The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2021

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Systematic evaluation of chromosome conformation capture assays, Betul Akgol-Oksuz, Liyan Yang, Sameer Abraham, Sergey V. Venev, Nils Krietenstein, Krishna M. Parsi, Hakan Ozadam, Marlies E. Oomen, Ankita Nand, Hui Mao, Ryan Genga, Rene Maehr, Oliver J. Rando, Leonid A. Mirny, Johan H. Gibcus, and Job Dekker

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Micro-Meta App: an interactive software tool to facilitate the collection of microscopy metadata based on community-driven specifications [preprint], Alessandro Rigano, Mathias Hammer, Karl D. Bellve, Kevin E. Fogarty, David Grunwald, and Caterina Strambio-De-Castilla

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Akt Is S-Palmitoylated: A New Layer of Regulation for Akt, Matias Blaustein, Estefania Piegari, Camila Martinez Calejman, Antonella Vila, Analia Amante, Maria Victoria. Manese, Ari Zeida, Laurence Abrami, Mariela Veggetti, David A. Guertin, F. Gisou van der Goot, Maria Martha Corvi, and Alejandro Colman-Lerner

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Insights into the Role of Oncogenic BRAF in Tetraploidy and Melanoma Initiation, Revati A. Darp

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Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity, William E. Diehl, Mehmet Hakan Guney, Teresa Vanzo, Pyae Phyo Kyawe, Judith M. White, Massimo Pizzato, and Jeremy Luban

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Dissection of Zebrafish Adult Melanocyte Stem Cell Signaling During Regeneration, William Tyler Frantz

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Disrupted glucose homeostasis and skeletal muscle-specific glucose uptake in an exocyst knockout mouse model, Brent A. Fujimoto, Madison Young, Nicole Nakamura, Herena Ha, Lamar Carter, Matthew W. Pitts, Daniel Torres, Hye Lim Noh, Sujin Suk, Jason K. Kim, and Noemi Polgar

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JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury, Keren Grynberg, Elyce Ozols, William R. Mulley, Roger J. Davis, Richard A. Flavell, David J. Nikolic-Paterson, and Frank Y. Ma

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SWI/SNF senses carbon starvation with a pH-sensitive low complexity sequence [preprint], J. Ignacio Gutiérrez, Gregory P. Brittingham, Yonca Karadeniz, Kathleen D. Tran, Arnob Dutta, Alex S. Holehouse, Craig L. Peterson, and Liam J. Holt

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Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model [preprint], Mathias Hammer, Maximiliaan Huisman, Farzin Farzam, David Grünwald, and Caterina Strambio-De-Castilla

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A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21, Myoung Souk Han, Rachel J. Perry, Joao-Paulo Camporez, Philipp E. Scherer, Gerald I. Shulman, Guangping Gao, and Roger J. Davis

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Loss of function of lysosomal acid lipase (LAL) profoundly impacts osteoblastogenesis and increases fracture risk in humans, Ron C. Helderman, Daniel G. Whitney, Madalina Duta-Mare, Alena Akhmetshina, Nemanja Vujic, Shobana Jayapalan, Jeffry S. Nyman, Biswapriya B. Misra, Clifford J. Rosen, Michael P. Czech, Dagmar Kratky, and Elizabeth Rendina-Ruedy

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A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection, Fiachra Humphries, Liraz Shmuel-Galia, Zhaozhao Jiang, Ruth Wilson, Philip Landis, Sze-Ling Ng, Krishna M. Parsi, Rene Maehr, John Cruz, Angel Morales-Ramos, Joshi M. Ramanjulu, John Bertin, G. Scott Pesiridis, and Katherine A. Fitzgerald

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Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions, Jong Hyuk Kim, Kate Megquier, Rachael Thomas, Aaron L. Sarver, Jung Min. Song, Yoon Tae Kim, Nuojin Cheng, Ashley J. Schulte, Michael A. Linden, Paari Murugan, LeAnn Oseth, Colleen L. Forster, Ingegerd Elvers, Ross Swofford, Jason Turner-Maier, Elinor K. Karlsson, Matthew Breen, Kerstin Lindblad-Toh, and Jaime F. Modiano

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Bacterial processing of glucose modulates C. elegans lifespan and healthspan, Samuel F. Kingsley, Yonghak Seo, Calista Allen, Krishna S. Ghanta, Steven Finkel, and Heidi A. Tissenbaum

