Program in Gene Function and Expression; Program in Molecular Medicine
Gene Regulatory Networks
Genetics and Genomics
Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.
DOI of Published Version
Genome Biol. 2011 Apr 11;12(4):109. Link to article on publisher's site
Walhout, Albertha J. M., "What does biologically meaningful mean? A perspective on gene regulatory network validation" (2011). Program in Gene Function and Expression Publications and Presentations. 158.