NURDs are required for diversity
Program in Gene Function and Expression; Program in Molecular Medicine; Department of Biochemistry and Molecular Pharmacology
Mi-2 Nucleosome Remodeling and Deacetylase Complex
Biochemistry, Biophysics, and Structural Biology | Genetics and Genomics
Embryonic stem cells (ESCs) can maintain their undifferentiated state indefinitely in culture (self-renewal), but must also retain the ability to differentiate into the various cell types found in the body (pluripotency). The co-existence of these two properties requires a balance between stable maintenance of ESC identity and the flexibility to reprogram cellular identity upon receiving a differentiation signal. The mechanisms underlying this developmental flexibility are largely unknown.
DOI of Published Version
EMBO J. 2012 May 11. doi: 10.1038/emboj.2012.137. Link to article on publisher's site
The EMBO journal
Fazzio, Thomas G. and Rando, Oliver J., "NURDs are required for diversity" (2012). Program in Gene Function and Expression Publications and Presentations. 194.