Powers

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Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates, Joana Damas, Elinor K. Karlsson, and Harris A. Lewin

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Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates [preprint], Joana Damas, Elinor K. Karlsson, and Harris A. Lewin

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Global community effect: large-scale cooperation yields collective survival of differentiating embryonic stem cells [preprint], Hirad Daneshpour, Pim van den Bersselaar, and Hyun Youk

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA, Sarah M. Davis, Jacquelyn Sousa, Lorenc Vangjeli, Matthew R. Hassler, Dimas Echeverria, Emily G. Knox, Anton A. Turanov, Julia F. Alterman, and Anastasia Khvorova

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Single Cell Transcriptomics Reveals Dysregulated Cellular and Molecular Networks in a Fragile X Syndrome model [preprint], Elisa Donnard, Huan Shu, and Manuel Garber

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Engineering essential genes with a "jump board" strategy using CRISPR/Cas9, Ye Duan, Sungwook Choi, Charles Nelson, and Victor R. Ambros

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RNA-seq with RNase H-based ribosomal RNA depletion specifically designed for C. elegans, Ye Duan, Yongming Sun, and Victor R. Ambros

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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics, Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, and James B. Munro

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A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears, Amanda Fazzalari, Giacomo Basadonna, Alper Kucukural, Kahraman Tanriverdi, Milka Koupenova-Zamor, Eric W. Dickson, Meghan Blackwood, Christian Mueller, Jane E. Freedman, and Mitchell A. Cahan

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From Tank to Treatment: Modeling Melanoma in Zebrafish, William Tyler Frantz and Craig J. Ceol

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The Tec kinase ITK differentially optimizes NFAT, NF-κB, and MAPK signaling during early T cell activation to regulate graded gene induction [preprint], Michael P. Gallagher, James M. Conley, Pranitha Vangala, Andrea Reboldi, Manuel Garber, and Leslie J. Berg

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Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides, Hirosha Geekiyanage, Shima Rayatpisheh, James A. Wohlschlegel, Robert H. Brown Jr., and Victor R. Ambros

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Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans, Krishna S. Ghanta and Craig C. Mello

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Melting dsDNA donor molecules potentiates precision genome editing in C. elegans [preprint], Krishna S. Ghanta and Craig C. Mello

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Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor, Gabrielle E. Giese, Melissa D. Walker, Olga Ponomarova, Hefei Zhang, Xuhang Li, Gregory Minevich, and Albertha J. M. Walhout

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Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor alpha and beta Repertoires, Anna Gil, Larisa Kamga, Ramakanth Chirravuri-Venkata, Nuray Aslan, Fransenio G. Clark, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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The Role of BMP Signaling in the Melanocyte Lineage and as a Therapeutic Target in Melanoma, Alec K. Gramann

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Control of Adipocyte Thermogenesis and Lipogenesis through beta3-Adrenergic and Thyroid Hormone Signal Integration, Adilson L. Guilherme, Batuhan Yenilmez, Alexander H. Bedard, Felipe Henriques, Dianxin Liu, Alexandra Lee, Lauren Goldstein, Mark Kelly, Sarah M. Nicoloro, Min Chen, Lee Weinstein, Sheila Collins, and Michael P. Czech

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Aberrant Ca2+ homeostasis in adipocytes links inflammation to metabolic dysregulation in obesity [preprint], Ekin Guney, Ana Paula Arruda, Gunes Parlakgul, Erika Cagampan, Nina Min, Yankun Lee, Lily Greene, Eva Tsaousidou, Karen Inouye, Myoung Souk Han, Roger J. Davis, and Harvard University

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Regulation of adipose tissue inflammation by interleukin 6, Myoung Souk Han, Alexis White, Rachel J. Perry, Joao-Paulo Camporez, Juan Hidalgo, Gerald I. Shulman, and Roger J. Davis

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Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone, Celine A. Hayden, Danilo Landrock, Chiung Yu Hung, Gary R. Ostroff, Gina M. Fake, John H. Walker, Ann Kier, and John A. Howard

