The Program in Molecular Medicine at the University of Massachusetts Medical School was established in a new research building in 1989. Faculty include both clinical investigators and basic scientists, many of whom focus their research on human disease processes. The laboratory groups and core facilities that compose Molecular Medicine represent many disciplines in the bio-medical sciences: biochemistry and molecular biology, cell biology, medicine, immunology, molecular genetics and microbiology, pediatrics, pharmacology, physiology, genomics, bioinformatics and proteomics. This diverse scientific environment makes the Program an exceptional training ground for graduate students and postdoctoral fellows, who in turn contribute much to its vitality and excitement. This collection showcases publications and presentations written by faculty and researchers of the Program in Molecular Medicine.

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Publications from 2020

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Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution, Gaurav Chauhan, Jesse McClure, Jessica Hekman, Patrick W. Marsh, Jeffrey A. Bailey, Rachel F. Daniels, Diane P. Genereux, and Elinor K. Karlsson

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen

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Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation, Asia N. Matthew-Onabanjo, Jenny Janusis, Jose Mercado-Matos, Anne E. Carlisle, Dohoon Kim, Fayola Levine, Peter Cruz-Gordillo, Ryan Richards, Michael J. Lee, and Leslie M. Shaw (Cancer research, 2020-01-15)

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Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice, Sambra D. Redick, Linda Leehy, Ann R. Rittenhouse, David M. Blodgett, Alan G. Derr, Alper Kucukural, Manuel Garber, Leonard D. Shultz, Dale L. Greiner, Jennifer P. Wang, David M. Harlan, Rita Bortell, and Agata Jurczyk

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An atlas of cell types in the mammalian epididymis and vas deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

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SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC, Christian F. Ruiz, Emily D. Montal, John A. Haley, and John D. Haley

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Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice, Zhenyu Wang, Yuqin Shi, Suheng Ma, Qian Huang, Yi Tian Yap, Lin Shi, Shiyang Zhang, Ting Zhou, Wei Li, Bo Hu, Ling Zhang, Stephen A. Krawetz, Gregory J. Pazour, Rex A. Hess, and Zhibing Zhang

Publications from 2019

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A novel vaccine platform using glucan particles for induction of protective responses against Francisella tularensis and other pathogens, Ambily Abraham, Gary R. Ostroff, Stuart M. Levitz, and P. C. F. Oyston

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Humanized immune system mouse models: progress, challenges and opportunities, Todd M. Allen, Michael A. Brehm, Sandra Bridges, Stacy Ferguson, Priti Kumar, Oleg Mirochnitchenko, Karolina Palucka, Roberta Pelanda, Brigitte Sanders-Beer, Leonard D. Shultz, Lishan Su, and Mercy PrabhuDas

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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Chantal M. Ferguson, Dimas Echeverria, Ellen Sapp, Reka A. Haraszti, Andrew H. Coles, Faith Conroy, Rachael Miller, Loic Roux, Paul Yan, Emily G. Knox, Anton A. Turanov, Robert M. King, Gwladys Gernoux, Christian Mueller, Heather Gray-Edwards, Richard P. Moser, N Bishop, Samer M. Jaber, Matthew J. Gounis, Miguel Sena-Esteves, Athma A. Pai, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

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Progressive alignment with Cactus: a multiple-genome aligner for the thousand-genome era, Joel Armstrong, Elinor K. Karlsson, and Benedict Paten

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Utilizing Humanized Mice to Study Human Specific Innate Immune Responses in Immuno-Oncology, Ken-Edwin Aryee

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Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo, Thiago M. Batista, Ruben Garcia-Martin, Weikang Cai, Masahiro Konishi, Brian T. O'Neill, Masaji Sakaguchi, Jong Hun Kim, Dae Young Jung, Jason K. Kim, and C. Ronald Kahn

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Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo, Annabelle Biscans, Andrew H. Coles, Reka A. Haraszti, Dimas Echeverria, Matthew R. Hassler, Maire F. Osborn, and Anastasia Khvorova

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Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism, Alecia M. Blaszczak, Valerie P. Wright, Kajol Anandani, Joey Liu, Anahita Jalilvand, Stephen Bergin, Sarah M. Nicoloro, Michael P. Czech, William Lafuse, Tuo Deng, David Bradley, and Willa A. Hsueh

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Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon

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Defective daily temperature regulation in a mouse model of amyotrophic lateral sclerosis, Maurine C. Braun, Alexandra Castillo-Ruiz, Premananda Indic, Dae Young Jung, Jason K. Kim, Robert H. Brown Jr., Steven J. Swoap, and William J. Schwartz

