Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation
Authors
Bach, IngolfDocument Type
Journal ArticlePublication Date
2012-06-26
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One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.Source
Cell Res. 2012 Jun 26. doi: 10.1038/cr.2012.98. Link to article on publisher's siteDOI
10.1038/cr.2012.98Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43994PubMed ID
22785560Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/cr.2012.98