Title

Development of the pancreas and pancreatic cancer

UMMS Affiliation

Program in Gene Function and Expression; Program in Molecular Medicine

Publication Date

2006-04-25

Document Type

Article

Subjects

Adenocarcinoma; Animals; Disease Models, Animal; Fetal Development; Hedgehog Proteins; Humans; Mice; Pancreas; Pancreatic Neoplasms; Receptors, Notch; Signal Transduction; Trans-Activators

Disciplines

Genetics and Genomics

Abstract

The pancreas is specified during embryonic development from the gut endoderm. Among the signaling pathways required for the proper development of the organ are the notch and hedgehog signaling pathways. Both of these pathways are reactivated in pancreatic cancers, and sustained hedgehog signaling is required for the viability of most pancreatic cancer cell lines. Further, mouse models of the disease show activation of these pathways, and expression of pancreas progenitor markers. These findings indicate that developmentally regulated gene expression programs are important in the pathogenesis of pancreatic cancer.

DOI of Published Version

10.1016/j.ecl.2006.02.003

Source

Endocrinol Metab Clin North Am. 2006 Jun;35(2):397-404, xi. Link to article on publisher's site

Journal/Book/Conference Title

Endocrinology and metabolism clinics of North America

Related Resources

Link to Article in PubMed

PubMed ID

16632101

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