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A Persistence Detector for Metabolic Network Rewiring in an Animal, Jote T. Bulcha, Gabrielle E. Giese, Zulfikar Ali, Yong-Uk Lee, Melissa D. Walker, Amy D. Holdorf, L. Safak Yilmaz, Robert C. Brewster, and Albertha J. M. Walhout

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Circulating microRNA Profiles in Acetaminophen Toxicity, Stephanie Carreiro, James Marvel-Coen, Rosalind Lee, Brittany Chapman, and Victor R. Ambros

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Bacillus thuringiensis Cry5B is Active against Strongyloides stercoralis in vitro, Sarit Charuchaibovorn, Vivornpun Sanprasert, Nataya Sutthanont, Yan Hu, Ambily Abraham, Gary R. Ostroff, Raffi V. Aroian, Tegegn G. Jaleta, James B. Lok, and Surang Nuchprayoon

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TRIM5alpha Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation, Abhilash I. Chiramel, Nicholas R. Meyerson, Kristin L. McNally, Rebecca M. Broeckel, Vanessa R. Montoya, Omayra Mendez-Solis, Shelly J. Robertson, Gail L. Sturdevant, Kirk J. Lubick, Vinod Nair, Brian H. Youseff, Robin M. Ireland, Catharine M. Bosio, Kyusik Kim, Jeremy Luban, Vanessa M. Hirsch, R. Travis Taylor, Fadila Bouamr, Sara L. Sawyer, and Sonja M. Best

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The C. elegans heterochronic gene lin-28 coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesis, Sungwook Choi and Victor R. Ambros

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Toll family members bind multiple Spatzle proteins and activate antimicrobial peptide gene expression in Drosophila, Munmun Chowdhury, Chun-Feng Li, Zhen He, Yuzhen Lu, Xu-Sheng Liu, Yu-Feng Wang, Y. Tony Ip, Michael R. Strand, and Xiao-Qiang Yu

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A big-data approach to understanding metabolic rate and response to obesity in laboratory mice, June K. Corrigan, Deepti Ramachandran, Yuchen He, Colin Palmer, Michael J. Jurczak, Bingshan Li, Randall H. Friedline, Jason K. Kim, Jon J. Ramsey, Louise Lantier, Owen P. McGuinness, Alexander S. Banks, and Mouse Metabolic Phenotyping Center Energy Balance Working Group

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A minimal CRISPR-Cas3 system for genome engineering, Bálint Csörgő, Lina M. León, Ilea J. Chau-Ly, Alejandro Vasquez-Rifo, Joel D. Berry, Caroline Mahendra, Emily D. Crawford, Jennifer D. Lewis, and Joseph Bondy-Denomy

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Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling, Luca D'Agostino, Yingchao Nie, Qi Li, Y. Tony Ip, and Nan Gao

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Harnessing robotic automation and web-based technologies to modernize scientific outreach, Orna Dahan, Bat-Shahar Dorfman, Serkan Sayin, Brittany Rosener, Tiffany Hua, Anat Yarden, and Amir Mitchell

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Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes, Sanchaita Das, Andrew W. Malaby, Agata Nawrotek, Wenhua Zhang, Mahel Zeghouf, Sarah Maslen, Mark Skehel, Srinivas Chakravarthy, Thomas C. Irving, Osman Bilsel, Jacqueline Cherfils, and David G. Lambright

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High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network, Antje Dittmann, Norman J. Kennedy, Nina L. Soltero, Nader Morshed, Miyeko D. Mana, Omer H. Yilmaz, Roger J. Davis, and Forest M. White

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TRAPPing a Rab GTPase by the Tail, Jianjun Duan and David G. Lambright

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Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver, Sabrina N. Dumas, Chang-An Guo, Jason K. Kim, Randall H. Friedline, and James M. Ntambi

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A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ildar Gainetdinov, Yeonsoo Yoon, Chun-Qing Song, Yueying Cao, Judith Gallant, Wen Xue, Jaime A. Rivera, and Erik J. Sontheimer

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Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans, Nicole Ehrhardt, Jinrui Cui, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Helen S. Goodridge, Jason K. Kim, Louise Lantier, Xiuqing Guo, Yii-Der I. Chen, Leslie J. Raffel, Thomas A. Buchanan, Willa A. Hsueh, Jerome I. Rotter, Mark O. Goodarzi, and Miklos Peterfy

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Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations, Shady Farah, Dale L. Greiner, and Daniel G. Anderson

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Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability, Jessica L. Feldman and Craig L. Peterson

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Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females, Sully Fernandez, John M. Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, and Kathryn E. Wellen