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Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis, Felipe Henriques, Alexander H. Bedard, Adilson L. Guilherme, Mark Kelly, Lawrence M. Lifshitz, Karl D. Bellve, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, and Michael P. Czech

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Single Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis [preprint], Felipe Henriques, Alexander H. Bedard, Adilson L. Guilherme, Mark Kelly, Lawrence M. Lifshitz, Karl D. Bellve, Leslie Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, and Michael P. Czech

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How to make a rodent giant: Genomic basis and tradeoffs of gigantism in the capybara, the world's largest rodent, Santiago Herrera-Alvarez, Elinor K. Karlsson, Oliver A. Ryder, Kerstin Lindblad-Toh, and Andrew J. Crawford

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Regulation of Translation and Synaptic Plasticity by TSC2, Annie Hien

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Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP, Annie Hien, Gemma Molinaro, Botao Liu, Kimberly M. Huber, and Joel D. Richter

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The Lipid Handling Capacity of Subcutaneous Fat Requires mTORC2 during Development, Wen-Yu Hsiao

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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development, Wen-Yu Hsiao, Su Myung Jung, Yuefeng Tang, John A. Haley, Rui Li, Huawei Li, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Chien-Min Hung, Amelia K. Luciano, Victoria DeMambro, Kathryn E. Wellen, Clifford J. Rosen, Lihua Julie Zhu, and David A. Guertin

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Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors [preprint], Raed Ibraheim, Phillip W. L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomas Rodriguez, Samantha J. Nelson, Eraj Khokhar, Esther Mintzer, Stacy Maitland​, Yueying Cao, Guangping Gao, and Erik J. Sontheimer

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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, Tingting Jiang, Xiao-Ou Zhang, Yueying Cao, Zhiping Weng, and Wen Xue

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HIV-1 Evasion of Human TRIM5α via Cyclophilin A, Kyusik Kim

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Ultrastructural Details of Mammalian Chromosome Architecture, Nils Krietenstein, Sameer Abraham, Sergey V. Venev, Nezar Abdennur, Johan H. Gibcus, Tsung-Han S. Hsieh, Krishna M. Parsi, Liyan Yang, Rene Maehr, Leonid A. Mirny, Job Dekker, and Oliver J. Rando (Molecular cell, 2020-03-14)

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An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes, Nathan D. Lawson, Rui Li, Masahiro Shin, Ann S. Grosse, Onur Yukselen, Oliver A. Stone, Alper Kucukural, and Lihua Julie Zhu

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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells, Nayara C. Leite, Elad Sintov, Torsten B. Meissner, Michael A. Brehm, Dale L. Greiner, David M. Harlan, and Douglas A. Melton

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Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events, Jacob E. Lemieux, Jeremy Luban, Lawrence C. Madoff, Pardis C. Sabeti, and Bronwyn L. MacInnis

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Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events [preprint], Jacob Lemieux, Katherine J. Siddle, Jeremy Luban, Glen R. Gallagher, Lawrence C. Madoff, Sandra Smole, Virginia M. Pierce, Eric Rosenberg, Pardis C. Sabeti, Daniel J. Park, and Bronwyn L. MacInnis

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Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Toward Goblet Cell Lineage in the Mouse Intestine, Joyce H. Li, Subir Ray, Alper Kucukural, Gerard Gradwohl, and Andrew B. Leiter

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Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111, Aaron E. Lin, William E. Diehl, Yingyun Cai, Courtney L. Finch, Chidiebere Akusobi, Robert N. Kirchdoerfer, Laura Bollinger, Stephen F. Schaffner, Elizabeth A. Brown, Erica Ollmann Saphire, Kristian G. Andersen, Jens H. Kuhn, Jeremy Luban, and Pardis C. Sabeti

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Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6, Wallace H. Liu, Jie Zheng, Jessica L. Feldman, Mark A. Klein, Vyacheslav I. Kuznetsov, Craig L. Peterson, Patrick R. Griffin, and John M. Denu

