Chemokine signaling guides regional patterning of the first embryonic artery
UMass Chan Affiliations
Program in Molecular MedicineDepartment of Biochemistry and Molecular Pharmacology
Program in Gene Function and Expression
Document Type
Journal ArticlePublication Date
2009-10-03Keywords
AnimalsAorta
Body Patterning
Chemokines
Endothelial Cells
Gene Expression Regulation, Developmental
Receptors, CXCR4
*Signal Transduction
Zebrafish
Genetics and Genomics
Metadata
Show full item recordAbstract
The aorta traverses the body, yet little is known about how it is patterned in different anatomical locations. Here, we show that the aorta develops from genetically distinct endothelial cells originating from diverse locations within the embryo. Furthermore, chemokine (C-X-C motif) receptor 4a (cxcr4a) is restricted to endothelial cells derived from anterior mesoderm, and is required specifically for formation of the lateral aortae. Cxcl12b, a cxcr4a ligand, is expressed in endoderm underlying the lateral aortae, and loss of cxcl12b phenocopies cxcr4a deficiency. These studies reveal unexpected endothelial diversity within the aorta that is necessary to facilitate its regional patterning by local cues.Source
Genes Dev. 2009 Oct 1;23(19):2272-7. Link to article on publisher's siteDOI
10.1101/gad.1813509Permanent Link to this Item
http://hdl.handle.net/20.500.14038/44097PubMed ID
19797767Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1101/gad.1813509