Program in Systems Biology; Program in Gene Function and Expression
Gene Expression Regulation
Genetics and Genomics
Recent advances in sequencing technologies have uncovered a world of RNAs that do not code for proteins, known as non-protein coding RNAs, that play important roles in gene regulation. Along with histone modifications and transcription factors, non-coding RNA is part of a layer of transcriptional control on top of the DNA code. This layer of components and their interactions specifically enables (or disables) the modulation of three-dimensional folding of chromatin to create a context for transcriptional regulation that underlies cell-specific transcription. In this perspective, we propose a structural and functional hierarchy, in which the DNA code, proteins and non-coding RNAs act as context creators to fold chromosomes and regulate genes.
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DOI of Published Version
F1000 Biology Reports 2012, 4:8 (doi:10.3410/B4-8). Link to article on publisher's website
F1000 biology reports
Gibcus JH, Dekker J. (2012). The context of gene expression regulation. Program in Gene Function and Expression Publications. https://doi.org/10.3410/B4-8. Retrieved from https://escholarship.umassmed.edu/pgfe_pp/189