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The History of Farm Foxes Undermines the Animal Domestication Syndrome, Kathryn A. Lord, Greger Larson, Raymond P. Coppinger, and Elinor K. Karlsson

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SARS-CoV-2, Jeremy Luban

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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines [preprint], Jeremy Luban, Caterina Strambio De Castilla, Yetao Wang, Allan Jacobson, and Stuart Peltz

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Immunotherapy for Infarcts: In Vivo Postinfarction Macrophage Modulation Using Intramyocardial Microparticle Delivery of Map4k4 Small Interfering RNA, Jun Luo, Matthew S. Weaver, Timothy P. Fitzgibbons, Myriam Aouadi, Michael P. Czech, and Margaret D. Allen

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Dormancy-to-death transition in yeast spores occurs due to gradual loss of gene-expressing ability, Theo Maire, Tim Allertz, Max A. Betjes, and Hyun Youk

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JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma, Elisa Manieri, Tamera Barrett, Julie Cavanagh-Kyros, Roger J. Davis, Alfonso Mora, and Guadalupe Sabio

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Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation, Asia N. Matthew-Onabanjo, Jenny Janusis, Jose Mercado-Matos, Anne E. Carlisle, Dohoon Kim, Fayola Levine, Peter Cruz-Gordillo, Ryan Richards, Michael J. Lee, and Leslie M. Shaw (Cancer research, 2020-01-15)

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Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt(Q140/Q140) mouse model of Huntington's disease, Robyn L. McAdam, Andrew Morton, Sarah L. Gordon, Julia F. Alterman, Anastasia Khvorova, Michael A. Cousin, and Karen J. Smillie

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Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a C. elegans propionic acidemia model, Huimin Na, Stefan Zdraljevic, Robyn E. Tanny, Albertha J. M. Walhout, and Erik C. Andersen

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Proteomic and Transcriptional Profiles of Human Stem Cell-Derived beta Cells Following Enteroviral Challenge, Julius O. Nyalwidhe, Agata Jurczyk, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Melanie I. Trombly, Pranitha Vangala, Riccardo Racicot, Rita Bortell, David M. Harlan, Dale L. Greiner, Michael A. Brehm, Jerry L. Nadler, and Jennifer P. Wang

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TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner, Molly Ohainle, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy Luban, and Michael Emerman

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Wild-type huntingtin regulates human macrophage function, Grace C. O'Regan, Sahar H. Farag, Gary R. Ostroff, Sarah J. Tabrizi, and Ralph Andre

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dagLogo: An R/Bioconductor package for identifying and visualizing differential amino acid group usage in proteomics data, Jianhong Ou, Haibo Liu, Niraj K. Nirala, Alexey Stukalov, Usha Acharya, Michael R. Green, and Lihua Julie Zhu

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The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV, Paolo Palma, Margaret M. McManus, Nicola Cotugno, Salvatore Rocca, Paolo Rossi, and Katherine Luzuriaga

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Adaptive Evolution Targets a piRNA Precursor Transcription Network, Swapnil Parhad, Tianxiong Yu, Gen Zhang, Nicholas P. Rice, Zhiping Weng, and William E. Theurkauf

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Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice, Sambra D. Redick, Linda Leehy, Ann R. Rittenhouse, David M. Blodgett, Alan G. Derr, Alper Kucukural, Manuel Garber, Leonard D. Shultz, Dale L. Greiner, Jennifer P. Wang, David M. Harlan, Rita Bortell, and Agata Jurczyk

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Drug antagonism and single-agent dominance result from differences in death kinetics, Ryan Richards, Hannah R. Schwartz, Megan E. Honeywell, Mariah S. Stewart, Peter Cruz-Gordillo, Anna J. Joyce, Benjamin D. Landry, and Michael J. Lee

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An atlas of cell types in the mammalian epididymis and vas deferens [preprint], Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

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An atlas of cell types in the mouse epididymis and vas deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

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Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host, Brittany Rosener, Serkan Sayin, Peter O. Oluoch, Aurian Garcia-Gonzalez, Hirotada Mori, Albertha J. M. Walhout, and Amir Mitchell