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SARS-CoV-2 Initiates Programmed Cell Death in Platelets, Milka Koupenova-Zamor, Heather A. Corkrey, Olga Vitseva, Kahraman Tanriverdi, Mohan Somasundaran, Ping Liu, Shaukat Soofi, Krishna M. Parsi, Alyssa Cousineau, Rene Maehr, Jennifer P. Wang, Jeffrey J. Rade, and Robert W. Finberg

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xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers, Namgyu Lee, Anne E. Carlisle, Austin Peppers, Sung Jin Park, Mihir B. Doshi, Meghan E. Spears, and Dohoon Kim

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Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans, Hanchen Li, Gary R. Ostroff, and Raffi V. Aroian

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines, Jeremy Luban, Caterina Strambio-De-Castilla, Yetao Wang, Allan Jacobson, and Stuart W. Peltz

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JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging, Katrin Muller, Roger J. Davis, Achim Weber, and Tom Luedde

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A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA, Charles J. Nelson and Victor R. Ambros

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Emerging Immunotherapies in the Treatment of Brain Metastases, Edwin Nieblas-Bedolla, Naema Nayyar, Mohini Singh, Ryan J. Sullivan, and Priscilla K. Brastianos

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Gaining Insight into Vitiligo Genetics through the Lens of a Large Epidemiologic Study, Ken Okamura, Manuel Garber, and John E. Harris

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Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation, Delayna Paulson, Rebecca Harms, Cody Ward, Mackenzie Latterell, Gregory J. Pazour, and Darci M. Fink

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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice, Pengpeng Liu, Shun-Qing Liang, Chunwei Zheng, Esther Mintzer, Yan G. Zhao, Karthikeyan Ponnienselvan, Aamir Mir, Erik J. Sontheimer, Guangping Gao, Terence R. Flotte, Scot A. Wolfe, and Wen Xue

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Biophysical basis of cellular multi-specificity encoded in a model molecular switch [preprint], Tina Perica, Christopher J. P. Mathy, Jiewei Xu, Gwendolyn M. Jang, Yang Zhang, Robyn Kaake, Noah Ollikainen, Hannes Braberg, Danielle L. Swaney, David G. Lambright, Mark J. S. Kelly, Nevan J. Krogan, and Tanja Kortemme

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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Restore Thymic Architecture and T Cell Function Disrupted by Neonatal Hyperoxia, Monica Reis, Gareth R. Willis, Angeles Fernandez-Gonzalez, Vincent Yeung, Elizabeth Taglauer, Margaret Magaletta, Teagan J. Parsons, Alan G. Derr, Xianlan Liu, Rene Maehr, Stella Kourembanas, and S. Alex Mitsialis

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The molecular biology of FMRP: new insights into fragile X syndrome, Joel D. Richter and Xinyu Zhao

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MethodsJ2: A Software Tool to Improve Microscopy Methods Reporting [preprint], Joel Ryan, Thomas Pengo, Alex Rigano, Paula Montero Llopis, Michelle S. Itano, Lisa Cameron, Guillermo Marqués, Caterina Strambio De Castilla, Mark A. Sanders, and Claire M. Brown

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Maternal exposure to high-fat diet during pregnancy and lactation predisposes normal weight offspring mice to develop hepatic inflammation and insulin resistance, Suchaorn Saengnipanthkul, Hye Lim Noh, Randall H. Friedline, Sujin Suk, Stephanie Choi, Nicholas K. Acosta, Duy A. Tran, Xiaodi Hu, Kunikazu Inashima, Allison M. Kim, Ki Won Lee, and Jason K. Kim

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mTOR-activating mutations in RRAGD cause kidney tubulopathy and cardiomyopathy (KICA) syndrome [preprint], Karl P. Schlingmann, Kuang Shen, and Jeroen H.F. de Baaij

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Lessons from a local effort to screen for SARS-CoV-2, Noah J. Silverstein and Jeremy Luban

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Innate lymphoid cells and disease tolerance in SARS-CoV-2 infection [preprint], Noah J. Silverstein, Yetao Wang, Zachary Manickas-Hill, Claudia C. Carbone, Ann Dauphin, MGH COVID-19 Collection & Processing Team, Jonathan Z. Li, Bruce D. Walker, Xu G. Yu, and Jeremy Luban

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Defining the Role of c-Jun N-terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease, Abigail O. Smith

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c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease [preprint], Abigail O. Smith, Julie A. Jonassen, Kenley Preval, Roger J. Davis, and Gregory J. Pazour

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Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release, Ernesto R. Soto, Florentina Rus, Hanchen Li, Carli Garceau, Jeffrey Chicca, Elfawal A. Mostafa, David Gazzola, Martin K. Nielsen, Joseph F. Urban Jr., Raffi V. Aroian, and Gary R. Ostroff