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Inferring population dynamics from single-cell RNA-sequencing time series data, David S. Fischer, Anna K. Fiedler, Eric M. Kernfeld, Ryan Genga, Aimee Bastidas-Ponce, Mostafa Bakhti, Heiko Lickert, Jan Hasenauer, Rene Maehr, and Fabian J. Theis

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Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat, Timothy P. Fitzgibbons, Nancy Lee, Khanh-Van T. Tran, Sarah M. Nicoloro, Mark Kelly, Stanley Kc Tam, and Michael P. Czech

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Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing, Bianca Garcia, Jooyoung Lee, Alireza Edraki, Yurima Hidalgo-Reyes, Steven Erwood, Aamir Mir, Chantel N. Trost, Uri Seroussi, Sabrina Y. Stanley, Ronald D. Cohn, Julie M. Claycomb, Erik J. Sontheimer, Karen L. Maxwell, and Alan R. Davidson

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Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1, Melissa A. Gawron, Mark Duval, Claudia Carbone, Smita Jaiswal, Aaron Wallace, Joseph C. Martin 3rd, Ann Dauphin, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Jeremy Luban, and Lisa A. Cavacini

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Towards Understanding the Molecular Basis of Human Endoderm Development Using CRISPR-Effector and Single-Cell Technologies, Ryan M. Genga

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Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development, Ryan M. Genga, Eric M. Kernfeld, Krishna M. Parsi, Teagan J. Parsons, Michael J. Ziller, and Rene Maehr

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Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis, Hilda E. Ghadieh, Lucia Russo, Harrison T. Muturi, Simona S. Ghanem, Iyad H. Manaserh, Hye Lim Noh, Sujin Suk, Jason K. Kim, Jennifer W. Hill, and Sonia M. Najjar

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Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling, Alec Gramann, Arvind M. Venkatesan, Melissa Guerin, and Craig J. Ceol

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Becoming a Principal Investigator: Designing and Navigating Your Academic Adventure, Paul L. Greer and Melanie A. Samuel

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Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus, Adilson L. Guilherme, Felipe Henriques, Alexander H. Bedard, and Michael P. Czech

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Preparation and characterization of yeast cell wall beta-glucan encapsulated humic acid nanoparticles as an enhanced aflatoxin B1 binder, Zeinab Hamza, Maher El-Hashash, Soher Aly, Amal Hathout, Ernesto Soto, Bassem Sabry, and Gary R. Ostroff

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, and Anastasia Khvorova

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Maize-Produced Ag2 as a Subunit Vaccine for Valley Fever, Celine A. Hayden, Chiung-Yu Hung, Hao Zhang, Austin Negron, Raymond Esquerra, Gary R. Ostroff, Ambily Abraham, Alejandro Gabriel Lopez, Juliet Elizabeth Gonzales, and John A. Howard

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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity, Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G. E. de Vries, Michael J. Lee, and Marcel A T M van Vugt

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WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data, Amy D. Holdorf, Daniel P. Higgins, Anne C. Hart, Peter R. Boag, Gregory J. Pazour, Albertha J. M. Walhout, and Amy K. Walker (Genetics, 2019-12-06)

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WormCat: an online tool for annotation and visualization of Caenorhabditis elegans genome-scale data, Amy D. Holdorf, Daniel P. Higgins, Anne C. Hart, Peter R. Boag, Gregory J. Pazour, Albertha J. M. Walhout, and Amy K. Walker

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De Novo Lipogenesis as a Source of Second Messengers in Adipocytes, Wen-Yu Hsiao and David A. Guertin

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A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis, Carmen Hurtado Del Pozo, Randall H. Friedline, Hye Lim Noh, Jason K. Kim, and Ann Marie. Schmidt

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Robustness Mechanisms of Temporal Cell-Fate Progression in C. Elegans, Orkan Ilbay

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Pheromones and Nutritional Signals Regulate the Developmental Reliance on let-7 Family MicroRNAs in C. elegans, Orkan Ilbay and Victor R. Ambros

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Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans, Orkan Ilbay and Victor R. Ambros

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Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim, Sonal Jangalwe, Varun N. Kapoor, Jia Xu, Nomeda Girnius, Norman J. Kennedy, Yvonne J. K. Edwards, Raymond M. Welsh, Roger J. Davis, and Michael A. Brehm

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1, Su Myung Jung, Chien-Min Hung, Samuel R. Hildebrand, Joan Sanchez-Gurmaches, Dimpi Mukhopadhyay, Camila Martinez Calejman, Amelia K. Luciano, Wen-Yu Hsiao, Yuefeng Tang, Huawei Li, and David A. Guertin

