Coordination of cell growth and division by the ubiquitin-proteasome system
Program in Gene Function and Expression; Program in Molecular Medicine
Ubiquitin-Protein Ligase Complexes; Ubiquitin; Cell Cycle; Proteolysis
Genetics and Genomics
The coupling of cellular growth and division is crucial for a cell to make an accurate copy of itself. Regulated protein degradation by the ubiquitin-proteasome system (UPS) plays an important role in the coordination of these two processes. Many ubiquitin ligases, in particular the Skp1-Cullin-F-box (SCF) family and the Anaphase-Promoting Complex (APC), couple growth and division by targeting cell cycle and metabolic regulators for degradation. However, many regulatory proteins are targeted by multiple ubiquitin ligases. As a result, we are only just beginning to understand the complexities of the proteolytic regulatory network that connects cell growth and the cell cycle.
DOI of Published Version
Semin Cell Dev Biol. 2012 Apr 19. [Epub ahead of print] doi 10.1016/j.semcdb.2012.04.005
Seminars in cell and developmental biology
Benanti, Jennifer A., "Coordination of cell growth and division by the ubiquitin-proteasome system" (2012). Program in Gene Function and Expression Publications and Presentations. 187.