Program in Gene Function and Expression
Animals; Chromatin; Chromosomes; DNA, Plant; Humans; Meiosis; Mitosis; Models, Biological; Nucleic Acid Conformation; Stress, Mechanical; Time Factors
Genetics and Genomics
We propose that chromosome function is governed by internal mechanical forces generated by programmed tendencies for expansion of the DNA/chromatin fiber against constraining features.
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Copyright © 2004, The National Academy of Sciences
Publisher PDF posted as allowed by the publisher's author rights policy at http://www.pnas.org/site/misc/authorfaq.shtml.
DOI of Published Version
Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12592-7. Epub 2004 Aug 6. Link to article on publisher's site
Proceedings of the National Academy of Sciences of the United States of America
Kleckner N, Zickler D, Jones GH, Dekker J, Padmore R, Henle J, Hutchinson JN. (2004). A mechanical basis for chromosome function. Program in Gene Function and Expression Publications. https://doi.org/10.1073/pnas.0402724101. Retrieved from https://escholarship.umassmed.edu/pgfe_pp/139