Program in Gene Function and Expression; Program in Molecular Medicine
Endoplasmic Reticulum; Unfolded Protein Response; Insulin-Secreting Cells; Diabetes Mellitus; Wolfram Syndrome
Genetics and Genomics
In pancreatic beta-cells, the endoplasmic reticulum (ER) is the crucial site for insulin biosynthesis, as this is where the protein-folding machinery for secretory proteins is localized. Perturbations to ER function of the beta-cell, such as a high demand for insulin secretion, can lead to an imbalance in protein homeostasis and lead to ER stress. This stress can be mitigated by an adaptive, cellular response, the unfolded protein response (UPR). UPR activation is vital to the survival of beta-cells, as these cells represent one of the most susceptible tissues for ER stress, due to their highly secretory function. However, in some cases, this response is not sufficient to relieve stress, leading to apoptosis and contributing to the pathogenesis of diabetes. Recent evidence shows that ER stress plays a significant role in both type 1 and type 2 diabetes. In this review, we outline the mechanisms of ER stress-mediated beta-cell death and focus on the role of ER stress in various forms of diabetes, particularly a genetic form of diabetes called Wolfram syndrome.
DOI of Published Version
Islets. 2010 Jan-Feb;2(1):1-9. Link to article on publisher's site
Fonseca, Sonya G.; Urano, Fumihiko; Burcin, Mark; and Gromada, Jesper, "Stress hypERactivation in the beta-cell" (2010). Program in Gene Function and Expression Publications and Presentations. 64.