Title

Genomics tools for unraveling chromosome architecture

UMMS Affiliation

Program in Gene Function and Expression

Publication Date

2010-10-15

Document Type

Article

Subjects

Chromosomes; Chromosome Structures; Chromosome Mapping

Disciplines

Genetics and Genomics

Abstract

The spatial organization of chromosomes inside the cell nucleus is still poorly understood. This organization is guided by intra- and interchromosomal contacts and by interactions of specific chromosomal loci with relatively fixed nuclear 'landmarks' such as the nuclear envelope and the nucleolus. Researchers have begun to use new molecular genome-wide mapping techniques to uncover both types of molecular interactions, providing insights into the fundamental principles of interphase chromosome folding.

DOI of Published Version

10.1038/nbt.1680

Source

Nat Biotechnol. 2010 Oct 13;28(10):1089-1095. Link to article on publisher's site

Journal/Book/Conference Title

Nature biotechnology

Related Resources

Link to Article in PubMed

PubMed ID

20944601

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