Title
Chromatin-mediated Candida albicans virulence
UMMS Affiliation
Program in Gene Function and Expression
Publication Date
2012-1
Document Type
Article
Subjects
Candida albicans; Candidiasis; Chromatin; DNA Repair; Genomic Instability; Host-Pathogen Interactions; Humans; Transcription, Genetic; Virulence
Disciplines
Biochemistry | Genetics and Genomics | Immunopathology | Pathogenic Microbiology
Abstract
Candida albicans is the most prevalent human fungal pathogen. To successfully propagate an infection, this organism relies on the ability to change morphology, express virulence-associated genes and resist DNA damage caused by the host immune system. Many of these events involve chromatin alterations that are crucial for virulence. This review will focus on the studies that have been conducted on how chromatin function affects pathogenicity of C. albicans and other fungi. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
Keywords
Candida albicans, Rtt109, Histone H3 lysine 56, Chromatin modification, DNA damage, Fungal pathogen
DOI of Published Version
10.1016/j.bbagrm.2011.08.007
Source
Jessica Lopes da Rosa, Paul D. Kaufman, Chromatin-mediated Candida albicans virulence, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1819, Issues 3–4, March–April 2012, Pages 349-355, http://dx.doi.org/10.1016/j.bbagrm.2011.08.007.
Journal/Book/Conference Title
Biochimica et biophysica acta
Related Resources
PubMed ID
24459737
Repository Citation
Lopes da Rosa, Jessica and Kaufman, Paul D., "Chromatin-mediated Candida albicans virulence" (2012). Program in Gene Function and Expression Publications and Presentations. 238.
https://escholarship.umassmed.edu/pgfe_pp/238
Comments
First author Jessica Lopes da Rosa is a doctoral student in the Interdisciplinary Graduate Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.