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Conserved Features of the T Cell Receptor Repertoire Contribute to the Persistence of EBV-Specific CD8 T Cells, Larisa Kamga

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CDR3alpha drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection, Larisa Kamga, Anna Gil, InYoung Song, Robin M. Brody, Dario Ghersi, Nuray Aslan, Lawrence J. Stern, Liisa K. Selin, and Katherine Luzuriaga

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Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis, Shashi Kant, Siobhan M. Craige, Kai Chen, Michaella M. Reif, Heather Learnard, Mark Kelly, Amada D. Caliz, Khanh-Van T. Tran, Kasmir Ramo, Owen M. Peters, Marc R. Freeman, Roger J. Davis, and John F. Keaney Jr.

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Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features, Joyce E. Karlinsey, Taylor A. Stepien, Matthew Mayho, Larissa A. Singletary, Lacey K. Bingham-Ramos, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Larry A. Gallagher, Matt Bawn, Robert A. Kingsley, Stephen J. Libby, and Ferric C. Fang

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Cyclophilin A protects HIV-1 from restriction by human TRIM5alpha, Kyusik Kim, Ann Dauphin, Sevnur Komurlu, Sean M. McCauley, Leonid Yurkovetskiy, Claudia Carbone, William E. Diehl, Caterina Strambio-De-Castilla, Edward M. Campbell, and Jeremy Luban

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DEBrowser: interactive differential expression analysis and visualization tool for count data, Alper Kucukural, Onur Yukselen, Deniz M. Ozata, Melissa J. Moore, and Manuel Garber

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Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes, Suet-Yan Kwan, Ankur Sheel, Chun-Qing Song, Xiao-Ou Zhang, Tingting Jiang, Hien Dang, Yueying Cao, Deniz M. Ozata, Haiwei Mou, Hao Yin, Zhiping Weng, Xin Wei Wang, and Wen Xue

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Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins, Jooyoung Lee, Haiwei Mou, Raed Ibraheim, Shun-Qing Liang, Pengpeng Liu, Wen Xue, and Erik J. Sontheimer

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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression, Huapeng Li, Qi Li, Kyvan Dang, Shan Ma, Jennifer L. Cotton, Sun Yang, Lihua Julie Zhu, April C. Deng, Y. Tony Ip, Randy L. Johnson, Xu Wu, Claudio Punzo, and Junhao Mao

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The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium, Qi Li, Niraj K. Nirala, Hsi-Ju Chen, Yingchao Nie, Wei Wang, Biliang Zhang, Michael P. Czech, Qi Wang, Lan Xu, Junhao Mao, and Y. Tony Ip

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Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice, Botao Liu, Gemma Molinaro, Huan Shu, Emily E. Stackpole, Kimberly M. Huber, and Joel D. Richter

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JNK(1/2) represses Lkb(1)-deficiency-induced lung squamous cell carcinoma progression, Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis, and Francesco J. DeMayo

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The History of Farm Foxes Undermines the Animal Domestication Syndrome, Kathryn A. Lord, Greger Larson, Raymond P. Coppinger, and Elinor K. Karlsson

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Oncogenic AKTivation by methylation, Amelia K. Luciano and David A. Guertin

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Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells, Leyuan Ma, Magnolia L. Pak, Jianhong Ou, Jun Yu, Pamela St Louis, Yi Shan, Lloyd Hutchinson, Shaoguang Li, Michael A. Brehm, Lihua Julie Zhu, and Michael R. Green

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mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis, Nuria Martinez, Catherine Y. Cheng, Natkunam Ketheesan, Aidan Cullen, Yuefeng Tang, Josephine Lum, Kim West, Michael Poidinger, David A. Guertin, Amit Singhal, and Hardy Kornfeld

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Nordic OCD and Related Disorders Consortium: Rationale, design, and methods, David Mataix-Cols, Bjarne Hansen, Manuel Mattheisen, Elinor K. Karlsson, Anjene M. Addington, Julia Boberg, Diana R. Djurfeldt, Matthew Halvorsen, Paul Lichtenstein, Stian Solem, Kerstin Lindblad-Toh, Jan Haavik, Gerd Kvale, Christian Ruck, and James J. Crowley

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma, Kate Megquier, Elinor K. Karlsson, and Kerstin Lindblad-Toh

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BarkBase: Epigenomic Annotation of Canine Genomes, Kate Megquier, Xue Li, Kathleen Morrill, Brittney Logan, and Elinor K. Karlsson