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SARS-CoV-2 Reinfection in a Liver Transplant Recipient, Christopher H. Tomkins-Tinch, Jennifer S. Daly, Nicole M. Theodoropoulos, Michael P. Madaio, Neng Yu, Vijay K. Vanguri, Babak Movahedi, Adel Bozorgzadeh, Karl J. Simin, Jeremy Luban, Bronwyn L. MacInnis, Pardis C. Sabeti, and Stuart M. Levitz

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Somatic piRNAs and Transposons are Differentially Regulated During Skeletal Muscle Atrophy and Programmed Cell Death [preprint], Junko Tsuji, Travis Thomson, Christine Brown, Subhanita Ghosh, William E. Theurkauf, Zhiping Weng, and Lawrence M. Schwartz

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An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals, Joseph F. Urban Jr, Martin K. Nielsen, David Gazzola, Yue Xie, Ethiopia Beshah, Yan Hu, Hanchen Li, Florentina Rus, Kelly Flanagan, Austin Draper, Sridhar Vakalapudi, Robert W. Li, Gary R. Ostroff, and Raffi V. Aroian

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Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma [preprint], Marc A. Vittoria, Nathan Kingston, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston- Lunel, Revati A. Darp, Joshua Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, and Neil J. Ganem

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Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence [preprint], Bryan Wang, Yu-Cheng Lin, Alejandro Vasquez-Rifo, Jeanyoung Jo, Alexa Price-Whelan, Shujuan Tao McDonald, Lewis M. Brown, Christian Sieben, and Lars E.P. Dietrich

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Role of epigenetics in unicellular to multicellular transition in Dictyostelium, Simon Yuan Wang, Elizabeth Ann Pollina, I-Hao Wang, Lindsay Kristina Pino, Henry L. Bushnell, Ken Takashima, Colette Fritsche, George Sabin, Benjamin Aaron. Garcia, Paul L. Greer, and Eric Lieberman Greer

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Clarification of human blood ILC subtype interrelatedness and discovery of amphiregulin production by human NK cells shed light on HIV-1 pathogenesis [preprint], Yetao Wang, Lawrence M. Lifshitz, Noah J. Silverstein, Esther Mintzer, Kevin Luk, Pamela St. Louis, Michael A. Brehm, Scot A. Wolfe, Steven G. Deeks, and Jeremy Luban

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DEVELOPMENT OF AN RNAi THERAPEUTIC STRATEGY AGAINST NON-ALCOHOLIC STEATOHEPATITIS (NASH), Batuhan O. Yenilmez

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Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes, Tianxiong Yu, Kaili Fan, Deniz M. Ozata, Gen Zhang, Yu Fu, William E. Theurkauf, Phillip D. Zamore, and Zhiping Weng

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A benchmark and an algorithm for detecting germline transposon insertions and measuring de novo transposon insertion frequencies, Tianxiong Yu, Xiao Huang, Shengqian Dou, Xiaolu Tang, Shiqi Luo, William E. Theurkauf, Jian Lu, and Zhiping Weng

Publications from 2020

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Systematic evaluation of chromosome conformation capture assays [preprint], Betul Akgol-Oksuz, Liyan Yang, Sergey V. Venev, Nils Krietenstein, Krishna M. Parsi, Hakan Ozadam, Marlies E. Oomen, Ankita Nand, Hui Mao, Ryan M.J. Genga, Rene Maehr, Oliver J. Rando, Johan H. Gibcus, and Job Dekker

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Progressive Cactus is a multiple-genome aligner for the thousand-genome era, Joel Armstrong, Elinor K. Karlsson, Guojie Zhang, and Benedict Paten

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The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy, Annabelle Biscans, Jillian Caiazzi, Sarah M. Davis, Nicholas McHugh, Jacquelyn Sousa, and Anastasia Khvorova

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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles, Annabelle Biscans, Jillian Caiazzi, Nicholas McHugh, Vignesh Hariharan, Manish Muhuri, and Anastasia Khvorova

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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis, Camila Martinez Calejman, S. Trefely, S. W. Entwisle, Amelia K. Luciano, Su Myung. Jung, Wen-Yu Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villen, K. E. Wellen, and David A. Guertin

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Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults [preprint], Yuming Cao, Zhiru Guo, Pranitha Vangala, Elisa Donnard, Ping Liu, Patrick McDonel, Jose Ordovas Montanes, Alex K. Shalek, Robert W. Finberg, Jennifer P. Wang, and Manuel Garber

