Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation
Program in Gene Function and Expression; Program in Molecular Medicine
X Chromosome Inactivation
Genetics and Genomics
One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.
DOI of Published Version
Cell Res. 2012 Jun 26. doi: 10.1038/cr.2012.98. Link to article on publisher's site
Bach I. (2012). Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation. Program in Gene Function and Expression Publications. https://doi.org/10.1038/cr.2012.98. Retrieved from https://escholarship.umassmed.edu/pgfe_pp/202