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SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC [preprint], Christian F. Ruiz, Emily D. Montal, John A. Haley, and John D. Haley

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A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep, John Sanders, David Gazzola, Hanchen Li, Ambily Abraham, Kelly Flanagan, Florentina Rus, Yan Hu, Gary R. Ostroff, and Raffi V. Aroian

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Thioredoxin Interacting Protein Is Required for a Chronic Energy-Rich Diet to Promote Intestinal Fructose Absorption, Anu Shah, Sezin Dagdeviren, Jordan P. Lewandowski, Angela B. Schmider, Elisabeth M. Ricci-Blair, Niranjana Natarajan, Henna Hundal, Hye Lim Noh, Randall H. Friedline, Charles Vidoudez, Jason K. Kim, Amy J. Wagers, Roy J. Soberman, and Richard T. Lee

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FMRP Links Optimal Codons to mRNA stability in Neurons [preprint], Huan Shu, Elisa Donnard, Botao Liu, Ruijia Wang, and Joel D. Richter

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Genomic Characterization of Endothelial Enhancers Reveals a Multifunctional Role for NR2F2 in Regulation of Arteriovenous Gene Expression, Samir Sissaoui, Jun Yu, Aimin Yan, Rui Li, Onur Yukselen, Alper Kucukural, Lihua Julie Zhu, and Nathan D. Lawson

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Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion [preprint], Søs Skovsø, Hye Lim Noh, Sujin Suk, Brian Gablaski, Jason K. Kim, and James D. Johnson

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YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells, Jordan L. Smith, Tomas Rodriguez, Haiwei Mou, Suet-Yan Kwan, Henry E. Pratt, Xiao-Ou Zhang, Yueying Cao, Shun-Qing Liang, Deniz M. Ozata, Tianxiong Yu, Qiangzong Yin, Max Hazeltine, Zhiping Weng, Erik J. Sontheimer, and Wen Xue

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Adenine base editing in an adult mouse model of tyrosinaemia, Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M. Schatoff, Jordan L. Doman, Yueying Cao, Lukas E. Dow, Lihua Julie Zhu, Daniel G. Anderson, David R. Liu, Hao Yin, and Wen Xue

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Innovations, challenges, and minimal information for standardization of humanized mice, Renata Stripecke and Michael A. Brehm

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INO80C Remodeler Maintains Genomic Stability by Preventing Promiscuous Transcription at Replication Origins, Salih Topal, Christopher Van, Yong Xue, Michael F. Carey, and Craig L. Peterson

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CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease [preprint], Emmanouela Tsagkaraki, Sarah M. Nicoloro, Tiffany DeSouza, Javier Solivan-Rivera, Anand Desai, Yuefei Shen, Mark Kelly, Adilson L. Guilherme, Felipe Henriques, Raed Ibraheim, Nadia Amrani, Kevin Luk, Stacy Maitland, Randall H. Friedline, Lauren Tauer, Xiaodi Hu, Jason K. Kim, Scot A. Wolfe, Erik J. Sontheimer, Silvia Corvera, and Michael P. Czech

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High-resolution analysis of differential gene expression during skeletal muscle atrophy and programmed cell death, Junko Tsuji, Travis Thomson, Elizabeth Chan, Christine K. Brown, Julia Oppenheimer, Carol Bigelow, Xianjun Dong, William E. Theurkauf, Zhiping Weng, and Lawrence M. Schwartz

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Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models, Jos L. van der Velden, John F. Alcorn, David G. Chapman, Lennart K. A. Lundblad, Charles G. Irvin, Roger J. Davis, Kelly Butnor, and Yvonne M. W. Janssen-Heininger

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High-Resolution Mapping of Multiway Enhancer-Promoter Interactions Regulating Pathogen Detection, Pranitha Vangala, Rachel Murphy, Sofia A. Quinodoz, Kyle J. Gellatly, Patrick E. McDonel, Mitchell Guttman, and Manuel Garber