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Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells, So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Tiffany DeSouza, Ryan Genga, Alper Kucukural, Lawrence M. Lifshitz, Soren Nielsen, Camilla Scheele, Rene Maehr, Manuel Garber, and Silvia Corvera

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Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue, So Yun Min, Heather Learnard, Shashi Kant, Olga Gaelikman, Raziel Rojas-Rodriguez, Tiffany DeSouza, Anand Desai, John F. Keaney Jr., Silvia Corvera, and Siobhan M. Craige

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Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes, Elfawal A. Mostafa, Sergey N. Savinov, and Raffi V. Aroian

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CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling, Haiwei Mou, Deniz M. Ozata, Jordan L. Smith, Ankur Sheel, Suet-Yan Kwan, Soren Hough, Alper Kucukural, Zachary Kennedy, Yueying Cao, and Wen Xue

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Kaposi Sarcoma-associated Herpesvirus Glycoprotein H is Indispensable for Infection of Epithelial, Endothelial, and Fibroblast Cell Types, Murali Muniraju, Lorraine Z. Mutsvunguma, Joslyn Foley, Gabriela M. Escalante, Esther Rodriguez, Romina Nabiee, Jennifer Totonchy, David H. Mulama, Joshua Nyagol, Felix Wussow, Anne K. Barasa, Michael A. Brehm, and Javier Gordon Ogembo

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Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity, Charles Nelson and Victor R. Ambros

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Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila, Yingchao Nie, Shiyan Yu, Qi Li, Niraj K. Nirala, Alla Amcheslavsky, Yvonne J. K. Edwards, Patrick W. Shum, Zhong Jiang, Wei Wang, Biliang Zhang, Nan Gao, and Y. Tony Ip

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A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection, Jason B. Noon, Erich M. Schwarz, Gary R. Ostroff, and Raffi V. Aroian

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TRIM34 acts with TRIM5 to restrict HIV and SIV capsids, Molly Ohainle, Kyusik Kim, Sevnur Keceli, Abby Felton, Ed Campbell, Jeremy Luban, and Michael Emerman

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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways, Maire F. Osborn, Andrew H. Coles, Annabelle Biscans, Reka A. Haraszti, Loic Roux, Sarah M. Davis, Socheata Ly, Dimas Echeverria, Matthew R. Hassler, Bruno M. D. C. Godinho, Mehran Nikan, and Anastasia Khvorova

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Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters, Samuel C. Pan, Doyle V. Ward, Yunqiang Yin, Yan Hu, Elfawal A. Mostafa, Robert E. Clark, and Raffi V. Aroian

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Rapid evolution and conserved function of the piRNA pathway, Swapnil S. Parhad and William E. Theurkauf

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Adaptive evolution targets a piRNA precursor transcription network, Swapnil S. Parhad, Tianxiong Yu, Gen Zhang, Nicholas P. Rice, Zhiping Weng, and William E. Theurkauf

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Ciliary Doublet Microtubules at Near-Atomic Resolution, Gregory J. Pazour and Stephen M. King

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Cilia in cystic kidney and other diseases, Gregory J. Pazour, Lynne Quarmby, Abigail O. Smith, Paurav B. Desai, and Miriam Schmidts

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Enhanced Cas12a editing in mammalian cells and zebrafish, Pengpeng Liu, Kevin Luk, Masahiro Shin, Feston Idrizi, Samantha F. Kwok, Benjamin P. Roscoe, Esther Mintzer, Sneha Suresh, Kyle Morrison, Josias B. Frazao, Mehmet Fatih Bolukbasi, Karthikeyan Ponnienselvan, Jeremy Luban, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4(th) pharyngeal arch artery morphogenesis, Helen M. Phillips, Rene Maehr, and Simon D. Bamforth

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A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia, Tyler Picariello, Jason M. Brown, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Oliver D. King, Karl Lechtreck, Gregory J. Pazour, and George B. Witman

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No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications, Briana Quitadamo, Paul J. Peters, Matthew Koch, Katherine Luzuriaga, Cecilia Cheng-Mayer, Paul R. Clapham, and Maria Paz Gonzalez-Perez

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Smooth muscle cell-specific TMEM16A deletion does not alter Ca2+ signaling, uterine contraction, gestation length or litter size in micedagger, Mingzi Qu, Ping Lu, Karl D. Bellve, Kevin E. Fogarty, Lawrence M. Lifshitz, Fangxiong Shi, and Ronghua ZhuGe

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Adaptations of Adipose Tissue Expandability in Gestation are Associated with Maternal Glucose Metabolism, Raziel Rojas-Rodriguez