Program in Gene Function and Expression; Program in Molecular Medicine
Gene Regulatory Networks
Genetics and Genomics
Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.
DOI of Published Version
Genome Biol. 2011 Apr 11;12(4):109. Link to article on publisher's site
Walhout AJ. (2011). What does biologically meaningful mean? A perspective on gene regulatory network validation. Program in Gene Function and Expression Publications. https://doi.org/10.1186/gb-2011-12-4-109. Retrieved from https://escholarship.umassmed.edu/pgfe_pp/158