Aneuploidy: cells losing their balance
Program in Gene Function and Expression; Program in Molecular Medicine
*Aneuploidy; Animals; Embryonic Development; Gene Dosage; Gene Duplication; Humans; Mice; Models, Genetic; Neoplasms
Cancer Biology | Cell Biology | Cellular and Molecular Physiology | Developmental Biology | Genetics and Genomics | Molecular Genetics
A change in chromosome number that is not the exact multiple of the haploid karyotype is known as aneuploidy. This condition interferes with growth and development of an organism and is a common characteristic of solid tumors. Here, we review the history of studies on aneuploidy and summarize some of its major characteristics. We will then discuss the molecular basis for the defects caused by aneuploidy and end with speculations as to whether and how aneuploidy, despite its deleterious effects on organismal and cellular fitness, contributes to tumorigenesis.
DOI of Published Version
Genetics. 2008 Jun;179(2):737-46. doi: 10.1534/genetics.108.090878. Link to article on publisher's site
Torres, Eduardo M.; Williams, Bret R.; and Amon, Angelika, "Aneuploidy: cells losing their balance" (2008). Program in Gene Function and Expression Publications and Presentations. 222.