Program in Gene Function and Expression; Information Services; Program in Molecular Medicine; Department of Biochemistry and Molecular Pharmacology
DNA-Binding Proteins; Drosophila Proteins; Transcription Factors; Databases, Protein; Protein Interaction Domains and Motifs
Genetics and Genomics
FlyFactorSurvey (http://pgfe.umassmed.edu/TFDBS/) is a database of DNA binding specificities for Drosophila transcription factors (TFs) primarily determined using the bacterial one-hybrid system. The database provides community access to over 400 recognition motifs and position weight matrices for over 200 TFs, including many unpublished motifs. Search tools and flat file downloads are provided to retrieve binding site information (as sequences, matrices and sequence logos) for individual TFs, groups of TFs or for all TFs with characterized binding specificities. Linked analysis tools allow users to identify motifs within our database that share similarity to a query matrix or to view the distribution of occurrences of an individual motif throughout the Drosophila genome. Together, this database and its associated tools provide computational and experimental biologists with resources to predict interactions between Drosophila TFs and target cis-regulatory sequences.
DOI of Published Version
Nucleic Acids Res. 2011 Jan;39(Database issue):D111-7. Epub 2010 Nov 19. Link to article on publisher's site
Nucleic acids research
Zhu, Lihua Julie; Christensen, Ryan G.; Kazemian, Majid; Hull, Christopher J.; Enuameh, Metewo Selase; Basciotta, Matthew D.; Brasefield, Jessie A.; Zhu, Cong; Asriyan, Yuna; Lapointe, David S.; Sinha, Saurabh; Wolfe, Scot A.; and Brodsky, Michael H., "FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system" (2011). Program in Gene Function and Expression Publications and Presentations. 37.