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Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression, Ming-Ling Chang, Zinger Yang, and Sien-Sing Yang

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Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution, Gaurav Chauhan, Jesse McClure, Jessica Hekman, Patrick W. Marsh, Jeffrey A. Bailey, Rachel F. Daniels, Diane P. Genereux, and Elinor K. Karlsson

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The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans [preprint], Daniel A. Chaves, Hui Dai, Lichao Li, James J. Moresco, Myung Eun Oh, Darryl Conte Jr., John R. Yates III, Craig C. Mello, and Weifeng Gu

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen, Qi Li, Niraj K. Nirala, and Y. Tony Ip

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Characterization of viral insulins reveals white adipose tissue-specific effects in mice, Martina Chrudinova, Francois Moreau, Hye Lim Noh, Terezie Panikova, Lenka Zakova, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiri Jiracek, C. Ronald Kahn, and Emrah Altindis

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Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice [preprint], Martina Chrudinová, Francois Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiri Jiracek, C. Ronald Kahn, and Emrah Altindis

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A big-data approach to understanding metabolic rate and response to obesity in laboratory mice, June K. Corrigan, Deepti Ramachandran, Yuchen He, Colin J. Palmer, Michael J. Jurczak, Rui Chen, Bingshan Li, Randall H. Friedline, Jason K. Kim, Jon J. Ramsey, Louise Lantier, Owen P. McGuinness, and Alexander S. Banks

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Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism, Maria Crespo, Norman J. Kennedy, Roger J. Davis, Nuria Matesanz, Magdalena Leiva, and Guadalupe Sabio

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Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma, Francisco Javier Cubero, Mohamed Ramadan Mohamed, Marius M. Woitok, Gang Zhao, Maximilian Hatting, Yulia A. Nevzorova, Chaobo Chen, Johannes Haybaeck, Alain de Bruin, Matias A. Avila, Mark V. Boekschoten, Roger J. Davis, and Christian Trautwein

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Mechanisms of insulin resistance related to white, beige, and brown adipocytes, Michael P. Czech

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Tacrolimus- and sirolimus-induced human beta cell dysfunction is reversible and preventable, Chunhua Dai, John T. Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle. Dean, Nripesh Prasad, Shawn E. Levy, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C. Powers

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Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates, Joana Damas, Elinor K. Karlsson, and Harris A. Lewin

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Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates [preprint], Joana Damas, Elinor K. Karlsson, and Harris A. Lewin

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Global community effect: large-scale cooperation yields collective survival of differentiating embryonic stem cells [preprint], Hirad Daneshpour, Pim van den Bersselaar, and Hyun Youk

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA, Sarah M. Davis, Jacquelyn Sousa, Lorenc Vangjeli, Matthew R. Hassler, Dimas Echeverria, Emily G. Knox, Anton A. Turanov, Julia F. Alterman, and Anastasia Khvorova

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Single Cell Transcriptomics Reveals Dysregulated Cellular and Molecular Networks in a Fragile X Syndrome model [preprint], Elisa Donnard, Huan Shu, and Manuel Garber

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Engineering essential genes with a "jump board" strategy using CRISPR/Cas9, Ye Duan, Sungwook Choi, Charles Nelson, and Victor R. Ambros

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RNA-seq with RNase H-based ribosomal RNA depletion specifically designed for C. elegans, Ye Duan, Yongming Sun, and Victor R. Ambros

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New Opportunities and Cautionary Insights about Decentralizing and Deglobalizing Clinical Trials During the Great Lockdown, Denise Dunlap, Roberto S. Santos, David D. McManus, Bryan O. Buchholz, Nathaniel S. Hafer, and MaryAnn Picard

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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics, Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, and James B. Munro

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A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears, Amanda Fazzalari, Giacomo Basadonna, Alper Kucukural, Kahraman Tanriverdi, Milka Koupenova-Zamor, Eric W. Dickson, Meghan Blackwood, Christian Mueller, Jane E. Freedman, and Mitchell A. Cahan

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From Tank to Treatment: Modeling Melanoma in Zebrafish, William Tyler Frantz and Craig J. Ceol

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The Tec kinase ITK differentially optimizes NFAT, NF-κB, and MAPK signaling during early T cell activation to regulate graded gene induction [preprint], Michael P. Gallagher, James M. Conley, Pranitha Vangala, Andrea Reboldi, Manuel Garber, and Leslie J. Berg

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Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides, Hirosha Geekiyanage, Shima Rayatpisheh, James A. Wohlschlegel, Robert H. Brown Jr., and Victor R. Ambros

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Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans, Krishna S. Ghanta and Craig C. Mello

