UMMS Affiliation

Program in Gene Function and Expression; Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology

Publication Date

2012-06-05

Document Type

Article

Subjects

Repressor Proteins; DNA-Binding Proteins; Chromosomal Proteins, Non-Histone; Neurons; Gene Expression Regulation

Disciplines

Genetics and Genomics

Abstract

In the brain neurons form extensively intermingled projections and synaptic interactions between them. To achieve proper neural connectivity, interactions between sections belonging to the same neuron are avoided. However, how can a cell tell, when it encounters another neuronal projection, whether it is part of the same cell? In other words, how do neurons become self-aware?

Rights and Permissions

Publisher PDF posted as allowed by the publisher's author rights policy at http://www.pnas.org/site/misc/authorfaq.shtml.

DOI of Published Version

10.1073/pnas.1206195109

Source

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8799-800. Epub 2012 May 21. Link to article on publisher's site

Journal/Book/Conference Title

Proceedings of the National Academy of Sciences of the United States of America

Related Resources

Link to Article in PubMed

PubMed ID

22615386

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