Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish
Program in Gene Function and Expression; Department of Biochemistry and Molecular Pharmacology
Zebrafish; Genetic Techniques
Genetics and Genomics
The development of facile forward and reverse genetic approaches has propelled the deconvolution of gene function in biology. While the origins of these techniques reside in the study of single-cell or invertebrate organisms, in many cases these approaches have been applied to vertebrate model systems to gain powerful insights into gene function during embryonic development. This perspective provides a summary of the major forward and reverse genetic approaches that have contributed to the study of vertebrate gene function in zebrafish, which has become an established model for the study of animal development.
DOI of Published Version
Dev Cell. 2011 Jul 19;21(1):48-64. Link to article on publisher's site
Lawson ND, Wolfe SA. (2011). Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish. Program in Gene Function and Expression Publications. https://doi.org/10.1016/j.devcel.2011.06.007. Retrieved from https://escholarship.umassmed.edu/pgfe_pp/167