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Melting dsDNA donor molecules potentiates precision genome editing in C. elegans [preprint], Krishna S. Ghanta and Craig C. Mello

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Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor, Gabrielle E. Giese, Melissa D. Walker, Olga Ponomarova, Hefei Zhang, Xuhang Li, Gregory Minevich, and Albertha J. M. Walhout

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Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor alpha and beta Repertoires, Anna Gil, Larisa Kamga, Ramakanth Chirravuri-Venkata, Nuray Aslan, Fransenio G. Clark, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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The Role of BMP Signaling in the Melanocyte Lineage and as a Therapeutic Target in Melanoma, Alec K. Gramann

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Control of Adipocyte Thermogenesis and Lipogenesis through beta3-Adrenergic and Thyroid Hormone Signal Integration, Adilson L. Guilherme, Batuhan Yenilmez, Alexander H. Bedard, Felipe Henriques, Dianxin Liu, Alexandra Lee, Lauren Goldstein, Mark Kelly, Sarah M. Nicoloro, Min Chen, Lee Weinstein, Sheila Collins, and Michael P. Czech

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Aberrant Ca2+ homeostasis in adipocytes links inflammation to metabolic dysregulation in obesity [preprint], Ekin Guney, Ana Paula Arruda, Gunes Parlakgul, Erika Cagampan, Nina Min, Yankun Lee, Lily Greene, Eva Tsaousidou, Karen Inouye, Myoung Souk Han, Roger J. Davis, and Harvard University

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Regulation of adipose tissue inflammation by interleukin 6, Myoung Souk Han, Alexis White, Rachel J. Perry, Joao-Paulo Camporez, Juan Hidalgo, Gerald I. Shulman, and Roger J. Davis

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Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone, Celine A. Hayden, Danilo Landrock, Chiung Yu Hung, Gary R. Ostroff, Gina M. Fake, John H. Walker, Ann Kier, and John A. Howard

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Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis, Felipe Henriques, Alexander H. Bedard, Adilson L. Guilherme, Mark Kelly, Lawrence M. Lifshitz, Karl D. Bellve, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, and Michael P. Czech

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Single Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis [preprint], Felipe Henriques, Alexander H. Bedard, Adilson L. Guilherme, Mark Kelly, Lawrence M. Lifshitz, Karl D. Bellve, Leslie Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, and Michael P. Czech

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How to make a rodent giant: Genomic basis and tradeoffs of gigantism in the capybara, the world's largest rodent, Santiago Herrera-Alvarez, Elinor K. Karlsson, Oliver A. Ryder, Kerstin Lindblad-Toh, and Andrew J. Crawford

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Regulation of Translation and Synaptic Plasticity by TSC2, Annie Hien

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Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP, Annie Hien, Gemma Molinaro, Botao Liu, Kimberly M. Huber, and Joel D. Richter

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The Lipid Handling Capacity of Subcutaneous Fat Requires mTORC2 during Development, Wen-Yu Hsiao

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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development, Wen-Yu Hsiao, Su Myung Jung, Yuefeng Tang, John A. Haley, Rui Li, Huawei Li, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Chien-Min Hung, Amelia K. Luciano, Victoria DeMambro, Kathryn E. Wellen, Clifford J. Rosen, Lihua Julie Zhu, and David A. Guertin

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Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors [preprint], Raed Ibraheim, Phillip W. L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomas Rodriguez, Samantha J. Nelson, Eraj Khokhar, Esther Mintzer, Stacy Maitland​, Yueying Cao, Guangping Gao, and Erik J. Sontheimer

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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, Tingting Jiang, Xiao-Ou Zhang, Yueying Cao, Zhiping Weng, and Wen Xue

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HIV-1 Evasion of Human TRIM5α via Cyclophilin A, Kyusik Kim

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Ultrastructural Details of Mammalian Chromosome Architecture, Nils Krietenstein, Sameer Abraham, Sergey V. Venev, Nezar Abdennur, Johan H. Gibcus, Tsung-Han S. Hsieh, Krishna M. Parsi, Liyan Yang, Rene Maehr, Leonid A. Mirny, Job Dekker, and Oliver J. Rando (Molecular cell, 2020-03-14)

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An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes, Nathan D. Lawson, Rui Li, Masahiro Shin, Ann S. Grosse, Onur Yukselen, Oliver A. Stone, Alper Kucukural, and Lihua Julie Zhu

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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells, Nayara C. Leite, Elad Sintov, Torsten B. Meissner, Michael A. Brehm, Dale L. Greiner, David M. Harlan, and Douglas A. Melton